EP3338786A4 - Granules de shen ling bai zhu et leur procédé de préparation - Google Patents

Granules de shen ling bai zhu et leur procédé de préparation Download PDF

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Publication number
EP3338786A4
EP3338786A4 EP16838544.1A EP16838544A EP3338786A4 EP 3338786 A4 EP3338786 A4 EP 3338786A4 EP 16838544 A EP16838544 A EP 16838544A EP 3338786 A4 EP3338786 A4 EP 3338786A4
Authority
EP
European Patent Office
Prior art keywords
shenlingbaizhu
granules
preparation
shenlingbaizhu granules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16838544.1A
Other languages
German (de)
English (en)
Other versions
EP3338786A1 (fr
EP3338786C0 (fr
EP3338786B1 (fr
Inventor
Deliang LIN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Handian Pharmaceutical Co Ltd
Original Assignee
Beijing Handian Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Handian Pharmaceutical Co Ltd filed Critical Beijing Handian Pharmaceutical Co Ltd
Publication of EP3338786A1 publication Critical patent/EP3338786A1/fr
Publication of EP3338786A4 publication Critical patent/EP3338786A4/fr
Application granted granted Critical
Publication of EP3338786C0 publication Critical patent/EP3338786C0/fr
Publication of EP3338786B1 publication Critical patent/EP3338786B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
EP16838544.1A 2015-08-21 2016-08-22 Granules de shen ling bai zhu et leur procédé de préparation Active EP3338786B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510520582.0A CN105056092B (zh) 2015-08-21 2015-08-21 一种参苓白术颗粒的制备方法及其制备的参苓白术颗粒
PCT/CN2016/096158 WO2017032285A1 (fr) 2015-08-21 2016-08-22 Granules de shen ling bai zhu et leur procédé de préparation

Publications (4)

Publication Number Publication Date
EP3338786A1 EP3338786A1 (fr) 2018-06-27
EP3338786A4 true EP3338786A4 (fr) 2019-05-01
EP3338786C0 EP3338786C0 (fr) 2023-12-20
EP3338786B1 EP3338786B1 (fr) 2023-12-20

Family

ID=54485762

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16838544.1A Active EP3338786B1 (fr) 2015-08-21 2016-08-22 Granules de shen ling bai zhu et leur procédé de préparation

Country Status (8)

Country Link
US (1) US10813964B2 (fr)
EP (1) EP3338786B1 (fr)
JP (1) JP6797202B2 (fr)
CN (1) CN105056092B (fr)
AU (1) AU2016312007B2 (fr)
PL (1) PL3338786T3 (fr)
RU (1) RU2722015C1 (fr)
WO (1) WO2017032285A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105056092B (zh) 2015-08-21 2019-05-03 北京汉典制药有限公司 一种参苓白术颗粒的制备方法及其制备的参苓白术颗粒
CN105559065A (zh) * 2015-12-23 2016-05-11 浙江省中药研究所有限公司 一种增强免疫力功能的中药保健食品
CN105748826A (zh) * 2016-04-08 2016-07-13 北京御心堂生物科技股份有限公司 一种调节脾胃失和的中药组合物及其口服液和制备方法
CN107412658A (zh) * 2017-05-08 2017-12-01 湖南知达医药科技有限公司 茯苓薏苡仁中药组合物及其质量控制方法
CN108271988A (zh) * 2017-12-29 2018-07-13 吉林新开河食品有限公司 一种人参大枣固体饮料及其制备方法
CN108578630B (zh) * 2018-07-19 2021-09-10 北京汉典制药有限公司 一种参苓白术颗粒剂的制备方法
CN110146623A (zh) * 2019-06-13 2019-08-20 山东孔圣堂制药有限公司 参苓白术丸hplc-elsd指纹图谱的建立方法及其标准图谱
CN111449274B (zh) * 2020-04-09 2022-02-15 福建中烟工业有限责任公司 一种人参提取物及其制备方法和应用
CN111869957A (zh) * 2020-07-13 2020-11-03 黑龙江东方学院 一种防菌吸雾口罩
CN113521213A (zh) * 2021-07-30 2021-10-22 余建社 一种疳积散的生产方法
JP2023066381A (ja) * 2021-10-28 2023-05-15 住友化学株式会社 痰湿に関連する症状の予防、改善又は緩和のための組成物
CN114166958B (zh) * 2021-10-29 2024-03-29 合肥创新医药技术有限公司 中药复方苍藿平胃颗粒的指纹图谱的检测方法及其应用
CN114931617A (zh) * 2022-06-10 2022-08-23 山西旺龙药业集团有限公司 一种治疗艾滋病相关症状的中药复方颗粒剂的制备方法
CN115944699B (zh) * 2022-12-14 2024-03-15 修正药业集团股份有限公司 一种具有运脾益气，消食化滞功效的中药组合物、其制备方法和应用
CN115804826A (zh) * 2022-12-21 2023-03-17 北京汉典制药有限公司 参苓白术在治疗新型冠状病毒感染者愈后的后遗症状、提高生活质量的应用
CN116549595B (zh) * 2023-07-12 2023-09-01 云南琼月企业管理有限公司 一种治疗儿童功能性消化不良的药物组合物及其制剂和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1788783A (zh) * 2005-10-20 2006-06-21 北京汉典中西药研究开发中心 参苓白术颗粒及其制备方法
CN101279017A (zh) * 2008-05-22 2008-10-08 云南植物药业有限公司 云南红药提取物及其提取方法和应用
CN104258327A (zh) * 2014-09-19 2015-01-07 河南福森药业有限公司 一种增强免疫力的保健颗粒剂及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1218726C (zh) * 2002-12-30 2005-09-14 承德中药集团有限责任公司 清热化滞颗粒药物及其制备工艺方法
CN1442165A (zh) * 2003-02-25 2003-09-17 河南省宛西制药股份有限公司 一种治疗慢性肾炎的中药及其制备方法
FR2868066B1 (fr) * 2004-03-26 2006-06-23 Snc Eurokera Soc En Nom Collec Plaques en vitroceramique et en verre, plaques de chauffe, preparation
CN1292789C (zh) * 2004-05-20 2007-01-03 张惠云 治疗小儿胃炎之脾胃不和证的小儿闰土颗粒及其制备方法
CN1803180B (zh) * 2005-01-13 2010-05-26 北京凯瑞创新医药科技有限公司 一种药物组合物及其制备方法和质量控制方法
CN101934045A (zh) 2009-07-01 2011-01-05 北京亚东生物制药有限公司 参苓白术制剂及其新用途
CN102114075B (zh) * 2010-01-06 2012-02-15 山东明仁福瑞达制药有限公司 一种治疗小儿感冒的系列中药制剂及其制备工艺和检测方法
CN102293995B (zh) * 2011-07-14 2014-04-16 北京汉典中西药研究开发中心 补中益气颗粒及其制备方法
CN102600444B (zh) * 2012-04-08 2014-03-12 郝卫平 一种治疗慢性结肠炎的中药及制备方法
CN104116713B (zh) * 2013-04-24 2016-10-19 南京亿华药业有限公司 一种头孢地尼颗粒及其制备方法
CN104524337A (zh) * 2014-12-31 2015-04-22 张衍蓉 一种治疗口腔溃疡的中药
CN105056092B (zh) 2015-08-21 2019-05-03 北京汉典制药有限公司 一种参苓白术颗粒的制备方法及其制备的参苓白术颗粒
CN110051791A (zh) * 2019-04-04 2019-07-26 云南大唐汉方制药股份有限公司 一种预防和治疗呼吸系统疾病中药组合物及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1788783A (zh) * 2005-10-20 2006-06-21 北京汉典中西药研究开发中心 参苓白术颗粒及其制备方法
CN101279017A (zh) * 2008-05-22 2008-10-08 云南植物药业有限公司 云南红药提取物及其提取方法和应用
CN104258327A (zh) * 2014-09-19 2015-01-07 河南福森药业有限公司 一种增强免疫力的保健颗粒剂及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2017032285A1 *

Also Published As

Publication number Publication date
CN105056092A (zh) 2015-11-18
US10813964B2 (en) 2020-10-27
US20180207215A1 (en) 2018-07-26
AU2016312007A1 (en) 2018-04-12
WO2017032285A1 (fr) 2017-03-02
RU2722015C1 (ru) 2020-05-26
CN105056092B (zh) 2019-05-03
JP2018523713A (ja) 2018-08-23
AU2016312007B2 (en) 2021-09-30
JP6797202B2 (ja) 2020-12-09
EP3338786A1 (fr) 2018-06-27
PL3338786T3 (pl) 2024-04-22
EP3338786C0 (fr) 2023-12-20
EP3338786B1 (fr) 2023-12-20

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