EP1490010B1 - Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives - Google Patents

Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives Download PDF

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Publication number
EP1490010B1
EP1490010B1 EP03717238A EP03717238A EP1490010B1 EP 1490010 B1 EP1490010 B1 EP 1490010B1 EP 03717238 A EP03717238 A EP 03717238A EP 03717238 A EP03717238 A EP 03717238A EP 1490010 B1 EP1490010 B1 EP 1490010B1
Authority
EP
European Patent Office
Prior art keywords
drinking straw
formulation
administration according
bent
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP03717238A
Other languages
German (de)
English (en)
Other versions
EP1490010A1 (fr
Inventor
Rasoul Sedaghat Kerdar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
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Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of EP1490010A1 publication Critical patent/EP1490010A1/fr
Application granted granted Critical
Publication of EP1490010B1 publication Critical patent/EP1490010B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0038—Straws
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47G—HOUSEHOLD OR TABLE EQUIPMENT
    • A47G21/00—Table-ware
    • A47G21/18—Drinking straws or the like
    • A47G21/183—Drinking straws or the like with means for changing the flavour of the liquid

Definitions

  • the invention relates to a dosage form for oral administration of active ingredients, vitamins and / or nutrients comprising a drinking straw with a reversibly bendable between the formulation and a drinking straw opening part of the drinking straw as a closure device, whereby in an angled position leakage of the formulation from the drinking straw is prevented according to the
  • the preamble of claim 1 a kit of the dosage form and a transport liquid according to the preamble of claim 19 and a method for producing the dosage form according to the preamble of claim 22.
  • EP 0383503, US 5718681, US 4792333 and US6210713 disclose the administration of active ingredients, vitamins and / or nutrients by means of a drinking straw containing a liquid, active substance, vitamin and / or nutrient formulation transportable by a liquid. Patients who have difficulty or a disinclination to take capsules or tablets, this is another form of active ingredients, vitamins or nutrients offered.
  • the drinking straws for oral administration of active ingredients, vitamins and / or nutrients described in the prior art have stoppers or caps as closure device for restraining the active ingredient, vitamin and / or nutrient formulation present in the drinking straw.
  • the plugs or caps must be removed before using the drinking straw. During the removal of these known closure devices there is a risk of spillage of the active ingredient, vitamin and / or nutrient formulation.
  • a dosage form for oral administration of drugs, vitamins and / or nutrients comprising a drinking straw having two openings and containing an impermeable to an active ingredient, vitamin and / or nutrient formulation, for air and a transport liquid permeable barrier device and one for the active ingredient, vitamin and / or nutrient formulation impermeable closure device, wherein a contained in the drinking straw active ingredient, vitamin and / or nutrient formulation is arranged between locking device and closure device, characterized in that the closure device from a reversible angled between the formulation and the formulation freely accessible for drinking straw opening part of the Drinking straw is, whereby leakage of the formulation is prevented from the drinking straw, solved.
  • This drinking straw opening is the opening from which the formulation is removed by means of the transport liquid, d. H. the opening on the side facing away from the locking device.
  • the bendable part of the drinking straw can be reversibly fixed in the angled position by means of a ring, a clamp, a collar or a tube.
  • the active ingredient, vitamin and / or nutrient formulation is preferably solid or pasty. Preference is given to a multiparticulate active ingredient, vitamin and / or nutrient formulation, wherein the particles of the multiparticulate formulation preferably have a diameter of 50-1500 ⁇ m.
  • the active ingredients, vitamins and / or nutrients alone or the active ingredient, vitamin and / or nutrient formulations as a whole may be insoluble or at least partially soluble in the transport liquid.
  • the active ingredients, vitamins or nutrients or their formulations are soluble in the transport liquid, they are dissolved by the transport fluid flowing past and taken in dissolved form. If the active ingredients, vitamins or nutrients or their formulations in the transport liquid, however, are insoluble, they are in the passing liquid transport suspended and taken in suspended form with the transport liquid. Preferably, multiparticulate formulations are used for this purpose.
  • the particles should be so small and light that they can be transported by the transport liquid.
  • the adhesion of the particles to each other or to the drinking straw walls should be as low as possible, which can optionally be achieved by a suitable surface treatment of the particles.
  • active ingredients preferably therapeutic agents, vitamins and nutrients, all orally administrable substances can be used in the form of a suitable formulation.
  • the drinking straw preferably contains a precisely determined dose of these substances.
  • the locking device is preferably a plug whose cross section is preferably adapted to the cross section of the drinking straw.
  • the plug may be fixed on the one hand in the drinking straw, wherein the plug is preferably fixed by constrictions of the drinking straw or glued into the drinking straw.
  • the plug can also be movable between two stops.
  • the constrictions are designed so that the plug, but not the transport liquid insoluble in the formulation particles are retained by it.
  • the plug preferably consists of filter material, more preferably nonwoven material or pressed fiber material.
  • a blocking device is a membrane fixed in the drinking straw, wherein the cross section of the membrane is preferably adapted to the cross section of the drinking straw and the membrane is preferably glued into the drinking straw.
  • the membrane is preferably made of synthetic material.
  • a blocking device is a grid fixed in the drinking straw whose mesh diameter is smaller than the diameter of the smallest Formulation particle.
  • the cross section of the grid is preferably adapted to the cross section of the drinking straw and the grid is preferably fixed by constrictions of the drinking straw in the drinking straw or glued into the drinking straw.
  • the grid is preferably made of synthetic material.
  • a blocking device is a constriction of the drinking straw, which is designed so that even the smallest formulation particles are retained by it.
  • the flow of the transport liquid must not be reduced so much that a solid, insoluble active ingredient, vitamin and / or nutrient formulation can no longer be taken.
  • the drinking straw is flexible, at least in the area in which it is reversibly bendable.
  • the drinking straw is preferably made of a synthetic material. At least the region in which the straw is reversibly bendable, is preferably constructed of an elastic, synthetic material or a synthetic material plastically deformable at a temperature below its softening point.
  • the area in which the drinking straw is reversibly angled, is preferably designed accordion-like.
  • the drinking straw inner diameter should preferably be at least 3 mm, so that a sufficient amount of transport liquid can be sucked through the drinking straw in order to transport the formulation.
  • Preferred is an inner diameter of 4-15 mm, most preferably 5-10 mm.
  • the drinking straw preferably has a round, oval, rectangular or square cross-section and preferably has a smooth inner side.
  • the drinking straw opening which is freely accessible for the formulation, is preferably designed as a mouthpiece, particularly preferably corrugated, while the drinking straw opening, which faces the blocking device, preferably as Connecting piece is formed to a reservoir of the transport liquid.
  • the drinking straw preferably has a marking for identifying the mouth part and / or for specifying the suction direction of the transport liquid. This marking facilitates handling.
  • At least the portion of the drinking straw containing the formulation is transparent and / or colored.
  • the uptake of the active ingredient, vitamin and / or nutrient formulation can be observed while the use of an opaque colored drinking straw offers the opportunity to obscure the administration of a drug, vitamin and / or nutrient formulation ,
  • Another object of the invention is also a kit of the dosage form according to the invention and a physiologically acceptable, optionally active substance, nutrient and / or vitamin-containing transport liquid.
  • the transport liquid is preferably an aqueous liquid, water, lemonade, fruit juice without pulp, tea or coffee are particularly preferred.
  • Another object of the invention is a method for producing the dosage form in which introduced the locking device in the drinking straw, introduced the formulation through the a drinking straw opening in the drinking straw and the straw between the formulation and the freely accessible for the formulation drinking straw opening, d. H. the formulation facing drinking straw is angled.
  • Another object of the invention is a method for producing the dosage form, in which the drinking straw is angled and the formulation and the locking device are successively introduced through the accessible drinking straw opening in the drinking straw.
  • the dosage form shown in FIG. 1 comprises a drinking straw (1) which has two openings (6, 9) and a stopper fixed in the drinking straw as a blocking device (2), a reversibly bendable part as a closure device (3) and a between blocking device and Closure device contained in the drinking straw formulation (4).
  • the drinking straw (1) has a round cross-section and is straight.
  • the plug (2) consists of filter material and is permeable to air and the transport liquid, but impermeable to the formulation.
  • the plug is cylindrical and has a round cross section, wherein the diameter of the plug is adapted to the inner diameter of the drinking straw. The plug is glued into the drinking straw.
  • Formulation (4) is in the form of spherical particles.
  • the area (10) in which the drinking straw (1) is reversibly bendable, is accordion-like design.
  • the dosage form shown in FIG. 2 substantially corresponds to the dosage form shown in FIG. However, instead of a fixed plug, a between two stops (7, 8) movable plug used as a locking device (2).
  • the diameter of the largest formulation particles is smaller than the inner diameter of the drinking straw at the location of the stop (7) so that the formulation particles can pass through this site.
  • the dosage form shown in FIGS. 3 a to 3 d comprises a drinking straw (1) with a reversibly bendable part (3).
  • the angled position can be reversibly fixed by means of a tube (5) open on both sides.
  • the drinking straw (1) is introduced in an angled position into the tube (5).
  • the tube (5) is moved so far that the reversibly angled part (3) of the drinking straw (1) is exposed and the reversible bendable part (3) of the drinking straw (1) can be adjusted as desired.
  • the inner diameter of the tube (5) is matched to the space requirement of the drinking straw (1) in an angled position.
  • the length of the tube (5) is smaller than the length of the drinking straw (1) in an angled position.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Table Equipment (AREA)

Claims (24)

  1. Forme galénique pour administration orale de principes actifs, de vitamines et/ou de substances nutritives comprenant une paille (1) qui a deux ouvertures (6, 9) et qui contient un dispositif de blocage (2) imperméable à une formulation de principe actif, de vitamine et/ou de substance nutritive, mais perméable à l'air et au liquide de transport et qui présente un dispositif de fermeture (3) imperméable à la formulation de principe actif, de vitamine et/ou de substance nutritive, une formulation (4) de principe actif, de vitamine et/ou de substance nutritive se trouvant dans la paille étant disposée entre le dispositif de blocage et le dispositif de fermeture, caractérisée en ce que le dispositif de fermeture (3) se compose d'une partie coudée (3) de la paille réversible entre la formulation (4) et l'ouverture de paille (6) librement accessible pour la formulation, de sorte qu'une sortie de la formulation hors de la paille soit évitée.
  2. Forme galénique selon la revendication 1, caractérisée en ce que la partie coudée (3) de la paille (1) est fixée de manière réversible au moyen d'une bague, d'un collier, d'une manchette ou d'un tube (5) dans la position coudée.
  3. Forme galénique selon la revendication 1 ou 2, caractérisée en ce que la formulation (4) de principe actif, de vitamine et/ou de substance nutritive est solide.
  4. Forme galénique selon la revendication 1 ou 2, caractérisée en ce que la formulation (4) de principe actif, de vitamine et/ou de substance nutritive est pâteuse.
  5. Forme galénique selon l'une quelconque des revendications 1 à 4, caractérisée en ce que la formulation (4) de principe actif, de vitamine et/ou de substance nutritive se présente sous forme multiparticulaire.
  6. Forme galénique selon l'une quelconque des revendications 1 à 5, caractérisée en ce que la formulation (4) de principe actif, de vitamine et/ou de substance nutritive est insoluble dans le liquide de transport.
  7. Forme galénique selon l'une quelconque des revendications 1 à 5, caractérisée en ce que la formulation (4) de principe actif, de vitamine et/ou de substance nutritive est au moins partiellement soluble dans le liquide de transport.
  8. Forme galénique selon l'une quelconque des revendications 1 à 7, caractérisée en ce que le dispositif de blocage (2) est un bouchon.
  9. Forme galénique selon la revendication 8, caractérisée en ce que le bouchon (2) peut être déplacé entre deux butées (7, 8).
  10. Forme galénique selon la revendication 8, caractérisée en ce que le bouchon (2) est fixe.
  11. Forme galénique selon l'une quelconque des revendications 1 à 7, caractérisée en ce que le dispositif de blocage (2) est une membrane fixée dans la paille.
  12. Forme galénique selon la revendication 5, caractérisée en ce que le dispositif de blocage (2) est une grille fixée dans la paille, dont le diamètre de maille est inférieur au plus petit diamètre des particules de la formulation (4).
  13. Forme galénique selon la revendication 5, caractérisée en ce que le dispositif de blocage (2) est formé par un rétrécissement de la paille, de sorte que la section transversale de la paille soit plus petite que le plus petit diamètre des particules de la formulation (4).
  14. Forme galénique selon l'une quelconque des revendications 1 à 13, caractérisée en ce qu'au moins la région (10) dans laquelle la paille (1) est coudée de manière réversible, est flexible.
  15. Forme galénique selon l'une quelconque des revendications 1 à 14, caractérisée en ce que la paille (1) se compose d'un matériau synthétique.
  16. Forme galénique selon la revendication 15, caractérisée en ce qu'au moins la région (10) dans laquelle la paille (1) est coudée de manière réversible, se compose d'un matériau synthétique élastique.
  17. Forme galénique selon la revendication 15, caractérisée en ce qu'au moins la région (10) dans laquelle la paille (1) est coudée de manière réversible, se compose d'un matériau synthétique déformable plastiquement à une température en dessous de son point de ramollissement.
  18. Forme galénique selon la revendication 16 ou 17, caractérisée en ce qu'au moins la région (10) dans laquelle la paille (1) est coudée de manière réversible, est configurée en forme d'accordéon.
  19. Kit constitué de la forme galénique selon l'une quelconque des revendications 1 à 18 et d'un liquide de transport physiologiquement neutre, contenant éventuellement des principes actifs, des vitamines et/ou des substances nutritives.
  20. Kit selon la revendication 19, caractérisé en ce que le liquide de transport est un liquide aqueux.
  21. Kit selon la revendication 19 ou 20, caractérisé en ce que le liquide de transport est de l'eau, de la limonade, du jus de fruit sans pulpe de fruit, du thé ou du café.
  22. Procédé de préparation d'une forme galénique selon l'une quelconque des revendications 1 à 18, caractérisé en ce que le dispositif de blocage (2) est introduit dans la paille (1), la formulation (4) est introduite par l'une des ouvertures de paille (6) dans la paille (1) et la paille (1) est coudée entre la formulation (4) et l'ouverture de paille (6).
  23. Procédé de préparation d'une forme galénique selon l'une quelconque des revendications 1 à 18, caractérisé en ce que la paille (1) est coudée et la formulation (4) et le dispositif de blocage (2) sont introduits l'un après l'autre dans la paille par l'ouverture de paille (9).
  24. Procédé de préparation d'une forme galénique selon la revendication 22 ou 23, caractérisé en ce que la partie coudée (3) de la paille est fixée de manière réversible au moyen d'une bague, d'un collier, d'une manchette ou d'un tube (5) dans la position coudée.
EP03717238A 2002-03-27 2003-03-26 Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives Expired - Lifetime EP1490010B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10213773 2002-03-27
DE10213773 2002-03-27
DE10228175 2002-06-24
DE10228175A DE10228175A1 (de) 2002-03-27 2002-06-24 Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen
PCT/EP2003/003133 WO2003079957A1 (fr) 2002-03-27 2003-03-26 Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives

Publications (2)

Publication Number Publication Date
EP1490010A1 EP1490010A1 (fr) 2004-12-29
EP1490010B1 true EP1490010B1 (fr) 2007-04-25

Family

ID=28455548

Family Applications (1)

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EP03717238A Expired - Lifetime EP1490010B1 (fr) 2002-03-27 2003-03-26 Forme galenique pour administration orale de principes actifs, vitamines et/ou substances nutritives

Country Status (7)

Country Link
US (1) US20050109858A1 (fr)
EP (1) EP1490010B1 (fr)
AT (1) ATE360410T1 (fr)
AU (1) AU2003221524A1 (fr)
DE (2) DE10228175A1 (fr)
ES (1) ES2286422T3 (fr)
WO (1) WO2003079957A1 (fr)

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DE10342514A1 (de) * 2003-09-12 2005-04-07 Grünenthal GmbH Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen, Kit und Verwendung
DE10342513A1 (de) * 2003-09-12 2005-05-12 Gruenenthal Gmbh Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen, Kit und Verwendung
US20060034886A1 (en) * 2004-07-23 2006-02-16 Ward Bennett C Bonded fiber structures for use in controlling fluid flow
DE102005042875A1 (de) * 2004-12-23 2006-09-21 Grünenthal GmbH Schnell freisetzende Darreichungsformen für Antibiotika
DE102005019458A1 (de) 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
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AR060029A1 (es) 2006-03-02 2008-05-21 Unistraw Patent Holdings Ltd Pajilla para beber adaptada para acondicionar progresivamente un ingrediente activo y metodo de fabricar dicha pajilla
AR063571A1 (es) * 2006-11-06 2009-02-04 Unistraw Patent Holdings Ltd Aparato para el agregado de agentes o ingredientes solubles a un líquido portador, para su administración oral a través de un sorbete
DE102006059510A1 (de) 2006-12-14 2008-06-19 Grünenthal GmbH Beschichtete Pellets
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FR2920308B1 (fr) * 2007-09-05 2011-02-25 Unither Dev Forme pharmaceutique pour l'administration par voie orale de principes actifs.
EP2394627A1 (fr) * 2010-06-14 2011-12-14 Nestec S.A. Dispositif d'alimentation
US8342422B2 (en) 2010-09-03 2013-01-01 Dominique Claessens Drink container straw
ES2649140T3 (es) 2012-07-05 2018-01-10 P.C.O.A. Devices Ltd. Dispensador de medicación
DK3284700T3 (da) 2012-07-30 2019-09-09 DosentRX Ltd En beholder til at indeholde og dispensere faste medicinpiller
CN103040315A (zh) * 2012-12-07 2013-04-17 李红彪 一种带补气功能的吸管
CN103976878B (zh) * 2014-05-08 2016-04-20 成都百草和济科技有限公司 一种矫味吸管及矫味剂
EP4042999A4 (fr) * 2019-09-30 2022-11-09 Shanghai WD Pharmaceutical Co., Ltd Dispositif récepteur de médicament de formulation orale solide, et appareil d'administration orale le comprenant

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Also Published As

Publication number Publication date
ATE360410T1 (de) 2007-05-15
AU2003221524A1 (en) 2003-10-08
DE50307131D1 (de) 2007-06-06
DE10228175A1 (de) 2003-10-09
EP1490010A1 (fr) 2004-12-29
WO2003079957A1 (fr) 2003-10-02
ES2286422T3 (es) 2007-12-01
US20050109858A1 (en) 2005-05-26

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