Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
  • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
  • A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
  • A61C8/0031—Juxtaosseous implants, i.e. implants lying over the outer surface of the jaw bone
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
  • A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
  • A61B5/0036—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room including treatment, e.g., using an implantable medical device, ablating, ventilating
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
  • A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
  • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
  • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
  • A61B6/03—Computerised tomographs
  • A61B6/032—Transmission computed tomography [CT]
• • A61B6/51—
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
  • A61C13/00—Dental prostheses; Making same
  • A61C13/0003—Making bridge-work, inlays, implants or the like
  • A61C13/0004—Computer-assisted sizing or machining of dental prostheses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
  • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
  • A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
  • A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
• • G—PHYSICS
  • G05—CONTROLLING; REGULATING
  • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
  • G05B19/00—Programme-control systems
  • G05B19/02—Programme-control systems electric
  • G05B19/18—Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form
  • G05B19/4097—Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by using design data to control NC machines, e.g. CAD/CAM
  • G05B19/4099—Surface or curve machining, making 3D objects, e.g. desktop manufacturing
• • G—PHYSICS
  • G05—CONTROLLING; REGULATING
  • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
  • G05B2219/00—Program-control systems
  • G05B2219/30—Nc systems
  • G05B2219/35—Nc in input of data, input till input file format
  • G05B2219/35012—Cad cam

Definitions

• the present invention relates to an implant for attachment to a bone, such as a mammal, such as a primate, for example, a human, having a support structure having at least one bone outer attachment section to be attached to the bone, and a method of making such an implant ,
• An implant is already known from the prior art, which is used inter alia as a jaw implant.
• This implant has a substantially plate-shaped configuration, which only conditionally in a maximum of two
• Planes can be aligned to the contour of the bone.
• the plate-shaped implant is adapted as far as possible to the bone structure, so that the implant on this best up or rests, so it rests only in one plane, and is fastened with a screw to the bone structure.
• Implant on the bone structure and a screw realized the position of the screw is predefined by the implant structure.
• the shape of the implant can only be adapted to the bone structure to a limited degree, it is not possible to ensure permanently stable positioning via support or support areas.
• the attachment of the entire implant by means of a single Screw can only prevent a shift transversely to the screw-in.
• the screw connection may at some time be released at least to the extent that a possible rotation of the implant about the screw-in axis can not be permanently prevented.
• the position of the attachment (the screw) is already defined by the given geometry of the implant. This has the consequence that the implant can not be used if necessary, because in the region of the attachment nerves and / or existing teeth are present, which by attaching the
• Implant damage by means of the screw In the event that existing, intact teeth hinder attachment of the implant, they must also be removed and replaced with artificial teeth.
• Bone structure be reconstructed in advance, for example, by replacing the missing structures with bone from the iliac crest or from the patient's fibula. This requires hospitalization of the patient.
• the implant has structures, such as. Holes with internal thread, which are prepared to receive one (or more) so-called abutment base. These are usually screwed into the structures provided.
• Abutmentsockel is in turn prepared for receiving a so-called abutment, which serves to receive an artificial denture. This means that the denture is connected to the implant via abutment base and abutments.
• the alignment of the dental prosthesis is fixed and can be adapted only slightly to the individual dentition structure of the patient.
• the screw-in axis of the abutment base in the implant usually also corresponds to the screw-in axis of the abutment into the abutment base.
• the implant can not (or only to a limited extent) be adapted to the force flow resulting from the chewing movement. This results in premature fatigue of the implant material up to fatigue fractures.
• the object of the invention is to avoid or at least mitigate the disadvantages of the prior art, and in particular an implant, even without
• previous implantations of the bone can be implanted thereby avoiding major surgery, and to provide a method of making such an implant and a method of implanting the implant.
• the object of the invention is achieved by projecting from the support structure a socket for receiving a prosthesis, such as an endoprosthesis or an exoprosthesis, directly or using an intermediate part (abutment).
• a prosthesis such as an endoprosthesis or an exoprosthesis
• the base is formed as an elevation or elevation contrasting with the surrounding outer contour of the support structure, for example in the manner of a projection.
• other components can be attached to or in or over this socket quickly and fatigue in a predetermined position.
• the base is an integral, one-piece and preferably einmaterialiger part of the support structure.
• the integral design of the support structure and base a connection point and thus a potential vulnerability is avoided.
• a particularly stable implant is the result.
• the base is prepared for receiving the prosthesis or an intermediate piece in a positive, positive and / or cohesive manner. This is a simple connection or recording of the prosthesis or the
• an advantageous embodiment provides that the preparation is a thread, such as an internal or external thread, or a retention shape, ie, such a contour, which facilitates or enables a positive and / or non-positive fastening.
• the retention form advantageously contains an undercut.
• the retention form has a dome-shaped, spherical or spherical distal part.
• the distal piece allows easy connection to or easy connection with the prosthesis or the
• the socket is a snap-lock type
• the prosthesis or the intermediate piece can be easily clipped onto the base and on other connecting elements, such as.
• a further advantageous embodiment provides that the intermediate piece is designed as a dental implant and preferably with the interposition of an abutment an artificial tooth or a crown holds or is prepared for holding, or is formed as an abutment.
• a plurality of pedestals are provided, which are designed in the manner of posts.
• Such a construction makes it possible to accommodate a plurality of artificial teeth and / or crowns or beam-like intermediate pieces which connect all pedestals to one another as transverse bars on the pedestals in order to improve the reception or connection of the prosthesis to the implant and / or increase the strength of the connection. or joint between prosthesis and implant to increase.
• a further possible advantageous embodiment provides that all longitudinal axes of the base extend transversely or obliquely to the longitudinal direction of the support structure. This makes it possible to align each of the pedestals for each patient individually adapted to the optimal positioning of the prosthesis.
• the bases can be connected to one another more easily with a transverse bar so as to increase the contact surface of the prosthesis and / or to improve the stability of the seat of the prosthesis.
• a further aspect of the invention provides that the support structure is formed like a grid or has one or more grid section (s) and / or perforated webs.
• the support structure is formed like a grid or has one or more grid section (s) and / or perforated webs.
• Lattice structure are promoted, resulting in a stable connection by the formation of a tertiary stability between the implant and the bone surrounding the implant. It is advantageous that the support structure, the grid section and / or the web has a perforation or a plurality of perforations in the manner of a through hole, something as a bore.
• the lattice structure can also simultaneously as
• Fastening device can be used and thus provided separately
• Attachment points / devices are dispensed with.
• the through hole is designed to receive a screw to be screwed into the bone. This makes it possible to dispense with the attachment of separate through holes on the implant for receiving screws.
• separating or spacing the distal piece from a cylinder stub portion over a dilution range is advantageous because it enables very low heights to be realized between the dental implant and the prosthesis seated thereon, because no minimum lengths, e.g. a minimum thread depth, must be observed.
• the base has a cylindrical outer contour or a power flow-optimized outer contour. As a result, fatigue of the implant material can be avoided due to non-power flow optimized design of the base.
• the base has an at least partially, preferably on the distal side hollow cylinder-like expression. This form offers the greatest possible variation for the design of the connection of the prosthesis.
• the pedestal (s) is / are advantageously inserted and / or positioned to replace bone material, or is / are bone material substitutes
• an implant has several components
• Bone form-fitting sections are present, and are geometrically formed and aligned so that a form-locking engagement with the bone
• the bone-form-fitting sections are aligned so geometrically with respect to us that the abutment forces a single stable bearing position of the implant on the bone.
• the positioning is simplified and the risk of incorrect positioning of the implant significantly reduced or almost completely avoided.
• Bone form-fitting sections are present has been found to be advantageous. By several spatially separated bone mold sections the investment and positioning accuracy of the implant is increased.
• each bone form-fitting section is prepared in another spatial direction at another bone section for installation.
• the investment and positioning accuracy of the implant is further increased, and the position stability of the implant is improved. This means that the implant can slip less in position.
• the preparation of the bone mold closure section for engaging a gripping of a bone section is advantageous.
• the risk of slippage of the implant is further reduced.
• the bone form-fitting section is formed by the support structure or a separate component, preferably in one piece, integrally and / or monotonously. Due to the one-piece training of
• Bone form-locking section and the support structure the number of parts can be reduced and material costs can be saved.
• the positioning accuracy of the support structure and / or the separate component is increased by the one-piece design.
• the patient-specific prefabricated embodiment of the bone mold closure section and / or the support structure as a solid component for example as a rod and / or with an individual bone and CAD / CAM insert with respect to this bone-near or bone-adjacent outer contour, has proved to be advantageous. As a result, an implant individually tailored to each patient's needs can be produced.
• the bone mold closure sections serve simultaneously as a drilling template and as a fastening device for attaching the implant to the bone.
• a further advantageous embodiment is that the bone form-fitting section and / or the support structure have a coupling region or a plurality of coupling regions in order to fix the bone-form-fitting section on the support structure.
• an implant is advantageous in which fixing regions are predefined and geometrically prepared on the support structure in order to receive one or more screws to be screwed into the bone, of which there are spatially spaced pedestals or a plurality of pedestals for receiving a prosthesis.
• the support structure serves both as a drilling and as a positioning template.
• the spatial separation of the attachment of the implant to the bone first Einschraubachse
• the attachment of the prosthesis second Einschraubachse
• a further advantageous embodiment provides that the attachment area by more than the length of a screw and / or more than 1, 2, 2 or 3 times the thickness in the mounting area and less than 500 times the length of a screw and / or less than 400 times the thickness in the attachment area from the socket.
• the base is designed so that it allows a connection of a prosthesis or an intermediate piece according to the locking or non-locking principle.
• the implant such as the support structure and / or the base or one of the base as a reservoir for a medical drug or a pharmacologically active ingredient is formed.
• active ingredients in particular those that must be administered / taken over a longer period, in the form of a drug-release system, such as. A drug-release capsule there to deposit and administer. This is an advantage especially for patients who need to take permanent medical or pharmacological agents, since such a dose is no longer forgotten and one
• Overdose can be avoided. It makes sense to use in this context, a probe metrology.
• Jaw implant such as a lower or upper jaw implant is formed. With such an implant partially edentulous and toothless jaws can be supplied.
• BMPs bone morphogenetic proteins
• Titanium alloys have a high biocompatibility and a high inertness and are therefore suitable as material for an implant.
• a further advantageous embodiment provides that a positioning aid is provided on the carrier structure and / or the base.
• the positioning aid is for the surgeon during insertion of the implant to control correct positioning and then in a follow-up to check if the implant may have moved.
• the positioning aid as a marker, such as
• Laser marking and / or grandeur, such as a bead is formed.
• the sublimity is particularly advantageous for a later control by means of an X-ray image, since it can be recognized on such images.
• Drilling template is an advantage. By integrating these functions into the implant or the support structure, additional means, usually as such, can be used
• the coupling region or the coupling regions has a hole that penetrates it partially or completely, somewhat in the manner of a borehole, preferably for receiving a screw.
• a method for producing an implant is described, with the step of acquiring individual patient data, such as the bone and / or soft tissue configuration, including the respective outer contour, for example using an MRI or CT, creating the support structure and / or the base on the basis of the individual patient data, for example with CAD / CAM techniques, preferably using a laser sintering production. Also described is a method of implanting an implant prepared as described above into an animal or human body.
• the implant has aligned screw holes so that they can be used as a drilling template for introducing holes in the bone.
• the implant also serves as a drilling template, which is why the surgeon no longer needs to position a separate surgical template. This will be the
• the screw holes are aligned at least obliquely / transversely or skewed.
• An oblique orientation of the screw holes here means that the screws are not arranged parallel to one another in a spatial direction, and skew describes the non-parallel alignment of the screw holes in at least two spatial directions.
• Screw hole is matched to the outer diameter of the drill and / or the planned hole in the bone.
• the implant also serves as a drilling template.
• the inner diameter of the screw hole is approximately 0.8, 0.85 or 0.9 to 0.99 times the planned bone hole. In this area, a precise positioning of the bone hole over the existing bone hole in the implant is possible.
• the implant itself is designed or usable as a drilling template with drill bushings / drill bushes.
• a further advantageous embodiment provides that the support structure has such an outer contour, such as by extensions, sublimities and / or depressions, the visible plastic changes to the implant
• implanted person leads This can be plastic corrections, or a
• the ringenagelocher be introduced so that after implanting the implant, the ringenagelocher be used as positive guidance for a drill, which is useful for the introduction of holes in the bone.
• the implant 1 has a numbering of the screw receiving holes, as well as two markings, of which one at the left and at the right end of the
• Bone contour sections is located.
• the numbering of the screw receiving holes serves the surgeon as
• Screw receiving holes screws should be placed, and he can make sure that he has placed all the necessary screws.
• the markings are formed as laser markings and / or sublime, which are recognizable by means of a probe. By means of such markings, the surgeon can firstly check the correct positioning of the implant. On the other hand, these markings can be used to mark the area in which the bone must be removed (for example due to tumor tissue) and thus serve as control marks during the procedure, which the surgeon can feel with the aid of a probe, and thus check can see if he has completely removed the bone area to be removed.
• the invention consists of an implant, which as
• Carrier structure serves and provides coupling regions for a prosthesis and a method for producing such an implant, and a method for implanting such an implant in an animal or human body.
• FIG. 1 is a perspective view of the implant in a first embodiment, for the lower jaw
• FIG. 2 shows a spatial representation of the implant in a second embodiment, for the lower jaw
• FIG. 4 is a perspective view of the implant in a third embodiment, for the lower jaw seen from above,
• 5 is a perspective view of the implant of the third embodiment, for the lower jaw obliquely lateral direction, 6 shows a front view of the implant in a fourth embodiment, for the upper jaw,
• FIG. 7 is a plan view of the implant of the fourth embodiment, for the
• FIG. 8 shows a spatial representation of the implant in a fifth embodiment, for the upper jaw in the implanted state
• FIG. 1 shows a spatial representation of the implant in a first embodiment, for the lower jaw.
• the implant 1 consists of a support structure 2, which has a plurality of bone outer structure-following attachment portions 3, and a plurality of sockets 4, which are integrally formed integrally with the support structure 2.
• the support structure 2 has a grid-like structure 5, which consists of annular
• the support structure 2 is precisely matched to the bone contour on which it rests or rests, adapted and can be divided into a main body 8 and distally extending sub-body 9, wherein the sub-body 9 correspond to the mounting portions 3.
• the attachment portions 3 extend in a line away from the main body 8 of the support structure 2 to the outside.
• the implant 1 has three pedestals 4, which are formed integrally with the support structure 2.
• the base 4 are hollow cylindrical and have different heights and inclinations. While the implant 1 is usually placed under the oral mucosa or the periosteum, the pedestals 4 project out of this, into the oral cavity and thus serve in this embodiment to receive an intermediate piece (not shown) or a so-called
• Fig. 2 shows a spatial representation of the implant in a second
• This second embodiment for the lower jaw.
• This second embodiment like the first embodiment, has a support structure 2 with a plurality of attachment sections 3.
• the contour of the support structure 2 with the attachment sections 3 is also exactly adapted in advance in this embodiment of the bone structure 10, on which the implant 1 rests.
• the second embodiment integrally integrally with the support structure 2
• this distal piece 12 can also be any other possible geometry instead of spherical, such as. Truncated pyramidal, cylindrical, cuboid,
• Distal piece 12 serves as part of a snap-lock type connection for receiving / attaching the prosthesis (not shown), such as a dental prosthesis, to implant 1.
• the prosthesis has the negative geometry matching the geometry of the distal piece 12.
• 3 shows an enlarged spatial representation of the implant 1 of the second embodiment. It can be clearly seen on this figure that the grid-like structure 5 or grid structure 5 is adapted exactly to the bone structure 10.
• the annular portions 6 of the grid-like structure 5 are in the manner of a
• Through hole 15 is formed, which for receiving a screwed into the bone structure 10 screw (not shown), as described above, is designed.
• the second embodiment shown here has two pedestals 4 with spherical distal pieces 12.
• the enlarged view clearly shows that the two pedestals 4 both different heights and different
• Embodiment for the lower jaw as seen from above.
• This embodiment also has two pedestals 4, which are formed integrally from a cylinder stump section 14 and a distal section 12.
• the implant 1 in the second embodiment has the third embodiment shown here along a direction of the longitudinal axis Li of the implant 1 (here in this figure above) longer attachment sections 3.
• Fig. 5 shows a three-dimensional view of the implant 1 of the third embodiment the lower jaw (from Fig. 4) from obliquely lateral direction.
• This view again illustrates the exact fit of the implant contour, or the support structure 2 with mounting portions 3 as a negative geometry to the underlying Bone structure 10 or as bone form-fitting sections 1 1.
• the contour of the implant 1 or the support structure 2 is exactly matched to the bone structure 10 on which the implant 1 or the support structure 2 rests in the fastened state.
• This precise shaping facilitates the surgeon's positioning of the implant 1 during the procedure for inserting the same.
• Positioning aids are largely dispensed with.
• one to three of the implant 1 teilezzierte or toothless lower jaw can be supplied to the number deficiency by means of a
• FIG. 6 shows a front view of the implant 1 in a fourth embodiment, which is designed for use in the upper jaw.
• the implant 1 also has a support structure 2 with attachment sections 3. However, this support structure 2 does not have a grid-like structure 5 (see FIGS. 1 to 5).
• the support structure 2 of this embodiment has a plurality of through-holes 15 in the form of bores with a counterbore section 16 for receiving, for example, countersunk screws (not shown), via which the implant 1 is connected to the bone structure 10 (not shown here, see FIGS. 1 to 5) is.
• the bases 4 each have different heights, which are precisely matched to the needs of the respective patient during the planning of the implant 1.
• the bases 4 are not located on one of the Longitudinal axis L2 of the implant 1 parallel lines, but are spaced from the longitudinal axis L2 of the implant 1 different (see also Fig. 7).
• Fig. 7 shows a plan view of the implant 1 of the fourth embodiment, for the upper jaw.
• the base 4 have different distances from the longitudinal axis L2 of the implant 1:
• the central axes M3, M 4 and M5 have different tilting or inclination angles to the longitudinal axis L2 of the implant 1. These angles are also determined during the planning of the implant in order to optimally adapt the prosthesis, which is received and worn by the implant 1, to the jaw and / or denture structure of the respective patient. In addition to the optimal alignment of the implant for the chewing load, this also makes it possible for the prosthesis to line up optimally in the partial dentition.
• the implant 1 again has a lattice-like design
• the support structure 2 has a plurality of attachment sections 3, which are adapted to the existing bone structure 10 in the contour
• the implant 1 has three pedestals 4, which each consist of a hollow cylindrical cylinder stump section 14.
• an abutment 17 is ever used, which consists of a cylinder stump portion 18 with a one-piece thus formed spherical Distal Swiss 19.
• the abutment 17 is screwed, for example, into the base 4.
• the spherical distal part 19 serves to connect the prosthesis (not shown) to the implant 1.
• FIG. 9 shows a side view of the implant of the fifth embodiment, for the upper jaw in the implanted state.
• the Central axes ⁇ , ⁇ and Ms of the respective base 4 again different Verkippungs- or inclination angle to a longitudinal axis l_3 of the support structure 2 have.
• the base 4 may also have slight curvatures, such as. Recognizable at the base 4 with the central axis ⁇ .
• the embodiment of the implant 1 depicted here is used, for example, to supply toothless upper jaw with frameworks or support structures 2 for receiving a prosthesis, wherein the frameworks connect both sides to one another via the palate.
• partially edentulous maxilla can be supplied, whereby the implant 1 conditions of larger bone defects (eg after tumor surgery with removal of parts of the upper jaw) can be treated.

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• 2015
  • 2015-12-23 DE DE102015122800.9A patent/DE102015122800B3/de active Active
• 2016
  • 2016-11-30 JP JP2018532701A patent/JP2018538101A/ja active Pending
  • 2016-11-30 CN CN201680076057.7A patent/CN108430382B/zh active Active
  • 2016-11-30 WO PCT/EP2016/079244 patent/WO2017108357A1/de active Application Filing
  • 2016-11-30 BR BR112018012778-7A patent/BR112018012778B1/pt active IP Right Grant
  • 2016-11-30 AU AU2016375815A patent/AU2016375815B2/en active Active
  • 2016-11-30 US US16/062,783 patent/US20200261189A1/en not_active Abandoned
  • 2016-11-30 EP EP16804779.3A patent/EP3393395A1/de not_active Withdrawn
  • 2016-11-30 RU RU2018126518A patent/RU2704916C1/ru active
  • 2016-11-30 CA CA3009091A patent/CA3009091A1/en not_active Abandoned
• 2021
  • 2021-08-27 JP JP2021139368A patent/JP7393399B2/ja active Active

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