EP2030910A1 - Ceinture transparente pour produits pharmaceutiques et/ou médicaux et/ou de complément alimentaire - Google Patents

Ceinture transparente pour produits pharmaceutiques et/ou médicaux et/ou de complément alimentaire Download PDF

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Publication number
EP2030910A1
EP2030910A1 EP07075763A EP07075763A EP2030910A1 EP 2030910 A1 EP2030910 A1 EP 2030910A1 EP 07075763 A EP07075763 A EP 07075763A EP 07075763 A EP07075763 A EP 07075763A EP 2030910 A1 EP2030910 A1 EP 2030910A1
Authority
EP
European Patent Office
Prior art keywords
blister strip
blister
nest
product
strip according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07075763A
Other languages
German (de)
English (en)
Inventor
Horst Kaplan
Stefan Kemner
Christoph Hammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koerber AG
Original Assignee
Koerber AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koerber AG filed Critical Koerber AG
Priority to EP07075763A priority Critical patent/EP2030910A1/fr
Priority to US12/675,325 priority patent/US8220635B2/en
Priority to AU2008295065A priority patent/AU2008295065A1/en
Priority to EP08801828A priority patent/EP2197764B9/fr
Priority to DK08801828.8T priority patent/DK2197764T3/da
Priority to PCT/EP2008/007211 priority patent/WO2009030475A1/fr
Priority to JP2010522267A priority patent/JP5073059B2/ja
Priority to AT08801828T priority patent/ATE548292T1/de
Priority to EP12156580.8A priority patent/EP2457843B1/fr
Priority to CA2697487A priority patent/CA2697487C/fr
Publication of EP2030910A1 publication Critical patent/EP2030910A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035Blister-type containers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2203/00Decoration means, markings, information elements, contents indicators

Definitions

  • the invention relates to a blister strip for receiving medical and / or pharmaceutical and / or food-supplementing products, comprising a rollable, divisible into individual blister sections product carrier, the one-lane product carrier in its conveying direction F successively individual the division T of the blister strip defining nests for receiving isolated Products, as well as a foil-like cover for closing the nests, such that each product is arranged sealed within a nest.
  • Such blister belts are used in particular in the production of patient-specific packaging.
  • Such packaging can be made manually or automatically.
  • sections of a single product or a plurality of products are unrolled from individual rolled-up blister straps, which are preferably each equipped with a product type, separated from the blister strip and positioned on a substrate and, if necessary, e.g. attached by gluing or the like.
  • the blister strip is sandwiched between the substrate and a lid member.
  • the lid member has openings through which the nests at least partially protrude.
  • the substrate is provided with perforations in the region of the products, so that the products are pushed through the foil-like cover of the blister strip and through the partially weakened material of the substrate during removal of the products by applying pressure to the nests.
  • Known blister belts are individually designed for each product or product type.
  • the blister straps and, in particular, the blister sections carrying the nests for the products also differ from product type to product type Geometries and depending on the product geometry on an individual nest size.
  • the nests of tablets differ from those of oblongs or of capsules in shape and size.
  • the product blister sections of different blister belts also have different lengths and / or widths.
  • the nests typically have a single, one-tiered containment space for each product. This means that the nest or the receiving space is designed exclusively product-specific and individualized. In other words, the size of the opening for expressing the product from the nest corresponds to the size of the product.
  • the blister belts known hitherto are disadvantageous for various reasons, both in the case of preferably automatic placement on a substrate and when expressing from the nest. Due to the different geometries of blister straps or blister sections, automated assembly is only possible with considerable measurement and control effort. In other words, the placement head of a placement machine must each control individual pick-up positions for the blister sections separated from the blister strip. This leads to an increased placement time and to an increase in the number of assembly errors, which is to be avoided especially in the production of patient-specific packaging. Furthermore, the different geometries of the nests necessitate a corresponding adaptation, in particular of the cover elements. More specifically, individual nest sizes require individual apertures in the lid members, resulting in an increased number of lid member formats.
  • each nest has an at least two-stage shaped receiving space.
  • This embodiment ensures in a surprisingly simple manner that a standardization of the nests is achieved, which leads on the one hand to improved handling in the production of packaging and on the other to improved handling in the "operation", ie the actual expressions of the products ,
  • each nest is formed in multiple stages, wherein the nest is formed of a product geometry independent depression and a product geometry dependent depression.
  • Multi-stage may mean that each nest may preferably have two different wells, but also three or more wells.
  • the recesses are not next to each other but virtually arranged inside each other, wherein the recesses are starting gradually smaller in size, starting from the cover in a cross-section extending parallel to the cover.
  • Product-independent geometry of the depression in this context means that the corresponding depression deviates in dimensions from the dimensions of the product received within the nest. It goes without saying that the depressions, which are independent of the product geometry, can also be somewhat product-dependent in their basic form. For example, the product-independent cavity for an oblong is elongated, while a product-independent cavity for a tablet is round shaped.
  • a further preferred embodiment provides that the product-independent depression in its parallel to the cover cross-section is greater than the product-dependent depression, so that the expressions and thus the handling is simplified.
  • An expedient development is characterized in that the depth of the product-independent depression, starting from the cover, is less than the minimum thickness / height of the product located within the nest.
  • the minimum thickness / height makes sense to refer to the outer contour of the product. This effectively prevents the products from getting into the space between the step or the shoulder and the cover.
  • this object is also achieved by a blister strip of the type mentioned above in that the ratio of the pitch T of the blister strip to the width B of the blister strip is fixed.
  • This standardization is achieved, which facilitates the automatic loading much easier.
  • any arrangement of blister sections with different products on a substrate is possible.
  • the blister sections can be arranged longitudinally and / or transversely on the substrate, so that a single standardized cover element can be used to produce a packaging.
  • the formation of the fixed ratio of pitch to width of the blister strip can independently solve the task independently of the formation of the nest.
  • the combination of the features of the preamble of claim 1 with the feature that the Ratio of the pitch T of the blister strip to the width B of the blister strip is fixed improve the handling in the production and in the operation.
  • An expedient development of the invention is characterized in that the distance A from center nest to center nest corresponds to the pitch T, whereby the above-mentioned advantages are particularly easy to achieve.
  • the geometric dimensions of the blister strip or blister sections are product-independent, so that in the production of packaging from multiple blister belts with different products, a common standard exists that greatly simplifies production. Regardless of the product or the product geometry, a defined pick-up position can be reached, so that the measurement or control effort is avoided or greatly reduced.
  • each nest is assigned a positioning aid, wherein the position of the positioning aid is fixed to the nest.
  • the positioning aid can be used to improve the positioning and control of the blister straps or blister sections, for example, on placement machines or the like.
  • each nest or each blister section is assigned an encoding. This coding enables the "nest-by-nest” identification of the products contained in the nests, thus preventing mishandling.
  • the invention relates to different variants of blister straps, which are particularly suitable to be assembled into a patient-specific packaging.
  • An inventive blister strip 10, as in FIG. 1 serves to receive medical and / or pharmaceutical and / or food supplementing products 11.
  • the products may be formed as tablets, oblongs, capsules or in other conventional dosage form.
  • the blister straps 10, which are basically formed in one lane, comprise a roll-up product carrier 12, which is divisible into individual blister sections 13.
  • the product carrier 12 in succession individual nests 14, which serve to receive isolated products 11.
  • the nests 14 or their distances from one another, which define the pitch T of the blister strip 10, are closed with a film-like cover 15, so that each individual product within the nest 14 is completely shielded from the environment.
  • a blister portion 13 is formed rectangular.
  • the length L of a Blisterabitess13, so the lateral edge length of a product 11 carrying Blisterabitess 13, in the conveying direction F is usually longer than the width B of the blister strip 10.
  • a Blisterabites 13 also have other shapes.
  • the pitch T may correspond to the width B of the blister strip 10, so that the blister sections 13 are square-shaped.
  • the distance A from center nest to center nest then corresponds to the width B of the blister strip 10.
  • the lateral edge length of a blister section 13 corresponds to the width B of the blister strip 10.
  • the geometric dimensions of the blister strip 10 and the individual blister sections 13 are product-independent. In other words, the blister strips 10 or blister sections 13 have common, standardized dimensions for all different products 11.
  • Each blister section 13 has exactly one nest 14 formed to receive a single product 11.
  • a plurality of blister sections 13 connected to a blister section strand can also be separated from the blister strip 10.
  • the nests 14 are aligned centrally on each or each blister section 13. This means that the center of a nest 14 lies above or at the center of a blister section 13.
  • the size of the nest 14 is variable.
  • blister section 13 may also correspond to the pitch T, while the width B is smaller with respect to the pitch T or the edge length. It is important, however, that the pitch T to the width B is in a fixed ratio.
  • the nest 14 may be formed in a conventional manner in one stage.
  • the nest 14 forms a step-free receiving space 16 for the product 11.
  • the nest 14 can assume different shapes on the side facing away from the cover 15.
  • a flattened, planar training as a so-called standard plateau, which is the simplified coupling, so the safe placement of suction nozzles or other suitable placement heads on the nest 14 is used.
  • a positioning aid may be formed between the nests 14 in the conveying direction F of the blister strip 10, which in the present example is a hole 17.
  • the training and the position of the positioning aid can of course vary. Namely, other particularly visually recognizable or readable markings or markings come into question as a positioning aid.
  • the hole 17 is always arranged in a defined and constant position relative to the nest 14 with respect to the width B of the blister strip 10.
  • the hole may be arranged centrally, for example, based on the width B of the blister strip 10.
  • a perforation 18 or the like can run between adjacent blister sections 13 transversely to the conveying direction F.
  • the perforation 18 may be formed by material weakening, for example by hole perforation, material reduction, etc.
  • the perforation 18 extends over the entire width B of the blister strip 10, but may also extend only partially across the width B. In the embodiment shown, the perforation 18 extends through the hole 17.
  • the blister strip 10 can optionally be formed perforation-free, as in the FIGS. 1 and 3 represented, or with a perforation 19, as in FIG. 4 represented provided.
  • the perforation 19 may be formed on one side or on both sides and serves the guided transport of the blister straps 10, for example, in placement machines.
  • the perforation 18 for separating individual Blisterabitese 13 from each other, for example by means of a theoretical cutting section with a blade can, like the FIG. 3 also be designed as a perforation 20.
  • each blister section 13 shortened by a small amount in its length L, whereby an optimized and non-overlapping placement of blister sections 13 on a substrate 21 or the like can be achieved.
  • FIG. 5 can be seen, various Blisterabsacrificinge 13 or blister section strands 22 formed therefrom with different products 11 in the longitudinal and / or transverse direction may be placed on the substrate 21.
  • all nests 14 with the most diverse products 11 are located at defined and standardized positions, such that despite the different products 11, a uniform format for a cover element (not shown) can be used .
  • the possibility of nesting in the longitudinal and transverse directions ensures a space-saving arrangement of the blister section strands 22 on the substrate 21. This nesting is ensured both with square and with rectangular or otherwise shaped blister sections 13 or corresponding blister section strands 22.
  • each nest 14 may have an at least two-stage shaped receiving space 23.
  • each nest 14 is multi-level, namely in particular formed in two stages. This means that the product carrier 12 in the region of each nest has 14 wells of different dimensions.
  • nest 14 is formed of a product geometry independent well 24 and a product geometry dependent well 25.
  • the recess 25, which is adapted to the product geometry, is arranged, starting from the cover 15, behind the recess 24, which depends on the product geometry.
  • the cross-section of the product-independent recess 24 in its parallel to the cover 15 extending cross section is greater than the product-dependent recess 25.
  • the recess 25 which has product-specific dimensions, the product 11 is centered with respect to held the nest 14, so that the pressure exerted during the expression of the products 11 pressure acts directly on the product 11.
  • the recess 24, which determines the size of the opening in an associated cover element (not shown) of a package is the same for all products 11.
  • the depth of the product-independent depression 24 is less than the minimum thickness of the product 11 located in the nest 11, starting from the cover. In this case, the thickness of the product 11 in its edge region is particularly important. As a preferred value, the depth of the recess 24 is two millimeters. Of course, other values are possible larger and less than two millimeters. In the plan view, the recess 24 has a substantially oval shape, although other shapes, e.g. Circles, rectangles, parallelograms etc. are possible.
  • Each nest 14 is optionally a positioning aid (see FIG. 14 ), wherein the position of the positioning aid, which may be formed by way of example as a punch hole 26, with respect to the position of the nest 14 is fixed. As a positioning aid but also other in particular visually recognizable or readable markings or markings come into question.
  • each nest 14 or each blister section 13 can be assigned an encoding 27.
  • the coding includes information about the corresponding nest 14 and the product 11 therein.
  • the blister strip 10 may also have a superordinate, central (not shown) coding which contains information on the blister strip 10 itself (for example, date of manufacture, etc.).
  • the two different embodiments concerning the formation of the blister strip 10 with a fixed and equal ratio of pitch T to width B of the blister strip 10 on the one hand and the formation of the nest 14 with a multi-level receiving space 23 on the other hand can be performed independently or in combination with each other.
  • a so-called bottom sheet which constitutes the product carrier 12 is unwound from an endless roll and fed to a thermoforming station consisting essentially of a preheater, a blowing head and a thermoforming mold.
  • the respective nest 14 is e.g. formed by compressed air.
  • the formation of the nest 14 can also be carried out at least partially by a stamp or the like. For the multi-stage nest 14, therefore, successively or simultaneously several of the forming steps are necessary.
  • each nest 14 is filled with only one product 11.
  • the filling may optionally be checked by inspection systems or the like.
  • a preferably manual refilling of empty nests 14 can take place.
  • the filled and controlled blister strip 10 is closed or sealed with the film-like cover 15, namely a cover film.
  • a punching station or the like is provided.
  • a punched hole 26 is introduced into the bottom foil / cover foil in the region of each nest 14 as a positioning aid.
  • a perforation 18 can take place transversely to the conveying direction F of the blister strip 10. As a result, a targeted separation of individual blister sections 13 from the blister strip 10 is simplified.
  • an encoding 27 is applied in the region of each nest 14, which allows the identification of the contents of the nest 14.
  • a 2D matrix code is lasered into the bottom film from the base film side.
  • other methods of application and other means of identification are possible.
  • the described production can also be carried out in parallel for a plurality of interconnected blister straps 10, whereby according to the method steps described a separation takes place in the longitudinal direction of the blister straps 10.
  • a separation takes place in the longitudinal direction of the blister straps 10.
  • the side edges can be trimmed so that blister straps 10 of the same width are formed.

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  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP07075763A 2007-08-30 2007-08-30 Ceinture transparente pour produits pharmaceutiques et/ou médicaux et/ou de complément alimentaire Withdrawn EP2030910A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP07075763A EP2030910A1 (fr) 2007-08-30 2007-08-30 Ceinture transparente pour produits pharmaceutiques et/ou médicaux et/ou de complément alimentaire
US12/675,325 US8220635B2 (en) 2007-08-30 2008-08-30 Blister belt for receiving medical and/or pharmaceutical and/or food supplement products
AU2008295065A AU2008295065A1 (en) 2007-08-30 2008-08-30 Blister belt for receiving medical and/or pharmaceutical and/or food supplement products
EP08801828A EP2197764B9 (fr) 2007-08-30 2008-08-30 Bande a blisters destinee a contenir des produits medicaux et/ou pharmaceutiques et/ou des complements alimentaires
DK08801828.8T DK2197764T3 (da) 2007-08-30 2008-08-30 Blisterbånd til optagelse af medicinske og/eller farmaceutiske og/eller kostsupplerende produkter
PCT/EP2008/007211 WO2009030475A1 (fr) 2007-08-30 2008-08-30 Bande à blisters destinée à contenir des produits médicaux et/ou pharmaceutiques et/ou des compléments alimentaires
JP2010522267A JP5073059B2 (ja) 2007-08-30 2008-08-30 医用製品、薬用製品及び栄養補給用製品の中の一つ以上を収容するためのブリスター包装ベルト
AT08801828T ATE548292T1 (de) 2007-08-30 2008-08-30 Blistergurt zur aufnahme von medizinischen und/oder pharmazeutischen und/oder nahrungsergänzenden produkten
EP12156580.8A EP2457843B1 (fr) 2007-08-30 2008-08-30 Ceinture transparente pour la réception de produits médicaux et/ou pharmaceutiques et/ou de compléments alimentaires
CA2697487A CA2697487C (fr) 2007-08-30 2008-08-30 Bande a blisters destinee a contenir des produits medicaux et/ou pharmaceutiques et/ou des complements alimentaires

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07075763A EP2030910A1 (fr) 2007-08-30 2007-08-30 Ceinture transparente pour produits pharmaceutiques et/ou médicaux et/ou de complément alimentaire

Publications (1)

Publication Number Publication Date
EP2030910A1 true EP2030910A1 (fr) 2009-03-04

Family

ID=38969465

Family Applications (3)

Application Number Title Priority Date Filing Date
EP07075763A Withdrawn EP2030910A1 (fr) 2007-08-30 2007-08-30 Ceinture transparente pour produits pharmaceutiques et/ou médicaux et/ou de complément alimentaire
EP08801828A Not-in-force EP2197764B9 (fr) 2007-08-30 2008-08-30 Bande a blisters destinee a contenir des produits medicaux et/ou pharmaceutiques et/ou des complements alimentaires
EP12156580.8A Not-in-force EP2457843B1 (fr) 2007-08-30 2008-08-30 Ceinture transparente pour la réception de produits médicaux et/ou pharmaceutiques et/ou de compléments alimentaires

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP08801828A Not-in-force EP2197764B9 (fr) 2007-08-30 2008-08-30 Bande a blisters destinee a contenir des produits medicaux et/ou pharmaceutiques et/ou des complements alimentaires
EP12156580.8A Not-in-force EP2457843B1 (fr) 2007-08-30 2008-08-30 Ceinture transparente pour la réception de produits médicaux et/ou pharmaceutiques et/ou de compléments alimentaires

Country Status (7)

Country Link
US (1) US8220635B2 (fr)
EP (3) EP2030910A1 (fr)
JP (1) JP5073059B2 (fr)
AT (1) ATE548292T1 (fr)
AU (1) AU2008295065A1 (fr)
CA (1) CA2697487C (fr)
WO (1) WO2009030475A1 (fr)

Cited By (1)

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EP2435333A1 (fr) * 2009-05-28 2012-04-04 Manrex Pty. Ltd Emballage-coque avec parois latérales à inclinaison

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EP2030910A1 (fr) * 2007-08-30 2009-03-04 Körber AG Ceinture transparente pour produits pharmaceutiques et/ou médicaux et/ou de complément alimentaire
EP2303219A1 (fr) * 2008-07-10 2011-04-06 2P2D Solutions Ltd Dispositif de distribution de médicament et procédé d utilisation de celui-ci
JP5001404B2 (ja) * 2010-05-10 2012-08-15 株式会社ゼンシン 化粧料及び同化粧料を収容してなる箱入り化粧料
WO2013013108A2 (fr) * 2011-07-19 2013-01-24 Id-Con, Llc Systèmes et procédés d'emballage
AU2013202919C1 (en) * 2012-07-03 2016-02-04 Advent Pharmaceuticals Pty Ltd Blister Pack
DE102014106427A1 (de) * 2014-05-08 2015-11-12 Technische Universität Dresden Verfahren und Vorrichtung zur Herstellung von Formteilen aus einer Faserwerkstoffbahn
HUE051758T2 (hu) * 2018-07-26 2021-03-29 Uhlmann Pac Systeme Gmbh & Co Kg Buborékcsomagolás gyógyászati termékekhez és szerszám a buborékcsomagolás elõállítására
EP3599176B1 (fr) * 2018-07-26 2020-12-30 Uhlmann Pac-Systeme GmbH & Co. KG Procédé de fabrication d'emballages à blister pour produits médicaux et emballage à blister
AR117777A1 (es) * 2019-01-09 2021-08-25 Csp Technologies Inc Envases alveolados que contienen un material activo y métodos para fabricarlos y usarlos
CN216510278U (zh) * 2021-03-16 2022-05-13 深圳市骄冠科技实业有限公司 一种药品链带包装
US11779518B2 (en) * 2021-08-09 2023-10-10 Express Scripts Strategic Development, Inc. Blister pack device and method
EP4358089A1 (fr) * 2022-10-18 2024-04-24 Medistac Inc. Limited Système et procédé d'assemblage d'un plateau de médicament
WO2024094329A1 (fr) * 2022-11-01 2024-05-10 Basilea Pharmaceutica International Ag, Allschwil Préparation de capsule sous emballage coque contenant du sulfate d'isavuconazonium

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ATE548292T1 (de) 2012-03-15
WO2009030475A8 (fr) 2010-03-04
EP2197764B1 (fr) 2012-03-07
EP2197764B9 (fr) 2012-06-20
WO2009030475A1 (fr) 2009-03-12
JP5073059B2 (ja) 2012-11-14
JP2010536681A (ja) 2010-12-02
AU2008295065A1 (en) 2009-03-12
EP2197764A1 (fr) 2010-06-23
CA2697487A1 (fr) 2009-03-12
US8220635B2 (en) 2012-07-17
CA2697487C (fr) 2016-02-02
EP2457843A1 (fr) 2012-05-30
US20100300924A1 (en) 2010-12-02

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