Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
  • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
  • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
  • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
  • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
  • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
  • A61J1/035—Blister-type containers
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D2203/00—Decoration means, markings, information elements, contents indicators

Definitions

• Blister strap for holding medical and / or pharmaceutical and / or nutritional supplement products
• the invention relates to a blister strip for receiving medical and / or pharmaceutical and / or food-supplementing products, comprising a rollable, divisible into individual blister sections product carrier, the one-lane product carrier in its conveying direction F successively individual the division T of the blister strip defining nests for receiving isolated Products, as well as a foil-like cover for closing the nests, such that each product is arranged sealed within a nest.
• Such blister belts are used in particular in the production of patient-specific packaging.
• Such packaging can be made manually or automatically.
• sections of a single product or a plurality of products are unrolled from individual rolled-up blister straps, which are preferably each equipped with a product type, separated from the blister strip and positioned on a substrate and, if necessary, e.g. attached by gluing or the like.
• the blister strip is sandwiched between the substrate and a lid member.
• the lid member has openings through which the nests at least partially protrude.
• the substrate is provided with perforations in the region of the products, so that the products are pushed through the foil-like cover of the blister strip and through the partially weakened material of the substrate during removal of the products by applying pressure to the nests.
• Known blister belts are designed individually with a single-stage nest for each product or product type. So have the blister straps and especially those for recording The product formed nests from product to product or product type to product type depending on the product geometry different geometries. Specifically, for example, the nests of tablets differ from those of oblongs or of capsules in shape and size. Correspondingly, the product blister sections of different blister belts also have different lengths and / or widths.
• the nests usually have a single, one-step holding space for each product. This means that the nest or the receiving space is designed exclusively product-specific and individualized. In other words, the size of the opening for expressing the product from the nest corresponds to the size of the product.
• the blister belts known hitherto are disadvantageous for various reasons, both in the case of preferably automatic placement on a substrate and when expressing from the nest. Due to the different geometries of the blister straps or the blister sections, automated assembly is only possible with considerable measurement and control effort possible. In other words, the placement head of a placement machine must each control individual pick-up positions for the blister sections separated from the blister strip. This leads to an increased placement time and to an increase in the number of assembly errors, which is to be avoided especially in the production of patient-specific packaging. Furthermore, the different geometries of the nests necessitate a corresponding adaptation, in particular of the cover elements. More specifically, individual nest sizes require individual apertures in the lid members, resulting in an increased number of lid member formats.
• a further disadvantage of the known blister belts is that there are large free spaces inside the nests which are not filled by the products, so that an insufficient durability of the products as a result of air entrapment can occur.
• each nest has a two-stage shaped receiving space with an independent of the product geometry well and a from the product geometry dependent depression, wherein the depth D of the product-independent depression starting from the cover on the one hand at least so large that the blister strip along the product-independent depression is mechanically laterally feasible, and on the other hand less than the thickness of the smallest product to be accommodated within the nest ,
• This embodiment ensures in a surprisingly simple manner that a standardization of the nests is achieved, which leads on the one hand to an improved automatic handling during the production of a package and on the other hand to an improved handling during the "operation" is particularly facilitated by the present invention achieved double effect of Ausdschreib Anlagen.
• the longer lever on each product during expression ensures lower ejection forces.
• the formation of the nest and in particular the product-independent depression leads to a dilution of the nest wall, so that the Eind Wegwiderstand is lowered.
• a preferred embodiment provides that the product-independent depression in its parallel to the cover cross-section is greater than the product-dependent depression, so that the expressions and thus the handling is simplified.
• the cross section parallel to the cover in this context means nothing more than the plan view of the recess in the plane of the cover.
• An expedient development of the invention is characterized in that the product-independent depression in its parallel to the cover extending cross-sectional geometry for all products is identical.
• the product-independent depression on the one hand which is also referred to as a standardized atrium
• the product-dependent depression on the other hand which is also known as product farm
• the logistical effort can be reduced because the Diversity of the necessary elements for production / parts, namely common cover elements for all products, is reduced.
• a preferred embodiment is characterized in that the depth D of the product-independent depression is at least 1.2 mm and at most 2.5 mm.
• the minimum depth of the product-independent recess of 1, 2mm ensures that the blister straps are still mechanically manageable.
• the side edge of the recess directed vertically to the conveying plane forms a guide means during transportation or during the conveyance of the blister straps, wherein the minimum height of the side edge corresponding to the depth D of the recess causes the blister straps to deflect laterally during transport or during conveyance effectively prevented.
• the maximum depth of the product-independent well ensures that products are within the product-dependent well after filling the nest and do not inadvertently reach the area between the product-independent well and the cover. In other words, the products within the product-dependent depression are quasi fixed by the inventive design or training of the product-independent depression.
• a further expedient refinement is characterized in that the cross-section of the product-independent depression extending parallel to the cover is designed and arranged geometrically to accommodate a wide variety of product types. This ensures that the filling of the individual nests with products of different product geometries can be achieved with a small number of nest geometries. This reduces the required number of format parts in the production or molding of the nests.
• the cross-section extending parallel to the cover corresponds to the product-independent depression of a rhombus with rounded corners.
• This special geometry of the product-independent recess ensures that a wide variety of products, eg maximum round flat or spherical tablets but also maximum size tablets in Oblong or capsule form are blisterable in a blister strip.
• Another advantage is that the inventive design and arrangement of the product-independent depression leads to space savings in width and length of the blister strip, as a space-optimized alignment of the product-independent depression is guaranteed.
• the geometric dimensions of the blister strip or blister sections are product-independent, so that in the production of packaging from multiple blister belts with different products, a common standard exists that simplifies the production considerably. Regardless of the product or the product geometry, a defined pick-up position can be reached, so that the measurement or control effort is avoided or greatly reduced.
• each nest is associated with a first positioning aid, wherein the position of the positioning aid is fixed to the nest.
• the positioning aid can be used to improve the positioning and control of the blister straps or blister sections, for example, on placement machines or the like.
• each nest or each blister section is assigned an encoding. This encoding allows the
• 1 is a plan view of a single-track blister strip
• FIG. 2 is a plan view of another embodiment of a blister
• FIG. 3 is a plan view of another embodiment of a blister
• 4 shows a plan view of a substrate equipped with a plurality of blister sections
• FIG. 5 is a side view of a two-stage nest according to the invention in section with a tablet
• FIG. 6 is a side view of another nest in section with an oblong
• FIG. 7 is a front view of the nest according to Figure 6,
• FIG. 11 is a plan view of the recess of Figure 10,
• FIG. 13 shows a plan view of the blister section according to FIG. 12.
• the invention relates to different variants of blister straps, which are particularly suitable to be assembled into a patient-specific packaging.
• a blister strip 10 according to the invention serves to receive medical and / or pharmaceutical and / or nutritional supplement products 11.
• the products 11 may be formed as tablets, oblongs, capsules or in another customary dosage form.
• the blister straps 10, which are basically designed as a single web, comprise a roll-up product carrier 12, which usually consists of polyvinyl chloride (PVC) or a material with comparable properties and can be divided into individual blister sections 13.
• PVC polyvinyl chloride
• the product carrier 12 in succession individual nests 14, which serve to receive isolated products 11.
• the nests 14 and their distances from one another, which define the pitch T of the blister strip 10, are closed with a film-like cover 15, which are preferably made of aluminum or a material with comparable properties, so that each individual product 11 within the nest 14 opposite the environment is completely shielded.
• Each blister strip 10, regardless of the type of filling or of the nests 14 associated products 11, has a pitch T, ie the distance from nest center to nest center on.
• a blister portion 13 is formed rectangular.
• the length L of a blister section 13, that is to say the lateral edge length of a blister section 13 carrying a product 11, in the conveying direction F is usually longer than the width B of the blister strip 10.
• a blister section 13 can also have other shapes.
• the length L may correspond to the width B of the blister strip 10, so that the blister sections 13 are square-shaped.
• the geometric dimensions of the blister strip 10 and the individual blister sections 13 are product-independent. In other words, the blister strips 10 or blister sections 13 have common, standardized dimensions for all different products 11.
• Each blister section 13 has exactly one nest 14 formed to receive a single product 11.
• a plurality of blister sections 13 connected to a blister section strand can also be separated from the blister strip 10.
• the nests 14 are aligned centrally on each or each blister section 13. This means that the center of a nest 14 lies above or at the center of a blister section 13. However, other positions of the nests 14 on the blister portion 13 are also possible.
• a positioning aid 17 is formed between the nests 14.
• the positioning aid 17 may be formed between two nests 14 in the conveying direction F of the blister strip 10, wherein the positioning aid 17 in the present Example is a hole.
• the formation and the position of the positioning aid 17 can of course vary. Namely, other particularly visually recognizable or readable markings or markings come into question as a positioning aid 17.
• the hole is always arranged relative to the nest 14 in a defined and constant position relative to the width B of the blister strip 10.
• the hole may be arranged centrally, for example, based on the width B of the blister strip 10.
• a perforation 18 or the like can run between adjacent blister sections 13 transversely to the conveying direction F.
• the perforation 18 may be formed by material weakening, for example by hole perforation, material reduction, etc. Preferably, the perforation 18 extends over the entire width B of the blister strip 10, but may also extend only partially across the width B. In the embodiment shown, the perforation 18 extends through the hole.
• the blister strip 10 can optionally be designed without perforation, as shown in FIGS. 1 and 2, or provided with a perforation 19, as shown in FIG.
• the perforation 19 may be formed on one side or on both sides and serves the guided transport of the blister straps 10, for example, in placement machines.
• the perforation 18 for separating individual blister sections 13 from one another, for example by means of a theoretical separating cut with a blade, can also be designed as a perforation area 20, as FIG. 2 shows.
• each blister section 13 is shortened by a small amount in its length L, whereby an optimized and overlapping-free placement of blister sections 13 on a substrate 21 or the like can be achieved.
• various blister sections 13 or blister section strands 22 formed therefrom with different products 11 can be placed on the substrate 21 in the longitudinal and / or transverse direction. Due to the constant and / or identical pitch and width ratios of all Blisterabitese 13 are all nests 14 with a variety of products 11 at defined and standardized positions, such that despite the different products 1 1 a uniform format for a (not shown) cover element used is. The possibility of nesting in the longitudinal and transverse directions ensures a space-saving arrangement of the blister section strands 22 on the substrate 21. These Nesting is ensured with square as well as rectangular or otherwise shaped blister sections 13 or corresponding blister section strands 22.
• nest 14 itself will be explained in more detail with reference to FIGS. 5 to 11, which show different nests 14 at different scales.
• Each nest 14 has an exactly two-stage shaped receiving space 23. This means that the product carrier 12 in the region of each nest 14 has two recesses of different dimensions.
• nest 14 is formed of a product geometry independent well 24 and a product geometry dependent well 25.
• the recess 25 adapted to the product geometry is arranged, starting from the cover 15 spanning a plane E, behind the recess 24 which is independent of the product geometry.
• the product-independent recess 24 in its parallel to the cover 15 extending cross-section is greater than the product-dependent recess 25 in the corresponding cross-section.
• the product 11 is held centered with respect to the nest 14, so that the pressure exerted during the expression of the products 11 acts directly on the product 11.
• the product-independent depression 24, which determines the size of the opening in an associated (not shown) cover element of a package, is chosen identical in its cross-sectional geometry for all products 11 and all nests 14.
• the two recesses 24, 25 thus form the two-stage receiving space 23.
• the product-independent recess 24 forms a universal forecourt
• the product-dependent recess 25 forms a special product court.
• the depth D of the product-independent recess 24 is of particular importance.
• the depth D is sufficiently large, so that the blister strip 10 can be mechanically guided laterally along the product-independent recess 24.
• the depth D is less than the thickness of the smallest product 11 to be received. In this case, the thickness of the product 11 in its edge region is particularly important.
• the chosen depth D of the recess 24 enables a secure holding of the products 11 in the product-dependent recess 25 in relation to the product thickness.
• the depth D lies in a selected range of approximately 1.2 mm to 2.5 mm and is preferably 2 mm. Minor deviations in the tolerance range, however, are also allowed.
• the shape of the product independent well 24 is also of particular importance, with the mold alone or in conjunction with the selected depth region of the well 24 providing distinct advantages.
• shape of the recess 24 is meant in particular the parallel to the cover 15 extending cross-section of the product-independent recess 24.
• the cross section is formed and arranged in a section parallel to the plane E geometrically for receiving a wide variety of product types.
• the outer edge describes the
• Recess 24 in cross section a shape that is optimized so that a wide variety of product shapes and / or product sizes can be included in the correspondingly formed product-dependent recess 25.
• the recess 24 corresponds to a rhombus with rounded corners.
• the outer edge of the recess 24 may also be described by an oval path with a centrally superimposed circular path, wherein the diameter of the circle is selected to be larger than the minor axis of the oval. In the transition region of the two geometric bodies, the track is smoothed.
• the shape of the product-independent depression 24 can also be described as follows.
• the outer contour, shown in particular in FIG. 11, of the cross-section of the product-independent recess 24, which runs parallel to the cover 15, is composed of a plurality of partial sections.
• the outer contour of the recess 24 is spanned by two at right angles intersecting distances a and b.
• the distance a forms the longitudinal axis of the cross section of the recess 24 and is opposite to a in
• FIG. 11 is a schematic Representation of an arrangement and formation of the contour of the atrium, wherein the representation is not true to scale.
• the angle ⁇ shown in FIG. 1 1 should be approximately 16.7 ° in a preferred embodiment.
• An inclination in the above-mentioned range, in particular in the preferred range and especially in the range specified as particularly preferred, makes it possible to accommodate also elongate products 11 in the nest 14 at a relatively short length L of a blister portion 13.
• an angle ⁇ of about 16.7 ° an optimal arrangement of the distance a of the cross section of the recess 24 of the blister section 13 is achieved and a still easy filling of the nest 14 is ensured.
• the distance b forms the transverse axis of the cross section of the recess 24 and is arranged at right angles to the distance a.
• the distance a and the distance b intersect each other halfway along the distance a or b.
• the ratio of the length of the distance b to the length of the distance a is preferably 0.55 to 0.75 and particularly preferably 0.6 to 0.7. At these ratios, especially at the most preferred ratio, both elongate and circular products 11 are accommodated with minimized clearance. In the embodiment shown in Figure 11, the ratio is about 0.656, the length of the distance a about 25.9mm and the length of the distance b about 17mm.
• the outer contour of the depression 24 composed of subsections forms an arc with a radius R 1 .
• the end of the distance a forms the outer contour of the recess 24 composed of sections of an arc with a radius R 2 .
• the radius R 1 is preferably 6 to 10 mm, more preferably 7 to 9 mm.
• the radius R 1 is about 8mm.
• the radius R 1 behaves in relation to the radius R 2 in the order of about 1.2 to 1.3.
• a radius Ri in the above-mentioned ranges, especially in the most preferred range, ensures that a wide variety of products 11 are accommodated while at the same time minimizing free space in the nests 14. As a result, only minimal amounts of air are trapped, which increases the so-called "shelf life" Result Therefore, in the nest 14 recorded products 11 can therefore be kept in stock for a longer period without having to fear any loss of quality.
• sections of the composite outer contour of the cross section of the recess 24 form - next to the two arcs with the radii Ri at the ends of the transverse axis (distance b) and the two arcs with the radii R 2 at the ends of the longitudinal axis (distance a) - sections S of four tangents, which are applied on the one hand to an arc with the radius Ri and the other to an arc with the radius R 2 .
• the aforementioned sections S each extend from the point of contact of the corresponding tagente with the arc of radius R 1 to the point of contact of this tangent with the arc of radius R 2 .
• the aforementioned outer contour thus results from an assembly of two opposing sheets having a radius R 1 and two opposing sheets having a radius R 2 and four these arches connecting, rectilinear sections S to the pair of sheets (the radii R 1 and R 2 ) applied tangents.
• a rectilinear, an arc with the radius R 1 and an arc with the radius R 2 connecting portion S is arranged parallel to the longitudinal extent of the blister strip 10 or the blister portion 13.
• at least one section S runs parallel to the side edge of the blister belt 10.
• a wall is formed by this section S which is particularly well suited for guiding the blister strip 10, for example along a filling station with a guide rail.
• a low surface pressure is achieved due to the relatively long, formed by the wall guide surface, which allows to work with very thin wall thicknesses. This in turn allows a low material consumption.
• the transversely to the longitudinal extent of the blister strip 10 or the blister portion 13 projected length d of the outer contour of the cross section of the recess 24 is preferably 22 to 28mm, more preferably 23 to 27mm. In the exemplary embodiment illustrated in FIG. 11, the length d is approximately 25 mm.
• the projected along the longitudinal extent of the blister strip 10 and the blister portion 13 width c of the outer contour of the cross section of the recess 24 is preferably 14 to 20mm, more preferably 15.5 to 18.5mm.
• the width c is about 17mm. If the length D and the width c are in the above-mentioned ranges, especially in the particularly preferred range, a multiplicity of different geometries of products 11 can be accommodated in the nests 14 with minimized clearances.
• the radius R 3 at the protruding, free step of the recess 24 is preferably 07, to 0.9 mm, more preferably 0.75 to 0.85 mm. In the exemplary embodiment illustrated in FIG. 10, the radius R 3 is approximately 0.8 mm.
• the radius R 4 is approximately 0.3 mm.
• Each nest 14 is optionally additionally associated with a further positioning aid 26 (see FIG. 13), wherein the position of the positioning aid 26, which may be formed by way of example as a punched hole, is fixed with respect to the position of the nest 14.
• a positioning aid 26 but also other in particular visually recognizable or readable markings or markings come into question.
• each nest 14 or each blister section 13 may be assigned an encoding 27.
• the coding 27 contains information about the corresponding nest 14 and the product 11 located therein.
• the blister strip 10 can also have a superordinate, central (not shown) coding which contains information on the blister strip 10 itself (for example, date of manufacture, etc.).
• thermoforming machine On a thermoforming machine or the like, a so-called bottom film made of PVC, which represents the product carrier 12, is unwound from an endless roll and a thermoforming station, which is essentially formed of a preheater, a blowing head and a thermoforming mold supplied.
• the respective nest 14 is formed, for example, by means of compressed air.
• the formation of the nest 14 can also be carried out at least partially by a stamp or the like. For the multi-stage nest 14, therefore, successively or simultaneously several of the forming steps are necessary.
• each nest 14 is filled with only one product 11.
• the filling may optionally be checked by inspection systems or the like.
• a preferably manual refilling of empty nests 14 can take place.
• the filled and controlled blister strip 10 is closed or sealed with the film-like cover 15, namely a cover sheet of aluminum or the like.
• a punching station or the like is provided. After the formation and sealing of the nest 14, a punching hole is introduced as a positioning aid 26 in the bottom foil / cover foil in the region of each nest 14. Subsequent to the application of the cover film, a perforation 18 can take place transversely to the conveying direction F of the blister strip 10. As a result, a targeted separation of individual blister sections 13 from the blister strip 10 is simplified.
• an encoding 27 is applied in the region of each nest 14, which allows the identification of the contents of the nest 14.
• a 2D matrix code is lasered into the bottom film from the base film side.
• the described production can also be carried out in parallel for a plurality of interconnected blister straps 10, whereby according to the method steps described a separation takes place in the longitudinal direction of the blister straps 10.
• a web consisting of several, eg five, tracks can be divided into five individual blister straps 10.
• the product-independent depressions 24 serve to guide the tray consisting of eg five webs. After separating into individual blister straps 10, the side edges can be cut so that blister straps 10 of the same width are produced.

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• 2007
  • 2007-08-30 EP EP07075763A patent/EP2030910A1/fr not_active Withdrawn
• 2008
  • 2008-08-30 JP JP2010522267A patent/JP5073059B2/ja not_active Expired - Fee Related
  • 2008-08-30 EP EP08801828A patent/EP2197764B9/fr not_active Not-in-force
  • 2008-08-30 EP EP12156580.8A patent/EP2457843B1/fr not_active Not-in-force
  • 2008-08-30 AU AU2008295065A patent/AU2008295065A1/en not_active Abandoned
  • 2008-08-30 WO PCT/EP2008/007211 patent/WO2009030475A1/fr active Application Filing
  • 2008-08-30 US US12/675,325 patent/US8220635B2/en active Active
  • 2008-08-30 CA CA2697487A patent/CA2697487C/fr not_active Expired - Fee Related
  • 2008-08-30 AT AT08801828T patent/ATE548292T1/de active

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