EP0813472B1 - Dispositif pour fabriquer des comprimes - Google Patents

Dispositif pour fabriquer des comprimes Download PDF

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Publication number
EP0813472B1
EP0813472B1 EP96943935A EP96943935A EP0813472B1 EP 0813472 B1 EP0813472 B1 EP 0813472B1 EP 96943935 A EP96943935 A EP 96943935A EP 96943935 A EP96943935 A EP 96943935A EP 0813472 B1 EP0813472 B1 EP 0813472B1
Authority
EP
European Patent Office
Prior art keywords
rotor
pressing tools
filling
pressure
exerting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP96943935A
Other languages
German (de)
English (en)
Other versions
EP0813472A1 (fr
Inventor
Rudolf Koch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GEA Process Engineering NV
Original Assignee
Courtoy NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Courtoy NV filed Critical Courtoy NV
Publication of EP0813472A1 publication Critical patent/EP0813472A1/fr
Application granted granted Critical
Publication of EP0813472B1 publication Critical patent/EP0813472B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/025—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space whereby the material is transferred into the press chamber by relative movement between a ram and the press chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/12—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds on the circumference of a rotating drum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30—Feeding material to presses
    • B30B15/302—Feeding material in particulate or plastic state to moulding presses
    • B30B15/308—Feeding material in particulate or plastic state to moulding presses in a continuous manner, e.g. for roller presses, screw extrusion presses

Definitions

  • the invention relates to a device for producing tablets or compacts according to the preamble of claim 1.
  • a pressing device for pressing coal briquettes with the subject Features of the preamble of claim 1 is already from US 1,448,982 known in 1923.
  • Such a briquette press is usually pulverized Coal pressed into briquettes together with a suitable binder.
  • a device for pressing feed is known from the press ram to form a compact by means of a controlled by setting discs Lever mechanism are movable.
  • Automatic devices for the production of tablets are based on the principle that a tablet is compressed into a tablet due to a pressing process.
  • two movable punches serve as pressing tools.
  • Known automatic Devices for producing tablets have a lower stamp aligned vertically, that runs in a die and an upper stamp that only goes into the die Pressing is introduced.
  • the upper punch slides into the die, pushes the powder together and squeezes the tablet. Thickness, strength depend on him and his pressure and press gloss of the tablet. Leave the insertion depth and pressure level regulate oneself.
  • the lower stamp is located inside the die. It limits the filling space down. During the pressing process, it usually forms the counter bearing.
  • the matrices are filled using a Filling funnel, the bottom part of which is called a filling shoe.
  • each die has an upper and a lower stamp.
  • the stamps are raised and lowered by rolling.
  • the dies are successively filled with their stamps Position brought under the filling shoe.
  • the object of the invention is therefore a device for producing tablets or tablets to hand, with the tablets or tablets without the so-called "Black spots" can be produced on the tablet surface.
  • the pressing tools which are movable relative to one another, are conventional Tablet machines no longer aligned vertically, but horizontally. By this measure can effectively prevent the occurrence of the "black spots" become.
  • the pressing tools are rotatable on one Rotor arranged.
  • a pressure roller is mounted eccentrically to the axis of rotation of the rotor and on the edge of the rotating part of the device are two further pressure rollers arranged so that over the eccentric pressure roller and the other two Pressure rollers the pressing tools arranged between them during the corresponding pass are pressed against each other.
  • the filling device can with be coupled to the rotor such that they rotate together with it is relocatable.
  • the rotor and the filling device can be connected to one another via the axis of rotation be coupled.
  • the filling device can consist of a bulbous shape
  • Filling hoppers exist, on which funnel-shaped tapered channels are attached are, the tapered ends of which open into a filling opening of the respective die. This arrangement of the hopper allows the dies to be centrifugally applied be filled with the tablets. This can also cause poorly flowing Materials are processed well and it can be dosed more precisely.
  • the mutually movable pressing tools are advantageous during their rotation moved in the horizontal direction by guide curves assigned to them. As a result, a correspondingly assigned one can be used for certain angular positions Work cycle to be carried out.
  • the two other pressure rollers can be at a different distance the associated pressing tools can be arranged that a different strength Press pressure can be generated. This allows through at a certain angular position a first pressure roller can be used to pre-press and at a second angular position complete pressing can be done by the second pressure roller.
  • the device shown in FIGS. 1 and 2 has one driven by a motor, not shown here Rotor 1, which rotates in the direction of rotation a according to FIG. 2 is relocatable. Aligned horizontally on this rotor in each case two pressing tools movably arranged relative to one another 2, 4 mounted.
  • the pressing tools 2, 4 are in the form of a inner stamp 4 and an outer stamp 2 formed, the Immerse in a corresponding hole in a die 3.
  • the circumference of the rotor 1 in the present exemplary embodiment four pairs of press tools with the corresponding dies interact, arranged.
  • a material hopper 5 is additionally arranged, which rotates together with the rotor 1.
  • the outer press tool 2 i.e. the outer stamp
  • the second press tool 4 i.e. the inner stamp
  • a guide curve 11 during the rotation of the rotor 1 shifted in the horizontal plane of the rotor.
  • the pressure rollers 6, 7 and 8 are adjustable.
  • the in middle region of the rotor 1 is arranged pressure roller 6 arranged eccentrically to the axis A of the rotor 1, wherein its eccentricity is adjustable.
  • the pressure rollers 7 and 8 are each adjustable in their distance from the rotor 1. Due to this adjustability, the pressing forces can form the tablet or the compact can be varied. Basically serve the pressure rollers 6, 7 and 8, as previously stated, to generate the necessary pressing forces and on the pressing tools transferred to. It comes with each passage of the pair of press tools 2, 4 between the respectively assigned pressure rollers 6 and 8 and 6 and 7 on the compression of the matrix content.
  • the filling device 5 is in the embodiment shown here designed as a bellied filling funnel, the funnel shape being formed by an inside of the hopper arranged cone is obtained. Between the hopper 5 and corresponding filling openings 10 in the matrices 3, funnel-shaped channels 9 are formed. Due to the centrifugal forces caused by the rotation of the Filling funnel on those located in the tapered ends Tablets particles act, is a safe promotion and thus filling the matrices 3 in position I guaranteed.
  • FIG. 3-5 are different working positions the pressing tools 2 and 4 shown to each other.
  • 3 the matrix filling phase is shown. This representation corresponds to position I in FIG. 2.
  • FIG. 4 the Compression of the tableted material shown. This corresponds to phase 2 positions II and III according to FIG. 2.
  • Phase III corresponds to position IV according to FIG. 2.
  • the finished tablet T by a corresponding Slit 13 downward due to gravity drop a collecting container, not shown here can.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (6)

  1. Dispositif de fabrication de comprimés ou pièces moulées avec au moins respectivement deux outils de pressage mobiles (2, 4) orientés l'un par rapport à l'autre horizontalement et au moins une matrice (3) coopérant avec ceux-ci et une installation de remplissage (5, 9) pour l'amenée du produit à configurer en comprimés dans la matrice, où les outils de pressage (2, 4) sont disposés sur un rotor (1) pouvant être entraíné en rotation, caractérisé en ce qu'un rouleau de pression (6) est logé d'une manière excentrique à l'axe de rotation du rotor (1) et que sont disposés au bord du rotor du dispositif deux autres rouleaux de pression (7, 8) de telle sorte que par le rouleau de pression excentrique (6) et les deux autres rouleaux de pression (7, 8), , les outils de pressage (2, 4) disposés entre eux peuvent être pressés l'un contre l'autre lors du passage correspondant.
  2. Dispositif selon la revendication 1, caractérisé en ce que sont disposés sur le pourtour du rotor (1), d'une manière répartie uniformément, plusieurs paires d'outils de pressage (2, 4) déplaçables les unes relativement aux autres.
  3. Dispositif selon la revendication 1 ou 2, caractérisé en ce que l'installation de remplissage (5) est couplée avec le rotor (1) de façon qu'elle puisse être entraínée en rotation conjointement avec celui-ci.
  4. Dispositif selon la revendication 3, caractérisé en ce que le rotor (1) et l'installation de remplissage (5) sont couplés l'un à l'autre par l'axe de rotation.
  5. Dispositif selon l'une des revendications précédentes, caractérisé en ce que l'installation de remplissage (5) est constituée d'une trémie de remplissage (5) réalisée d'une manière ventrue à laquelle font suite des canaux rétrécissant en forme de trémie dont les extrémités rétrécies débouchent dans une ouverture de remplissage de la matrice (3) .
  6. Dispositif selon l'une des revendications précédentes, caractérisé en ce que les deux autres rouleaux de pression (7, 8) sont disposés à un tel écart différent aux outils de pressage associés (2, 4) qu'une valeur de pression d'une force différente peut être produite.
EP96943935A 1995-12-22 1996-12-12 Dispositif pour fabriquer des comprimes Expired - Lifetime EP0813472B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE29520473U 1995-12-22
DE29520473U DE29520473U1 (de) 1995-12-22 1995-12-22 Vorrichtung zur Herstellung von Tabletten
PCT/EP1996/005569 WO1997023347A1 (fr) 1995-12-22 1996-12-12 Dispositif pour fabriquer des comprimes

Publications (2)

Publication Number Publication Date
EP0813472A1 EP0813472A1 (fr) 1997-12-29
EP0813472B1 true EP0813472B1 (fr) 2001-11-21

Family

ID=8017170

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96943935A Expired - Lifetime EP0813472B1 (fr) 1995-12-22 1996-12-12 Dispositif pour fabriquer des comprimes

Country Status (4)

Country Link
US (1) US5910324A (fr)
EP (1) EP0813472B1 (fr)
DE (2) DE29520473U1 (fr)
WO (1) WO1997023347A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292853B1 (it) * 1997-04-08 1999-02-11 Mg 2 Spa Macchina comprimitrice per compresse multistrato.
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
ES2280396T3 (es) 2001-09-05 2007-09-16 Courtoy N.V. Prensa de comprimidos rotativa y procedimiento para la limpieza de dicha prensa.
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP2172192A1 (fr) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Forme de dosage dotée d'un comprimé central d'ingrédient actif insérée dans un corps annulaire comprimé de poudre de matériau granulaire et procédé et outillage pour la produire
EP1489161B1 (fr) * 2002-03-27 2005-06-01 Bostlan, S.A. Procede et dispositif de production de mini-tablettes de manganese a forte concentration pour l'alliage de bains d'aluminium
US20040026812A1 (en) * 2002-08-12 2004-02-12 Tiy Inc. Apparatus for bench scale tablet-making
CN101657179B (zh) * 2007-02-19 2012-12-05 帝人制药株式会社 转送盘
CN104309154B (zh) * 2013-12-17 2017-06-16 深圳市华创精科生物技术有限公司 一种双冲回转式压片机

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR352070A (fr) * 1905-03-06 1905-08-02 John Treadwell Presse pour la fabrication des briquettes
US852457A (en) * 1906-07-18 1907-05-07 Robert Schorr Briqueting-machine.
US1448982A (en) * 1921-09-13 1923-03-20 Treadwell John Briquette press
GB1070587A (en) * 1964-09-16 1967-06-01 V Nauciino I I T Electromashin Method and apparatus for compressing flowable powder materials
FR2397227A1 (fr) * 1977-07-13 1979-02-09 Thierion Gabriel Dispositif pour compacter des produits vegetaux, notamment du fourrage
SU770836A1 (ru) * 1978-11-30 1980-10-15 Предприятие П/Я В-8906 Автомат дл таблетировани порошка
US4403935A (en) * 1980-03-27 1983-09-13 Manesty Machines Limited Tabletting machines
IT1221567B (it) * 1987-12-30 1990-07-12 Ima Spa Macchina comprimitrice per la realizzazione di compresse
NL9100383A (nl) * 1991-03-01 1992-10-01 Derckx Henricus A J M Machine voor het vervaardigen van snoepgoed.

Also Published As

Publication number Publication date
DE59608266D1 (de) 2002-01-03
WO1997023347A1 (fr) 1997-07-03
US5910324A (en) 1999-06-08
EP0813472A1 (fr) 1997-12-29
DE29520473U1 (de) 1996-03-28

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