EP2419041B1 - Implant delivery system - Google Patents

Implant delivery system Download PDF

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Publication number
EP2419041B1
EP2419041B1 EP10765197.8A EP10765197A EP2419041B1 EP 2419041 B1 EP2419041 B1 EP 2419041B1 EP 10765197 A EP10765197 A EP 10765197A EP 2419041 B1 EP2419041 B1 EP 2419041B1
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EP
European Patent Office
Prior art keywords
delivery system
implant
tether
elongated body
capture member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP10765197.8A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2419041A1 (en
EP2419041A4 (en
Inventor
Tai D. Tieu
Hideo Morita
Helen Nguyen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MicroVention Inc
Original Assignee
MicroVention Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of EP2419041A1 publication Critical patent/EP2419041A1/en
Publication of EP2419041A4 publication Critical patent/EP2419041A4/en
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Publication of EP2419041B1 publication Critical patent/EP2419041B1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214—Coils or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2439—Expansion controlled by filaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • A61F2002/9511—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument the retaining means being filaments or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable

Definitions

  • This invention relates to an improved delivery system for delivering an implantable medical device. More specifically, this invention relates to an implant delivery system with an improved implantable device release mechanism.
  • Implantable medical devices and their accompanying delivery systems are well known in the art. These implantable devices include stents, microcoils, valves and similar types of devices which are used to treat a variety of different medical conditions.
  • Implantable devices are delivered within a patient by way of a catheter-style delivery device.
  • One type of delivery system commonly used with self-expanding implantable devices utilizes two concentrically arranged catheters or shafts.
  • the implantable device is disposed axially around a distal end of the inner catheter or pusher and held in a compressed position by the outer sleeve. Once the implantable device is positioned at a target location, the outer shaft is withdrawn, releasing the implantable device at the target location.
  • Other deployment systems also typically include a mechanism for selectively uncoupling the implantable device from the delivery system.
  • some delivery systems for non-expandable implants include a tether fixed to both the delivery catheter and the implantable device. When the user wishes to release the implantable device, a nearby heater melts the tether, thereby releasing the device.
  • this tether remnant may cause complications in the patient such as blood clots, especially if located within a blood vessel. In other procedures, this tether remnant may pose less risk for complications and therefore may be of less concern to a physician.
  • US 5 676 671 discloses A device for introducing an implantable appliance into a catheter including an attachment connected to said open end of catheter, the attachment being closed at its open end by a flexible check valve.
  • WO 03/101518 discloses A trigger wire guide for a prosthesis deployment device.
  • One preferred embodiment according to the present invention relates to a mechanically releasable delivery system. More specifically, this embodiment includes an implantable device secured by tether at a distal end of the delivery system.
  • the tether is fixed (e.g., a knot, adhesive, welding, etc.) to the implantable device and looped around a selectively slidable mandrel. When the mandrel is retracted to expose its distal end, the looped tether slides off the mandrel, freeing the implantable device.
  • the tether can be fixed to the delivery system, wrapped around a portion of the implantable device and looped on to the slidable mandrel.
  • movement of the mandrel is controlled by grasping the mandrel at a proximal end of the mandrel and sliding the mandrel in a proximal direction, thereby causing the implantable device to be released within the patient.
  • Figure 1 illustrates a preferred embodiment of a delivery system 100.
  • the delivery system 100 includes an elongated body 102, such as a pusher body for advancing within a patient (e.g., within a pre-positioned catheter or with a retractable outer sheath).
  • the distal end of the delivery system 100 includes an implantable device 104 (e.g., stent, valve, microcoil, etc.).
  • a proximal end of the delivery device 100 may include a grip or handle 106 for grasping the device 100 and advancing it into the patient.
  • an outer sheath is used to introduce a microcatheter to a desired target location. The delivery system is introduced into the microcatheter and advanced to the target location.
  • the proximal end of the delivery device 100 further includes an implantable device release control 108 which allows the user to cause the implantable device 104 to be released from the delivery system and left within the patient. More specifically, and as discussed in greater detail below, the release control 108 allows the user to retract (i.e., move proximally) a detachment mandrel 118 (i.e., an implant capture member, actuating member, or an elongated locking member). As a distal end of the detachment mandrel 118 retracts, it releases a tether 116 that secures the implantable device 104 to the delivery system 100.
  • a detachment mandrel 118 i.e., an implant capture member, actuating member, or an elongated locking member.
  • the release control 108 is formed by the proximal end of the detachment mechanism which slides relative to the body 102 or the handle 106.
  • a hypotube can be further included near or in the handle 106, through which the detachment mandrel 118 slides.
  • a wire can also be connected to the detachment mandrel 118, allowing a user to pull the wire and therefore pull the detachment mandrel 118 proximally.
  • the detachment mandrel 118 can be spring biased to a closed position, for example, by disposing a spring at a proximal end of the detachment mandrel 118, within the handle 106.
  • this release control 108 may be a slider, lever, mechanical button, electrical button or any other type of actuation mechanism.
  • the release mechanism 110 is preferably located within a passage of the body 102 near a distal end of the body 102.
  • Figure 2 illustrates an exploded view of the release mechanism 110 according to a preferred embodiment
  • Figure 3 illustrates an assembled view of the mechanism 110
  • Figure 4 illustrates a magnified view of area 4-4.
  • the release mechanism 110 selectively releases an implantable device 104 by sliding a detachment mandrel 118 to release a tether 116 that is looped around the detachment mandrel 118. More specifically, a free end (e.g., a distal free end) of the mandrel 118 is slid past an opening, free space or aperture located near a distal end of the delivery device 100.
  • the tether 116 is attached to the implantable device 104 (e.g., by adhesive, a knot, clip, etc.).
  • the loop of the tether 116 slides off the mandrel 118, releasing the implantable device 104 from the delivery system 100.
  • both ends of the tether 116 can be fixed to the delivery system 100 (e.g., the outer coil 112), positioned through a portion of the implantable device 104 (e.g., a loop or coil), then looped over the mandrel 118.
  • the mandrel 118 acts as a sliding or lateral moving latch member.
  • the mandrel 118 is an elongated cylindrical member that extends to the proximal end of the delivery device 100, or is attached to other mechanisms that extend to the distal end of the delivery device 100, thereby allowing control of the mandrel 118 from a user at the proximal end.
  • the mandrel may have a variety of cross sectional shapes, such as circular, square, rectangular and hexagonal. Additionally, this mandrel 118 preferably either extends to the proximal end or the delivery device 100 or mechanically connects to the proximal end to allow a user at the proximal end to manipulate the mandrel 118 and thereby cause the release of the implant.
  • the release system 110 is at least partially contained within an outer coil 112, which provides support and protection for the release mechanism 110.
  • this outer coil 112 is located at the distal end of the body 102; however, it may also be fully or partially embedded in the body 102, an outer sheath or outer layer.
  • the outer coil 112 is preferably composed of a semi-rigid material (e.g., Nitinol, stainless steel, or radiopaque material) to maintain the overall shape of the device, yet flex as it is passed through a patient.
  • the release system 110 further comprises a distal tube member 122 and a proximal tube member 124, each of which are attached to a support mandrel 114 along their outer surface.
  • the tube members 122 and 124 are positioned in line with each other so as to leave a gap or open space large enough for the tether 116 to pass through, as seen best in Figure 3 .
  • the tube members 122 and 124 are preferably sized to fit within the passage of the body 102 (i.e., within coil 112) and are further composed of a rigid or semi-rigid material such as Nitinol or stainless steel.
  • the support mandrel 114 is also preferably composed of a rigid material such as Nitinol or stainless steel and is fixed to the tubes 122, 124 and outer coil 112.
  • the detachment mandrel 118 and the interior passages within the tubes 122 and 124 are sized such that the detachment mandrel 118 can freely move through these passages axially.
  • a distal end of the detachment mandrel 118 can further slide at least partially past the gap or open space, exposing the distal end (so that the tether 116 can slide off, releasing the implant 104).
  • the tubes 122 and 124 act as a housing for the detachment mandrel 118.
  • the delivery system 100 also includes an inner coil 120 that acts as a guide or passage for the detachment mandrel 118 as it slides back and forth to release the tether 116 and provides kink resistance.
  • the inner coil 120 is disposed around the detachment mandrel 118 and is further fixed to proximal tube 124.
  • the inner coil 120 also includes a different pitch than the outer coil 112 which helps prevent the inner coil 120 from wedging between the loops of the outer coil 112.
  • the inner coil 120 is composed of a rigid material such as Nitinol or stainless steel and extends proximally past the outer coil 112 as seen best in Figure 3 .
  • the user advances the distal end of the delivery system 100 to a target location within a patient.
  • the implantable device release control 108 is actuated (e.g., the detachment mandrel 118 is pulled proximally), causing the distal end of the detachment mandrel 118 to move in a proximal direction.
  • the distal end of the detachment mandrel 118 moves past the proximal end of distal tube 122, creating a gap between the mandrel 118 and the tube 122.
  • the tether 116 is under tensions and therefore immediately slides off the mandrel 118 as soon as the previously mentioned gap opens up.
  • the implantable device 104 is free from the delivery system 100 and the delivery system 100 can be removed from the patient.
  • a sheath can be used over the body 102 to control the expansion of implantable device 104 (e.g., prevents a stent from expanding until the sheath is pulled away from the device 104).
  • additional lumens containing additional tools or controls are possible.
  • Figures 5-7 illustrate another preferred embodiment of a implantable device release mechanism 130.
  • the release mechanism 130 is similar to the previously described release mechanism 110.
  • the present release mechanism 130 includes a single tube 132 instead of the two previous tubes 122 and 124.
  • the single tube 132 includes an aperture or cut-away portion 132A.
  • the tether 116 is looped over the detachment mandrel 118 and passes through the cut-away portion 132A.
  • the looped portion of the tether 116 slides off the detachment mandrel 118 and out the cut-away portion 132A, releasing the device 104.
  • the aperture or cut-away portion 132A can be formed by laser or mechanical cutting of a tube or adhering two tubes together.
  • the cut-away portion 132A preferably includes an angled cut (i.e., an edge surface not at 90 degrees to the length of the tube 132) to prevent rubbing or friction against the tether 116 and thereby minimizing damage to the tether 116.
  • at least the distal portion of the aperture 132A has a non 90 degree cut angle (i.e., the portion on which the tether 116 rests). In one example, at least the distal portion of the aperture 132A has a cut angle between about 10 and 80 degrees relative to an axis of the length of the tube 132.
  • the free ends of the tether 116 can be connected to the delivery device 100 (e.g., coil 112) for procedures when the tether 116 may pose a high risk of complications to a patient.
  • the tether 116 may remain with the implant 104 after implantation (i.e., both free ends of the tether are connected to the implant 104) for procedures when the tether 116 may pose a low risk of complications to a patient.
  • the tether 116 either remains in the patient or degrades if composed of a biodegradable material.
  • Figures 8 and 9 illustrate an alternative tether configuration as part of another preferred embodiment of a release mechanism 140.
  • the free ends of the tether 116 are fixed (e.g., adhesive, tying, or similar methods of fixation) to the outer coil 112.
  • the tether 116 passes through apertures or around spokes or coils of the device 104, then through cut-away portion 132A and around the detachment mandrel 118.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Prostheses (AREA)
EP10765197.8A 2009-04-15 2010-04-15 Implant delivery system Active EP2419041B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16963209P 2009-04-15 2009-04-15
PCT/US2010/031268 WO2010121049A1 (en) 2009-04-15 2010-04-15 Implant delivery system

Publications (3)

Publication Number Publication Date
EP2419041A1 EP2419041A1 (en) 2012-02-22
EP2419041A4 EP2419041A4 (en) 2015-11-04
EP2419041B1 true EP2419041B1 (en) 2017-06-21

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Family Applications (1)

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EP10765197.8A Active EP2419041B1 (en) 2009-04-15 2010-04-15 Implant delivery system

Country Status (9)

Country Link
US (1) US9968358B2 (enrdf_load_stackoverflow)
EP (1) EP2419041B1 (enrdf_load_stackoverflow)
JP (2) JP5771188B2 (enrdf_load_stackoverflow)
KR (1) KR101828088B1 (enrdf_load_stackoverflow)
CN (1) CN102596083B (enrdf_load_stackoverflow)
AU (1) AU2010236349B2 (enrdf_load_stackoverflow)
BR (1) BRPI1014971A2 (enrdf_load_stackoverflow)
CA (1) CA2758511C (enrdf_load_stackoverflow)
WO (1) WO2010121049A1 (enrdf_load_stackoverflow)

Cited By (15)

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US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US10940001B2 (en) 2012-05-30 2021-03-09 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US11311376B2 (en) 2019-06-20 2022-04-26 Neovase Tiara Inc. Low profile prosthetic mitral valve
US11357622B2 (en) 2016-01-29 2022-06-14 Neovase Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US11389291B2 (en) 2013-04-04 2022-07-19 Neovase Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US11413139B2 (en) 2011-11-23 2022-08-16 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11419720B2 (en) 2010-05-05 2022-08-23 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US11464631B2 (en) 2016-11-21 2022-10-11 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US11497602B2 (en) 2012-02-14 2022-11-15 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US11779742B2 (en) 2019-05-20 2023-10-10 Neovasc Tiara Inc. Introducer with hemostasis mechanism
US11998447B2 (en) 2019-03-08 2024-06-04 Neovasc Tiara Inc. Retrievable prosthesis delivery system
US12109111B2 (en) 2015-12-15 2024-10-08 Neovasc Tiara Inc. Transseptal delivery system

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US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US9220522B2 (en) 2007-10-17 2015-12-29 Covidien Lp Embolus removal systems with baskets
US8585713B2 (en) 2007-10-17 2013-11-19 Covidien Lp Expandable tip assembly for thrombus management
US8088140B2 (en) 2008-05-19 2012-01-03 Mindframe, Inc. Blood flow restorative and embolus removal methods
US9198687B2 (en) 2007-10-17 2015-12-01 Covidien Lp Acute stroke revascularization/recanalization systems processes and products thereby
US11337714B2 (en) 2007-10-17 2022-05-24 Covidien Lp Restoring blood flow and clot removal during acute ischemic stroke
US8926680B2 (en) 2007-11-12 2015-01-06 Covidien Lp Aneurysm neck bridging processes with revascularization systems methods and products thereby
US8066757B2 (en) 2007-10-17 2011-11-29 Mindframe, Inc. Blood flow restoration and thrombus management methods
US10123803B2 (en) 2007-10-17 2018-11-13 Covidien Lp Methods of managing neurovascular obstructions
AU2008340276B2 (en) 2007-12-21 2014-08-07 Microvention, Inc. System and method for locating detachment zone of a detachable implant
CN102036619B (zh) 2007-12-21 2014-07-23 微排放器公司 检测植入物的脱卸的系统
ES2737991T3 (es) 2008-02-22 2020-01-17 Covidien Lp Aparato para el restablecimiento de flujo
JP2011517607A (ja) 2008-04-11 2011-06-16 マインドフレーム， インコーポレイテッド 脳卒中を処置する医療デバイスの送達のためのモノレール神経マイクロカテーテル、モノレール神経マイクロカテーテルによるプロセス、およびモノレール神経マイクロカテーテルによる製品
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KR20120025466A (ko) 2012-03-15
WO2010121049A9 (en) 2010-12-02
AU2010236349A1 (en) 2011-11-17
KR101828088B1 (ko) 2018-02-09
BRPI1014971A2 (pt) 2016-04-26
JP5771188B2 (ja) 2015-08-26
WO2010121049A1 (en) 2010-10-21
JP2015110113A (ja) 2015-06-18
CA2758511C (en) 2017-06-27
US9968358B2 (en) 2018-05-15
EP2419041A1 (en) 2012-02-22
JP2012523933A (ja) 2012-10-11
CN102596083A (zh) 2012-07-18
AU2010236349B2 (en) 2015-04-02
CN102596083B (zh) 2016-11-16
EP2419041A4 (en) 2015-11-04

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