EP1517628B1 - Forme d'administration orale de substances actives, de vitamines et/ou de substances nutritives - Google Patents

Forme d'administration orale de substances actives, de vitamines et/ou de substances nutritives Download PDF

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Publication number
EP1517628B1
EP1517628B1 EP03735654A EP03735654A EP1517628B1 EP 1517628 B1 EP1517628 B1 EP 1517628B1 EP 03735654 A EP03735654 A EP 03735654A EP 03735654 A EP03735654 A EP 03735654A EP 1517628 B1 EP1517628 B1 EP 1517628B1
Authority
EP
European Patent Office
Prior art keywords
drinking straw
dosage form
form according
formulation
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP03735654A
Other languages
German (de)
English (en)
Other versions
EP1517628A1 (fr
Inventor
Rasoul Sedaghat Kerdar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of EP1517628A1 publication Critical patent/EP1517628A1/fr
Application granted granted Critical
Publication of EP1517628B1 publication Critical patent/EP1517628B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0038—Straws
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47G—HOUSEHOLD OR TABLE EQUIPMENT
    • A47G21/00—Table-ware
    • A47G21/18—Drinking straws or the like
    • A47G21/183—Drinking straws or the like with means for changing the flavour of the liquid

Definitions

  • the invention relates to a dosage form for oral administration of. Active ingredients, vitamins and / or nutrients comprising a drinking straw with a cap with a shock-resistant, embedded via a line of weakness, removable by shock plastic or metal bottom as closure device, a kit of the dosage form and a transport liquid and a method for producing the dosage form.
  • the drinking straws for oral administration of active ingredients, vitamins and / or nutrients described in the prior art have stoppers or caps as closure device for restraining the active ingredient, vitamin and / or nutrient formulation present in the drinking straw.
  • the plugs or caps must be removed from the drinking straw before using the drinking straw. During the removal of these known closure devices there is a risk of spillage of the active ingredient, vitamin and / or nutrient formulation.
  • a dosage form for oral administration of drugs, vitamins and / or nutrients comprising a drinking straw having two openings and a barrier device permeable to an active ingredient, vitamin and / or nutrient formulation but permeable to air and a transport liquid, a closure device impermeable to the active substance, vitamin and / or nutrient formulation and the between the locking device and closure device arranged in the drinking straw containing active ingredient, vitamin and / or nutrient formulation, characterized in that the closing device is a closing the formulation facing drinking straw opening cap, the total of the same material, plastic or metal, preferably aluminum , Is manufactured and their otherwise shock-resistant floor over the entire outer circumference has a line of weakness and is thus removed by shock, solved.
  • the cap is generally made of the same material, plastic or metal, such as aluminum, optionally laminated for reinforcement, the bottom of which has a line of weakness over its entire outer circumference. This makes it possible to remove the otherwise impact-resistant soil by impact.
  • the active ingredient, vitamin and / or nutrient formulation is preferably solid or pasty. Preference is given to a multiparticulate active ingredient, vitamin and / or nutrient formulation, wherein the particles of the multiparticulate formulation preferably have a diameter of 50-1500 ⁇ m.
  • the active ingredients, vitamins and / or nutrients alone or the active ingredient, vitamin and / or nutrient formulations as a whole may be insoluble or at least partially soluble in the transport liquid.
  • the active ingredients, vitamins or nutrients or their formulations are soluble in the transport liquid, they are dissolved by the transport fluid flowing past and taken in dissolved form.
  • the active ingredients, vitamins or nutrients or their formulations are insoluble in the transport fluid, they are suspended in the transport fluid flowing past and taken in suspended form with the transport fluid.
  • multiparticulate formulations are used for this purpose.
  • the particles should be so small and light that they can be transported by the transport liquid.
  • the adhesion of the particles to each other or to the drinking straw walls should be as low as possible, which can optionally be achieved by a suitable surface treatment of the particles.
  • active ingredients preferably therapeutic agents, vitamins and nutrients, all orally administrable substances can be used in the form of a suitable formulation.
  • the drinking straw preferably contains a precisely determined dose of these substances.
  • the locking device is preferably designed as a plug whose cross section is preferably adapted to the cross section of the drinking straw.
  • the loosely present plug can also have a larger cross section, provided that this plug can be compressed to a cross section corresponding to the inner cross section of the drinking straw.
  • the locking device may be permanently fixed or movably mounted in the drinking straw.
  • the plug can be permanently fixed on the one hand in the drinking straw by the plug, for example, fixed by constrictions of the drinking straw or by the plug is glued into the drinking straw.
  • the plug is fixed by constrictions of the drinking straw.
  • the plug can also be moved by the transport liquid between two stops.
  • the constrictions are designed so that the plug, but not the transport liquid insoluble in the formulation particles are retained by it.
  • the plug preferably consists of filter material, more preferably of nonwoven material or pressed fiber material.
  • a blocking device is a membrane fixed in the drinking straw, wherein the cross section of the membrane is preferably adapted to the cross section of the drinking straw and the membrane is preferably glued into the drinking straw.
  • the membrane is preferably made of synthetic material.
  • a blocking device is a grid fixed in the drinking straw whose mesh diameter is smaller than the diameter of the smallest formulation particle.
  • the cross section of the grid is preferably adapted to the cross section of the drinking straw and the grid preferably fixed by constrictions of the drinking straw in the drinking straw or glued into the drinking straw.
  • the grid is preferably made of synthetic material.
  • a blocking device is a constriction of the drinking straw, which is designed so that even the smallest formulation paticles are retained by it.
  • the flow of the transport liquid must not be reduced so much that a solid, insoluble active ingredient, vitamin and / or nutrient formulation can no longer be taken.
  • the drinking straw may be rigid or flexible, straight, preferably reversibly angled, or angled.
  • the drinking straw is preferably made of a synthetic material. At least the possibly existing area in which the drinking straw is reversibly angled, is preferably composed of an elastic, synthetic material or a plastically deformable at a temperature below its softening point, synthetic material. The area in which the drinking straw is reversibly angled, is preferably designed accordion-like.
  • the drinking straw inside diameter should preferably be at least 3 mm, so that a sufficient amount of transport liquid can be sucked through the drinking straw in order to transport the formulation.
  • Preferred is an inner diameter of 4-15 mm, most preferably 5-10 mm.
  • the drinking straw preferably has a round, oval, rectangular or square cross-section and preferably has a smooth inner side.
  • the drinking straw opening which faces the formulation, is preferably designed as a mouthpiece, particularly preferably corrugated, while the drinking straw opening, which faces the blocking device, is preferably designed as a connecting piece to a reservoir of the transporting liquid.
  • the drinking straw preferably has a marking for identifying the mouth part and / or for specifying the suction direction of the transport liquid. This marking facilitates handling.
  • At least the portion of the drinking straw containing the formulation is transparent and / or colored.
  • the uptake of the active ingredient, vitamin and / or nutrient formulation can be observed while the use of an opaque colored drinking straw offers the opportunity to obscure the administration of a drug, vitamin and / or nutrient formulation ,
  • Another object of the invention is also a kit of the dosage form according to the invention and a physiologically acceptable, optionally varkstoff-, nutrient and / or vitamin-containing transport liquid.
  • transport liquid is preferably an aqueous liquid
  • water, lemonade, fruit juice without pulp, tea or coffee are particularly preferred.
  • Another object of the invention is a method for producing the dosage form, in which the locking device introduced into the drinking straw, introduced the formulation in the drinking straw through a drinking straw and the formulation facing the drinking straw opening is provided with the closure device.
  • Figures 1a, 1 b and 1c show a dosage form according to the invention with a removable cap with pierceable bottom (a), an attached cap with pierceable bottom (b) and a cap pierced bottom (c) in side view.
  • Figures 2a, 2b and 2c show a further dosage form according to the invention with a removed cap with pierceable bottom (a), an attached cap with pierceable bottom (b) and a cap pierced bottom (c) in side view.
  • the dosage form shown in Figures 1 a, 1 b and 1 c comprises a drinking straw (1) having two openings (6, 7) and a fixed in the drinking straw plug as a locking device (2), a cap with a pierceable bottom ( 5) as a closure device (3) and located between locking device and closure device in the drinking straw formulation (4).
  • the drinking straw (1) has a round cross-section and is straight.
  • the serving as a locking device plug (2) consists of filter material and is permeable to air and the transport liquid, for the formulation, however, impermeable.
  • the plug is cylindrical and has a round cross section, wherein the diameter of the plug is adapted to the inner diameter of the drinking straw.
  • the plug is permanently fixed in the drinking straw.
  • Formulation (4) is in the form of spherical particles.
  • the serving as a closure device cap (3) is impermeable to the formulation.
  • the inner diameter of the cap (3) is adapted to the outer diameter of the drinking straw (1), so that the cap can be placed on the drinking straw.
  • the bottom (5) of the cap (3) is pierced by means of the drinking straw (1).
  • the cap (3) with the destroyed bottom (5) is pulled over the drinking straw.
  • the dosage form shown in FIGS. 2 a, 2 b and 2 c essentially corresponds to the administration form shown in FIGS. 1 a, 1 b and 1 c.
  • a plug which can be moved by the transport liquid between two stops (8, 9) is used as the blocking device (2).
  • the diameter of the largest formulation particles is smaller than the inner diameter of the drinking straw at the location of the stop (8), so that the formulation particles can pass through this site.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (18)

  1. Forme d'administration orale de substances actives, de vitamines et/ou de substances nutritives, comprenant une paille (1), qui présente deux ouvertures (6, 7), et un dispositif de blocage (2) imperméable à une formulation de substance active, de vitamine et/ou de substance nutritive mais perméable à l'air et à un fluide de transport, un dispositif de fermeture (3) imperméable à la formulation de substance active, de vitamine et/ou de substance nutritive et contenant la formulation de substance active, de vitamine et/ou de substance nutritive (4) se trouvant entre le dispositif de blocage et le dispositif de fermeture dans la paille, caractérisée en ce que l'on utilise comme dispositif de fermeture un capuchon (3) fermant l'ouverture de la paille (6) tournée vers la formulation, lequel est fabriqué dans l'ensemble à partir du même matériau, en plastique ou en métal, de préférence en aluminium, et dont le fond par ailleurs résistant aux chocs présente sur toute la périphérie extérieure une ligne d'affaiblissement et peut de ce fait être enlevé par un choc.
  2. Forme d'administration selon la revendication 1,
    caractérisée en ce que la formulation de substance active, de vitamine et/ou de substance nutritive (4) est solide.
  3. Forme d'administration selon la revendication 1 ou 2, caractérisée en ce que la formulation de substance active, de vitamine et/ou de substance nutritive (4) est pâteuse.
  4. Forme d'administration selon l'une quelconque des revendications 1 à 3, caractérisée en ce que la formulation de substance active, de vitamine et/ou de substance nutritive (4) se présente sous forme multiparticulaire.
  5. Forme d'administration selon l'une quelconque des revendications 1 à 4, caractérisée en ce que la formulation de substance active, de vitamine et/ou de substance nutritive (4) est insoluble dans le liquide de transport.
  6. Forme d'administration selon l'une quelconque des revendications 1 à 4, caractérisée en ce que la formulation de substance active, de vitamine et/ou de substance nutritive (4) est au moins partiellement soluble dans le liquide de transport.
  7. Forme d'administration selon l'une quelconque des revendications 1 à 6, caractérisée en ce que le dispositif de blocage (2) est un bouchon.
  8. Forme d'administration selon la revendication 7, caractérisée en ce que le bouchon (2) peut être déplacé par le liquide de transport entre deux butées (8, 9).
  9. Forme d'administration selon la revendication 7, caractérisée en ce que le bouchon (2) est fixe.
  10. Forme d'administration selon l'une quelconque des revendications 1 à 8, caractérisée en ce que le dispositif de blocage (2) est une membrane fixée dans la paille.
  11. Forme d'administration selon la revendication 4,
    caractérisée en ce que le dispositif de blocage (2) est une grille fixée dans la paille, dont le diamètre de maille est inférieur au plus petit diamètre des particules de la formulation (4).
  12. Forme d'administration selon la revendication 4, caractérisée en ce que le dispositif de blocage (2) est constitué par un rétrécissement de la paille, de sorte que la section transversale de la paille est plus étroite que le plus petit diamètre des particules de la formulation (4).
  13. Forme d'administration selon l'une quelconque des revendications 1 à 12, caractérisée en ce que la paille (1) est rigide ou flexible, droite ou courbe et/ou peut être fléchie de préférence de manière réversible.
  14. Kit constitué de la forme d'administration selon l'une quelconque des revendications 1 à 13 et d'un liquide de transport physiologiquement acceptable, contenant éventuellement des substances actives, des substances nutritives et/ou des vitamines.
  15. Kit selon la revendication 14, caractérisé en ce que le liquide de transport est un liquide aqueux.
  16. Kit selon la revendication 14 ou 15, caractérisé en ce que le liquide de transport est de l'eau, de la limonade, du jus de fruit ou de la pulpe de fruit, du thé ou du café.
  17. Procédé de préparation d'une forme d'administration selon l'une quelconque des revendications 1 à 13, caractérisé en ce que le dispositif de blocage (2) est introduit dans la paille (1), la formulation (4) est introduite dans la paille (1) par l'une des ouvertures (6) de la paille et cette ouverture (6) de la paille est pourvue du dispositif de fermeture (3).
  18. Procédé de préparation d'une forme d'administration selon l'une quelconque des revendications 1 à 13, caractérisé en ce que l'une des ouvertures (6) de la paille est pourvue du dispositif de fermeture (3) et la formulation (4) et le dispositif de blocage (2) sont introduits dans la paille (1) par l'autre ouverture (7) de la paille.
EP03735654A 2002-06-24 2003-06-20 Forme d'administration orale de substances actives, de vitamines et/ou de substances nutritives Expired - Lifetime EP1517628B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10228176 2002-06-24
DE10228176A DE10228176A1 (de) 2002-06-24 2002-06-24 Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen
PCT/EP2003/006533 WO2004000080A1 (fr) 2002-06-24 2003-06-20 Forme d'administration orale de substances actives, de vitamines et/ou de substances nutritives

Publications (2)

Publication Number Publication Date
EP1517628A1 EP1517628A1 (fr) 2005-03-30
EP1517628B1 true EP1517628B1 (fr) 2008-01-09

Family

ID=29761359

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03735654A Expired - Lifetime EP1517628B1 (fr) 2002-06-24 2003-06-20 Forme d'administration orale de substances actives, de vitamines et/ou de substances nutritives

Country Status (6)

Country Link
EP (1) EP1517628B1 (fr)
AT (1) ATE383097T1 (fr)
AU (1) AU2003237964A1 (fr)
DE (2) DE10228176A1 (fr)
ES (1) ES2299708T3 (fr)
WO (1) WO2004000080A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005004257A1 (de) * 2005-01-28 2006-08-24 Grünenthal GmbH Verfahren zur Herstellung eines Trinkhalms mit Controller
DE102005004256A1 (de) * 2005-01-28 2006-08-10 Grünenthal GmbH Trinkhalm mit einer Versteifung
CN111407663A (zh) 2019-01-07 2020-07-14 上海汉都医药科技有限公司 一种口服给药递送装置

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US38871A (en) * 1863-06-09 Improvement in labels or tags
US1236029A (en) * 1916-08-10 1917-08-07 George H Williams Drinking device.
US3610483A (en) * 1969-12-01 1971-10-05 Ralph Visconti Dispenser with liquid-impervious vent
US3824322A (en) * 1971-12-20 1974-07-16 J Fiorella Flavored stirrer for alcoholic beverages
US4581013A (en) * 1982-04-19 1986-04-08 Jane C. A. Hayes Doser for orally administering medicine
US4792333A (en) * 1986-11-04 1988-12-20 Strawdose, Inc. Unit dose drug package and administering device
US4981468A (en) * 1989-02-17 1991-01-01 Eli Lilly And Company Delivery device for orally administered therapeutic agents
US5780058A (en) * 1995-07-21 1998-07-14 Alza Corporation Oral delivery of discrete units
US5718681A (en) * 1996-01-11 1998-02-17 Christopher E. Manning Medication delivery straw
AU729769B2 (en) * 1996-10-18 2001-02-08 Alza Corporation Closure system for an active agent delivery device
US5866185A (en) * 1997-07-22 1999-02-02 Burkett; Edward K. Method and device for dispensing an ingestible soluble material for further dissolving in a liquid
AUPP412898A0 (en) * 1998-06-17 1998-07-09 Raponi, Anthony Pasquale Flavoured drinking straw
US6217545B1 (en) * 1999-02-08 2001-04-17 Porex Technologies Corp. Filter with varying density which is responsive to fluid flow
US6283294B1 (en) * 1999-09-01 2001-09-04 Biogaia Biologics Ab Enclosed living cell dispensing tube
GB2366178A (en) * 2000-09-02 2002-03-06 Dan Drake Flavouring device for a liquid
DE20017686U1 (de) * 2000-10-12 2001-02-22 Schneickert, Thomas, 90765 Fürth Trinkhalm mit Füllung
EP1331960A2 (fr) * 2000-11-03 2003-08-06 Recovery Pharmaceuticals, Inc. Dispositif et procede pour arreter de fumer

Also Published As

Publication number Publication date
AU2003237964A1 (en) 2004-01-06
DE50308974D1 (de) 2008-02-21
WO2004000080A1 (fr) 2003-12-31
ATE383097T1 (de) 2008-01-15
DE10228176A1 (de) 2004-01-22
EP1517628A1 (fr) 2005-03-30
ES2299708T3 (es) 2008-06-01

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