Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
  • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
  • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
  • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
  • B05C17/01—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with manually mechanically or electrically actuated piston or the like
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
  • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
  • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
  • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
  • B05C17/01—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with manually mechanically or electrically actuated piston or the like
  • B05C17/0116—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with manually mechanically or electrically actuated piston or the like characterised by the piston driving means
  • B05C17/0133—Nut and bolt advancing mechanism, e.g. threaded piston rods
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
  • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
  • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
  • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
  • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
  • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
  • G01F11/025—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons
  • G01F11/026—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons of the gun type
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
  • A61C5/00—Filling or capping teeth
  • A61C5/60—Devices specially adapted for pressing or mixing capping or filling materials, e.g. amalgam presses
  • A61C5/62—Applicators, e.g. syringes or guns
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
  • A61M2005/3104—Caps for syringes without needle
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
  • A61M5/31533—Dosing mechanisms, i.e. setting a dose
  • A61M5/31545—Setting modes for dosing
  • A61M5/31548—Mechanically operated dose setting member
  • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
  • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
  • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
  • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
  • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
  • A61M5/31581—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
  • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
  • A61M5/3159—Dose expelling manners
  • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Definitions

• the invention relates to an applicator and an exchangeable container with a liquid or pasty medium, which can be attached to the Aplikatotr, for oral administration of liquid or pasty media, in particular on the animal.
• DE 103 48 186 A1 discloses an injection device for administering a fluid product, for example a medicament, in osteoporosis therapy.
• DE 100 20 591 A1 relates to an applicator for dental material, which has a high dose accuracy through a pawl mechanism and a blocking mechanism and is free from Nachström-phenomena.
• EP 0 806 187 B1 also relates to an applicator in the dental field which is intended to avoid repressing the mass to be applied.
• the object of the invention to provide an easy-to-use applicator for the application of liquid or pasty media.
• the applicator should in particular be suitable for applying different metering volumes selected by the user.
• the solution according to the invention consists in an applicator for the application of liquid or pasty media, comprising a housing for receiving a dosing unit and an adapter for fixing a container for the medium to be applied to the applicator, a means for setting a dosage, a lever for the application of metered amount, which is in mechanical interaction with the dosing unit and with the means for adjusting the dosage, wherein the lever is movably mounted with its proximal end within the housing and in the ready-to-use state, the distal end of the lever spreads from the housing, wherein the distance of the distal end of the lever from the housing is dependent on the set dosage.
• the lever has near its proximal end mounted in the housing a ball which is in contact with the dosing unit.
• the dosing unit includes a threaded spindle, a threaded sleeve, a pressure medium, a locking mechanism for the threaded sleeve and a locking mechanism for the threaded spindle.
• the housing has at its front end an opening for attachment of a container which is filled with the medium to be applied.
• the threaded spindle and the threaded sleeve are coaxially mounted in the housing so that the external thread of the threaded sleeve engages in the internal thread of the threaded spindle.
• the lever associated ball is arranged in an axis with the threaded sleeve, threaded spindle and housing opening so that movement of the splayed distal end of the lever to the housing causes a movement of the ball towards the front, open end of the housing.
• the ball presses the threaded sleeve with the threaded spindle mounted therein also in the direction of the front open housing end.
• the movement of the splayed distal end of the lever toward the housing takes place against the pressure of the pressure medium, so that when the lever is released, it returns to the spread position and the ball moves away from the front open housing end.
• Threaded sleeve, ball and pressure medium are mounted to each other so that the threaded sleeve with the ball from the front open housing end wegschiebt when the ball from the front open housing end away.
• the threaded spindle has a coarse thread.
• an axial force acting on the threaded sleeve can be converted into a rotational movement of the threaded sleeve relative to the threaded spindle.
• the locking mechanism for the threaded sleeve allows inserted cartridge only a displacement of the threaded sleeve relative to the threaded spindle in the axial direction to the rear end of the housing, but not in the opposite direction.
• the latching mechanism for the threaded spindle permits only a displacement of the threaded spindle in the axial direction to the front end of the housing, but not in the opposite direction, so that the threaded spindle does not follow the threaded sleeve when moving toward the rear housing end.
• the threaded spindle pushes a little further out of the front end of the threaded sleeve.
• the locking mechanism for the threaded spindle is connected to the adapter for the cartridge that at the same time the locking mechanism for the threaded spindle is released when removing the cartridge from the adapter and any displacement of the threaded spindle in the axial direction relative to the threaded sleeve and the housing is possible.
• the length of the threaded spindle is dimensioned such that its front end moves out of the front housing opening slightly further with each application. If a container for holding the medium to be applied is attached to the adapter at the front end of the housing, the threaded spindle pushes further into this container with each application, that is, with each lever pressure.
• the means for adjusting the dosage determines the degree of spreading of the lever before application and thus the stroke to the front end of the housing, the ball, the threaded sleeve and thus perform the threaded spindle.
• the means for adjusting the dosage may be a metering wheel, which is mounted on the side of the ball remote from the front housing end in an axis with the ball and the front housing opening and the axialxsspiel- limited space of the ball.
• the metering wheel can also be connected to the threaded sleeve.
• a metering scale may be attached to the distal end of the lever so that the scale is visible to a greater or lesser extent, depending on the degree of spreading of the lever.
• a scale can also be attached directly to the metering wheel or at another suitable location, for example, lying outside on the housing.
• the lever may be designed so that when the position of the lever, the scale is covered, and with swung lever, the scale, according to the dosage, is visible.
• the lever on the housing is preferably child-resistant.
• the parental control can e.g. The fact that after an application initially applied to the housing lever can be brought back into the splayed position only after over-fertilization of a detent of the lever on the housing.
• a reduction sleeve threaded inside and a rectified thread is mounted concentrically outside between the threaded sleeve and the threaded spindle.
• the internal thread of the reduction sleeve has a different pitch than the internal thread of the threaded sleeve.
• the feed of the threaded spindle changes according to the ratio between the pitch of the internal thread of the threaded sleeve to the pitch of the internal thread of the translation sleeve.
• the adapter for fastening a container to the medium is e.g. a cartridge adapted to a specific adapter.
• the container is e.g. a cartridge adapted to a specific adapter.
• the interaction of adapter and container is explained as an example of other possible containers.
• the cartridge according to the invention which can be filled with a liquid or pasty medium, preferably a veterinary medicinal product to be administered, has a cylindrical housing with an opening for filling on one side and with a tapered region, the mouthpiece , on the other side of the case.
• the opening for filling is closed with a filled cartridge by a piston, which is successively moved during application further into the interior of the cartridge to the mouthpiece.
• the mouthpiece has an opening for dispensing the liquid or pasty medium from inside the carton. ink.
• the cartridge typically has a volume in the range of 5 ml to 50 ml, preferably in the range of 8 ml to 20 ml, particularly preferably 1 1 to 13 ml.
• the passage opening Through the opening at the front end of the housing of the applicator, the passage opening, a cartridge ready for use can be brought with its side closed by the piston to the adapter in the interior of the housing.
• the passage opening is circular, but has one or more additional openings, whereby the diameter of the circular shape is partially increased.
• the adapted to such a passage opening cartridge has accordingly in the area around its circular opening for filling lugs, which are inversely to the additional openings.
• the passage opening has two to five, particularly preferably two, mutually opposite additional openings.
• the cartridge has correspondingly two to five, more preferably two opposing lugs.
• the adapter Behind the passage opening is the adapter.
• the adapter has a lock nut and a pressure means, for example, a compression spring.
• the lock nut is a tubular sleeve which is mounted concentrically to the threaded spindle directly behind the passage opening in the axial direction displaceable.
• the pressure medium pushes the lock nut in the direction of the passage opening at the front end of the housing.
• the cartridge is attached to the adapter, in which it is guided with its closed by the piston side to the passage opening so that the lugs enter through the additional openings in the interior of the applicator housing.
• axial pressure is exerted on the pressure medium in the direction of the rear end of the housing and at the same time the cartridge is rotated so that the extension pieces come to lie behind the circular areas of the passage opening away from the additional openings and pinch or snap into place there.
• the lock nut also has the function in the ready-to-use state, ie when a cartridge is attached to the adapter, a positive connection is produced between the threaded sleeve or the reduction sleeve and the threaded spindle. This happens because the front end of the threaded sleeve or the reduction sleeve is only within the tubular sleeve of the lock nut when a cartridge is attached to the adapter. If there is no cartridge on the adapter, the lock nut is displaced towards the front end of the housing by the pressure medium closure such that the front end of the threaded sleeve or the reduction sleeve is no longer located inside the tubular sleeve of the lock nut.
• the threaded sleeve or the reduction sleeve is longitudinally slotted so that it spreads as soon as its front end is no longer held together by the tubular part of the lock nut. This spread tion is sufficient to cancel the close contact between the threaded spindle and threaded sleeve or reduction sleeve, so that the threaded spindle can then be moved in the axial direction through the threaded sleeve or reduction sleeve without taking the threaded sleeve or reduction sleeve.
• This axial movement possibility of the threaded spindle relative to the threaded sleeve or reduction sleeve is necessary so that after removing a spent cartridge, the threaded spindle can be pushed back into the housing before a new, unused cartridge is attached.
• the adapter has a lock nut element.
• the lock nut member is a two-part tubular sleeve which is mounted concentrically to the threaded spindle and the threaded sleeve or reduction sleeve, rotatable and displaceable in the axial direction. It has on its side facing the passage opening at its outer periphery on one or more axially extending grooves or projections on which a suitably adapted cartridge can be coupled. Preference is given to one to eight, more preferably two opposing grooves or projections.
• the cartridge has on its side facing away from the passage opening at its outer periphery at least one cam which engages in at least one groove, which is attached to the inner wall of the housing.
• the one or more flutes extend on the inner wall of the housing at an angle in the range between 90 and 100 degrees, preferably between 90.5 and 95 degrees, to the axial direction.
• a bushing Centrally located inside the lock nut element is a bushing with a central bore through which the threaded spindle passes.
• the sleeve slides with axial displacement of the lock nut member in a direction away from the passage opening of the housing, over the passage opening facing the end of the threaded sleeve or reduction sleeve. Since the threaded sleeve or reduction sleeve is designed to be elastic by slots and spreads, the positive connection between the threaded spindle and the threaded sleeve or reduction sleeve is produced by the displacement of the sleeve over the end of the threaded sleeve or reduction sleeve.
• the cartridge which is adapted for the second embodiment of the adapter, has in its inner periphery in the region of the opening for filling one or more axially extending elongated grooves or projections. Preference is given to one to eight, more preferably two opposing grooves or projections.
• the position of these elongate grooves or protrusions is chosen to match the position of the grooves or protrusions in the match outer circumference of the lock nut member and the cartridge cooperates with the lock nut element according to the key-lock principle when it is pushed over the lock nut element. Therefore, the cartridge has projections in its inner periphery when the lock nut member has grooves on its outer periphery and vice versa.
• the cartridge When attaching the cartridge to the adapter according to the second embodiment, it is rotated so that the positions of the lugs match the position of the additional openings in the passage opening. This means that at the same time coincide the position of the grooves or projections on the lock nut member and the grooves or projections on the inner wall of the cartridge.
• the cartridge is pushed over the lock nut element in this way.
• the lock nut element Upon rotation of the cartridge, the lock nut element performs an axial movement relative to the housing via the interaction of cam and groove.
• the threaded sleeve or reduction sleeve is enclosed and made the positive connection to the thread of the threaded spindle.
• the lugs engage in recesses or apertures on the inner wall of the housing.
• the applicator according to the invention has an additional cartridge lock, in order to prevent that strong rotational forces acting on the cartridge, for example when turning off a closure cap (see below) from the mouthpiece of the cartridge, do not lead to a detachment of the cartridge from the adapter to lead.
• the cartridge lock consists in an approximately semicircular locking arc.
• the locking arc is mounted concentrically in the region of the adapter in the housing and has locking cams which engage with corresponding locking cams on the attachment pieces of the cartridge.
• the locking arc has two arranged at the bow ends opposite each other buttons. Due to the curved shape of the locking arc is elastic and can be deformed by radial pressure from the outside on the probe so that the buttons come closer to each other. After releasing the button, the latch arch returns to its original shape.
• sawtooth-shaped locking cams are arranged on the inside of the locking arc, which point with their tips both in the same direction of rotation.
• the locking arc is arranged in the housing of the applicator so that the buttons come to lie in openings through the housing and operated from outside the housing, that can be pressed. If a cartridge is in the latched state, sawtooth-shaped latching cams engage on the attachment pieces of the cartridge in the sawtooth-shaped latching cams of the latching arc such that no reverse rotation of the cartridge is possible. Only by pressing both buttons simultaneously, the locking of the respective locking cam at the two opposite positions is released. This happens in that the buttons are compressed so far that the locking cams of the locking arc are moved so far into the interior of the housing that the locking cams of the cartridge can be passed outside of the locking cams of the locking arc.
• the cartridge has a closure cap on the mouthpiece.
• This may be an internally threaded rotary cap known per se, which is screwed onto the mouthpiece provided with an external thread.
• the cap is child resistant.
• a child-resistant cap may be constructed as follows: The child-resistant cap has an outer cylindrical wall and an end wall. The outer diameter of the cap corresponds to the outer diameter of the cartridge, on the mouthpiece of which it should be screwed. Concentric within the outer wall is an inner cylindrical wall. On the inside of the inner wall is a thread. On the open side of the cap are located on the end face of the outer wall, two opposing cams. The mouthpiece of the cartridge has an external thread that matches the thread on the inside of the inner wall.
• the wall forms an annular edge, on the inside of which two sawtooth-shaped protrusions lying opposite one another are located.
• the invention furthermore relates to an applicator system comprising an applicator described above to which a cartridge described above is attached.
• the attachment is reversible, so that an empty cartridge can be replaced by a new, full.
• the cartridge attached to the applicator is emptied by a predetermined volume at each lever stroke by pushing the plunger a little farther into the cartridge at each lever pressure by the threaded spindle protruding coaxially with the cartridge from the housing.
• a dosing volume is preferably applied in the range of, for example, 0.1 to 2.5 ml, wherein the dosage can be varied in, for example, 0.1 ml steps.
• the applicator system according to the invention is particularly suitable for oral administration, especially for oral administration of a drug to animals.
• cartridges with different diameters can be used, in which case also for each cartridge diameter a separate scale is attached to the lever or at another suitable location on the applicator.
• Fig. 1 shows an outside view of a first embodiment of the applicator with the
• Fig. 2 shows an interior view of a first embodiment of the applicator with the lever fitting
• Fig. 3a, b show an interior view of a first embodiment of the applicator with the
• Fig. 4 shows an interior view of a first embodiment of the applicator with the
• FIG. 5 outer view of a second embodiment of the applicator with the lever fitting
• Fig. 6 shows an interior view of a second embodiment of the applicator with the
• Fig. 7 shows an interior view of a second embodiment of the applicator with the lever swung maximum
• Fig. 8a, b show an interior view of a variant of the first embodiment of the applicator with the Hubuntersburg
• Fig. 9 shows a cartridge
• Fig. 10 shows the mouthpiece area of a cartridge
• Figures 11a, b show the cap and mouthpiece area of a cartridge
• Fig. 12 shows a slotted reduction sleeve
• Fig. 13 shows the adapter for the cartridge in a variant
• Fig. 14 shows the cartridge lock for mounting the cartridge to the applicator
• Figs. 15a-c show detailed views of the mechanism of the cartridge lock
• FIGS. 1 to 4 show a first embodiment of the applicator according to the invention.
• the applicator 100 has an elongated housing 10 for receiving a metering unit.
• the housing 10 has at its front end a passage opening 25 (see also Fig. 3b).
• an adapter for attaching a container for example a cartridge 14 for the liquid or pasty medium.
• the housing 10 has an opening 26 for a metering wheel 2.
• a female thread 27 is mounted inside the rear end of the housing 10 in which the metering wheel 2 is rotatably mounted.
• the dosage for the application is set.
• the lever 1 is used to apply the metered amount and is movably mounted with its proximal end 21 within the housing 10.
• the distal end 22 of the lever 1 is spread apart from the housing 10, wherein the distance of the distal end 22 of the lever 1 from the housing 10 is dependent on the set dose.
• the lever 1 is rotatably connected to the housing 10 at a pivot point 4.
• a scale 16 is mounted, which lies relative to the pivot point 4 on the section of the circular path of a circle whose radius corresponds to the distance between the pivot point 4 and the point 221 at which the scale 16 attached to the lever 1 is.
• the scale 16 is depending on the degree of spreading of the lever 1 more or less inside or outside the housing 10. At high dosages, a higher proportion of the scale 16 is outside the housing 10, at low dosages corresponding to a smaller part.
• the lever 1 has a ball 3, which is in contact with the metering wheel 2 on the one hand and the metering unit.
• the metering unit contains a threaded spindle 9, a threaded sleeve 8, a compression spring metering 7, a latching mechanism for the threaded sleeve 8 and a latching mechanism for the threaded spindle 9.
• the compression spring metering 7 is mounted between a ring 29 which is fixedly connected to the housing 10, and the rear end of the threaded sleeve 8 so that it exerts axial pressure on the rear end of the threaded sleeve 8 towards the rear end of the housing 10.
• the threaded spindle 9 has a coarse thread. As a result, an axial force acting on the threaded sleeve 8 can be converted into a rotational movement of the threaded sleeve 8 relative to the threaded spindle 9.
• the locking mechanism for the threaded sleeve 8 allows cartridge inserted 14 only a displacement of the threaded sleeve 8 relative to the threaded spindle 9 in the axial direction to the rear end of the housing 10, but not in the opposite direction.
• the locking mechanism for the Threaded spindle 9 allows inserted cartridge 14 only a displacement of the threaded spindle 9 in the axial direction to the front end of the housing 10, but not in the opposite direction.
• the latching mechanism for the threaded spindle 9 is connected to the adapter for the cartridge 14 so that when removing the cartridge 14 from the adapter at the same time the locking mechanism for the threaded spindle 9 is released and any displacement of the threaded spindle 9 in the axial direction relative to Threaded sleeve 8 and the housing 10 is possible.
• a cartridge 14 is shown, which is fastened via the adapter at the front end of the housing 10.
• An individual view of the cartridge is shown in FIG. 9.
• the end of the cartridge 14 facing the applicator 100 has an opening 31 for filling the cartridge 14, which is closed by a piston 13 in the ready-to-use state.
• the other end of the cartridge 14 tapers to a mouthpiece 28 which is closed by a closure cap 15
• the metering wheel 2 To dose setting the metering wheel 2 is rotated in the female thread 27 out of the housing 10 out.
• the compression spring dosage 7 presses against the rear end of the threaded sleeve 8, which in turn is in contact with the sleeve 5, the knob 6 and the ball 3.
• the ball 3 moves with the sleeve 5 and the knob 6 in the axial direction towards the rear end of the housing 10.
• the lever 1 By moving the ball 3 in the direction of the rear end of the housing 10, the lever 1 pivots over the pivot point 4 to the outside and spreads with increasing axial displacement with its distal end 22 more and more from the housing 10.
• the set dose can be found on the scale 16.
• the threaded sleeve 8 screws on the thread of the threaded spindle 9 to the rear.
• the threaded sleeve 8 is rotatably supported via the sleeve 5 and knob 6.
• the threaded spindle 9 is prevented by the locking mechanism for the threaded spindle 9 from moving axially with the threaded sleeve 8 to the rear.
• the distal end 22 of the lever 1 is pressed in the direction of the housing 10.
• the ball 3 is moved against the pressure of the compression spring dosing 7 in the axial direction to the front end of the housing 10.
• the sleeve 5, the knob 6 and the threaded sleeve 8 move axially toward the front end of the housing 10. Because of the locking mechanism for the threaded sleeve 8, the threaded spindle 9 moves axially with the threaded sleeve 8 in the direction of the front End of the case.
• the locking mechanism for the threaded sleeve 8 allows in this direction no relative displacement between the threaded spindle 9 and threaded sleeve 8, while the locking mechanism for the threaded spindle 9 allows movement towards the front end of the housing 10.
• the threaded spindle 9 presses against the piston 13 of the cartridge 14, which is attached to the adapter at the front end of the housing 10.
• the piston 13 is moved into the cartridge 14 and pushes its time the set dose corresponding amount of medium through the mouthpiece 28 from the cartridge 14 out.
• FIGS. 5 to 7 show a second embodiment of the applicator according to the invention.
• the applicator 200 has an elongate housing part 210 for receiving a metering unit and a housing part 220 protruding in the middle region of the elongate housing part 210.
• the housing part 210 has an opening 225 at its front end and an adapter in the area of the passage opening 225 for attaching a container, for example a cartridge 214 for the liquid or pasty medium.
• a metering wheel 202 is rotatably mounted within the housing part 210 via the threaded spindle 209. About the metering wheel 202, the dosage for the application is set.
• the lever 201 is used to apply the metered amount and is mounted with its proximal end 221 movable in the transition region between the housing part 210 and the housing part 220 protruding therefrom.
• the distal end 222 of the lever 201 is spread apart from the protruding housing part 220, wherein the distance of the distal end 222 of the lever 201 from the housing part 220 is dependent on the set dose.
• the lever 201 is rotatably connected to the housing parts 210 and 220 at a pivot 204.
• a scale 216 is mounted, which lies relative to the pivot point 204 on the section of the circular path of a circle whose radius is the distance between Fulcrum 204 and the point 221, where the scale 216 is attached to the lever 201.
• the scale 216 is depending on the degree of spreading of the lever 201 more or less inside or outside of the housing part 220. At high dosages, a higher proportion of the scale 216 is outside the housing part 220, at low dosages corresponding to a smaller part.
• a scale may also be mounted directly on the metering wheel 202 or at another suitable location.
• the lever 201 has a ball 203 which is in contact with the dosing unit.
• the metering unit includes a threaded spindle 209, a threaded sleeve 208, a metering wheel 202, which is part of the threaded sleeve 208, and a latching mechanism for the threaded spindle 209.
• the compression spring metering 207 is mounted between a web 229 fixedly connected to the housing part 210 or 220 and the proximal end 221 of the lever 201 so as to exert on the ball 203 axial pressure toward the front end of the housing part 210.
• the latching mechanism for the threaded sleeve 202 allows only a displacement of the threaded sleeve 202 relative to the threaded spindle 209 in the axial direction to the rear end of the housing 210, but not in the opposite direction.
• the locking mechanism for the threaded spindle 9 allows inserted cartridge 14 only a displacement of the threaded spindle 9 in the axial direction to the front end of the housing 10, but not in the opposite direction.
• the locking mechanism for the threaded spindle 9 is connected to the adapter for the cartridge 14, that at the same time the locking mechanism for the threaded spindle 9 is released when removing the cartridge 14 from the adapter and any displacement of the threaded spindle 9 in the axial direction relative to the housing 210 and to the threaded sleeve 208 is possible.
• a cartridge 14 is shown, which is fastened via the adapter at the front end of the housing part 210.
• the metering wheel 202 and thus the threaded sleeve 208 is rotated and thus moved over the thread of the threaded spindle 209 axially to the rear end of the housing part 210.
• the ball 203 also moves in the axial direction to the rear end of the housing part 210.
• the threaded spindle 209 is prevented by the locking mechanism for the threaded spindle 209 from moving axially with the threaded sleeve 208 to the rear.
• the lever 201 is pressed in the direction of the housing part 220.
• the ball 203 is displaced in the axial direction in the direction of the front end of the housing part 210.
• the threaded sleeve 208 and the threaded spindle 209 move axially toward the front end of the housing part 210.
• the threaded spindle 209 presses against the piston 213 of the cartridge 14, which is fixed to the adapter at the front end of the housing part 210.
• the piston 13 is moved in the cartridge 14 and in turn pushes the dose of the appropriate amount of medium through the mouthpiece 28 from the cartridge 14 out.
• the feed of the threaded spindle 9, 209 depends on the path of the ball at a lever pressure, the stroke, and the pitch of the helical thread of the threaded sleeve 8, 208.
• the feed of the threaded spindle per lever pressure can be varied beyond by a reduction means, which is arranged concentrically between the threaded sleeve 8, 208 and the threaded spindle 9, 209.
• FIGS. 8a and 8b Such an embodiment with stroke reduction is described using the example of the applicator 800 of FIGS. 8a and 8b.
• the adapter is not located at the passage opening 825 at the front end of the housing 80, but is located inside the housing 80.
• a cartridge 814 attached to the applicator 800 is thus partially within of the housing 80.
• the metering unit in the applicator 800 has a metering wheel 802, a ball 803, a threaded spindle 809, a compression spring metering 807 and a threaded sleeve 808, which cooperate as described for the adapter 100 in FIGS. 1-4.
• the lever for dosing is not shown for this embodiment.
• a slotted reduction sleeve 817 (see also Fig. 12, here shown without thread) with internal thread and a rectified thread (eg both right-hand thread) is located outside concentrically between the threaded sleeve 808 and the threaded spindle 809 stored.
• the reduction sleeve 817 has an annular broadening 830 in its central region.
• the reduction sleeve 817 is rotatably mounted in the housing 80.
• the reduction sleeve 817 is available its annular widening 830, which has a sawtooth-shaped structuring on its outer circumference, interacts with a detent element 818 such that only a rotation in a direction opposite to the thread direction (eg left-hand rotation with right-hand thread inside and outside) is possible for the reduction sleeve 817, but not in the opposite direction.
• the internal thread of the reduction sleeve 817 has a different pitch than the internal thread of the threaded sleeve 808.
• the feed of the threaded spindle 809 changes according to the ratio between the pitch of the internal thread of the threaded sleeve 808 to the pitch of the internal thread of the translation sleeve 817th
• the internal thread of the threaded sleeve 808 (and also the external thread of the reduction sleeve 817) is e.g. has a pitch of 5 mm, a stroke of 10 mm produces two turns of the reduction sleeve 817. If the internal thread of the reduction sleeve 817 (and the thread of the threaded spindle 809) is e.g. has a pitch of 10 mm, then in two turns of the reduction sleeve 817, the threaded spindle 809 is moved 20 mm forward. This results in a reduction of the original hub of 1: 2.
• the reduction sleeve 817 performs no return stroke when turning back the threaded sleeve 808, the return movement is blocked with the locking element 818.
• the adapter for fastening the cartridge 14 may be arranged at the passage opening 25 at the front end of the housing 10 (FIGS. 3 a, 4) or also inside the housing 80 as shown in FIGS. 8 a, b.
• the mode of operation of the adapter will be described below by way of example with reference to the embodiment of the applicator from FIG. 3a.
• the adapter in the applicator 100 has a compression spring closure 1 1 and a lock nut 12.
• the lock nut 12 is a tubular sleeve which is mounted concentrically to the threaded spindle 9 directly behind the passage opening 25 in the axial direction slidably.
• the passage opening 25 has a circular shape which is perforated at two opposite points, the additional openings 39, and has a slightly larger diameter at these additional openings 39 than in the circular area (FIG. 3b).
• the lock nut 12 At its front, the passage opening 25 facing the end, the lock nut 12 has an annular broadening, whose diameter is greater than the diameter of the passage opening 25 in the circular shape.
• the lock nut 12 has on its inner wall an annular thickening on the clear opening corresponds to the diameter of the threaded spindle 9.
• the front end of the threaded sleeve 8 is within the tubular sleeve of the lock nut 12.
• the annular thickening on the inner wall of the lock nut 12 stops axial displacement of the threaded sleeve 8 toward the front end of the housing 10.
• the compression spring shutter 11 is supported between a ring 30 fixedly connected to the housing 10 and the rear end of the lock nut 12 so as to exert axial pressure on the rear end of the lock nut 12 toward the front end of the housing 10.
• the lock nut 12 is displaced by the compression spring closure 11 as far as the front end of the housing 10 that the front end of the threaded sleeve 8 is no longer within the tubular sleeve of the lock nut 12.
• the threaded sleeve 8 is longitudinally slotted so that it spreads as soon as its front end is no longer held together by the tubular part of the lock nut 12. This spread is sufficient to cancel the close contact between the threaded spindle 9 and threaded sleeve 8, so that the threaded spindle 9 can then be moved in the axial direction through the threaded sleeve 8 without taking the threaded sleeve 8.
• the cartridge 14 (FIGS. 3 a, 9) has a cylindrical wall 21.
• the end of the cartridge 14 facing the applicator 100 has an opening 931 for filling the cartridge 14, which is closed by a piston 13 in the ready-to-use state.
• the other end of the cartridge 14 tapers to a mouthpiece 28 which is closed by a closure cap 15.
• the wall 21 of the cartridge 14 is widened into a ring 33.
• the diameter of the ring 33 corresponds to the diameter of the passage opening 25 of the applicator 100.
• At two opposite points of the ring 33 is widened by the extension pieces 34.
• the diameter of the cartridge 14 in the region of the lugs 34 corresponds to the inner diameter of the additional openings in the passage opening 25 (FIGS. see Fig. 3b).
• the cartridge 14 is attached to the applicator 100, in which it is guided with the opening 31 to the passage opening 25, so that the extension pieces 34 enter through the additional openings 39 into the interior of the housing 10. It is exerted on the compression spring closure 1 1 axial pressure in the direction of the rear end of the housing 10 and at the same time the cartridge 14 is rotated by 90 degrees, so that the extension pieces 34 come to rest behind the circular passage opening 25 and pinch there or engage.
• the cartridge 14 is normally removed from the applicator 100 when its contents have been consumed, that is, when the threaded spindle 9 has pushed as far as possible from the front end of the housing 10 out. She is under slight pressure against the Compression spring closure 11 is rotated by 90 degrees, so that the detent is overcome and the extensions 34 free in the additional openings 39. Before attaching another cartridge 14, the threaded spindle 9 must be pushed back to its initial position in the housing 10. This is possible, characterized in that the threaded sleeve 8 is slotted longitudinally. As long as a cartridge 14 is located on the applicator 100, the longitudinally slotted threaded sleeve 8 is held together by the lock nut 12. If the lock nut 12 is released, because the cartridge 14 is removed from the adapter, the threaded sleeve spreads easily and the threaded spindle 9 can be pushed back at axial pressure without turning.
• a variant of the adapter will be described with reference to the embodiment of the applicator according to FIG. 8a, b. However, the variant can also be analogously combined with the embodiment of the applicator according to FIG. 3a. Notwithstanding the embodiment described above, in the variant, the locking of the cartridge 814 is not by means of a spring but by a lock nut member 819.
• the passage opening 825 is designed in the applicator 800 of FIG. 8a analogous to the applicator 100 of FIG. 3a, circular with additional openings 39 (see Fig. 3b).
• the adapter on the applicator 800 has a lock nut element 819 and a socket 820 in this variant.
• the lock nut element 819 is rotatably mounted in the housing 80.
• the lock nut element 819 is a two-part tubular sleeve, which is mounted concentrically to the threaded spindle 809 and the reduction sleeve 817 in the axial direction slidably. It has on its side facing the passage opening 825 on its outer periphery in the axial direction extending grooves, with a suitably adapted cartridge 814 can be coupled.
• ⁇ as drawn in Fig. 13 is between 90 and 100 degrees, preferably between 90.5 and 95 degrees.
• the lock nut element 819 Upon rotation of the lock nut element 819, the lock nut element 819 is displaced, guided by the cam 821 in which the groove 822 simultaneously in the axial direction.
• a bush 820 Centrally in the interior of the lock nut element is a bush 820 with a central bore through which the threaded spindle 809 passes.
• the sleeve 820 pushes in axial direction of the lock nut member in a direction away from the passage opening 825, over the füreriesöffhung 825 facing the end of the reduction sleeve 817th Since the reduction sleeve (see also Fig.
• the cartridge 814 differs from the cartridge 14 (FIG. 9) in that it has one or more elongated projections 823 extending in the axial direction in its inner circumference in the region of the opening 31. The position of these elongated protrusions 823 is chosen to match the position of the grooves in the outer circumference of the lock nut member 819 (see FIG. 13).
• the cartridge 814 When attaching the cartridge 814, the cartridge 814 is rotated so that the positions of the extension pieces 34 coincide with the position of the additional openings 39 in the passage opening 825. That is, at the same time, the position of the grooves on the lock nut member 819 and the protrusions 862 on the inner wall of the cartridge 814 are coincident. As positioned, the cartridge 814 is slipped over the lock nut member 819. With a rotary movement of the cartridge 814, e.g. 90 degrees, performs the lock nut member 819 via the interaction of cam 921 and groove 822 relative to the housing 80 from an axial movement. In this movement, the reduction sleeve 817 is enclosed and made the positive connection to the thread of the threaded spindle 809. The bushing 820 also prevents lateral forces from acting on the bearing of the reduction sleeve 817.
• extension pieces 34 engage in recesses or openings on the inner wall of the housing 80.
• the cartridge 814 is normally removed from the applicator 800 when its contents have been consumed, that is, when the threaded spindle 809 has pushed a maximum distance out of the front end of the housing 80.
• To remove the cartridge 814 is rotated with light pressure until the latching of the lugs 934 has overcome the housing 80 and the lock nut member 819 has moved in the axial direction of the passage opening 825 back to the starting position before attaching the cartridge 814.
• the threaded spindle 809 Before attaching a further cartridge 814, the threaded spindle 809 must be pushed back into its initial position in the housing 80 again. As long as a cartridge 814 is mounted in the applicator 800, the longitudinally slotted reduction sleeve 817 is held together by the bushing 820. However, as the lock nut member 819 moves axially toward the passageway 825, the bushing 820 eventually does not surround the end of the reduction sleeve 817 and the reduction sleeve 817 spreads easily and the threaded spindle 809 can be pushed back without axial rotation.
• the closure cap 15 has an outer cylinder-shaped wall 70 and an end wall 79.
• the outer diameter of the closure cap 15 corresponds Concentrically within the outer wall 70 is an inner cylindrical wall 76.
• On the open side of the cap 15 are located on the end face of the outer wall 70 and two opposing cams 74 are located at a small distance from the outside of the outer wall 70.
• On the outer side of the outer wall 70 structures 75 are incorporated in the area of the cams 74, which ensure the secure gripping and holding of the closure elements.
• the mouthpiece 28 of the cartridge 14, 814 has threaded wings 72 (FIGS. 10, 11b) which are arranged to engage the thread 71 when the closure cap 15 is screwed to the mouthpiece 28.
• the wall 21 forms an annular edge 77, on the inside of which two sawtooth-shaped projections 73 located opposite one another are located.
• the adapter for fastening the cartridge 14 or 814 additionally comprises an approximately semicircular latching bow 910 for locking the cartridge 14, 814.
• the latching arc (FIGS. 14, 15a-c) is concentric in the housing 10, 80 and has locking cams 915, which engage with corresponding locking cams 875 on the extension pieces 34 on the cartridge 14, 814.
• latching bow 910 in connection with the applicator 800 in the embodiment according to FIGS. 8 a, b and with a cartridge 814 will now be described. It should be appreciated that the function of the latch arch 910 may be practiced in the same way as the other embodiments of the applicator described herein.
• FIG. 14 shows the approximately semicircular locking arc 910 with the two mutually opposite buttons 920. Due to the arch shape of the locking arc 910 is elastic and can be deformed by radial pressure from the outside on the button 920 so that the buttons 920 come closer to each other. After releasing the button 920, the latching arch 910 returns to its original shape. In the area of the buttons 920, 910 sawtooth-shaped latching cams 920 are arranged on the inner side of the latching arch, both of which point with their tips in the same direction of rotation.
• FIGS. 15a-c show how the locking arc 910 is arranged in the housing 80 of the applicator 800. In this case, the cartridge 814 is shown in the unlatched position in FIG. 15a and in the latched position in FIG. 15c.
• the buttons 920 are arranged in openings through the housing 80 of the applicator 800 so that they can be operated from outside the housing, that is to say can be pressed.
• the sawtooth-shaped latching cams 875 engage on the attachment pieces 39 of the cartridges 814 in the sawtooth-shaped latching cams 915 of the latching arch 910 such that no reverse rotation of the cartridge 814 is possible. Only by pressing both buttons 920 simultaneously, the locking of the respective locking cam 975 and 915 is released at the two opposite positions. This is done in that the buttons 920 are compressed so far that the locking cams 915 of the locking arch 910 are moved so far into the interior of the housing 800, that the locking cams 875 of the cartridge 814 can be passed inside the locking cam 915 of the locking arch 910.

Landscapes

• Engineering & Computer Science (AREA)
• Health & Medical Sciences (AREA)
• Mechanical Engineering (AREA)
• Physics & Mathematics (AREA)
• Fluid Mechanics (AREA)
• General Physics & Mathematics (AREA)
• Hematology (AREA)
• Veterinary Medicine (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Vascular Medicine (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Anesthesiology (AREA)
• Coating Apparatus (AREA)
• Food-Manufacturing Devices (AREA)
• Media Introduction/Drainage Providing Device (AREA)
• Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
• Medicinal Preparation (AREA)
• Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=38293958

Family Applications (1)

Country Status (24)

Families Citing this family (19)

Family Cites Families (15)

• 2006
  • 2006-04-22 DE DE102006018827A patent/DE102006018827A1/de not_active Ceased
• 2007
  • 2007-04-10 AU AU2007241452A patent/AU2007241452A1/en not_active Abandoned
  • 2007-04-10 US US12/297,586 patent/US20090224004A1/en not_active Abandoned
  • 2007-04-10 CN CNA2007800144472A patent/CN101501459A/zh active Pending
  • 2007-04-10 KR KR1020087028531A patent/KR20090014169A/ko not_active Application Discontinuation
  • 2007-04-10 NZ NZ572067A patent/NZ572067A/en not_active IP Right Cessation
  • 2007-04-10 MX MX2008013463A patent/MX2008013463A/es not_active Application Discontinuation
  • 2007-04-10 EP EP07724107A patent/EP2013589A2/de not_active Withdrawn
  • 2007-04-10 RU RU2008145983/28A patent/RU2008145983A/ru not_active Application Discontinuation
  • 2007-04-10 WO PCT/EP2007/003166 patent/WO2007121854A2/de active Application Filing
  • 2007-04-10 BR BRPI0710834-6A patent/BRPI0710834A2/pt not_active IP Right Cessation
  • 2007-04-10 JP JP2009506942A patent/JP2009534137A/ja not_active Withdrawn
  • 2007-04-10 CA CA002649564A patent/CA2649564A1/en not_active Abandoned
  • 2007-04-19 AR ARP070101694A patent/AR060550A1/es unknown
  • 2007-04-20 TW TW096113865A patent/TW200808391A/zh unknown
  • 2007-04-20 UY UY30299A patent/UY30299A1/es not_active Application Discontinuation
  • 2007-04-20 CL CL2007001139A patent/CL2007001139A1/es unknown
  • 2007-04-20 PE PE2007000495A patent/PE20080598A1/es not_active Application Discontinuation
• 2008
  • 2008-10-17 GT GT200800220A patent/GT200800220A/es unknown
  • 2008-10-17 CR CR10373A patent/CR10373A/es not_active Application Discontinuation
  • 2008-10-17 CO CO08110986A patent/CO6190570A2/es not_active Application Discontinuation
  • 2008-10-17 SV SV2008003066A patent/SV2009003066A/es not_active Application Discontinuation
  • 2008-10-17 ZA ZA200808930A patent/ZA200808930B/xx unknown
  • 2008-10-20 EC EC2008008834A patent/ECSP088834A/es unknown

Non-Patent Citations (1)

Also Published As

Similar Documents

Legal Events