EP1732651A1 - Topische zubereitung zur anwendung auf der haut enthaltend natürliches öl der nachtkerze (oenothera biennis) (=oleum oenotherae) und osmolyte aus extremophilen mikroorganismen - Google Patents

Topische zubereitung zur anwendung auf der haut enthaltend natürliches öl der nachtkerze (oenothera biennis) (=oleum oenotherae) und osmolyte aus extremophilen mikroorganismen

Info

Publication number
EP1732651A1
EP1732651A1 EP05716456A EP05716456A EP1732651A1 EP 1732651 A1 EP1732651 A1 EP 1732651A1 EP 05716456 A EP05716456 A EP 05716456A EP 05716456 A EP05716456 A EP 05716456A EP 1732651 A1 EP1732651 A1 EP 1732651A1
Authority
EP
European Patent Office
Prior art keywords
osmolyte
oil
evening primrose
formulation
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05716456A
Other languages
German (de)
English (en)
French (fr)
Inventor
Thomas Schwarz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bitop AG
Original Assignee
Bitop AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bitop AG filed Critical Bitop AG
Publication of EP1732651A1 publication Critical patent/EP1732651A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • Topical preparation for use on the skin containing natural evening primrose oil (Oenothera biennis) ( Oleum Oenotherae) and osmolytes from extremophilic microorganisms
  • the invention relates to a formulation which contains an osmolyte from extremophilic microorganisms and unsaturated fatty acids containing natural oils and fats.
  • the formulation contains at least one osmolyte in an amount of 0.01 to 50 wt .-%, based on the total weight of the formulation.
  • the invention relates to the use of an osmolyte formed by extremophilic bacteria (e.g. ectoin, hydroxyectoin, Firoin, Firoin-A, diglycerol phosphate, cyclic diphosphoglycerate, di-inositol phosphate; hereinafter referred to as Osmolyte X) in combination with natural evening primrose oil (Oleum Oenotherae) for the production of drugs, medical devices or cosmetics for external treatment, prophylaxis or care of the skin.
  • extremophilic bacteria e.g. ectoin, hydroxyectoin, Firoin, Firoin-A, diglycerol phosphate, cyclic diphosphoglycerate, di-inositol phosphate; hereinafter referred to as Osmolyte X
  • Osmolyte X natural evening primrose oil
  • Certain fatty acids are essential for the human organism, i.e. they must be ingested with the food if there are no symptoms of deficiency.
  • These include polyunsaturated fatty acids (PUFAs) from the Omega 6 and Omega 3 series, such as linoleic acid and alpha-linolenic acid, which, as precursors to eicosanoids, influence a wide range of physiological functions.
  • PUFAs polyunsaturated fatty acids
  • the stability of the fats is also heavily dependent on the percentage of PUFAs.
  • the influence of oxygen, light and heat can lead to the formation of
  • PUFA polyunsaturated fatty acids
  • Naturally occurring unsaturated fatty acids usually have the cis configuration on the double bonds. So-called.
  • Trans fats result from the "hardening" of fat, whereby the double bonds of the unsaturated fatty acids are hydrogenated with hydrogen and vegetable fats are formed which are solid even at room temperature.
  • Osmolytes or compatible solutes from extremophilic microorganisms form a well-known group of low-molecular protective substances. Extremophiles are very unusual microorganisms, because they optimally e.g. grow at high salt concentrations (up to 200 g NaCI / l) and high temperatures (60-110 ° C), which would lead to massive damage to cellular structures in mesophilic ("normal") organisms.
  • the osmolytes (compatible solutes) found in the extremophilic microorganisms are not produced by human or animal cells.
  • the osmolyt ectoin was previously used as a moisturizer and active ingredient in cosmetic products with the aim of protecting healthy, clinically unremarkable human skin against the damaging effects of ultraviolet solar radiation (e.g. Use of ectoine or ectoine derivatives in cosmetic formulations, EP19990941; Use of ectoine or ectoine derivatives for the prophylaxis and / or treatment of UV induced immunosuppression).
  • the evening primrose (Oenothera biennis; Onagraceae plant family), also known as the "Queen of the Night", is a plant and bears its name because it opens its bright yellow flowers in the evening or in cloudy weather.
  • the Algonkin Indians treated various skin conditions with a slurry of crushed evening primrose oil seeds (Oleum Oenotherae) over 500 years ago.
  • the oil obtained from the evening primrose's flower seeds has a high proportion of polyunsaturated fatty acids such as linoleic acid and gamma-linolenic acid.
  • the seeds used for oil production come from plants grown without chemical pesticides.
  • Evening primrose oil is a natural and biologically active source of essential fatty acids, including cis-gammalinolenic acid (GLA) with a share of approx. 10%.
  • GLA cis-gammalinolenic acid
  • the acidity is active thanks to the unique triglizeryd structure, which is unique to evening primrose oil.
  • Cold-extracted evening primrose oil contains important amino acids, minerals and vitamins, including vitamin E, which plays the natural role of an antioxidant.
  • the oil is not only used in high-quality cosmetic products, but is also used as a valuable nutritional supplement. Numerous cosmetic products describe the care effects of evening primrose oil on very dry, irritated, flaky and problematic skin. Evening primrose oil can also be used internally as a nutritional supplement.
  • evening primrose oil (Oleum Oenotherae) in topical preparations is severely limited due to its short shelf life. Since it is perishable, evening primrose oil is usually preserved with vitamin E. In addition, evening primrose oil is always mixed with another base oil to increase stability. This significantly improves the durability. Heating evening primrose oil e.g. for conservation purposes is not possible due to instability.
  • fish oil e.g. mackerel, tuna, salmon, herring
  • coconut oil palm oil
  • Cocoa oil olive oil, peanut oil, cottonseed oil, sesame oil, corn oil, safflower oil, soybean oil, wheat oil, borage oil, linseed oil, rapeseed oil, black nettle oil, castor oil, black cumin oil, rose hip seed oil, hemp oil and the like.
  • an evening primrose-oil based care product of the same composition with the addition of 0.5% (weight percent) of the osmolyte ectoin has a significantly better care effect with very dry, irritated, flaky and problematic Skin showed.
  • the care effect of the combination product of evening primrose oil and osmolyte was significantly better than that of a care product that only contained the osmolyte in a 0.5% concentration.
  • a topical preparation containing a combination of evening primrose oil (Oleum Oenotherae) and Osmolyte X for cosmetic and dermatological applications thus surprisingly had the significant advantage of a significantly improved preservation and longer shelf life with a synergistically increased care effect for very dry, irritated, flaky and problematic skin ,
  • This means that a preparation made from osmolyte and evening primrose oil is also ideal for the care of inflamed areas of the skin, such as those e.g. in people suffering from atopic dermatitis.
  • the cosmetic and dermatological formulations are produced by one or more compounds from the group of the osmolytes, the physiologically tolerable salts of the compounds of the osmolyte in
  • the auxiliaries and carriers come from the group of carriers, preservatives and other customary auxiliaries.
  • the osmolytes contained in cosmetic and dermatological formulations and the evening primrose oil are used externally.
  • solutions, suspensions, emulsions, pastes, ointments, gels, creams, lotions, powders, soaps, surfactant-containing cleaning preparations, oils and sprays e.g., any customary carriers, auxiliaries and, if appropriate, further active compounds can be added to the formulations.
  • Preferred additives come from the group of preservatives, antioxidants, stabilizers, solubilizers, vitamins, colorants and
  • ointments, pastes, creams and gels can contain the usual carriers, e.g. animal and vegetable fats, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide or mixtures of these substances.
  • carriers e.g. animal and vegetable fats, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide or mixtures of these substances.
  • Powder and sprays can, in addition to one or more compounds from the group of osmolytes plus evening primrose oil, in addition to the usual carriers, the usual blowing agents, e.g. Chlorofluorocarbons, propane / butane or dimethyl ether.
  • the usual blowing agents e.g. Chlorofluorocarbons, propane / butane or dimethyl ether.
  • solutions and emulsions may contain the usual carriers such as solvents, solubilizers and emulsifiers.
  • Suspensions can be selected in addition to one or more compounds from the group of Osmolyte X plus evening primrose oil (Oleum Oenotherae) such as. B. contain water or ethanol.
  • Other application forms are e.g. B. soaps, surfactant-containing cleaning agents, facial and body oils, lipsticks, lip care sticks, mascara, eyeliner, eye shadow, blush, powder, emulsion and wax make-up as well as sunscreen, pre-sun and after-sun preparations.
  • the proportion of the compounds of the Osmolyte X group in cosmetic and dermatological formulations is preferably 0.0001 to 50% by weight, particularly preferably 0.001 to 10% by weight, based on the preparation as a whole.
  • the proportion of evening primrose oil (Oleum Oenotherae) in cosmetic and dermatological formulations is preferably 0.0001 to 50% by weight, particularly preferably 0.001 to 10% by weight, based on the preparation as a whole.
  • a lotion (O / W) according to the invention containing Osmolyte X and evening primrose oil (Oleum Oenotherae) is produced from the following components:
  • a cream (O / W) according to the invention containing Osmolyt X is produced from the following components:
  • a cream (O / W) according to the invention containing osmolyte cyclic diphosphoglycerate (cDPG) is produced from the following components:
  • the stability of evening primrose oil at higher temperatures strongly depends on the proportion of ⁇ -linolenic acid and the purity of the evening primrose oil.
  • room temperature 25 ° C
  • diglycerol phosphate 0.1% (percent by weight) of diglycerol phosphate to a preparation of evening primrose oil
  • an increased storage stability of evening primrose oil of five days was found compared to the control without diglycerol phosphate.
  • the stability of the preparation was assessed based on the first appearance of a rancid smell of evening primrose oil.
  • a gel (O / W) according to the invention containing diinositol phosphate and evening primrose oil is produced from the following components:
  • a sun protection emulsion according to the invention containing evening primrose oil and hydroxyectoin is produced from the following components:

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP05716456A 2004-03-30 2005-03-30 Topische zubereitung zur anwendung auf der haut enthaltend natürliches öl der nachtkerze (oenothera biennis) (=oleum oenotherae) und osmolyte aus extremophilen mikroorganismen Withdrawn EP1732651A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004016045 2004-03-30
DE102004049062A DE102004049062A1 (de) 2004-03-30 2004-10-08 Topische Zubereitung zur Anwendung auf der Haut enthaltend natürliches Öl der Nachtkerze (Oenothera biennis) (=Oleum Oenothera) und Osmolyte aus extremophilen Mikroorganismen
PCT/EP2005/003342 WO2005094771A1 (de) 2004-03-30 2005-03-30 Topische zubereitung zur anwendung auf der haut enthaltend natürliches öl der nachtkerze (oenothera biennis) (=oleum oenotherae) und osmolyte aus extremophilen mikroorganismen

Publications (1)

Publication Number Publication Date
EP1732651A1 true EP1732651A1 (de) 2006-12-20

Family

ID=34965024

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05716456A Withdrawn EP1732651A1 (de) 2004-03-30 2005-03-30 Topische zubereitung zur anwendung auf der haut enthaltend natürliches öl der nachtkerze (oenothera biennis) (=oleum oenotherae) und osmolyte aus extremophilen mikroorganismen

Country Status (5)

Country Link
US (1) US20080014153A1 (enExample)
EP (1) EP1732651A1 (enExample)
JP (1) JP2007530624A (enExample)
DE (1) DE102004049062A1 (enExample)
WO (1) WO2005094771A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9089568B2 (en) * 2005-03-12 2015-07-28 Bitop Ag Method of using compatible solutes containing ectoine and/or hydroxyectoine
DE102006056766A1 (de) * 2006-12-01 2008-06-05 Bitop Ag Verwendung von kompatiblen Soluten
DE102007013857A1 (de) * 2007-03-20 2008-09-25 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Neue Zusammensetzungen, insbesondere für die topische Behandlung von Hauterkrankungen
FR2916977A1 (fr) * 2007-06-06 2008-12-12 Engelhard Lyon Sa STIMULATION DE LA SYNTHESE DES RECPTEURS MCR1, MCR2 ET µ OPIOIDE.
DE102007040615A1 (de) * 2007-08-27 2009-03-05 Bitop Ag Osmolyte zur Behandlung von allergisch oder viral bedingten Atemwegserkrankungen
DE102007052380A1 (de) † 2007-10-31 2009-05-07 Bitop Ag Osmolythaltige Zubereitungen zur Anwendung bei trockenen Schleimhäuten
DE102008039231A1 (de) * 2008-08-22 2010-02-25 Bitop Ag Verwendung von Glucosylglycerol
EP2184052B1 (en) * 2008-11-11 2017-09-20 Kao Germany GmbH Composition for hair
WO2011082025A1 (en) * 2009-12-30 2011-07-07 The Procter & Gamble Company Absorbent article comprising lotion composition comprising omega-6 fatty acid
KR101275351B1 (ko) * 2010-06-29 2013-06-17 (주)아모레퍼시픽 노화방지용 화장료 조성물
WO2012075093A2 (en) * 2010-12-01 2012-06-07 Nostrum Laboratories, Inc. Topical formulations for administration of omega-3 fatty acids
CN102274229A (zh) * 2011-09-01 2011-12-14 朱道辰 一种治疗皮炎的外用药物及其制法
KR101694938B1 (ko) * 2013-04-10 2017-01-11 주식회사 유엑스엔 골드비드를 함유한 비누, 화장품 조성물 및 이를 이용한 비누, 화장품 제조방법
US11576853B2 (en) 2015-04-29 2023-02-14 CSI: Create.Solve. Innovate. LLC Antioxidant compositions and methods of protecting skin, hair and nails against high energy blue-violet light

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2557452B1 (fr) * 1983-12-28 1986-08-14 Roussel Uclaf Nouvelles compositions pour les soins de la peau renfermant de l'huile d'onagre et des traits tissulaires de rate
JPS61178908A (ja) * 1984-02-27 1986-08-11 Kanebo Ltd 皮膚化粧料
JPS6416890A (en) * 1987-07-10 1989-01-20 Shiseido Co Ltd Antioxidant
DE4342560A1 (de) * 1993-12-14 1995-06-22 Marbert Gmbh Ectoin und Ectoinderivate als Feuchtigkeitsspender in Kosmetikprodukten
PT101887A (pt) * 1996-06-28 1998-01-30 Inst De Biolog Ex E Tecnologic Utilizacao de 2-0- -manosilglicerato para termoestabilizacao, osmoproteccao e proteccao contra a desidratacao de enzimas, outros componenetes celulares e celulas
DE19911775A1 (de) * 1998-08-01 2000-02-03 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten in kosmetischen Formulierungen
AU750027B2 (en) * 1998-08-01 2002-07-11 Merck Patent Gmbh Use of ectoine or ectoine derivatives in cosmetic formulations
DE19834818A1 (de) * 1998-08-01 2000-02-03 Merck Patent Gmbh Kosmetische Formulierung
JP2003531833A (ja) * 2000-04-12 2003-10-28 ビトプ アクチェンゲゼルシャフト フューア ビオテヒニシェ オプティミールング フリーラジカル捕捉特性を有する物質としての適合溶質の使用
DE10040933A1 (de) * 2000-08-18 2002-03-07 Bitop Gmbh Verwendung von beta-Mannosylglycerat (Firoin) und/oder Derivaten, insbesondere dem beta-Mannosylglyceramid (Firoin-A), in kosmetischen und dermatologischen Formulierungen
DE10040931A1 (de) * 2000-08-18 2002-03-07 Bitop Gmbh Verwendung von cyclischem 2,4 Diphosphoglycerat (cDGP) und/oder Derivaten in kosmetischen und dermatologischen Formulierungen
DE10330243A1 (de) * 2003-07-03 2005-01-20 bitop Aktiengesellschaft für biotechnische Optimierung Verwendung von aus extremophilen Bakterien gewonnenen Osmolyten zur Herstellung von Arzneimitteln zur äusserlichen Behandlung der Neurodermitis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005094771A1 *

Also Published As

Publication number Publication date
DE102004049062A1 (de) 2005-10-13
JP2007530624A (ja) 2007-11-01
WO2005094771A1 (de) 2005-10-13
US20080014153A1 (en) 2008-01-17

Similar Documents

Publication Publication Date Title
KR101219520B1 (ko) 항염증, 항산화 또는 항세균 조성물
KR102391657B1 (ko) 해조류 추출물을 포함하는 화장료 조성물
EP1732651A1 (de) Topische zubereitung zur anwendung auf der haut enthaltend natürliches öl der nachtkerze (oenothera biennis) (=oleum oenotherae) und osmolyte aus extremophilen mikroorganismen
EP1635782A1 (de) Gewebekulturmedien als bestandteil von kosmetika
KR100962052B1 (ko) 락토바실러스 람노서스 유산균주 또는 이의 배양액을함유하는 여드름 개선용 화장료 조성물
EP1100456A1 (de) Verwendung von ectoin oder ectoin-derivaten in kosmetischen formulierungen
KR20180069756A (ko) 용안육 추출물을 포함하는 화장료 조성물
WO2004031122A1 (de) Neue curcumin/tetrahydrocurcumin-derivate für den einsatz in kosmetika, pharmazeutika und bei der ernährung
KR101574556B1 (ko) 둥근마, 신선초, 오크라 및 토란추출물을 유효성분으로 함유하는 피부보습용 화장료조성물
KR20210093662A (ko) 해조류 추출물을 유효성분으로 포함하는 화장료 조성물
KR20190048564A (ko) 용암해수를 이용하여 발효한 오메기주의 농축물을 포함하는 피부의 주름개선, 탄력개선 또는 보습용 화장료 조성물
EP1666099B1 (de) Kosmetisches Hautmattierungsmittel
KR101688691B1 (ko) 주름개선용 화장료 조성물
CN112245314A (zh) 一种含四氢嘧啶的润唇膏及其制备方法
KR100722673B1 (ko) 방부제로서 글리세릴 카프릴레이트 및 고삼 추출물을함유하는 화장료 조성물
KR20230065023A (ko) 제주산 천연물을 포함하는 피부 개선용 화장료 조성물
KR102587124B1 (ko) 보습성 및 롤링성이 향상된 마사지용 화장료 조성물 및 이를 포함하는 젤
KR100722674B1 (ko) 방부제로서 글리세릴 카프릴레이트 및 맹죽엽 추출물을함유하는 화장료 조성물
KR20180069528A (ko) 용안육 추출물을 포함하는 화장료 조성물
KR102818523B1 (ko) 식물 추출물을 포함하는 항산화, 항염, 보습용 조성물과 이를 포함하는 화장료 및 아토피 피부염, 습진 및 피부건조증 예방 및 개선용 피부 외용제
KR20210043098A (ko) 영실 추출물 또는 이의 분리화합물을 함유하는 피부 미생물 조절용 화장료 조성물
DE10042710A1 (de) Dermatologische oder kosmetische Zubereitung auf der Basis von Säugetierbutter
KR101993324B1 (ko) 피부 장벽 개선용 화장료 조성물
KR20140110565A (ko) 율피 추출물 또는 정제물을 유효성분으로 함유하는 피부노화의 예방 및 치료용 조성물
EP1311237A2 (de) VERWENDUNG VON CYCLISCHEM 2,4 DIPHOSPHOGLYCERAT (cDGP) UND/ODER DERIVATEN IN KOSMETISCHEN UND DERMATOLOGISCHEN FORMULIERUNGEN

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20061021

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20080508

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20121002