EP1490010A1 - Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives - Google Patents

Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives

Info

Publication number
EP1490010A1
EP1490010A1 EP03717238A EP03717238A EP1490010A1 EP 1490010 A1 EP1490010 A1 EP 1490010A1 EP 03717238 A EP03717238 A EP 03717238A EP 03717238 A EP03717238 A EP 03717238A EP 1490010 A1 EP1490010 A1 EP 1490010A1
Authority
EP
European Patent Office
Prior art keywords
drinking straw
dosage form
form according
formulation
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP03717238A
Other languages
German (de)
English (en)
Other versions
EP1490010B1 (fr
Inventor
Rasoul Sedaghat Kerdar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of EP1490010A1 publication Critical patent/EP1490010A1/fr
Application granted granted Critical
Publication of EP1490010B1 publication Critical patent/EP1490010B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0038—Straws
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47G—HOUSEHOLD OR TABLE EQUIPMENT
    • A47G21/00—Table-ware
    • A47G21/18—Drinking straws or the like
    • A47G21/183—Drinking straws or the like with means for changing the flavour of the liquid

Definitions

  • the invention relates to a dosage form for oral administration of active ingredients, vitamins and / or nutrients comprising a drinking straw with a part of the drinking straw which can be reversibly angled between the formulation and a drinking straw opening as a closure device, thereby preventing the formulation from escaping from the drinking straw in an angled position Kit consisting of the dosage form and a transport liquid and a method for producing the dosage form.
  • the drinking straws described in the prior art for the oral administration of active ingredients, vitamins and / or nutrients have stoppers or caps as a closure device for retaining the active ingredient, vitamin and / or nutrient formulation contained in the drinking straw.
  • the plugs or caps must be removed before using the drinking straw. During the removal of these known closure devices there is a risk of spilling the active ingredient, vitamin and / or nutrient formulation.
  • a dosage form for the oral administration of active ingredients, vitamins and / or nutrients comprising a drinking straw which has two openings and which contains a barrier device which is impermeable to an active ingredient, vitamin and / or nutrient formulation, but which is permeable to air and a transport liquid, and one for the active ingredient, vitamin and / or nutrient Formulation impermeable closure device, wherein the active ingredient, vitamin and / or nutrient formulation located in the drinking straw is arranged between the blocking device and the closing device, characterized in that the closing device is reversible from between the formulation and between the drinking straw opening which is freely accessible for the formulation there is angled part of the drinking straw, which prevents the formulation from escaping from the drinking straw in an angled position.
  • This straw opening is the opening from which the formulation is removed using the transport liquid, i.e. H. the opening on the side facing away from the locking device.
  • the angled part of the drinking straw can be reversibly fixed in the angled position with the help of a ring, a clamp, a cuff or a tube.
  • the active ingredient, vitamin and / or nutrient formulation is preferably solid or pasty.
  • a multiparticulate active substance, vitamin and / or nutrient formulation is preferred, the particles of the multiparticulate formulation preferably having a diameter of 50-1500 ⁇ m.
  • the active substances, vitamins and / or nutrients alone or the active substance, vitamin and / or nutrient formulations as a whole can be insoluble or at least partially soluble in the transport liquid.
  • the active ingredients, vitamins or nutrients or their formulations are soluble in the transport liquid, they are dissolved by the transport liquid flowing past and taken away in dissolved form. If, on the other hand, the active substances, vitamins or nutrients or their formulations are insoluble in the transport liquid, they become in the transport liquid flowing past suspended and carried in suspended form with the transport liquid. Multiparticulate formulations are preferably used for this.
  • the particles should be so small and light that they can be transported by the transport liquid.
  • the adhesion of the particles to each other or to the drinking straw walls should be as low as possible, which can be achieved if necessary by a suitable surface treatment of the particles.
  • active ingredients preferably therapeutic active ingredients, vitamins and nutrients, all orally administrable substances can be used in the form of a suitable formulation.
  • the drinking straw preferably contains a precisely defined dose of these substances.
  • the locking device is preferably a plug, the cross section of which is preferably adapted to the cross section of the drinking straw.
  • the plug can be fixed in the drinking straw, the plug being preferably fixed by narrowing the drinking straw or glued into the drinking straw.
  • the stopper can also be movable between two stops.
  • the drinking straw is narrowed by the stops, the narrowings being designed in such a way that the plug, but not the formulation particles which are insoluble in the transport liquid, are retained thereby.
  • the plug preferably consists of filter material, particularly preferably of non-woven material or compressed fiber material.
  • a membrane fixed in the drinking straw is also preferred as the blocking device, the cross section of the membrane preferably being adapted to the cross section of the drinking straw and the membrane preferably being glued into the drinking straw.
  • the membrane is preferably made of synthetic material.
  • a blocking device is a grid fixed in the drinking straw, the mesh diameter of which is smaller than the diameter of the smallest Formulation particle.
  • the cross section of the grid is preferably adapted to the cross section of the drinking straw and the grid is preferably fixed in the drinking straw by constrictions of the drinking straw or glued into the drinking straw.
  • the grid is preferably made of synthetic material.
  • a constriction of the drinking straw which is designed in such a way that even the smallest formulation particles are retained, is also suitable as a blocking device.
  • the blocking device must not reduce the flow of the transport liquid to such an extent that a solid, insoluble active substance, vitamin and / or nutrient formulation can no longer be taken along.
  • the drinking straw is flexible, at least in the area in which it can be reversibly bent.
  • the drinking straw is preferably made of a synthetic material. At least the area in which the drinking straw can be reversibly angled is preferably constructed from an elastic, synthetic material or a synthetic material that is plastically deformable at a temperature below its softening point. The area in which the drinking straw can be reversibly angled is preferably designed like an accordion.
  • the inside diameter of the drinking straw should preferably be at least 3 mm, so that a sufficient amount of transport liquid can be drawn through the drinking straw to transport the formulation.
  • An inner diameter of 4-15 mm is preferred, very particularly preferably 5-10 mm.
  • the drinking straw preferably has a round, oval, rectangular or square cross section and preferably has a smooth inside.
  • the drinking straw opening which is freely accessible for the formulation, is preferably designed as a mouthpiece, particularly preferably corrugated, while the drinking straw opening, which faces the blocking device, preferably as Connection piece to a reservoir of the transport liquid is formed.
  • the drinking straw preferably has a marking to identify the mouth part and / or to indicate the direction of suction of the transport liquid. This marking makes handling easier.
  • At least the part of the drinking straw containing the formulation is transparent and / or colored.
  • a transparent drinking straw the absorption of the active ingredient, vitamin and / or nutrient formulation can be observed, while the use of an opaque colored drinking straw offers the possibility of masking the administration of an active ingredient, vitamin and / or nutrient formulation ,
  • Another object of the invention is also a kit consisting of the dosage form according to the invention and a physiologically harmless, optionally active substance, nutrient and / or vitamin-containing transport liquid.
  • An aqueous liquid is preferably suitable as the transport liquid, with water, lemonade, fruit juice without pulp, tea or coffee being particularly preferred.
  • Another object of the invention is a method for producing the dosage form, in which the blocking device is inserted into the drinking straw, the formulation is introduced through the one drinking straw opening into the drinking straw, and the drinking straw between the formulation and the drinking straw opening which is freely accessible for the formulation, i.e. H. the opening facing the straw is angled.
  • Another object of the invention is a method for producing the dosage form, in which the drinking straw is angled and the formulation and the blocking device are successively introduced into the drinking straw through the accessible drinking straw opening.
  • a method for producing the dosage form according to the invention is preferred, in which the bendable part of the drinking straw is formed using a Ring, a clamp, a cuff or a tube is reversibly fixed in the angled position.
  • Figure 1 shows a dosage form according to the invention in side view.
  • Figure 2 shows a further dosage form according to the invention in side view.
  • FIGS. 3a to 3d show a dosage form according to the invention with a tube open on both sides for the reversible fixing of the reversibly angled part of the drinking straw before, during and after use.
  • the dosage form shown in Figure 1 comprises a drinking straw (1) which has two openings (6, 9) and a plug fixed in the drinking straw as a locking device (2), a reversibly angled part as a locking device (3) and one between the locking device and Sealing device contained in the drinking straw formulation (4).
  • the drinking straw (1) has a round cross section and is straight.
  • the plug (2) consists of filter material and is permeable to air and the transport liquid, but impermeable to the formulation.
  • the plug is cylindrical and has a round cross-section, the diameter of the plug being adapted to the inside diameter of the drinking straw. The plug is glued into the drinking straw.
  • the formulation (4) is in the form of spherical particles.
  • the area (10) in which the drinking straw (1) can be reversibly bent is designed like an accordion.
  • the dosage form shown in FIG. 2 essentially corresponds to the dosage form shown in FIG. 1. Instead of a fixed plug, however, a between two stops (7, 8) movable plug used as a locking device (2).
  • the diameter of the largest formulation particles is smaller than the inside diameter of the drinking straw at the location of the stop (7), so that the formulation particles can pass through this location.
  • the dosage form shown in FIGS. 3a to 3d comprises a drinking straw (1) with a reversibly angled part (3).
  • the angled position can be reversibly fixed using a tube (5) that is open on both sides.
  • the drinking straw (1) is inserted into the tube (5) in an angled position.
  • the tube (5) is moved so far that the reversibly angled part (3) of the drinking straw (1) is exposed and the reversibly angled part (3) of the drinking straw (1) can be adjusted as desired.
  • the inside diameter of the tube (5) is matched to the space requirement of the drinking straw (1) in an angled position.
  • the length of the tube (5) is less than the length of the drinking straw (1) in the angled position.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Table Equipment (AREA)
EP03717238A 2002-03-27 2003-03-26 Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives Expired - Lifetime EP1490010B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10213773 2002-03-27
DE10213773 2002-03-27
DE10228175 2002-06-24
DE10228175A DE10228175A1 (de) 2002-03-27 2002-06-24 Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen
PCT/EP2003/003133 WO2003079957A1 (fr) 2002-03-27 2003-03-26 Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives

Publications (2)

Publication Number Publication Date
EP1490010A1 true EP1490010A1 (fr) 2004-12-29
EP1490010B1 EP1490010B1 (fr) 2007-04-25

Family

ID=28455548

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03717238A Expired - Lifetime EP1490010B1 (fr) 2002-03-27 2003-03-26 Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives

Country Status (7)

Country Link
US (1) US20050109858A1 (fr)
EP (1) EP1490010B1 (fr)
AT (1) ATE360410T1 (fr)
AU (1) AU2003221524A1 (fr)
DE (2) DE10228175A1 (fr)
ES (1) ES2286422T3 (fr)
WO (1) WO2003079957A1 (fr)

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* Cited by examiner, † Cited by third party
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AUPS270602A0 (en) 2002-05-31 2002-06-20 Baron, Peter Drink flavouring straw
US20030087005A1 (en) 1996-10-10 2003-05-08 Peter Baron Drink flavouring straw
DE10342514A1 (de) * 2003-09-12 2005-04-07 Grünenthal GmbH Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen, Kit und Verwendung
DE10342513A1 (de) * 2003-09-12 2005-05-12 Gruenenthal Gmbh Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen, Kit und Verwendung
US20060034886A1 (en) * 2004-07-23 2006-02-16 Ward Bennett C Bonded fiber structures for use in controlling fluid flow
DE102005042875A1 (de) * 2004-12-23 2006-09-21 Grünenthal GmbH Schnell freisetzende Darreichungsformen für Antibiotika
DE102005019458A1 (de) 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
WO2007009294A1 (fr) * 2005-07-20 2007-01-25 Chang-Ming Yang Appareil d’alimentation/ d'extraction de mucosités automatique
DE102006007830A1 (de) * 2006-02-17 2007-08-30 Grünenthal GmbH Lagerstabile orale Darreichungsform von Amoxicillin und Clavulansäure
AR060029A1 (es) 2006-03-02 2008-05-21 Unistraw Patent Holdings Ltd Pajilla para beber adaptada para acondicionar progresivamente un ingrediente activo y metodo de fabricar dicha pajilla
AR063571A1 (es) * 2006-11-06 2009-02-04 Unistraw Patent Holdings Ltd Aparato para el agregado de agentes o ingredientes solubles a un líquido portador, para su administración oral a través de un sorbete
DE102006059510A1 (de) 2006-12-14 2008-06-19 Grünenthal GmbH Beschichtete Pellets
MX2009010891A (es) 2007-04-10 2010-02-17 Sandoz Ag Dispositivo para la aplicacion oral de una sustancia.
FR2920308B1 (fr) * 2007-09-05 2011-02-25 Unither Dev Forme pharmaceutique pour l'administration par voie orale de principes actifs.
EP2394627A1 (fr) * 2010-06-14 2011-12-14 Nestec S.A. Dispositif d'alimentation
US8342422B2 (en) 2010-09-03 2013-01-01 Dominique Claessens Drink container straw
ES2649140T3 (es) 2012-07-05 2018-01-10 P.C.O.A. Devices Ltd. Dispensador de medicación
DK3284700T3 (da) 2012-07-30 2019-09-09 DosentRX Ltd En beholder til at indeholde og dispensere faste medicinpiller
CN103040315A (zh) * 2012-12-07 2013-04-17 李红彪 一种带补气功能的吸管
CN103976878B (zh) * 2014-05-08 2016-04-20 成都百草和济科技有限公司 一种矫味吸管及矫味剂
EP4042999A4 (fr) * 2019-09-30 2022-11-09 Shanghai WD Pharmaceutical Co., Ltd Dispositif récepteur de médicament de formulation orale solide, et appareil d'administration orale le comprenant

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Also Published As

Publication number Publication date
ATE360410T1 (de) 2007-05-15
AU2003221524A1 (en) 2003-10-08
DE50307131D1 (de) 2007-06-06
EP1490010B1 (fr) 2007-04-25
DE10228175A1 (de) 2003-10-09
WO2003079957A1 (fr) 2003-10-02
ES2286422T3 (es) 2007-12-01
US20050109858A1 (en) 2005-05-26

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