EP2070692B1 - Procédé de vérification de comprimés multicouches - Google Patents

Procédé de vérification de comprimés multicouches Download PDF

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Publication number
EP2070692B1
EP2070692B1 EP08020369.8A EP08020369A EP2070692B1 EP 2070692 B1 EP2070692 B1 EP 2070692B1 EP 08020369 A EP08020369 A EP 08020369A EP 2070692 B1 EP2070692 B1 EP 2070692B1
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EP
European Patent Office
Prior art keywords
layer
station
pellets
inspection procedure
die
Prior art date
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Application number
EP08020369.8A
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German (de)
English (en)
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EP2070692A2 (fr
EP2070692A3 (fr
Inventor
Heinrich Behrmann
Kurt Marquardt
Jan Naeve
Harald Römer
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Fette GmbH
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Fette GmbH
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Publication of EP2070692A3 publication Critical patent/EP2070692A3/fr
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Publication of EP2070692B1 publication Critical patent/EP2070692B1/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B30B11/085—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable for multi-layer articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/005—Control arrangements

Definitions

  • the present invention relates to a method for testing multilayer tablets in a multi-rotor press, in which die holes of a rotating die plate in successive filling devices are successively filled with tablet material of different layers, and the tablet material is pressed by means of synchronously rotating press stamp layer to layer of compacts with n layers and the Subsequently, compacts are ejected and removed in a removal station, in which compacts with m layers are taken in a sampling station in a test operation and fed to a test station, wherein 1 ⁇ m ⁇ n, wherein before the removal of the compacts at least the m -th layer is compressed more than during normal production of the multilayer tablets, where m ⁇ n.
  • a matrix disk which is usually driven about a vertical axis, has matrices arranged on a circle, to which rotating punch pairs are assigned synchronously with the disk.
  • the actuation of the ram is done by cams and pressure rollers.
  • the lower punch of a pair forms the bottom of a mold cavity, wherein its height in the die dictates the dosage.
  • the compression of the tablet material to a desired thickness (web height).
  • the pressing station usually has a form and a main printing station. Subsequent to compaction, the lower punches, controlled by an ejector cam, at a certain point on the machine push the tablets out of the die, while the opposite row of punches (upper punches) gradually move away from the die plate. This allows a scraper strip the ejected compacts of the die plate and feed a drain channel.
  • the stations described in each case are provided several times in accordance with the number of layers provided.
  • first a first layer is filled in a first filling device and slightly compacted by means of the pressing die.
  • the die hole filled with the first layer then reaches a subsequent filling device, in which the second layer is filled over the first layer.
  • This second layer is then again slightly compacted. This process is repeated until the last layer of the tablet to be produced (the nth layer) has been filled into the die hole.
  • the compression takes place in a multilayer tablet with subsequent removal from the device, as explained.
  • a corresponding test method for a two-layer tablet is known, for example DE 42 18 122 C1 .
  • a test procedure compacts with the first layer are removed after pressing and fed to a test station, where the weight of the first layer is measured.
  • the first layer of the compact is compressed more strongly before being taken out for testing than during the normal production of the multilayer tablet is the case.
  • the object of the invention is therefore to specify a method of the type mentioned at the outset, with which a representative test of the layers of a multilayer tablet is possible.
  • the invention solves the problem in that the test station only moldings are supplied from die holes, which were filled before the initiation of the test process completely with the usually powdery tablet material of the mth layer.
  • the compacts are produced up to the mth layer, ie until the last layer is reached before the test procedure, in each case in the manner explained above.
  • the first, second, third, etc. layers are successively filled in successive filling devices. Each time after filling a layer, this layer can be easily pressed before the next layer is filled.
  • the final layer is compressed more strongly before the removal of the compacts for a test (the mth layer) than is the case during normal operation in the context of light compression or compression.
  • the mth layer can be compressed more than usual.
  • the greater compression can be achieved by reducing the web height. In this way, patterns of greater hardness are produced.
  • the respective sampling station for the test or the last pressing station before the test and the previous filling device can be easily determined how many of the starting from the initiation of the test process subsequent die holes already completely with the mth Layer were filled, so how many of the subsequent die holes have already left the last filling station.
  • a drain switch the respective drain channel are switched so that the unwanted pellets of the test station are no longer supplied.
  • the test procedure is initiated by the initiation of the first compression of a tablet layer, which is stronger than during normal plant operation.
  • the decisive factor is the time from which the press leaves its normal operating conditions, that is to say, the conditions that exist during normal tablet production. This can for example be the case from a deceleration of the die plate for the inspection process.
  • the number of layers of the tablets normally produced with the multiple rotary press is basically arbitrary. In particular, n ⁇ 2.
  • 2-, 3-, 4- etc. layered tablets can be produced.
  • each pressing station for the tablet layers can be assigned corresponding (intermediate) removal stations, to which, in turn, corresponding supply lines to the test station are assigned.
  • pressed compacts also sort out. In this case, therefore, of the already at the time of initiation of the test process already completely filled with the m-th layer of compacts the first not so long directed to the test station until the stronger compression (eg changed web height) finally set is. This avoids unwanted accumulation of material on the press.
  • pressed compacts can be sorted out after the end of the testing process until the normal re-adjustment of the normal compression ratios.
  • the weight of the compacts can be measured in the test station.
  • other parameters can also be measured.
  • the respective (intermediate) removal station can be assigned a switch between a bad channel and a supply to the test station drain.
  • the tablets led into the bad channel can either be disposed of or, if possible, be re-processed into tablet powder and reused.
  • the die plate for the inspection operation can be rotated into a first pressing position for greater compression of at least the mth layer of a first compact to be tested, after compressing the first compact into a next pressing position to compress at least the mth layer of a be rotated next press compacting after compression of the next compact until all compacts from die holes, which were already filled before the initiation of the test process completely with the tablet material of the mth layer, the test station were supplied.
  • the system thus gradually or continuously further rotated while each pressed a further compact in the next die hole.
  • a lower punch can be moved upwards from the ejector cam to an ejector position, so that the compact can be pushed by a stripper into the channel, which feeds the compact to the testing station.
  • the drainage channel can be changed so that further pellets are fed to a return channel of the plant in its normal operation to a bad channel.
  • the term pressing position includes both printing stations. If, for example, the stronger compression of the m-th layer takes place only in the main printing station, the first and the next pressing position are the positions at the main printing stations. Nevertheless, the system between the defined pressing positions can of course also always approach the pre-press station for pre-pressing. The rotor with the die plate can continue to rotate. So it is not necessary that he comes to a stop at the respective pressing positions.
  • the die plate can be stopped to initiate the testing process and / or to terminate the testing process.
  • the compression for example, the web height
  • the rotor can be stopped with the die plate again, so that the web height can be adjusted back to its normal position. Subsequently, the rotor can be accelerated and normal tablet production can be continued. The number of slips to be sorted out can thus be minimized.
  • a die to be tested ejecting punch the rotary press at least during the passage of a subsequent filling station for filling tablet material of the m + 1-th layer, preferably all subsequent filling stations, are held flush with the top of the die plate. A filling of the corresponding cavity with tablet material is thus avoided.
  • die holes which have been filled with tablet material downstream of the filling device for the mth layer following introduction of the test procedure can be emptied by means of a suction device for the duration of the test procedure.
  • filled tablet material is thus suctioned into filling devices which follow the filling device last passed before the testing process (filling device for the mth layer).
  • the subsequent filling devices can each be assigned suction devices.
  • the extracted material can then be disposed of, for example, or, if possible, be reused. In this way, a pressing of incorrect, especially less filled cavities is avoided.
  • the method according to the invention described can be applied to all pressing stations of a multiple rotary press.
  • a first tablet layer can be pulled for a test
  • at a second pressing station the first and second layers together
  • at a third pressing station the first, second and third layers are pulled together for a testing operation, etc.
  • the weights of the individual layers can then be determined by forming the difference between the weights measured in each case. For example, the weight of the second tablet layer results from the weight of the two-layered pattern minus a previously measured weight of the first layer.
  • the rotary press shown in the embodiment in the figures is a double rotary press with two pressing stations, which in the Figures 1 and 2 are shown.
  • Fig. 3 the die plate of the double rotary press is shown in a plan view.
  • like reference numerals designate like objects.
  • the rotary press has a die plate 10, which is driven to rotate about a vertical axis.
  • the die plate 10 has a series of continuous die holes 12.
  • Each die hole 12 is associated with a pair of dies 14, 16.
  • the upper ram 14 are axially movably mounted in a disc 18 which is driven synchronously with the die plate 10.
  • the lower ram 16 are axially movably mounted in a disc 20, which also rotates synchronously.
  • the axial position of the ram 14, 16 is determined by cams with which the rear ends of the ram 14, 16 cooperate in a conventional manner.
  • a first filling station with a first filling device 22 is arranged above the die plate 10.
  • powdered tablet material for a first layer of a double-layer tablet to be produced in the press is introduced into the passing template holes 12.
  • the filling depth is determined by the position of the lower ram 16 whose position in turn is determined by curve segments 24 lower cams.
  • the lower pressing dies 16 gradually release the passing template holes 12.
  • An adjoining the Grerides 22, resting on the die plate 10 plate 26 prevents swelling of the material from the die holes 12 by means of an upper curve segment 28 of a pre-press station 30 and the upper punch 14 cooperate with the die holes 12.
  • the pre-printing station 30 is formed by upper and lower pre-pressure rollers 32, 34, which determine by their height the extent to which the filling in the die holes 12 is compressed.
  • the height of the compact obtained in this way is also referred to as ridge height.
  • the final web height is then also determined by vertically adjustable main pressure rollers 38, 40 in the subsequent main press station 36.
  • Fig. 2 the second pressing station of the double rotary press is shown.
  • a filling device 42 is shown, with the normal operation of the press a second layer of a other powdered tablet material is filled to the first compressed in the first compression station first layer.
  • the second filling device 42 in turn has a resting on the die plate 10 plate 44, which prevents swelling of the material from the die holes 12, with the help of Vorpressstation 46 of the second pressing station, and in particular the pre-pressure rollers 48, 50, the upper ram 14th in turn interact with the die holes 12.
  • the die plate 10 is first stopped. Subsequently, by means of a vertical adjustment of the main pressure rollers 38, 40 of the Fig. 1 shown first press station reduces the web height of pressed in the first pressing station compacts and thus increases the hardness of a pattern pressed therein. The compact is thus compressed more strongly with its first layer for the testing process than during a low-pressure operation during normal operation. Subsequently, the rotor 10 is set in motion again and by means of Ejector curve 24a in Fig.
  • the lower pressing dies 16 are pushed onto the surface of the die plate 10 and guided from there by means of a scraper 64 into a discharge channel 66. From the drainage channel 66, the compacts 68 with the first layer of a test station, not shown, here for weight measurement, can be supplied.
  • a test station not shown, here for weight measurement
  • the test station is fed only moldings 68 from die holes 12, which were already completely filled with the tablet material of the first layer before the initiation of the test procedure, ie in this case before stopping the die plate 10 So at this time the first filling device 22 had already left.
  • Subsequent pellets are also guided by the scraper 64 in the outlet channel 66 during the ongoing testing process; from this, however, the compacts are fed by means of a drain switch not shown a bad channel. They can then be re-processed into powdered tablet material and reused.
  • the rotor 10 is stopped again and the web height defined by the vertical position of the main pressure rollers 38, 40 of the first pressing station is restored to the value during normal production operation.
  • the Auswerferkurve 24a is moved back to a lower position so that compacts after passing through the first pressing station not ejected and thus can not be directed by the scraper 64 in the outlet channel 66. Once this is done, the rotor 10 is accelerated back to its normal production speed and normal production of bilayer tablets is resumed.
  • the suction device 70 is deactivated after the second filling device 42. Pressings that are compressed during the restart of the rotor 10 until it reaches its operating rotation speed can in turn be fed to a bad channel.
  • the method according to the invention ensures that only such compacts are fed to the test station, the layers of which have been filled under conditions representative of the normal operation of the press. The test and in particular the weight measurement are therefore not adversely affected.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (7)

  1. Procédé de vérification de comprimés multicouches dans une presse rotative multiple, dans laquelle des trous de matrice d'un disque à matrice rotatif sont remplis successivement avec du matériau de comprimé de différentes couches dans des dispositifs de remplissage consécutifs, et le matériau de comprimé est comprimé couche sur couche pour former des comprimés avec n couches au moyen de poinçons de pressage effectuant une rotation synchrone, et les comprimés sont ensuite éjectés dans une station de prélèvement et prélevés,
    • dans lequel, au cours d'une opération de vérification, des comprimés avec m couches sont prélevés dans une station de prélèvement respective suite à la compression, et guidés vers une station de vérification, sachant que 1 <= m < n,
    • dans lequel, avant le prélèvement des comprimés, au moins la m-ième couche est comprimée plus fortement que pendant la production normale des comprimés multicouches, sachant que m < n,
    caractérisé en ce que
    • la station de vérification reçoit uniquement des comprimés (68) venant de trous de matrice (12) déjà complètement remplis avec le matériau de comprimé de la m-ième couche avant de commencer l'opération de vérification.
  2. Procédé selon la revendication 1, caractérisé en ce que le poids des comprimés (68) est mesuré dans la station de vérification.
  3. Procédé selon l'une des revendications 1 ou 2, caractérisé en ce que des comprimés (68) issus de trous de matrice (12) qui n'étaient pas encore complètement remplis avec le matériau de comprimé de la m-ième couche avant de commencer l'opération de vérification sont guidés vers un canal de refus.
  4. Procédé selon l'une des revendications précédentes, caractérisé en ce que pour l'opération de vérification, le disque à matrice (10) est tourné dans une première position de pressage pour une compression plus forte d'au moins la m-ième couche d'un premier comprimé (68) à vérifier, le disque à matrice est tourné dans une position de pressage consécutive, après la compression du premier comprimé (68), pour la compression d'au moins la m-ième couche d'un comprimé (68) suivant à vérifier, et, suite à la compression du comprimé (68) suivant, la rotation est poursuivie successivement jusqu'à ce que tous les comprimés (68) issus de trous de matrice (12) déjà entièrement remplis avec le matériau de comprimé de la m-ième couche avant de commencer l'opération de vérification aient été guidés vers la station de vérification.
  5. Procédé selon l'une des revendications précédentes, caractérisé en ce que le disque à matrice (10) est arrêté pour commencer l'opération de vérification et/ou pour terminer l'opération de vérification.
  6. Procédé selon l'une des revendications précédentes, caractérisé en ce que pendant l'opération de vérification, un poinçon inférieur (16) de la presse rotative délivrant le comprimé (68) à vérifier est maintenu en affleurement avec la face supérieure du disque à matrice (10), au moins pendant le passage dans une station de remplissage (42) consécutive.
  7. Procédé selon l'une des revendications précédentes, caractérisé en ce que des trous de matrice (12) qui ont été remplis de matériau de comprimé après avoir commencé l'opération de vérification, dans des dispositifs de remplissage (42) consécutifs au dispositif de remplissage (22) destiné à la m-ième couche, sont vidés pendant la durée de l'opération de vérification au moyen d'un dispositif d'aspiration (70).
EP08020369.8A 2007-12-14 2008-11-22 Procédé de vérification de comprimés multicouches Active EP2070692B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007061081A DE102007061081B4 (de) 2007-12-14 2007-12-14 Verfahren zum Prüfen von Mehrschichttabletten

Publications (3)

Publication Number Publication Date
EP2070692A2 EP2070692A2 (fr) 2009-06-17
EP2070692A3 EP2070692A3 (fr) 2011-05-04
EP2070692B1 true EP2070692B1 (fr) 2015-01-14

Family

ID=40328394

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08020369.8A Active EP2070692B1 (fr) 2007-12-14 2008-11-22 Procédé de vérification de comprimés multicouches

Country Status (3)

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US (1) US8454868B2 (fr)
EP (1) EP2070692B1 (fr)
DE (1) DE102007061081B4 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008046422B3 (de) 2008-09-09 2009-11-12 Fette Gmbh Verfahren zum Prüfen von Mehrschichttabletten in einer Mehrfachrundläuferpresse
DE102011101287B4 (de) * 2011-05-10 2013-11-14 Fette Compacting Gmbh Abstreifeinrichtung für eine Rundläuferpresse, Rundläuferpresse und Verfahren zum Betreiben einer Rundläuferpresse
DE102011101286B4 (de) * 2011-05-10 2013-10-17 Fette Compacting Gmbh Rundläuferpresse und Verfahren zum Betreiben einer Rundläuferpresse
EP4010181A4 (fr) * 2019-08-07 2023-10-18 Scitech Centre Échantillonnage de comprimés bicouches

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Publication number Priority date Publication date Assignee Title
US2944493A (en) * 1956-11-23 1960-07-12 Stokes F J Corp Multi-layer tablet manufacture
US3063390A (en) * 1960-07-27 1962-11-13 Stokes F J Corp Tablet machine with inspection means
GB952006A (en) * 1962-02-21 1964-03-11 John Holroyd & Company Ltd Multi-layer tablet making machines
US3255716A (en) * 1962-12-10 1966-06-14 Upjohn Co Measurement of forces within a tableting machine
US3332367A (en) * 1965-07-15 1967-07-25 Upjohn Co Apparatus for making tablets
JPS5334187B1 (fr) * 1966-07-02 1978-09-19
DE3477057D1 (en) * 1984-11-10 1989-04-13 Fette Wilhelm Gmbh Device for withdrawing and weighing especially for tablets
US4817006A (en) * 1986-03-28 1989-03-28 Thomas Engineering, Inc. Pharmaceutical tablet press control mechanism
IT1238959B (it) * 1990-05-21 1993-09-17 Ima Spa Dispositivo per il prelevamento ed il convogliamento di compresse in uscita da una macchina comprimitrice.
DE9107053U1 (de) * 1991-06-09 1992-07-02 Krämer, Norbert, 6100 Darmstadt Vorrichtung zum Entsorgen und Weiterverarbeiten von aus einer Tabletten- oder Pillenpreßmaschine kommenden Tabletten oder Pillen o.ä.
DE4218122C1 (de) * 1992-06-02 1994-01-20 Fette Wilhelm Gmbh Verfahren zum Pressen von Zweischichttabletten in einer Doppelrundläuferpresse und Vorrichtung zur Durchführung des Verfahrens
US5322655A (en) * 1993-02-19 1994-06-21 Thomas Engineering, Inc. Method for monitoring and controlling the weights of each layer of a multilayer tablet
CN1606434A (zh) * 2001-12-19 2005-04-13 株式会社三和化学研究所 控制释放成型品
US20050200038A1 (en) * 2004-03-12 2005-09-15 Courtoy Nv Method for controlling a rotary tablet press and such a press
DE102008046422B3 (de) * 2008-09-09 2009-11-12 Fette Gmbh Verfahren zum Prüfen von Mehrschichttabletten in einer Mehrfachrundläuferpresse

Also Published As

Publication number Publication date
EP2070692A2 (fr) 2009-06-17
US20090152751A1 (en) 2009-06-18
DE102007061081A1 (de) 2009-06-18
DE102007061081B4 (de) 2010-04-08
EP2070692A3 (fr) 2011-05-04
US8454868B2 (en) 2013-06-04

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