EP3351165A1 - Sonde ultrasonore et système photo-acoustique ultrasonore et appareil d'imagerie d'objet d'inspection comprenant la sonde ultrasonore - Google Patents

Sonde ultrasonore et système photo-acoustique ultrasonore et appareil d'imagerie d'objet d'inspection comprenant la sonde ultrasonore Download PDF

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Publication number
EP3351165A1
EP3351165A1 EP17201053.0A EP17201053A EP3351165A1 EP 3351165 A1 EP3351165 A1 EP 3351165A1 EP 17201053 A EP17201053 A EP 17201053A EP 3351165 A1 EP3351165 A1 EP 3351165A1
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EP
European Patent Office
Prior art keywords
array device
ultrasonic
photoacoustic
ultrasonic probe
array
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17201053.0A
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German (de)
English (en)
Inventor
Yasuhiro Someda
Keishi Saito
Yasufumi Asao
Katsumi Nakagawa
Shigeru Ichihara
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Canon Inc
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Canon Inc
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Filing date
Publication date
Application filed by Canon Inc filed Critical Canon Inc
Publication of EP3351165A1 publication Critical patent/EP3351165A1/fr
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4416—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13—Tomography
    • A61B8/14—Echo-tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13—Tomography
    • A61B8/14—Echo-tomography
    • A61B8/145—Echo-tomography characterised by scanning multiple planes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • A61B8/4494—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer characterised by the arrangement of the transducer elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0825—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the breast, e.g. mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/483—Diagnostic techniques involving the acquisition of a 3D volume of data

Definitions

  • the present invention relates to an ultrasonic probe for transmitting and receiving an ultrasonic wave and for receiving a photoacoustic wave, and to a photoacoustic-ultrasonic system and an inspection object imaging apparatus including the ultrasonic probe.
  • a conventional tomographic imaging apparatus which obtains a tomographic image using an ultrasonic wave includes: a probe for transmitting an ultrasonic wave to a sample and receiving the reflected ultrasonic wave; a transmitting portion for supplying an ultrasonic signal to the probe; a receiving portion for receiving the reflected wave; and a unit for converting the received reflected wave signal into a luminance signal for visualization.
  • a time-series tomographic image acquired by the apparatus it is possible to observe an inside of a sample.
  • a unit for performing scanning of a probe two-dimensionally scans a sample with an ultrasonic wave to obtain a three-dimensional image.
  • an apparatus which utilizes a photoacoustic spectroscopy.
  • a photoacoustic spectroscopy visible light, near-infrared light, or mid-infrared light each having a predetermined wavelength is applied to the inspection object.
  • a specific substance inside the inspection object absorbs energy of the applied light, and as a result of the absorption, an elastic wave (photoacoustic wave) is generated and detected. In this manner, concentration of the specific substance is quantitatively measured.
  • the specific substance inside the inspection object is, for example, glucose or hemoglobin contained in blood.
  • a technology of acquiring a photoacoustic image through the photoacoustic spectroscopy is disclosed in, for example, Japanese Patent Application Laid-Open No. 2001-507952 .
  • the technology is referred to as a photoacoustic tomography (PAT).
  • PAT photoacoustic tomography
  • Japanese Patent Application Laid-Open No. 2005-021380 discloses a method of reconstructing both a photoacoustic image and a normal ultrasonic echo image using a one-dimensionally-arranged electromechanical transducer which is common to the both images; and a structure in which a lighting system using a glass fiber is provided between one-dimensionally-arranged electromechanical transducers.
  • the ultrasonic echo image and the photoacoustic image are simultaneously acquired, thereby displaying a morphologic image and a functional image.
  • a common probe is used to transmit and receive an ultrasonic wave for forming the ultrasonic echo image and to receive a photoacoustic wave for forming the photoacoustic image.
  • an elastic wave generated by the photoacoustic spectroscopy is referred to as a photoacoustic wave
  • a sonic wave which is transmitted and received in a normal pulse echo method is referred to as an ultrasonic wave.
  • the frequency band of a photoacoustic wave used in the photoacoustic spectroscopy is generally lower than the frequency band of an ultrasonic wave used in ultrasonography.
  • the frequency band of the photoacoustic wave is distributed within a range of 200 KHz to 2 MHz with 1 MHz being a center frequency.
  • the distribution of the frequency band of the photoacoustic wave is lower than a center frequency of 3.5 MHz of the ultrasonic wave used in ultrasonography.
  • the common probe is used to receive the photoacoustic wave and the ultrasonic wave used in ultrasonography.
  • the above-mentioned problem becomes more remarkable when the common probe is used to receive the waves as described in Japanese Patent Application Laid-Open No. 2005-021380 .
  • a photoacoustic-ultrasonic system including an ultrasonic probe and an optical system
  • the following problem arises.
  • a laser light is introduced using an optical fiber.
  • an extremely strong laser light is required, which may adversely affect the fiber.
  • the above-mentioned problem becomes more serious.
  • the optical fiber may not be selected as the optical system for detecting a sample having a certain volume.
  • An object of the present invention is to provide an ultrasonic probe capable of forming an image without degradation even when a frequency band of a photoacoustic wave and a frequency band of an ultrasonic wave used in ultrasonograpy are separated from each other, and an inspection object imaging apparatus including the ultrasonic probe.
  • Another object of the present invention is to provide a photoacoustic-ultrasonic system including the ultrasonic probe and an optical system, which is capable of applying pulse light having a strong light intensity for detecting a sufficient photoacoustic wave.
  • the present invention provides an ultrasonic probe, comprising: a first array device capable of transmitting and receiving an ultrasonic wave; and a second array device capable of receiving a photoacoustic wave, wherein the first array device includes plural electromechanical transducers arranged in a first direction; the second array device includes plural electromechanical transducers arranged two-dimensionally; and the first array device and the second array device are provided on the same plane and in a second direction perpendicular to the first direction.
  • the present invention also provides a photoacoustic-ultrasonic system, comprising: an optical system for introducing light emitted from a light source into an inspection object; and the ultrasonic probe, wherein the optical system is provided in an interspace between the first array device and the second array device.
  • the present invention also provides an inspection object imaging apparatus, comprising: a light source for generating pulse light; the ultrasonic probe; and a system control unit for controlling the light source and the ultrasonic probe to form an image.
  • the system control unit forms an image based on morphologic information inside an inspection object by using the first array device and forms an image based on functional information inside the inspection object by using the light source and the second array device.
  • an ultrasonic probe capable of forming an image without degradation even when the frequency band of the photoacoustic wave and the frequency band of the ultrasonic wave used in ultrasonography are separated from each other, and an inspection object imaging apparatus including the ultrasonic probe.
  • An ultrasonic probe includes a first array device capable of transmitting and receiving an ultrasonic wave; and a second array device capable of receiving a photoacoustic wave.
  • the first array device includes plural electromechanical transducers arranged in a first direction.
  • the second array device includes plural electromechanical transducers arranged two-dimensionally.
  • the first array device and the second array device are provided on the same plane and in a second direction.
  • the "same plane" is not necessarily required to be strictly the same plane as long as the plane can be regarded as substantially the same plane.
  • the plane on which the array devices are provided includes irregularities within a range of processing accuracy and includes inclination or level difference as long as the contact condition between an inspection object and the array device is not adversely affected. Even when irregularities or the like are intentionally provided on a surface of the plane in order to reduce contact resistance with the inspection object, similarly to the above-mentioned case, the irregularities or the like are acceptable as long as the contact condition between the inspection object and the array device is not adversely affected.
  • the second direction is typically a scanning direction and the first direction is typically a direction perpendicular to the scanning direction.
  • the ultrasonic probe and the inspection object imaging apparatus including the ultrasonic probe according to this embodiment may acquire an image of the inspection object even in a rest state without scanning the first array device and the second array device.
  • FIGS. 1A and 1B are structural views of the ultrasonic probe according to the present invention.
  • FIG. 1A is a schematic view and FIG. 1B is an enlarged view illustrating a transducer portion.
  • the ultrasonic probe includes a probe case 30, a cable 31, and a transducer 4.
  • the transducer 4 is comprised of an ultrasonic transducer 4a which is the first array device capable of transmitting and receiving an ultrasonic wave; and a photoacoustic transducer 4b which is the second array device capable of receiving a photoacoustic wave.
  • a one-dimensional (linear) array is employed for the ultrasonic transducer 4a while a two-dimensional array is employed for the photoacoustic transducer 4b.
  • the ultrasonic transducer 4a is used for revealing morphologic information of the inside of the inspection object, and therefore is a transducer capable of transmitting and receiving an ultrasonic wave higher in frequency than a photoacoustic wave received by the photoacoustic transducer 4b which acquires functional information.
  • the frequency band of the ultrasonic transducer 4a is 7 to 12 MHz as a typical value.
  • the "morphologic information" is information which is based on a morphology of the inside of the inspection object and obtained by a normal pulse echo method.
  • the photoacoustic transducer 4b is used for revealing functional information of the inside of the inspection object, and therefore is a transducer capable of receiving an ultrasonic wave (photoacoustic wave) lower in frequency than an ultrasonic wave transmitted and received by the ultrasonic transducer 4a which acquires morphologic information.
  • the frequency band of the photoacoustic transducer 4b is 1 to 4 MHz as a typical value.
  • the "functional information" is information which is obtained by a photoacoustic spectroscopy (photoacoustic imaging method) and relates to concentration of a specific substance inside the inspection object, such as glucose or hemoglobin contained in blood.
  • the reason why the one-dimensional array is employed for the ultrasonic transducer 4a is as follows.
  • the ultrasonic transducer 4a transmits and receives an ultrasonic wave having a relatively high frequency, and hence the device density thereof needs to be made high.
  • the number of transducer arrays is as large as 128 to 256 even in the one-dimensional array. Therefore, when the two-dimensional array is employed for the ultrasonic transducer 4a, it is not appropriate in terms of costs.
  • the main reason why the two-dimensional array is employed for the photoacoustic transducer 4b is that light utilization efficiency is regarded as important. Specifically, when photoacoustic waves generated by one irradiation with laser light are received by two-dimensionally-arranged devices, larger number of photoacoustic waves can be received compared with a case where the devices are one-dimensionally arranged.
  • the photoacoustic wave is generally lower in frequency than an ultrasonic echo, and hence the device density can be suppressed to be small. Accordingly, the two-dimensional array has a small influence on costs.
  • the number of transducer arrays in one line is approximately 10 to 50.
  • the ultrasonic transducer 4a includes the plural electromechanical transducers.
  • the electromechanical transducer is a device which conducts mutual conversion between an electrical signal and a mechanical vibration (ultrasonic wave), and, for example, a piezoelectric device is used therefor.
  • the plural electromechanical transducers are arranged in a direction (first direction) perpendicular to the scanning direction.
  • the photoacoustic transducer 4b is a device in which the electromechanical transducers are two-dimensionally arranged.
  • the electromechanical transducer include a transducer using a piezoelectric phenomenon, a transducer using optical resonance, and a transducer using a change in capacity.
  • Any detector may be employed as the electromechanical transducer as long as the detector can detect an acoustic wave. In a case where sizes of detection targets vary widely, bands of generated photoacoustic waves are also widened, and hence a required transducer favorably has a wide detection band.
  • an electrostatic capacity type ultrasonic transducer which has actively been studied in recent years, is one of most suitable transducers for the object of the present invention.
  • the same effect can be expected.
  • the ultrasonic probe according to this embodiment is manufactured in the following manner.
  • the ultrasonic transducer 4a one-dimensional array transducer
  • the photoacoustic transducer 4b two-dimensional array transducer
  • the method includes cutting out a piezoelectric transducer; fixing the transducer to a backing material; dicing the transducer; bonding an acoustic matching layer; and leading out a wiring portion.
  • an acoustic lens is attached to the ultrasonic transducer.
  • the ultrasonic transducer and the photoacoustic transducer are arranged with a space therebetween, and then fixed by molding. After that, the ultrasonic transducer and the photoacoustic transducer are fit into a housing, whereby the ultrasonic probe is completed.
  • the acoustic matching layer, the backing, and the wiring are provided on an upper surface and a lower surface of each of the transducers, and the acoustic lens is provided on the upper surface of the ultrasonic transducer. Those components are omitted in FIGS. 1A and 1B .
  • the ultrasonic transducer 4a and the photoacoustic transducer 4b have a positional relation in which the ultrasonic transducer 4a is provided in parallel to any one of four sides of the photoacoustic transducer 4b which is two-dimensionally arrayed.
  • the two array devices are housed in one probe case 30.
  • a probe case that houses the ultrasonic transducer 4a and a probe case that houses the photoacoustic transducer 4b may be provided to form one probe as a whole.
  • the two array devices are only required to be on the same plane and may be located with a certain space therebetween.
  • FIG. 2 is a block diagram illustrating an inspection object imaging apparatus using the ultrasonic probe according to this embodiment.
  • an ultrasonic signal is generated through a system control unit 1, a transmission beam former 2, and a transmission amplifier 3, and then a voltage is applied to the ultrasonic transducer 4a.
  • the transmitted ultrasonic wave is reflected on an inspection object 14 and received by the ultrasonic transducer 4a.
  • the received ultrasonic signal each of the signals of the respective devices in the ultrasonic probe, is subjected to phasing addition through a reception amplifier 5 and a reception beam former 6.
  • the reception beam former 6 performs analog-digital conversion, delay, and weighting control.
  • the ultrasonic signal is detected and converted into a luminance signal by an ultrasonic signal processing unit 10, and is accumulated in an image memory within an image processing unit 11.
  • a photoacoustic wave is detected in the following manner.
  • a light source 13 irradiates the inspection object 14 with pulse laser light.
  • the pulse laser light is emitted by transmitting a drive signal from the system control unit 1 to the light source 13.
  • a detection target inside the inspection object 14 such as hemoglobin, absorbs energy of the laser light.
  • the temperature of the detection target rises in accordance with the amount of the absorbed energy. As a result of the temperature rise, the detection target momentarily expands to generate an elastic wave (photoacoustic wave).
  • the generated photoacoustic wave is received by the photoacoustic transducer 4b, passes through a reception amplifier 7 and an analog-digital converter 8, and then is subjected to an image reconstruction processing by a photoacoustic signal processing unit 9.
  • the reconstructed photoacoustic signal is accumulated as a luminance signal in the image memory within the image processing unit 11.
  • the image processing unit 11 superimposes the accumulated ultrasonic signals on the accumulated photoacoustic signals followed by image display by an image display unit 12.
  • the one-dimensional array is employed for the ultrasonic transducer and the two-dimensional array is employed for the photoacoustic transducer, and hence, in order to acquire volume data with the use of the ultrasonic probe according to this embodiment, scanning is performed with the ultrasonic probe.
  • FIG. 3 is a conceptual diagram of scanning performed with the ultrasonic probe according to this embodiment, and illustrates scanning areas 20a, 20b, and 20c.
  • the ultrasonic probe is moved in the second direction (X direction of FIG. 3 ) in which the ultrasonic transducer 4a and the photoacoustic transducer 4b are arranged.
  • the ultrasonic probe is moved in a longitudinal direction (Y direction of FIG. 3 ) by a stripe width of the scanning area and then is moved over the scanning area 20b in the opposite direction.
  • the above-mentioned scanning is repeatedly performed, whereby signals of an entire inspection area are acquired.
  • the following three patterns of methods are conceivable for the scanning: (a) a method in which a photoacoustic signal is acquired during a stage suspension period and an ultrasonic signal is acquired during a stage moving period; (b) a method in which a photoacoustic signal and an ultrasonic signal are both acquired during the stage suspension period; and (c) a method in which a photoacoustic signal and an ultrasonic signal are both acquired during the stage moving period.
  • the same signals can be acquired by any one of the above-mentioned methods.
  • the pulse laser is irradiated during the stage suspension period to acquire the photoacoustic signal.
  • the ultrasonic signals are continuously transmitted and received during the stage moving period, and a process of acquiring a slice image at each position is repeated.
  • the length of the photoacoustic transducer 4b in the scanning direction (X direction) is taken as one step width, and one set of pulse laser irradiation, photoacoustic signal detection and moving by one-step width is repeated.
  • the ultrasonic wave is acquired using the ultrasonic transducer 4a.
  • the step width of the transducer 4 may be determined based on a range in which the photoacoustic transducer 4b can detect the photoacoustic wave. In other words, in a case where a range in the X direction in which the photoacoustic transducer 4b can detect a photoacoustic wave is narrow, the step width of the transducer 4 is made narrow.
  • the pulse laser is first irradiated during the stage suspension period to acquire the photoacoustic signal. After that, the ultrasonic signals are transmitted and received, and a slice image is acquired. Those procedures may be performed in the opposite order. After the stage is moved, the same process is repeated.
  • the amount of one stage moving corresponds to that of such an extent that the volume data can be created from the slice image generated by the ultrasonic signal, that is, that of the same order of resolution of the slice image.
  • the image can be obtained while the stage is suspended without being moved.
  • the pulse laser irradiation, the photoacoustic signal acquisition, and the transmission and reception of the ultrasonic signal are performed during the stage moving period.
  • the pulse laser is emitted at an operating frequency of ten to several tens hertz, and the transmission and reception of the ultrasonic signal are performed at an operating frequency on the order of kilohertz. Therefore, each data is acquired with a duty ratio therebetween of approximately 100.
  • the stripe width (length in Y direction) of the scanning by the transducer 4 is equal to the width of the photoacoustic transducer 4b (two-dimensional array) which is the photoacoustic probe. This is because luminance signals within the volume area are calculated based on the photoacoustic signals at all positions when an image is reconstructed from the photoacoustic signals. Specifically, in a case where the stripe width is thicker than the width of the photoacoustic transducer 4b, there is a portion which is not inspected. Conversely, in a case where the width of the photoacoustic transducer 4b is thicker than the stripe width, there are devices which are not used. Accordingly, an optimum condition for each width is such that the stripe width and the width of the photoacoustic transducer 4b are made equal to each other.
  • the ultrasonic transducer 4a which is the ultrasonic probe acquires the ultrasonic signal in the stripe
  • the length of the one-dimensional array of the ultrasonic transducer 4a needs to be made longer than the stripe width.
  • FIG. 4 is a diagram illustrating the ultrasonic transducer 4a viewed from the scanning direction (X direction) of the transducer 4.
  • X direction scanning direction
  • FIG. 4 is a diagram illustrating the ultrasonic transducer 4a viewed from the scanning direction (X direction) of the transducer 4.
  • a beam center 22 in a Z direction of FIG. 4 inevitably lies inside with respect to an end surface of the probe.
  • an ultrasonic image obtained by the ultrasonic transducer 4a in a beam scanning direction 23 (Y direction) is narrower than the array width of the ultrasonic transducer 4a by an aperture width used for the beam transmission and reception. Therefore, when the scanning is performed using a linear probe having the same width as the stripe width, there is a portion in which signals are not acquired between the stripes.
  • the array length of the ultrasonic transducer 4a is made longer than the stripe width, whereby loss of the ultrasonic signals between the stripes can be avoided.
  • the length of the ultrasonic transducer 4a in the direction perpendicular to the scanning direction may be set to be longer than the length of the photoacoustic transducer 4b in the direction perpendicular to the scanning direction.
  • the length of the ultrasonic transducer 4a in the direction perpendicular to the scanning direction may be made longer at respective longitudinal ends thereof by one half the length (aperture width) of the device used for transmitting and receiving an ultrasonic wave.
  • the aperture width is formed of several tens of devices, and hence the array length of the ultrasonic transducer 4a may be set to be longer than the stripe width by a length corresponding to several tens of devices.
  • FIG. 5 illustrates a state in which a beam generated by the ultrasonic transducer 4a is focused in a depth direction of the inspection object.
  • the ultrasonic transducer 4a for transmitting and receiving an ultrasonic signal includes an acoustic lens 25 on an entire surface thereof in order to focus a beam also in a height direction thereof (Z direction).
  • an ultrasonic beam is focused while following a locus 24 of FIG. 5 .
  • a range of acquiring an ultrasonic signal has a certain distance from immediately below the probe, and hence it is difficult to prevent the ultrasonic beam from spreading.
  • the spreading of the ultrasonic beam in this case depends on focus conditions and lens conditions, and may be substantially equal to the height of the probe or may be wider than the height of the probe.
  • FIG. 6 illustrates a form of the beam generated by the ultrasonic transducer 4a.
  • the width of the beam generated by the ultrasonic transducer 4a exceeds the width of the ultrasonic transducer 4a in a shallower portion and a deeper portion in the depth direction of the inspection object.
  • the photoacoustic transducer 4b is provided in a portion close to the ultrasonic transducer 4a. Therefore, there is a fear that an interference (crosstalk) between the ultrasonic wave from the ultrasonic transducer 4a and the photoacoustic wave detected by the photoacoustic transducer 4b may be generated. Accordingly, in this embodiment of the present invention, an interspace is provided between the ultrasonic transducer 4a and the photoacoustic transducer 4b, whereby the crosstalk can be prevented.
  • the size of the interspace depends on the width of the ultrasonic transducer 4a, the focus conditions, and the like.
  • a calculation reveals that there is no problem when the ultrasonic transducer 4a and the photoacoustic transducer 4b are separated from each other in the scanning direction by a distance corresponding to 20% or more of the length of the ultrasonic transducer 4a in the scanning direction.
  • the ultrasonic probe described above With the use of the ultrasonic probe described above, all ultrasonic signals and photoacoustic signals can be acquired within the scanning range.
  • the one-dimensional array probe is employed for acquiring the ultrasonic signal, but the present invention is not limited thereto. Probes generally referred to as 1.25-dimensional array probe, 1.5-dimensional array probe, and 1.75-dimensional array probe, in which devices are further divided in a direction orthogonal to the array direction, may be employed.
  • the 1.25-dimensional array probe in which the devices are divided into an odd number of parts in the direction orthogonal to the array direction, has an aperture control function by switching the other devices than a central device.
  • the 1.5-dimensional array probe in which the devices are divided in the direction orthogonal to the array direction as in the case of the 1.25-dimensional array probe, is capable of independently controlling a central device and symmetrical devices.
  • the 1.75-dimensional array probe in which the devices are divided in the direction orthogonal to the array direction as in the case of the 1.25-dimensional array probe, is capable of independently controlling all devices in the direction orthogonal to the array direction.
  • Each of the 1.25-dimensional, 1.5-dimensional, and 1.75-dimensional array probes is mounted for improving focusing and steering functions in the direction orthogonal to the array direction, and the same effect can be obtained by the above-mentioned array probes as in the case where the one-dimensional array probe is employed.
  • the one-dimensional array probe is employed for acquiring the ultrasonic signal and the two-dimensional array probe is employed for acquiring the photoacoustic signal.
  • the one-dimensional array probe may be employed for acquiring both the ultrasonic signal and the photoacoustic signal.
  • the array length of an array probe for acquiring the ultrasonic signal is set to be longer than the array length of an array probe for acquiring the photoacoustic signal, thereby obtaining the same effect.
  • FIG. 7A is a perspective view illustrating the photoacoustic-ultrasonic system including the ultrasonic probe and the optical system according to this embodiment.
  • a first probe for transmitting and receiving an ultrasonic wave includes a probe case 30a, a cable 31a, and a transducer 4a.
  • a second probe for receiving a photoacoustic wave includes a probe case 30b, a cable 31b, and a transducer 4b.
  • the transducer 4a is a first array device capable of transmitting and receiving the ultrasonic wave.
  • the transducer 4b is a second array device capable of receiving the photoacoustic wave.
  • a one-dimensional (linear) array is employed for the ultrasonic transducer 4a while a two-dimensional array is employed for the photoacoustic transducer 4b.
  • An optical prism 32a is provided in an interspace between the ultrasonic transducer 4a and the photoacoustic transducer 4b.
  • the optical prism 32a serves as an optical system for introducing pulse light emitted from a light source into an inspection object.
  • An optical prism 32b may similarly be provided on a side of the second probe, which is opposite to the optical prism 32a, so as to guide light from both sides of the photoacoustic-ultrasonic system. This is because a target region may need to be irradiated as uniformly as possible due to the fact that the intensity of the generated photoacoustic wave largely depends on an irradiation intensity of laser.
  • FIG. 7B is a cross-sectional view of the photoacoustic-ultrasonic system according to this embodiment, which illustrates incidence of light.
  • the light enters a sample as indicated by a broken line of FIG. 7B .
  • the light from the light source (not shown) is first guided in a direction perpendicular to a plane on which the two array devices 4a and 4b are provided.
  • the traveling direction of the guided light is changed by the optical prisms 32a and 32b, whereby the light is emitted toward below the second array device 4b.
  • the optical prism 32a is provided between the two probes in this manner. Accordingly, even in a case where the two-dimensional array device 4b is used, light can be effectively applied to the photoacoustic transducer 4b which detects the photoacoustic wave. In addition, the two array devices 4a and 4b naturally need to be spaced apart from each other, and hence the crosstalk described in the first embodiment can be prevented.
  • the space between the two array devices 4a and 4b is described. It is understood that, in order to realize uniform irradiation as described above, the thickness of an optical path needs to be a half or more of the width of the photoacoustic transducer 4b for each side irrespective of an irradiation angle of laser. Therefore, an interspace having a size equal to at least a half of the width of the photoacoustic transducer 4b needs to be provided between the ultrasonic transducer 4a and the photoacoustic transducer 4b. In other words, the two array devices 4a and 4b may be separated from each other in the second direction by a distance corresponding to 50% or more of the length of the second array device in the second direction.
  • a method of manufacturing the photoacoustic-ultrasonic system according to this embodiment is the same as that of the first embodiment, and hence the description thereof is omitted.
  • the optical prisms are provided on both sides of the second probe.
  • optical prisms are provided so as to surround a probe, a more favorable irradiation amount distribution can be obtained.
  • the probe according to the present invention is used for a mammary examination.
  • a mammary examination it is sufficient that an ultrasonic signal and a photoacoustic signal for up to a depth of 4 cm are acquired.
  • the probe used in this case is the probe of FIGS. 1A and 1B which is used in the description above.
  • a laser light intensity allowable to be applied to a human body is 100 mJ/cm 2 , and hence a range in which a sufficient photoacoustic signal can be acquired is 4 cm in depth and 4 cm in width. Accordingly, one side of a photoacoustic probe was set to 4 cm. Accordingly, one side of the photoacoustic probe was set to 4 cm.
  • the device pitch was set to 2 mm in consideration of probe sensitivity and a frequency of 1 MHz to be used, whereby a two-dimensional array probe including 400 devices was formed.
  • An electrostatic capacity type ultrasonic transducer having a band width of 130% was used as the two-dimensional array probe because the two-dimensional array probe is required to detect targets having various sizes.
  • the ultrasonic probe beam forming was performed with a 32-device aperture in order to sufficiently converge beams. Therefore, the ultrasonic probe is longer than the photoacoustic probe by 16 devices on each of the left and right sides.
  • the total number of devices was set to 192, the device pitch was set to 0.25 mm, the center frequency was set to 10 MHz, and the array length was set to 48 mm.
  • an acoustic lens which is formed on a surface of the ultrasonic probe had a radius of R8.
  • the beam formed under the above-mentioned conditions spreads to 7 mm in the vicinities of the ultrasonic probe and the vicinities of a depth of 4 cm, and hence an interspace between the ultrasonic probe and the photoacoustic probe was set to 1 mm.
  • the mamma is scanned using the above-mentioned probes
  • five strips each having a size of 4 cm ⁇ 20 cm were formed because the scanning region is 20 cm ⁇ 20 cm and the stripe width is 4 cm.
  • the scanning with the probes was performed in a step-and-repeat manner. Laser was applied while the probes were suspended, and the photoacoustic signal was acquired by the two-dimensional array probe. Then, while the probes were moving, the ultrasonic signal was acquired by the one-dimensional array probe, and an ultrasonic image of each slice surface was generated and stored as volume data after being subjected to an interpolation processing.
  • the image is reconstructed using the photoacoustic signal.
  • a photoacoustic image generated by the reconstruction is accumulated as volume data and superimposed on the ultrasonic image.
  • the resultant image is displayed on a screen.
  • the photoacoustic signal and the ultrasonic signal can be superimposed on each other by the above-mentioned method, with the result that information containing a morphologic image and a functional image can be provided to a user.
  • the 32-device aperture for an ultrasonic beam was adopted.
  • the size of the aperture is changed according to required beam resolution or a required beam forming method, the same effect can also be obtained.
  • the photoacoustic-ultrasonic system illustrated in FIGS. 7A and 7B can also be used for the mammary examination.
  • the interspace between the ultrasonic probe and the photoacoustic probe needs to be at least 1.4 mm.
  • the necessary thickness of a prism is 2.83 cm, and hence the space between the probes was set to 2.83 cm.
  • Subject-matter A An ultrasonic probe, comprising: a first array device capable of transmitting and receiving an ultrasonic wave; and a second array device capable of receiving a photoacoustic wave, wherein the first array device includes a plurality of electromechanical transducers arranged in a first direction; the second array device includes a plurality of electromechanical transducers arranged in a two-dimensional manner; and the first array device and the second array device are provided on the same plane and in a second direction perpendicular to the first direction.
  • Subject-matter B An ultrasonic probe according to Subject-matter A, wherein the length of the first array device in the first direction is longer than the length of the second array device in the first direction.
  • Subject-matter C An ultrasonic probe according to Subject-matter A or B, wherein the first array device and the second array device are separated from each other in the second direction by a distance corresponding to 20% or more of the length of the first array device in the second direction.
  • Subject-matter D An ultrasonic probe according to Subject-matter A or B, wherein the first array device and the second array device are separated from each other in the second direction by a distance corresponding to 50% of the length of the second array device in the second direction.
  • Subject-matter E An ultrasonic probe according to any one of Subject-matter A to D, wherein the second direction corresponds to a scanning direction in which the first array device and the second array device are scanned.
  • Subject-matter F An ultrasonic probe according to any one of Subject-matter A to E, wherein the second array device comprises an electrostatic capacity type ultrasonic transducer.
  • Subject-matter G A photoacoustic-ultrasonic system, comprising: an optical system for introducing light emitted from a light source into an inspection object; and the ultrasonic probe according to any one of Subject-matter A to F, wherein the optical system is provided in an interspace between the first array device and the second array device.
  • Subject-matter H A photoacoustic-ultrasonic system according to Subject-matter G, wherein the optical system is provided so that light guided between a first probe including the first array device and a second probe including the second array device in a direction perpendicular to the plane is emitted from the interspace between the first array device and the second array device toward below the second array device.
  • Subject-matter I A photoacoustic-ultrasonic system according to Subject-matter H, wherein the optical system is provided so that light is guided from both sides of the second probe.
  • Subject-matter J An inspection object imaging apparatus, comprising: a light source for generating pulse light; the ultrasonic probe according to any one of Subject-matter A to F; and a system control unit for controlling the light source and the ultrasonic probe to form an image, wherein the system control unit forms an image based on morphologic information of the inside of an inspection object by using the first array device and forms an image based on functional information of the inside of the inspection object by using the light source and the second array device.
  • Subject-matter K An inspection object imaging apparatus according to Subject-matter J, wherein the first array device transmits and receives an ultrasonic wave having a frequency higher than the frequency of an ultrasonic wave received by the second array device.
  • Subject-matter L An inspection object imaging apparatus according to Subject-matter J, wherein the first array device transmits and receives an ultrasonic wave having a frequency of 7 to 12 MHz; and wherein the second array device receives an ultrasonic wave having a frequency of 1 to 4 MHz.

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EP17201053.0A 2008-06-18 2009-06-17 Sonde ultrasonore et système photo-acoustique ultrasonore et appareil d'imagerie d'objet d'inspection comprenant la sonde ultrasonore Withdrawn EP3351165A1 (fr)

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EP09766746A EP2303103A1 (fr) 2008-06-18 2009-06-17 Sonde ultrasonore, système photo-acoustique ultrasonore et appareil d'imagerie d'objet d'inspection utilisant ladite sonde ultrasonore
PCT/JP2009/061434 WO2009154298A1 (fr) 2008-06-18 2009-06-17 Sonde ultrasonore, système photo-acoustique ultrasonore et appareil d'imagerie d'objet d'inspection utilisant ladite sonde ultrasonore

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US20170258441A1 (en) 2017-09-14
US10561396B2 (en) 2020-02-18
JP5294998B2 (ja) 2013-09-18
CN103099644B (zh) 2016-03-30
CN102065748A (zh) 2011-05-18
US20110088477A1 (en) 2011-04-21
CN103099644A (zh) 2013-05-15
JP2010022816A (ja) 2010-02-04
WO2009154298A1 (fr) 2009-12-23
US8997571B2 (en) 2015-04-07
US20150164472A1 (en) 2015-06-18
US9693753B2 (en) 2017-07-04
CN102065748B (zh) 2013-02-27

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