EP1663101B1 - Forme galenique servant a l'administration orale de principes actifs, vitamines et/ou substances nutritives, kit et utilisation - Google Patents

Forme galenique servant a l'administration orale de principes actifs, vitamines et/ou substances nutritives, kit et utilisation Download PDF

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Publication number
EP1663101B1
EP1663101B1 EP04765071A EP04765071A EP1663101B1 EP 1663101 B1 EP1663101 B1 EP 1663101B1 EP 04765071 A EP04765071 A EP 04765071A EP 04765071 A EP04765071 A EP 04765071A EP 1663101 B1 EP1663101 B1 EP 1663101B1
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EP
European Patent Office
Prior art keywords
dosage form
form according
drinking straw
barrier device
hydrophobic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP04765071A
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German (de)
English (en)
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EP1663101A1 (fr
Inventor
Elke Sternberger
Rasoul Sedaghat Kerdar
Johannes Bartholomäus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
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Gruenenthal GmbH
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Publication date
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Priority to PL04765071T priority Critical patent/PL1663101T3/pl
Publication of EP1663101A1 publication Critical patent/EP1663101A1/fr
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Publication of EP1663101B1 publication Critical patent/EP1663101B1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0038—Straws
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47G—HOUSEHOLD OR TABLE EQUIPMENT
    • A47G21/00—Table-ware
    • A47G21/18—Drinking straws or the like
    • A47G21/183—Drinking straws or the like with means for changing the flavour of the liquid

Definitions

  • the invention relates to a dosage form for oral administration of active ingredients, vitamins and / or nutrients comprising a drinking straw and an impermeable to an active ingredient, vitamin and / or nutrient formulation, for air and a transport liquid permeable barrier device, wherein the locking device is a uniform Has density and a hydrophobic finish (see US-B-6,224,908).
  • the drinking straws for oral administration of active ingredients, vitamins and / or nutrients described in the prior art contain plugs or blocking devices which are both complicated and expensive. Furthermore, the known locking devices on properties that are not or only poorly reproducible, so that there is a variable and therefore intolerable behavior in routine investigations or repeated use in standard situations.
  • the object is achieved by providing a dosage form according to claim 1.
  • a uniform density is understood to mean a density of the blocking device which varies by a maximum of 10%. This is advantageous both in the event that the transport liquid moves through the locking device during a suction process of the user of the drinking straw, as well as in the event that the transport liquid past the locking device, i. So between the locking device and the inner wall of the straw, moves.
  • the hydrophobic equipment causes as little as possible of the transport liquid to remain in the barrier device, thereby increasing the reproducibility of the characteristics of the drinking straw. Furthermore, it is thereby achieved that in a one-time (incomplete) sucking the locking device is not so difficult because less transport fluid remains in the locking device.
  • the locking device over the entire cross section of the drinking straw is uniformly permeable to the transport liquid, whereby their transport is facilitated.
  • the hydrophobic equipment of the locking device and their uniform density act together according to the invention to ensure an advantageous and in particular better reproducible behavior of the locking device.
  • the active ingredient, vitamin and / or nutrient formulation is preferably solid or pasty, more preferably solid and is hereinafter referred to as "formulation" according to the invention.
  • formulation Preference is given to a multiparticulate formulation, wherein the particles of the multiparticulate formulation preferably have a diameter of 50 ⁇ m to 1500 ⁇ m and in particular are spherical.
  • the formulation is in the form of tablets, microtablets, granules, crystals or pellets.
  • the formulation can also be immobilized in the drinking straw with the aid of a binding, physiologically acceptable material which is soluble in the transport liquid.
  • the active ingredients and / or vitamins and / or nutrients per se or the formulation as a whole can be insoluble or else soluble in the transport fluid or be at least partially soluble. If the active ingredients, vitamins or nutrients or their formulations are soluble in the transport liquid, they are dissolved by the transport fluid passing by and taken in dissolved form. On the other hand, if the active ingredients, vitamins or nutrients or their formulations are insoluble in the transport fluid, they are suspended in the transport fluid flowing past and taken in suspended form with the transport fluid. Preferably, multiparticulate formulations are used for this purpose. Such particles should be so small and light that they can be transported by the transport liquid. The adhesion of the particles to each other or to the drinking straw walls should be as low as possible, which can optionally be achieved by a suitable surface treatment of the particles.
  • active ingredients preferably therapeutic agents, vitamins and nutrients, all orally administrable substances can be used in the form of a suitable formulation.
  • the drinking straw preferably contains a precisely defined dose of these substances, in particular a single dose for a single administration.
  • the locking device is designed such that it does not affect the movement of the transport liquid (and also the movement of air) within the drinking straw substantially, but at most slows down a bit, as they walk through the transport liquid (and air) through the locking device or on the blocking device only by a certain resistance opposes. It is different, however, for the formulation or its constituents.
  • the locking device first holds the formulation in a specific position of the drinking straw, so that it remains in the drinking straw.
  • the blocking device however, the flow of the transport liquid must not be reduced so far that a solid and insoluble active ingredient, vitamin and / or nutrient formulation would not be taken.
  • the formulation is preferably arranged in the drinking straw between the blocking device and the mouth opening of the drinking straw, to which the formulation can pass unhindered.
  • the blocking device is preferably designed as a type of plug whose cross section is preferably adapted to the cross section of the drinking straw.
  • the outer diameter of the (loose, ie not in the drinking straw) locking device in the preferred embodiment is at least as large as the inner diameter of the drinking straw.
  • a locking device can therefore - if it is loose - have a larger cross section than the cross section of the drinking straw. In this case, the locking device must be compressible and at least partially compressed before it can be inserted into the drinking straw.
  • the locking device is constructed of fibers which are thermally connected to each other.
  • the fibers have in particular a thickness of 1.3 dtex to 8 dtex.
  • the fibers are based on cellulose or cellulose derivatives and more preferably on cellulose acetate.
  • the fibers may be pressed into filter material to preferably produce the barrier as a plug.
  • This plug can also consist of appropriate nonwoven material.
  • the locking device corresponds to a cigarette filter.
  • a cost-effective production of the locking device is possible with particularly simple means. It is important to ensure that the cigarette filter is preferably hydrophobic before use as a blocking device, if the material of the cigarette filter does not already have intrinsic hydrophobic properties. Particularly preferred is the use of a cigarette filter as a blocking device, wherein the cigarette filter comprises cellulose acetate, in particular compacted cellulose acetate fibers.
  • the locking device may also be constructed of a foam, preferably of an open-cell foam and permeable to the air and transport fluid and permeable.
  • the locking device is particularly simple and can be produced with particularly advantageous properties.
  • the locking device is made of a foam made of a plastic, which is approved under food law.
  • the plastics such as polyesters, preferably polyethylene terephthalate, polystyrenes, or polyolefins, preferably polyethylene, can preferably be used for the production of the blocking device.
  • the fibers or the foam are at least partially hydrophobic.
  • the blocking device which is constructed from such fibers, is also hydrophobic.
  • the blocking device when the individual fibers are intrinsically hydrophobic, the blocking device will be referred to as an "inside" hydrophobic barrier device, so that it is hydrophobic overall (inside and outside).
  • the foam may also be hydrophobic as a whole, either because the foam plastic is already intrinsically hydrophobic or because the foam has been rendered hydrophobic.
  • the locking device is at least partially outwardly hydrophobic equips. or the blocking device has a peripheral area which is more hydrophobic in relation to an interior.
  • Such an embodiment has the advantage that not all fibers have to be individually rendered hydrophobic, but that only the fibers present in the outer region of the blocking device are either intrinsically hydrophobic or hydrophobic.
  • a built-up of foam barrier device can be hydrophobic in its outer region. By such a hydrophobic equipment only in the outer region of the locking device, the manufacturing cost of the locking device can be reduced.
  • this embodiment of the locking device will be referred to as an "outside" hydrophobic locking device.
  • the hydrophobic finish of the barrier device is based on Teflon, a silicone or silicone derivative, a hydrophobic acrylic or other hydrophobic material, preferably a food approved material.
  • the locking device for at least 15 minutes in contact with the transport liquid (for example, at the lower end of the locking device) without so much transport liquid penetrates into or through the locking device that above wetting the barrier device is wetted.
  • the transport liquid for example, at the lower end of the locking device
  • no suction takes place at the mouth of the drinking straw and / or that during this time the transport liquid is not pressed from below through the locking device.
  • Preferred acrylic resins for the hydrophobic finish are water-insoluble acrylic resins, such as poly (meth) acrylates, more preferably poly (C 1-4 ) alkyl (meth) acrylates, poly (C 1-4 ) trialkylamino (C 1-4 ) alkyl ( Meth) acrylates and / or their copolymers, most preferably copolymers of ethyl acrylate and methyl methacrylate with a monomeric molar ratio of 2: 1 (Eudragit NE30D®), copolymers of ethyl acrylate, methyl methacrylate and trimethylammonium-ethyl methacrylate chloride with a monomeric molar ratio of 1: 2 : 0.1 (Eudragit RS®), copolymers of ethyl acrylate, methyl methacrylate and trimethyl ammonium ethyl methacrylate chloride with a monomeric molar ratio of 1: 2: 0.2 (
  • polyvinyl acetates preferably Kollicoat SR 30 D®
  • cellulose derivatives preferably alkyl cellulose, ethyl cellulose or cellulose esters, for example cellulose acetate.
  • the said polymers or copolymers can be further equipped to increase their hydrophobic property with other hydrophobic groups, so that their hydrophobic property is increased.
  • silicone or silicone derivatives or Teflon can be used for hydrophobing.
  • the material used for the hydrophobization is applied according to the invention to the blocking device preferably by means of a spraying process or a dipping process or generally an impregnation process.
  • a spraying process or a dipping process or generally an impregnation process it is either possible that the hydrophobic effect of the hydrophobic material is achieved only by the application, ie directly (or after a certain reaction time) after contact with the fibers or the foam of the blocking device, or that the hydrophobizing effect only after activation takes place, for example after an electromagnetic activation by means of UV radiation or other radiation or after a thermal activation or after a chemical activation.
  • the hydrophobic material preferably penetrates from the outside to the inside in the blocking device during application, so that the amount of hydrophobic material applied or the choice of the hydrophobic material (which in turn determines the reaction time) or, if appropriate, the type of activation of the hydrophobic material hydrophobizing effect the penetration depth into the locking device can be influenced.
  • an intrinsically hydrophobic material is used on the surface of the blocking device and an intrinsically non-hydrophobic material is used in the interior of the blocking device.
  • the blocking device preferably comprises only food law harmless, ie approved, material. For a cost-effective production of the locking device is possible.
  • the locking device is arranged movably in the drinking straw.
  • the position of the locking device can also serve as a measure of the amount of formulation supplied to the user.
  • at least the portion of the drinking straw containing the formulation or the portion of the drinking straw in which the blocking device can move is at least partially transparent and / or colored, in particular colored such that the position of the blocking device is visible from the outside.
  • an embodiment is also possible in which the drinking straw is opaque at the beginning of the region of movement of the blocking device and is made transparent at the end of this movement region.
  • the administered administration of the formulation is indicated by the fact that the locking device reaches the transparent area, which is visible from the outside.
  • the transparent and opaque areas can also be reversed.
  • the movable locking device is preferably movable in the drinking straw only in a certain range.
  • the locking device is fixed in the drinking straw.
  • the barrier effect of the locking device ie its blocking effect on the formulation and its constituents and their permeability to the transport liquid (as well as for air), easier and safer to implement.
  • the hydrophobically equipped locking device is movable.
  • the drinking straw has a first opening and a second, the active ingredient, vitamin and / or nutrient formulation facing opening, wherein the drinking straw is narrowed at least at one of the openings to a smaller compared to the cross section of the locking device cross-section.
  • the drinking straw is at least partially maintained upright, so that the first opening at its lower end and the second opening results at its upper end.
  • the drinking straw may have a curvature area or be designed to be bendable or curvable in order, on the one hand, to open the lower end, i. the first opening, easier to dive into the transport liquid and on the other hand at the upper end, i. at the second opening to allow easier suction.
  • the drinking straw in the region of its first opening preferably extends largely vertically and in the region of its second opening preferably at an angle of approximately 10 ° to 90 ° relative to the vertical, preferably at an angle of approximately 30 ° to 70 °. This results in a total of a curvature angle for the position of use of about 0 ° to a maximum of 90 °, preferably from about 20 ° to about 60 °, most preferably from about 30 ° to about 45 °.
  • the locking device is arranged above the curvature in one and the same leg of the drinking straw as the formulation.
  • the straw can be rigid or flexible, straight or angled - preferably reversible angled.
  • the drinking straw is preferably made of a synthetic material.
  • At least the optionally existing curvature region in which the drinking straw is reversibly bendable is preferably constructed of an elastic, synthetic material or of a synthetic material plastically deformable at a temperature below its softening point.
  • the area in which the drinking straw is reversibly angled, is preferably designed accordion-like.
  • the drinking straw inner diameter should preferably be at least 3 mm, so that a sufficient amount of transport liquid can be sucked through the drinking straw in order to transport the formulation.
  • Preferred is an inner diameter of 4-15 mm, most preferably 5-10 mm.
  • the drinking straw preferably has a round, oval, rectangular or square cross-section and preferably has a smooth inner side. A round cross section is preferred.
  • the second opening is provided with a removable and formulation impermeable closure device.
  • the closure device is reversible to close and open.
  • the formulation can also be supplied to a user in a plurality of time-sequential sub-steps, the formulation being reliably enclosed by the reversibly closable closure device in between.
  • this closure device is a plug, a plug, a foil, a grid or a cap, so that a closure of the drinking straw can be effected with very simple means.
  • the closure device is preferably made of an insoluble in the transport liquid or at least only partially soluble, air-impermeable or at least only partially permeable to air and preferably physiologically harmless material.
  • the inner diameter of the closure device is adapted to the outer diameter of the drinking straw, so that the closure device can be placed on the drinking straw.
  • the closure device may preferably also be embodied in the form of a part of the drinking straw which is reversibly angled between the first opening and the second opening and which is preferably reversibly fixable in the angled position with the aid of a clamp, a collar or a cap.
  • the straw is closed, ie the curvature set in such a way causes a closure of the drinking straw at least at its second opening. This results in a curvature angle for the closed position of preferably approximately 180 °.
  • the second opening of the drinking straw is designed as a mouthpiece and has in particular a corrugation.
  • the formulation can be safely and easily supplied to those drinking straw users who, due to their age or due to an infirmity, have difficulty in swallowing or coordination difficulties (for example with regard to movements of their mouths).
  • the first opening is formed as a connecting piece to a reservoir of the transport liquid. This makes it possible with particularly simple means to produce a secure connection of the drinking straw with a reservoir of the transport liquid and thus to prevent spillage of the transport liquid.
  • the drinking straw further comprises a mark for identifying the mouth part and / or for indicating the suction direction of the transport liquid.
  • a use and handling of the drinking straw is greatly simplified, because such use is intuitively possible. It is particularly advantageous if the marking is represented by a symbol, for example an arrow or the like. In this case, a user must recognize any characters, making the use of the dosage form according to the invention is simpler and thus safer.
  • Another object of the invention is also a kit of the dosage form according to the invention and a physiologically acceptable, optionally active substance, nutrient and / or vitamin-containing transport liquid, which is preferably present in a container.
  • As transport liquid is preferably an aqueous liquid, wherein water, lemonade, fruit juice without pulp, tea, coffee, milk and / or a milk constituents having liquid are particularly preferred.
  • Another object relates to the use of a cigarette filter as a blocking device for a dosage form according to the invention.
  • FIG. 1 shows a dosage form according to the invention which comprises a drinking straw 1 with a blocking device 3 and a formulation 2 located therein.
  • the drinking straw 1 has a drinking straw wall 10 or a drinking straw wall 10, a first opening 5 and a second opening 6, wherein the second opening 6 is closed by way of example by means of a closure device 4.
  • the first opening 5 is also referred to below as the inlet opening 5 and the second opening 6 is also referred to below as the mouth opening 6.
  • a section line II is further drawn transversely to the longitudinal extent of the drinking straw 1 at the height of the locking device 3.
  • the formulation 2 is arranged on the second opening 6 facing side of the locking device 3 and also remains there, which is caused by the blocking effect of the locking device 3 for the formulation 2.
  • the serving as a blocking device 3 plug 3 is exemplified by hydrophobic filter material, in particular in the form of a cigarette filter, and is permeable to air and a transport liquid in particular during suction, for the Formulation 2, however, impermeable.
  • the plug 3 is exemplified as a compact, cylindrical body and has a round cross-section.
  • the plug 3 is permanently fixed in the straw 1 or arranged to be movable within limits.
  • the locking device 3 or the plug 3 is arranged to be movable, then its mobility is limited in any case, for example already in that the straw 1 according to the invention preferably at both its mouth opening 6 and at its inlet opening 5 has a cross-sectional reduction, ie a reduction of at least the inner diameter or in general the inner cross-section of the drinking straw 1, wherein it is preferably provided that the reduction in cross-section is accompanied by a reduction of the outer diameter of the drinking straw 1, ie that the "wall thickness" of the drinking straw 1 is substantially constant in the area of the cross-sectional reduction.
  • a first such cross-sectional reduction 11 is arranged by way of example in FIG.
  • the cross-sectional reductions 11, 14 cause the (movably provided) locking device 3 in any case can not escape from the drinking straw 1 (through one or the other opening 5, 6).
  • the area between the cross-sectional reductions 11, 14 could therefore be referred to as the "maximum range of movement" of the locking device 3. According to the invention, however, it can be provided that the range of movement is further limited by other cross-sectional constrictions, such as a bendable area.
  • FIG. 2 shows a cross-sectional view of the drinking straw 1 along the section line II from FIG. 1 , a section also being drawn through the blocking device 3.
  • the outer diameter of the locking device 3 is adapted to the inner diameter of the drinking straw 1, that the formulation 2 can not get from the second opening 6 facing side of the locking device 3 to the other side.
  • This is accomplished in particular by a sufficiently small distance between the wall 10 of the drinking straw 1 and the locking device 3.
  • This distance is chosen such that - if the locking device 3 is movable - between the locking device 3 and the wall 10 of the drinking straw is a sufficiently large friction, which causes the locking device 3 is not more or only difficult of a once taken position in the direction of the second opening 6 out back to their starting position.
  • the hydrophobic equipment of the locking device assists in fixing the locking device in any position.
  • the round cross section of both the drinking straw 1 and the blocking device 3 shown in FIG. 2 is chosen merely by way of example and can also be replaced by another cross-sectional configuration - for example square, rectangular, triangular, pentagonal, hexagonal or octagonal is.
  • FIG. 3 shows a side view of a blocking device 3 constructed from fibers 31.
  • the blocking device 3 shown in FIG . 3 furthermore has a hydrophobic edge region 32.
  • the edge region 32 causes the transport liquid 7 to pass substantially inside 34 from the blocking device 3 or laterally past the blocking device 3 , ie between the blocking device 3 and the wall 10 of the drinking straw 1, flows past.
  • the edge region 32 is dispensable, in particular, if the fibers 31 of the blocking device 3 themselves are rendered hydrophobic, be they constructed from an intrinsically hydrophobic material or indeed constructed from an intrinsically less hydrophobic material, but subsequently hydrophobicized overall ,
  • the locking device 3 is, however, according to the invention quite well designed so that it is hydrophobic both inside 34 and outside - ie in the edge region 32.
  • the blocking device 3 can alternatively also be designed as a hydrophobicized and / or optionally hydrophobically "coated" cigarette filter.
  • FIG. 4 shows a side view of a blocking device 3 made of foam 33, in particular of open-cell foam 33.
  • the foam 33 is in particular partially permeable and according to the invention can of course - as indicated in Figure 3 for the case of a fiber comprising blocking device - also in a (preferably "hydrophobic") edge region 32 and a (preferably less hydrophobic) interior 34 be structured.
  • the pore size of the foam is inventively chosen such that the Transport liquid in contact with the locking device 3 does not penetrate too fast, but in particular by the hydrophobic equipment of the locking device. 3
  • FIG. 5 shows an illustration of a kit according to the invention or a situation of use of the dosage form according to the invention.
  • the (only schematically shown in Figure 5 ) drinking straw 1 dives with its first opening 5 in the transport liquid 7, which is located in a reservoir 50.
  • transport liquid 7 is sucked through the drinking straw 1 and conveys the formulation 2 or its components to the opening 6 and thus into the mouth of the user.
  • the drinking straw 1 can be provided bendable or bendable in a curvature region 15 by a curvature angle 16.
  • the curving portion 15 divides the straw 1 into a first (lower) part 17 and a second (upper) part 18.
  • the first part 17 is also referred to as the area 17 of the first opening 5, and the second part 18 is also called the area 18 of the second opening 6 denotes.
  • the region 17 of the first opening 5 extends largely vertically and the region 18 of the second opening 6 is angled by the angle of curvature 16.
  • the second part 18 should be at most horizontal, because otherwise the liquid from the second opening 6 may leak uncontrollably.
  • the blocking device 3 In the presence of a curvature region 15, the blocking device 3 according to the invention is provided in the upper part 18 of the drinking straw 1 as the formulation.
  • FIG. 5 also shows diagrammatically a connecting piece 52 between the drinking straw and the reservoir 50, which prevents spillage of the transporting fluid 7 either from the reservoir 50 or from the drinking straw 1, for example due to a decrease in the suction effect of the user of the drinking straw 1.
  • a marker 22 as a mouth representing a sign on the drinking straw 1 is shown schematically in Figure 5 , which is clearly closer to the second opening 6 than at the first opening 5 to indicate that for proper operation of the dosage form at the second opening 6 has to be sucked.
  • FIG 5 a corrugation 24 of the second opening 6 adjacent mouthpiece of the drinking straw 1 is shown.
  • the corrugation 24 serves that the user of the straw 1 can hold this better.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Table Equipment (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (20)

  1. Forme galénique destinée à l'administration orale de principes actifs, de vitamines et/ou de substances nutritives, qui comporte un chalumeau, (1) et un dispositif de blocage (3) qui ne laisse pas passer la formulation (2) de principes actifs, de vitamines et/ou de substances nutritives mais laisse passer l'air et un liquide de transport (7), le dispositif de blocage (3) présentant une densité uniforme et étant rendu hydrophobe, caractérisée en ce que la garniture hydrophobe est configurée de telle sorte que l'extrémité inférieure du dispositif de blocage peut rester pendant au moins 15 minutes en contact avec le liquide de transport sans que la quantité de liquide de transport qui pénètre dans le dispositif de blocage ou le traverse suffise pour mouiller la formulation située au-dessus du dispositif de blocage si pendant ledit laps de temps d'au moins 15 minutes, aucune aspiration n'est appliquée sur l'embouchure (6) du chalumeau et que pendant ledit laps de temps d'au moins 15 minutes, le liquide de transport n'est pas refoulé depuis le bas à travers le dispositif de blocage.
  2. Forme galénique selon la revendication 1, caractérisée en ce que le dispositif de blocage (3) est constitué de fibres (31).
  3. Forme galénique selon la revendication 2, caractérisée en ce que les fibres (31) sont à base de cellulose, de préférence de dérivés de cellulose et de façon particulièrement préférable d'acétate de cellulose.
  4. Forme galénique selon l'une des revendications précédentes, caractérisée en ce que le dispositif de blocage (3) est un filtre à cigarette.
  5. Forme galénique selon la revendication 1, caractérisée en ce que le dispositif de blocage (3) est constitué d'une mousse (33) et en particulier d'une mousse perméable (33) à pores ouverts.
  6. Forme galénique selon l'une des revendications précédentes, caractérisée en ce qu'au moins une partie des fibres (31) ou de la mousse (33) est hydrophobe et/ou rendue hydrophobe.
  7. Forme galénique selon l'une des revendications précédentes, caractérisée en ce que le dispositif de blocage (3) présente une bordure (32) plus hydrophobe que son âme intérieure (34).
  8. Forme galénique selon l'une des revendications précédentes, caractérisée en ce que la garniture hydrophobe est à base de Téflon, de silicone ou d'un dérivé de silicone ou encore d'un autre matériau hydrophobe, ce matériau étant de préférence un matériau légalement admis dans les produits alimentaires.
  9. Forme galénique selon l'une des revendications précédentes, caractérisée en ce que le dispositif de blocage (3) est disposé dans le chalumeau (1) de manière à pouvoir s'y déplacer.
  10. Forme galénique selon l'une des revendications précédentes, caractérisée en ce qu'au moins la partie du chalumeau (1) qui contient la formulation est transparente et/ou colorée.
  11. Forme galénique selon l'une des revendications précédentes, caractérisée en ce que le chalumeau (1) présente une première ouverture (5) et une deuxième ouverture (6) tournées vers la formulation (2) de principes actifs, de vitamines et/ou de substances nutritives, le chalumeau (1) se rétrécissant au moins à l'une de ses ouvertures (5, 6) jusqu'à une section transversale plus petite que la section transversale du dispositif de blocage (3).
  12. Forme galénique selon la revendication 11, caractérisée en ce que la deuxième ouverture (6) est dotée d'un dispositif de fermeture (4).
  13. Forme galénique selon la revendication 12, caractérisée en ce que le dispositif de fermeture (4) est un bouchon, un tampon, une feuille, une grille ou un capuchon.
  14. Forme galénique selon l'une des revendications 11 à 13 qui précèdent, caractérisée en ce que la deuxième ouverture (6) est configurée comme embouchure et présente en particulier des cannelures (24).
  15. Forme galénique selon l'une des revendications 11 à 14 qui précèdent, caractérisée en ce que la première ouverture (5) est configurée comme pièce (52) de raccordement à un réservoir (50) de liquide de transport (7).
  16. Forme galénique selon l'une des revendications précédentes, caractérisée en ce que le chalumeau (1) présente un repère (22) qui permet d'identifier la pièce d'embouchure et/ou qui indique la direction d'aspiration du liquide de transport (7).
  17. Utilisation d'un filtre à cigarette comme dispositif de blocage (3) pour une forme galénique selon l'une des revendications précédentes, le filtre à cigarette étant imperméable à une formulation (2) de principes actifs, de vitamines et/ou de substances nutritives mais étant perméable à l'air et à un liquide de transport (7), le filtre à cigarette présentant une densité uniforme et une garniture hydrophobe, la garniture hydrophobe étant configurée de telle sorte que l'extrémité inférieure du filtre à cigarette peut rester pendant au moins 15 minutes en contact avec le liquide de transport sans que la quantité de liquide de transport qui pénètre dans le filtre à cigarette ou qui la traverse soit suffisante pour mouiller la formulation située au-dessus du filtre à cigarette si pendant ledit laps de temps d'au moins 15 minutes, aucune aspiration n'est exercée sur l'embouchure du chalumeau et que pendant ledit laps de temps d'au moins 15 minutes, le liquide de transport n'est pas refoulé depuis le bas à travers le filtre à cigarette.
  18. Trousse constituée de la forme galénique selon l'une des revendications 1 à 16 qui précèdent et d'un liquide de transport (7) physiologiquement compatible et contenant éventuellement des principes actifs, de préférence dans un récipient.
  19. Trousse selon la revendication 18, caractérisée en ce que le liquide de transport (7) est un liquide aqueux.
  20. Trousse selon les revendications 18 ou 19, caractérisée en ce que le liquide de transport (7) est de l'eau, de la limonade, du jus de fruit ou de la chair de fruit, du thé, du café, du lait ou un liquide qui présente des composants du lait.
EP04765071A 2003-09-12 2004-09-10 Forme galenique servant a l'administration orale de principes actifs, vitamines et/ou substances nutritives, kit et utilisation Active EP1663101B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL04765071T PL1663101T3 (pl) 2003-09-12 2004-09-10 Postać stosowana do doustnego podawania substancji czynnych, witamin i/lub substancji odżywczych, zestaw i zastosowanie

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10342513A DE10342513A1 (de) 2003-09-12 2003-09-12 Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen, Kit und Verwendung
PCT/EP2004/010145 WO2005025485A1 (fr) 2003-09-12 2004-09-10 Forme galenique servant a l'administration orale de principes actifs, vitamines et/ou substances nutritives, kit et utilisation

Publications (2)

Publication Number Publication Date
EP1663101A1 EP1663101A1 (fr) 2006-06-07
EP1663101B1 true EP1663101B1 (fr) 2007-01-17

Family

ID=34305756

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04765071A Active EP1663101B1 (fr) 2003-09-12 2004-09-10 Forme galenique servant a l'administration orale de principes actifs, vitamines et/ou substances nutritives, kit et utilisation

Country Status (6)

Country Link
US (1) US20060147497A1 (fr)
EP (1) EP1663101B1 (fr)
DE (2) DE10342513A1 (fr)
ES (1) ES2280048T3 (fr)
PL (1) PL1663101T3 (fr)
WO (1) WO2005025485A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060034886A1 (en) * 2004-07-23 2006-02-16 Ward Bennett C Bonded fiber structures for use in controlling fluid flow
US20080312587A1 (en) * 2005-06-10 2008-12-18 Gruenethal Gmbh System for the Oral Administration of Solids to Persons Suffering from Dementia
DE102006059510A1 (de) * 2006-12-14 2008-06-19 Grünenthal GmbH Beschichtete Pellets
MX2009010891A (es) 2007-04-10 2010-02-17 Sandoz Ag Dispositivo para la aplicacion oral de una sustancia.
FR2920308B1 (fr) * 2007-09-05 2011-02-25 Unither Dev Forme pharmaceutique pour l'administration par voie orale de principes actifs.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792333A (en) * 1986-11-04 1988-12-20 Strawdose, Inc. Unit dose drug package and administering device
US4981468A (en) * 1989-02-17 1991-01-01 Eli Lilly And Company Delivery device for orally administered therapeutic agents
DE69612098T2 (de) * 1995-07-21 2001-06-21 Alza Corp Vorrichtung zur oralen verabreichung von diskreten einheiten
US5780058A (en) * 1995-07-21 1998-07-14 Alza Corporation Oral delivery of discrete units
US5718681A (en) * 1996-01-11 1998-02-17 Christopher E. Manning Medication delivery straw
AU721882B2 (en) * 1996-10-10 2000-07-13 Club Investments (Aust) Pty Ltd Method and apparatus for producing a flavoured beverage
ATE221762T1 (de) * 1997-05-16 2002-08-15 Alza Corp Durchflussreglerkonfigurationen für ein wirkstoff abgebendes gerät
AUPP412898A0 (en) * 1998-06-17 1998-07-09 Raponi, Anthony Pasquale Flavoured drinking straw
US6217545B1 (en) * 1999-02-08 2001-04-17 Porex Technologies Corp. Filter with varying density which is responsive to fluid flow
US20020092919A1 (en) * 2001-01-16 2002-07-18 Campagna Jason Patrick Filtered drinking straw
US20030042324A1 (en) * 2001-09-04 2003-03-06 Party Products Manufacturing Limited Drinking straw
US6718681B2 (en) * 2001-12-03 2004-04-13 Tarseam S. Bhullar Pest deterrent
DE10228175A1 (de) * 2002-03-27 2003-10-09 Gruenenthal Gmbh Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen
DE10228173A1 (de) * 2002-03-27 2003-10-09 Gruenenthal Gmbh System zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen

Also Published As

Publication number Publication date
PL1663101T3 (pl) 2007-06-29
WO2005025485A1 (fr) 2005-03-24
US20060147497A1 (en) 2006-07-06
DE10342513A1 (de) 2005-05-12
DE502004002706D1 (de) 2007-03-08
ES2280048T3 (es) 2007-09-01
EP1663101A1 (fr) 2006-06-07

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