EP1686855A2 - Verwendungen eines schichtmaterials - Google Patents
Verwendungen eines schichtmaterialsInfo
- Publication number
- EP1686855A2 EP1686855A2 EP04818793A EP04818793A EP1686855A2 EP 1686855 A2 EP1686855 A2 EP 1686855A2 EP 04818793 A EP04818793 A EP 04818793A EP 04818793 A EP04818793 A EP 04818793A EP 1686855 A2 EP1686855 A2 EP 1686855A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- layer
- packaging
- transport control
- biocide
- layer material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/32—Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
- A61L29/106—Inorganic materials other than carbon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Definitions
- the invention relates to uses of an antimicrobial and preferably non-cytotoxic layer material.
- Biocides with broadband activity and in particular inorganic biocides such as silver and its ions have proven to be particularly effective.
- the material treated with the biocide releases the biocide contained in it over time and reduces or completely prevents the settlement or multiplication of microorganisms on the material itself, but also in its surroundings.
- the conventional antimicrobial materials initially release a high biocide concentration, so that the concentration of the released biocide is not only toxic to the microorganisms to be controlled, but also to higher cells.
- concentration of the released biocide is not only toxic to the microorganisms to be controlled, but also to higher cells.
- medical devices such as wound dressings, catheters, contact lenses and implants, since a medical device treated in this way can delay wound healing and cause tissue irritation and allergies.
- Corresponding disadvantages also occur in the case of hygiene products that release biocides, such as sanitary napkins, tampons or diapers, and in the production and processing of foodstuffs, in particular in connection with packaging that releases biocide and components that release biocide to produce or process foodstuffs.
- the antimicrobial effect is quickly exhausted by leaching out the material containing the biocidal active ingredient. Furthermore, it is disadvantageous in the case of conventional coatings that they can often release a very high amount of biocide, at least locally, if they are damaged, for example by abrasion, as can also occur when the appropriately coated objects are used as intended.
- Silver particles containing less than 5 ppm of silver, sodium and contains potassium ions the adhesive and coating material being a synthetically produced, organic-based material which generally hardens after processing.
- the silver particles are evenly distributed in the adhesive and coating material.
- the adhesive and coating material should be a lacquer or adhesive, in particular on a thermoset or thermoplastic basis.
- a disadvantage of this, however, is that the metal release rate is difficult to control or adjust.
- a wiper provided with an antimicrobial agent is known from US 2002/0006887 A1.
- the wiper is provided with a polyethylene vinyl acetate layer, the antimicrobial agent calcium hypochlorite being completely or partially encapsulated in the coating.
- the amounts of active substance released are far too high to exclude a cytotoxic effect.
- the use of a coating as described in this document is therefore only useful for a wiper, but not generally for medical products, and in particular not for implantable products.
- a tube provided with an antimicrobial agent is known from WO 00/60297. However, this also does not contain a transprot control layer that is free of particles of the antimicrobial agent. The active ingredient therefore always comes into direct contact with the surface of the tube and can therefore also be released in cytotoxic concentrations.
- the invention is based on the knowledge that a layer material that can be produced simply and inexpensively can be used as a coating on a packaging, the layer material having antimicrobial properties, but should preferably not be cytotoxic.
- a layer material is antimicrobial if it inhibits the multiplication of Staphylococcus epidermidis for at least ten hours, measured as described in DE 197 58 598 A1. It is determined whether, for example, bacteria of the type mentioned above can only produce less than 0.1% and daughter cells within 18 hours on the surface of the layer material compared to a biocide-free control sample.
- a layer material is also cytotoxic if it has a cytotoxic effect as described in DIN ISO 10993-5.
- the layer material should also have a long-lasting antimicrobial and non-cytotoxic effect. It should be possible to use it as universally as possible, for example on foils, plastics, metals and material combinations, and also enable the production of thin coatings, in particular from 40 to 200 nm thick.
- the layer material should also contain as little biocide as possible.
- the surface properties of the layer material should be adjustable over the widest possible range.
- the layer material should also have the best possible adhesion to a substrate to be coated, it should be as transparent as possible, food-resistant and hydrolysis-stable and have adjustable barrier layer properties.
- an antimicrobial and preferably non-cytotoxic layer material for coating a packaging material, in particular for perishable goods is specified, the layer material comprising: a) a biocide layer with a biocidal active ingredient, and b) a transport control layer covering the biocide layer with one Thickness and porosity set to deliver the biocidal agent from the biocide layer through the transport control layer in an antimicrobial and preferably non-cytotoxic amount.
- the layer material used according to the invention makes it possible to produce a packaging material that can be easily sterilized, in particular can advantageously reduce the adhesion of microorganisms on the side of the packaging material coated according to the invention compared to conventional packaging materials.
- the use according to the invention also makes it possible to produce packaging materials which have an improved barrier property against oxygen, water vapor, carbon dioxide and / or flavors. These properties are retained even in moist environments.
- the migration properties of additives lubricants, antiblocking agents, antistatic agents, antioxidants, light stabilizers, colorants
- residual monomers and oligomers from the packaging substrate are additionally reduced. Conversely, the penetration behavior of e.g. Fats and oils reduced.
- the layer material is used as a coating on a packaging film, in particular a sealing film.
- a major advantage of the use according to the invention and the corresponding packaging materials is that the layer material used does not impair the sealing properties of a packaging film, even if other sealing parameters are to be sought.
- material combinations can also be provided with the layer material. This is particularly advantageous for the production of cardboard packaging such as PE cardboard boxes and / or PP cardboard boxes, which are preferably coated on both sides.
- the use according to the invention is advantageously also suitable for hot-fil cartons and UHT products and is also suitable for autoclaving.
- the packaging film is usefully coated on the side with the layer material that is to come into contact with the goods to be packaged.
- the packaging film is then folded and sealed to form the final packaging.
- the sealing creates overlapping sealing areas, especially on the seams of a cardboard packaging. These sealing areas are difficult or impossible to sterilize using conventional sterilization processes.
- the packaging film according to the invention is also easy to sterilize in these problematic areas, since it itself releases an antimicrobial agent. It is particularly advantageous here that the layer material used according to the invention does not impair the sealing properties of the packaging film, so that the tightness of the sealing areas is maintained. To this extent, conventional thick-film coatings cannot be used or can only be used to a limited extent.
- the packaging film can moreover be used in a conventional manner and therefore advantageously without major changes in conventional processing methods. This applies in particular to layer materials applied in vacuum processes such as sputtering and plasma polymerisation.
- the packaging or according to the invention provided with the layer material. Sealing films can be applied to a basic packaging such as cardboard using a lamination process. This is where the high flexibility and high temperature stability come into play. The dimensional stability of packaging and closures is not changed by the layer material used according to the invention.
- Another advantage of the use according to the invention, in particular for food packaging, is that the layer material is corrosion-stable. Otherwise the layer material would be attacked and damaged by the cleaning media used for cleaning packaging machines; this disadvantage, which is used in conventional packaging materials and in particular sealing films, does not occur or only occurs to a very limited extent in the uses according to the invention and the packaging according to the invention.
- Another advantage is that the (surface) properties of the transport control layer are adjustable.
- the adhesive properties, the gas tightness, the surface energy, the hydrolysis stability, the corrosion resistance and the chemical stability are adjustable.
- the layer material used according to the invention can be used to produce packaging which is very pH-stable.
- the layer material is not or hardly attacked even by extreme pH values. This is particularly advantageous for packaging fruit juices, sauces, ketchup and other tomato products.
- the layer material is used as a coating for a carrier of the food, for example a food carrier.
- a carrier of the food for example a food carrier.
- Such carriers are sometimes exposed to considerable thermal loads.
- the layer material used according to the invention can withstand these loads and at the same time bring about improved cleaning and poor or sterile condition of the wearer.
- a packaging material for packaging a good is also specified, the packaging material being characterized in that it comprises a coating with a layer material, the layer material comprising:
- a transport control layer covering the biocide layer with a thickness and a porosity which is set to release the biocidal active substance from the biocide layer through the transport control layer in an antimicrobial and preferably non-cytotoxic amount.
- the packaging material according to the invention is particularly advantageously suitable for packaging milk (especially mare's milk) and milk products such as cheese and yogurt, juice, baby food, pet food, baked goods such as bread and rolls, fish products, egg products, meat and meat products such as in particular sausages, salads and delicatessen salads, egg products, ketchup and other tomato products and (ready) sauces and food soups.
- the packaging material is also suitable, in particular, for packaging infusion solutions, blood plasma and blood preserves and entereal nutritional products. Sports drinks.
- the packaging material according to the invention is not intended to sterilize the packaged goods, but merely to simplify the keeping of the packaging sterile or low in germs during its processing. This considerably simplifies and improves the processing of packaging material, without additional measures being taken against an unintentionally high concentration of the biocidal active ingredients would have to be taken in a good packed according to the invention.
- the total amount of biocide in the packaging material according to the invention can therefore advantageously remain low.
- Such a packaging material which comprises a packaging film, in particular a sealing film
- Tubular bag packaging especially for infusion solutions, one
- Cardboard packaging a cup packaging with a film lid, a closure, a filling valve, a hose connector or a fermentation product carrier.
- a packaging material With such a packaging material, the advantages described above, in particular the sealability, of those used according to the invention can be achieved
- Layer material can be realized particularly well.
- the layer material is also particularly suitable as a coating for food-side parts of
- the layer material used according to the invention makes it possible to provide a high biocide concentration in the layer material itself, which would normally have a cytotoxic effect.
- the biocide layer forms a depot of the biocidal active substance, as it were, in order to enable long-term release of the biocidal active substance.
- the transport control layer can thus have a controlling and regulating function.
- the transport control layer can prevent direct contact of the environment with the biocide layer.
- the transport control layer can be on both sides or only on one side of the Biocide layer can be arranged. The latter is particularly preferred when the layer material according to the invention forms a coating on a solid body. In such a case, the body coated with the layer material according to the invention can cover the side of the biocide layer not covered by the transport control layer.
- a biocidal active substance is any substance which can have an antimicrobial activity in the sense described above (biocidal active substance in the narrower sense).
- the biocidal active substances also include substances which, by conversion, produce the biocidal active substance in the narrower sense in the environment in which a particular layer material is intended to be used.
- the biocidal active ingredient is a metal ion in the narrower sense, in particular a silver, copper and / or zinc cation, metallic silver, copper or zinc and alloys, complexes and other substances are also biocidal active ingredients from which the cations mentioned can be released in a suitable environment, for example in the area of a wound.
- Metallic biocides are preferred according to the invention.
- a layer material used according to the invention can also have an antimicrobial activity against other microorganisms and not or not only against Staphylococcus epidetnidis.
- the antimicrobial activity of the layer material used according to the invention with regard to other microorganisms is carried out in accordance with DE 197 58 598 A1 with the microorganism to be examined in each case instead of Staphylococcus epidermidis.
- the layer material according to the invention can also have an antiviral effect.
- the layer material used according to the invention is preferably designed such that it has a gas permeability to oxygen (O 2 ) in the range from 100 to 1000 (cm 3 bar) / (day m 2 ), preferably 600 to 700 (cm 3 bar) / (day m 2 ).
- Such transport control layers can be produced particularly expediently by vacuum evaporation processes or plasma polymerization.
- the person skilled in the art can determine suitable starting materials and parameters for the production of a corresponding transport control layer by carrying out customary routine tests. Particularly preferred
- Transport control layers are given later in this description and in the examples.
- the hydrophilicity of the layer material 0.07 is preferably influenced by the fact that the oxygen content "of the selected for preparing the coating atmosphere is high.
- an advantageously highly hydrophobic layer material is achieved (see examples).
- Hydrophilic layer materials according to the invention can preferably be obtained with an O 2 content of 40 to 95% ( Rest of the working atmosphere: HMDSO), the higher the O 2 content of the working atmosphere, the more hydrophobic the layer material will be is chosen.
- the diffusion rate of silver ions from the transport control layer can also be influenced in an advantageously simple manner; the diffusion rate is generally higher the more hydrophilic the layer material is.
- a hydrophilic layer material can be produced according to the invention by a vacuum-assisted thin-layer process, in which after the production of a transport control layer, the layer material in a pure oxygen atmosphere at a working atmosphere pressure of 0.02 to 0.04 mbar, preferably 0.06 mbar, and one Plasma power of 500 to 2000 W, preferably 1000 W, is treated in a 400 I reactor.
- Hydrophobic layer materials can be produced according to the invention by a vacuum-assisted thin-layer process with a working atmosphere made of hydrogen and hexafluoroethane (C 2 F 6 ), optionally with a post-activation step.
- the ratio of hydrogen to hexafluoroethane is 2: 1 to 4: 1, preferably 3: 1, with a plasma power of 400 W and a reactor volume of 400 I.
- the surface processes of the layer material according to the invention are also influenced by the above-described methods, in particular the surface energy can be chosen freely in the range from 10 to 105 mN / m.
- the higher the surface energy the lower the tendency to adhesion • of Staphylococcus epidermidis and other microorganisms.
- the antimicrobial effect of the layer materials according to the invention is therefore advantageously easy to control.
- a high degree of biocompatibility can be achieved through a silicate-like structure.
- biocidal active ingredient is an inorganic biocide
- Such biocidal agents are usually inexpensive, readily available and easy to process.
- the biocidal active ingredient can be presented by various methods, in particular it can be applied to a surface which is to be coated with a layer material according to the invention. Vacuum evaporation, sputtering and chemical vapor deposition are particularly suitable for applying an inorganic biocidal active ingredient.
- the biocidal active ingredient is selected from the group consisting of silver, copper and zinc, their ions and their metal complexes or a mixture or alloy of these elements.
- biocidal agents act against a large number of different microorganisms and intervene in their metabolism in numerous ways. Accordingly, when these biocidal active substances are used, resistance formation in bacteria occurs less frequently than when using specifically acting organic biocides, in particular antibiotics.
- a layer material according to the invention in which the biocidal active ingredient is silver, a silver cation or a silver or silver cation-releasing complex or such an alloy has proven to be particularly advantageous.
- Metallic silver in particular is easy to process and is available in high quality at a relatively low price, so that the layer material used in accordance with the invention can in turn also be produced relatively inexpensively.
- the biocidal active ingredient is expediently present in granular form in the layer material used according to the invention, an average grain size of the primary particles of 5 to 100 nm being preferred.
- Such fine powders of biocidal active substances can be used, in particular for inorganic biocides, and in particular for silver, but also for copper and zinc, as well easily produce mixtures, complexes and alloys of the three metals mentioned. Due to the small average grain size, the biocidal active substance has a high specific surface, so that it can be released from the biocide layer particularly well by diffusion.
- biocidal active substance due to the high specific surface area, chemical inactivation of the granular active substance usually only affects part of the surface, so that the biocidal active substance can be released from the biocide layer even under adverse conditions.
- the biocide layer can have a thickness of at least 1 nm, and preferably not more than 1 mm.
- the biocide layer is at least as thick as the granular agent.
- the thickness of the biocide layer is preferably at least 5 nm to 100 nm, layer thicknesses of 10 nm to 50 nm being particularly preferred, in particular if the biocidal active ingredient is silver, copper and / or zinc or their ions, metal complexes or a mixture or alloy of these elements is.
- a biocidal active substance in particular a biocidal active substance containing nanoscale silver
- a biocidal active substance containing nanoscale silver are sufficient to be able to achieve an antimicrobial, non-cytotoxic effect in the long term.
- the biocide layer is preferably not applied over the entire surface of the substrate provided with the layer material, but rather only covers part of this substrate.
- the transport control layer is then in direct local contact with the substrate and therefore adheres particularly well to the substrate. This improved adhesion of the transport control layer also improves the adhesion of a granular biocidal active ingredient such as silver particles, especially nanoscale silver.
- Vacuum-assisted processes are very suitable for producing the layer material used according to the invention, in particular if the production of very thin layers is required.
- the biocide layer is then particularly preferably produced by means of a sputtering or vapor deposition process, since metallic biocides can be deposited directly on the substrate without a chemical process taking place.
- a metal salt is used in impregnation or sol-gel methods that is reduced to metal in or on the substrate. It is precisely this reduction process that often does not run completely, making the production difficult to reproduce.
- residues arise in the production of conventional coatings, in particular using sol-gel methods, which have to be washed off and disposed of in a complex manner. Such residues can be avoided with layer materials produced according to the invention by vacuum-assisted thin-film processes.
- the biocide layer further comprises: gold, platinum, palladium, iridium, tin, antimony, their ions, their metal complexes, or a mixture or alloy of the biocidal active ingredient with one or more of these elements.
- the addition of the elements mentioned to the biocidal active ingredient increases and / or extends the antimicrobial activity.
- the elements mentioned are preferably bound in cationic form in ion exchangers, in the form of a complex or as a salt, preferably a polymeric carboxylic acid.
- the transport control layer has a base material which is selected from the group consisting of a) an organic base material, in particular a piasmapolymer, a sol-gel, a lacquer, and a siliconized base material, or
- an inorganic base material in particular SiO 2 and SiC, a metal oxide, in particular TiO 2 and Al 2 O 3 , and a non-biocidal metal, in particular titanium or medical stainless steel.
- the base material has a thickness and porosity in order to enable the biocidal active substance to be released through the transport control layer in a concentration at which the biocidal active substance thus released can have an antimicrobial and non-cytotoxic effect. It is particularly preferred here if the base material is microporous. In particular for the production of thin layers, it is preferred to protect the transport control layer by plasma
- the transport control layer is preferably produced in such a way that its layer thickness, density, its moisture absorption capacity, its diffusion tightness against water vapor and other gases or vapors, its chemical composition and its cross-linking structure enable the biocidal active substance to be released through the transport control layer, so that the biocidal active substance thus released can have an antimicrobial and non-cytotoxic effect.
- a sputtered or plasma-polymer layer serves as a transport control layer, it is preferably strongly cross-linked and has a high diffusion-tightness against water vapor and a low moisture absorption capacity.
- Transport control layer only needs a very small layer thickness in order to to ensure sufficient antimicrobial, but not yet cytotoxic, effectiveness of the biocidal active ingredient.
- Such a layer material used according to the invention is particularly preferred in which the transport control layer has a silicon content of 20 to 60%, preferably 20 to 33%, a carbon content of up to 50%, in particular 10 to 30%, and an oxygen content of 25 to 66 %, in particular also from 30 to 50%.
- the proportions must be coordinated so that they total no more than 100%.
- the proportions are determined by X-ray photoelectron spectroscopy (XPS); elements in the determination of the silicon, carbon and oxygen content, which, for example, like hydrogen cannot be determined by XPS analysis, are disregarded.
- silicon, carbon and oxygen there may also be other elements in the transport control layer (namely those that cannot be detected by XPS) without these additional elements being taken into account when determining the silicon, carbon and oxygen content.
- the silicon, carbon and oxygen content is given in atomic percent or mole percent of the elements detectable by XPS analysis.
- the transport control layer of a layer material used according to the invention preferably has an average thickness of 5 nm to 500 nm.
- an average thickness of 5 nm to 500 nm preferably when using a plasma polymer
- the transport control layer has a thickness of 5 to 200 nm, particularly preferably not more than 100 nm, preferably 10 to 100 nm.
- excellent antimicrobial and non-cytotoxic layer materials can be produced, in particular, with transport control layers produced by plasma polymerization.
- these transport control layers are very thin, so that they are hardly noticeable or even transparent.
- the transport control layer is preferably chosen so that the lowest possible bacterial adhesion takes place. This can be achieved, for example, by adjusting the surface energy depending on the type of bacteria examined. The surface energy is set via the layer deposition parameters as indicated in Example 7.
- the quantitative measurement of bacterial adhesion is carried out using the method described in DE 197 51 581 C2. This enables the layer properties to be optimized with regard to biocompatibility (especially non-cytotoxic properties) with the lowest possible biocide content.
- the transport control layer according to the invention therefore makes it possible to specifically promote or suppress both the cytotoxicity and surface properties such as bacterial adhesion and adhesion of biomolecules and cells of a preselected tissue type.
- the layer material used according to the invention is particularly preferred to provide with a transport control layer that can be produced by sputtering or plasma polymerization.
- a transport control layer that can be produced by sputtering or plasma polymerization.
- a particularly good coating of even complex-shaped bodies can be achieved, in particular fine-pored bodies, in particular nonwovens, can be provided with a transport control layer, while maintaining their mobility, permeability and breathability.
- sputtering and plasma polymerization enable the coating of substrates which can only be coated with considerable disadvantages in thick-film processes; this particularly includes bone nails and other bone implants.
- the coating In the case of a conventional coating, it can happen in particular with these substrates that the coating is pushed off during further processing of the substrate, in particular when it is installed in a bone, and forms a local bulge; in this case the release rate of the biocidal active substance would no longer be uniform and controllable over the entire substrate body.
- the biocidal active ingredient could be released in a cytotoxic concentration, which in particular delays or prevents healing processes could become.
- the layer materials according to the invention can also be used to produce transport control gradient layers via plasma polymerization, the surface properties of which (in particular hydrophilic, hydrophobic, non-sticky and / or transparent, more on this below) can vary from place to place in a preselected manner.
- the layer structure during sputtering or during plasma polymerization can be monitored ellipsometrically during the deposition in order to ensure the reproducibility of the layer structure.
- the same control can also be carried out during the separation of the biocide using a sputtering or vapor deposition process.
- Thin (preferably up to 100 nm, see above) layer materials according to the invention are also preferred. These layered materials have advantageous properties which still enable the sealing of a coated sealing film, which opens up their use as a coating for packaging in the food and medical sectors.
- biocide layer and the transport control layer both have common base materials.
- a biocidal active substance in particular silver, copper and / or zinc
- the layer material used in accordance with the invention in a single further step by applying the base material of the transport control layer, and thereby the biocidal active substance to be embedded in this layer material.
- the base material of the transport control layer can also be selected such that the transport control layer has other and advantageous properties in addition to or instead of the property that enables the delivery of the biocidal active ingredient through the transport control layer.
- the transport control layer can be transparent, hydrophilic, hydrophobic, oleophobic and / or (also for bacteria) by suitable choice of the base material or by further measures. be non-sticky.
- Layer materials used according to the invention with a more hydrophobic transport control layer are in turn particularly preferred where good wipability and cleanability of a surface are important, in particular in the processing of foods.
- the transport control layer is preferably chosen so that the lowest possible bacterial adhesion takes place. This can e.g. by adjusting the surface energy depending on the type of bacteria examined. The surface energy is set via the layer deposition parameters as indicated in Example 7. The quantitative measurement of bacterial adhesion is carried out using the method described in DE 197 51 581 C2. This enables the layer properties to be optimized with regard to biocompatibility (especially non-cytotoxic properties) with the lowest possible biocide content.
- the biocide layer and also the layer material used according to the invention as a whole can be in any form.
- the biocide layer and the layer material used according to the invention can form a coating on a solid body, for example on a fiber, on a metal, plastic and / or glass surface.
- the biocide layer and the layer material used according to the invention can also form a coating on particles.
- the silver content of the layer material according to the invention is preferably 1 to 100 ppm.
- FIG. 1 a cross section of an antimicrobial and non-cytotoxic layer material
- Figure 2 A time course of the bacterial growth of different polyurethane surfaces.
- Example 1 Production of a layer material used according to the invention
- a solid substrate that is to be provided with an antimicrobial and non-cytotoxic layer material used according to the invention is coated with a layer of porous, nanoscale silver in a first coating step.
- a protective gas atmosphere of e.g. Argon evaporates metallic silver at about 10 mbar working pressure.
- a silver layer (biocide layer) is created on the substrate, which consists of individual or interlinked silver particles.
- the average primary particle size of the silver particles is approximately 10 to 20 nm.
- the thickness of the silver layer (biocide layer) is approximately 20 nm.
- a plasma polymer layer is applied with hexamethyldisiloxane (HMDSO) as a precursor.
- the plasma polymerization is carried out at a working pressure of 0.07 mbar with a working gas composed of 95% O 2 and 5% HMDSO.
- the silver layer is provided with a 45 nm thick and highly hydrophilic plasma polymer layer (transport control layer).
- the surface energy of the coating is 105 mN / m. In this way, in particular medical products such as wound dressings and catheters can be coated with a layer material according to the invention.
- Example 2 Production of a layer material used according to the invention using an adhesion promoter layer
- a substrate to be provided with a layer material used according to the invention is provided with a titanium dioxide film by plasma polymerization. Titanium tetraisopropyl oxide mixed with oxygen is used as the precursor. The polymerization time is five minutes. A 25 nm thick, well adhering TiO 2 film is formed.
- a thin metallic silver layer is evaporated onto the TiO 2 film in an ultra-high vacuum.
- the process pressure is 10 "4 mbar.
- the evaporation is carried out in such a way that a silver layer (biocide layer) with a thickness of 10 to 20 nm is deposited on the TiO 2 film.
- a plasma polymer film (transport control layer) is applied to the silver layer.
- the plasma polymerization is carried out as described in Example 1. A 45 nm thick and highly hydrophilic plasma polymer layer is formed.
- Example 3 Application of a transport control layer to a biocidal solid
- a plasma polymer film is deposited as a transport control layer on a solid copper layer by plasma polymerization as described in Example 1. In contrast to Example 1, the plasma coating was carried out for 450 seconds.
- the transport control layer produced in this way has a thickness of 100 nm.
- a layer material according to the invention is formed, the biocide layer being the original, solid copper layer.
- Example 4 Examination of a layer material produced according to Example 1
- the surface of the transport control layer has a silicon content of 36.6%, a carbon content of 24% and an oxygen content of 39.4%.
- the hydrogen content cannot be determined using XPS analysis.
- the infrared spectrum of the layer material still shows a small proportion of methyl groups.
- the transport control layer is therefore primarily inorganic, but still has a low concentration of organic groups.
- the concentration ratio between silicon and silver ⁇ of the layer material according to the invention is energy-Disperse X-ray analysis, about 10: 1. Based on all chemical elements (without hydrogen) that build up the layer material according to the invention, the silver content is below 3% by weight.
- FIG. 1 shows schematically that only a very small proportion of silver is present in the outer 40 to 50 nm of the layer material facing away from the substrate.
- this outer 40 to 50 nm thick layer transport control layer
- a nanoscale silver-containing layer of approx. 20 nm Thickness biocide layer
- the nanoscale silver is therefore embedded in the base material of the transport control layer as a biocide layer.
- FIG. 2 shows a proof of the antimicrobial effect of a polyurethane surface provided with a layer material according to example 1 in comparison to an untreated polyurethane surface.
- the antimicrobial effect was tested as described in DE 197 58 598 A1 with Staphylococcus epidermidis.
- Figure 2 shows the development of the optical density and thus the number of bacteria over a period of 24 hours.
- the left figure shows the development of bacterial growth on an untreated polyurethane surface.
- the middle and the right part of the figure each show the developments of bacterial growth on polyurethane surfaces coated with different layer materials according to the invention.
- bacterial growth takes place on the untreated polyurethane surface within a very short time, while there is no increase in the bacterial cell count on the layer material according to the invention within the time period shown (right part of the figure), or a significantly delayed bacterial growth takes place (middle part of the figure) ).
- the layer material is therefore antimicrobial. It is also not cytotoxic according to DIN-ISO10993-5 (no figure here).
- Example 5 Manufacturing process of a further layer material
- a solid substrate that is to be provided with an antimicrobial and non-cytotoxic layer material used according to the invention is coated with a layer of porous, nanoscale silver in a first coating step.
- metallic silver is evaporated under a protective gas atmosphere of, for example, argon at about 10 mbar working pressure.
- a silver layer is created on the substrate (Biocide layer), which consists of individual or interlinked silver particles.
- the average primary particle size of the silver particles is approximately 10 to 20 nm.
- the thickness of the silver layer (biocide layer) is approximately 20 nm.
- a transport control plasma polymer layer is applied with hexamethyldisiloxane (HMDSO) as a precursor.
- HMDSO hexamethyldisiloxane
- the plasma polymerization is carried out in a reactor with a volume of 400 l at a working pressure of 0.07 mbar, with a plasma power of 2500 W and with a working gas composed of 95% O2 and 5% HMDSO. After 45 seconds of the plasma polymerization carried out in this way, the silver layer is provided with a 45 nm thick plasma polymer layer.
- the antimicrobial effect leads to a shift of the measurement signal according to DE 197 58 598 A1 by 35 hours, so that the layer material is practically self-sterilizing; however, the bacterial adhesion is not reduced in comparison to the uncoated polyurethane substrate.
- oxygen activation is carried out for two minutes at an output of 1500 W, an oxygen flow of 100 sccm and a working pressure of 0.04 mbar. After oxygen activation, the surface energy increases to 105 nNJ / m and the bacterial adhesion is reduced to approx. 10% of the initial value. '
- Example 6 Manufacturing process of a further layer material
- An anti-bacterial and a haemocompatible transport control layer are combined by preparing a copper-containing fluorocarbon layer.
- the biocide layer is applied by a DC magnetron sputtering process using a copper target.
- a porous Cu layer is formed on the substrate.
- the transport control layer is in a second step by a plasma polymerization process Precursors hexafluoroethane (C2F6) applied to the biocide layer.
- C2F6 hexafluoroethane
- hydrogen is added to the C2F6 in a ratio of 3: 1.
- a fluorocarbon layer with a film thickness of 55 nm and a surface energy of 19 mN / m is formed after a process time of 3 min.
- the copper of the biocide layer is oxidized to copper (I) oxide by an annealing step at 50 ° C in an oxygen-containing atmosphere.
- the fluorine content in the transport control layer corresponds to 54.8%, the carbon content 42.5% and the oxygen content 2.7%.
- the fluorine itself is present as 1/2 as CF2, 1/3 as CF3 and 1/6 as CF group.
- Example 7 Manufacturing process of a further layer material
- a plasma polymer film with hexamethyldisiloxane (HMDSO) as precursor is used as the transport control layer.
- the surface of this layer can be modified in a third step.
- the surface energy can be set anywhere between 105 mN / m and 22 mN / m without significantly influencing the anti-bacterial properties.
- the growth behavior of bacteria and other cells can be controlled via the surface modified in this way.
- Example 8 Manufacturing process of a further layer material
- a vanadium target is used in non-reactive DC sputtering, corresponding porous vanadium films can be produced as biocide layers.
- the thickness of this layer is in the range of 50 nm.
- a plasma polymer film based on acrylic acid is deposited as a transport control layer by means of plasma polymerization. After a half-hour separation with an acrylic acid flow of 40 sccm and an Ar flow of 200 sccm, a 50 nm thick film is built up, the infrared spectrum of which corresponds to that of polyacrylic acid.
- the layers prepared in this way have a high and long-term stable surface energy of approx. 55 mN / m.
- the transport control layer does not necessarily have to be produced by a plasma polymerization process, but a reactive medium frequency (MF) sputtering process also leads to a layer that can be used.
- the Si target is sputtered at a partial pressure of the ionizing gas argon of 8 * 10-4 mbar and at a partial pressure oxygen of 2 * 10-4 mbar.
- an impregnation process e.g. Introduce calcium ions into the layer.
- the anti-bacterial layer is immersed in a 0.01 molar calcium hydroxide solution for 24 hours.
- a so-called "ship-in-a-bottle" reaction the stored calcium hydroxide can be converted into calcium chloride, calcium sulfate or calcium carbonate, for example.
- Example 10 Particularly preferred embodiments of the layer material to be used according to the invention
- Embodiment 1 Antimicrobial and preferably non-cytotoxic layer material, comprising a) a biocide layer with a biocidal active ingredient, and b) a transport control layer covering the biocidal layer with a thickness and a porosity which are adjusted to remove the biocidal active ingredient from the biocidal Deliver the layer through the transport control layer in an antimicrobial and preferably non-cytotoxic amount.
- Embodiment 4 Layer material according to embodiment 3, wherein the biocidal active ingredient is selected from the group consisting of silver, copper and zinc, their ions and their metal complexes, or a mixture or alloy comprising two or more of these elements.
- Embodiment 5 Layer material according to one of the embodiments 3 or 4, the biocidal active substance having an average grain size of 5 to 100 nm.
- Embodiment 6 Layer material according to one of the preceding embodiments, wherein the biocide layer further comprises: gold, platinum, palladium, iridium, tin, antimony, their ions, their metal complexes, or an alloy of the biocidal active ingredient with one or more of these elements.
- Embodiment 7 layer material according to one of the previous embodiments, the transport control layer having a base material which is selected from the group consisting of a) an organic base material, in particular one
- Plasma polymer Plasma polymer, a sol-gel, a lacquer, and a siliconized
- Base material or b) an inorganic base material, in particular SiO 2 and SiC, a metal oxide, in particular TiO 2 and Al 2 O 3 , and a non-biocidal
- Metal especially titanium or medical stainless steel.
- Embodiment 10 layer material according to one of the previous embodiments, wherein the transport control layer has an average thickness of 5 to 500 nm.
- Embodiment 11 layer material according to one of the previous embodiments, the surface energy being less than 28 mN / m and the transport control layer being hydrolysis-stable.
Description
Claims
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DE10353756A DE10353756A1 (de) | 2003-11-17 | 2003-11-17 | Schichtmaterial |
PCT/EP2004/013035 WO2005049699A2 (de) | 2003-11-17 | 2004-11-17 | Verwendungen eines schichtmaterials |
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EP04797950A Not-in-force EP1691606B1 (de) | 2003-11-17 | 2004-11-17 | Antimikrobielles schichtmaterial |
EP04818793A Withdrawn EP1686855A2 (de) | 2003-11-17 | 2004-11-17 | Verwendungen eines schichtmaterials |
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EP07102968A Not-in-force EP1790224B1 (de) | 2003-11-17 | 2004-11-17 | Antimikrobielles Schichtmaterial |
EP04797950A Not-in-force EP1691606B1 (de) | 2003-11-17 | 2004-11-17 | Antimikrobielles schichtmaterial |
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EP (3) | EP1790224B1 (de) |
JP (1) | JP2007517772A (de) |
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CN (1) | CN100563440C (de) |
AT (2) | ATE358417T1 (de) |
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DE (3) | DE10353756A1 (de) |
ES (2) | ES2282919T3 (de) |
NO (1) | NO20062826L (de) |
WO (2) | WO2005049699A2 (de) |
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CA2546230C (en) | 2013-05-28 |
JP2007517772A (ja) | 2007-07-05 |
CN100563440C (zh) | 2009-12-02 |
ATE358417T1 (de) | 2007-04-15 |
DE10353756A1 (de) | 2005-06-30 |
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US9622471B2 (en) | 2017-04-18 |
ES2282919T3 (es) | 2007-10-16 |
US10299472B2 (en) | 2019-05-28 |
CA2546230A1 (en) | 2005-06-02 |
WO2005049699A3 (de) | 2005-07-21 |
KR101177104B1 (ko) | 2012-09-28 |
AU2004290901A1 (en) | 2005-06-02 |
WO2005048708A1 (de) | 2005-06-02 |
ATE494779T1 (de) | 2011-01-15 |
NO20062826L (no) | 2006-08-09 |
US20090035341A1 (en) | 2009-02-05 |
EP1790224A1 (de) | 2007-05-30 |
US20170181428A1 (en) | 2017-06-29 |
CN1893822A (zh) | 2007-01-10 |
ES2355298T3 (es) | 2011-03-24 |
EP1790224B1 (de) | 2011-01-12 |
WO2005049699A2 (de) | 2005-06-02 |
KR20060132834A (ko) | 2006-12-22 |
EP1691606A1 (de) | 2006-08-23 |
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