WO2004000264A1 - Paille permettant d'administrer des substances actives, des vitamines et/ou des substances nutritives - Google Patents

Paille permettant d'administrer des substances actives, des vitamines et/ou des substances nutritives Download PDF

Info

Publication number
WO2004000264A1
WO2004000264A1 PCT/EP2003/006532 EP0306532W WO2004000264A1 WO 2004000264 A1 WO2004000264 A1 WO 2004000264A1 EP 0306532 W EP0306532 W EP 0306532W WO 2004000264 A1 WO2004000264 A1 WO 2004000264A1
Authority
WO
WIPO (PCT)
Prior art keywords
dosage form
form according
drinking straw
film
vitamin
Prior art date
Application number
PCT/EP2003/006532
Other languages
German (de)
English (en)
Inventor
Rasoul Sedaghat Kerdar
Johannes Bartholomäus
Norbert Lamm
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Priority to AU2003278969A priority Critical patent/AU2003278969A1/en
Publication of WO2004000264A1 publication Critical patent/WO2004000264A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47G—HOUSEHOLD OR TABLE EQUIPMENT
    • A47G21/00—Table-ware
    • A47G21/18—Drinking straws or the like
    • A47G21/183—Drinking straws or the like with means for changing the flavour of the liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0038—Straws

Definitions

  • the invention relates to a dosage form for oral administration of active ingredients, vitamins and / or nutrients comprising a drinking straw with a removable and / or destructible film with lines of weakness, which are preferably designed as predetermined separation points or predetermined breaking points, as a closure device, a kit of the dosage form and a transport liquid and a process for their manufacture.
  • the drinking straws described in the prior art for the oral administration of active ingredients, vitamins and / or nutrients have stoppers or caps as a closure device for retaining the active ingredient, vitamin and / or nutrient formulation contained in the drinking straw.
  • the plugs or caps are not firmly connected to the drinking straw and therefore do not allow the drinking straw to be sealed.
  • a dosage form for the oral administration of active substances, vitamins and / or nutrients comprising a drinking straw which has two openings, one impermeable to an active substance, vitamin and / or nutrient formulation, to air and one Transport liquid, however, permeable barrier device and the active ingredient, vitamin and / or nutrient formulation contains and at least one at least one closing device closing the drinking straw opening facing the formulation from an at least partially removable and / or destructible film attached to the drinking straw opening, the Lines of weakness, preferably predetermined separation points or predetermined breaking points, solved.
  • the sealing film can be impermeable to air, porous or lattice-like, whereby it must be impermeable to the active substance, vitamin and / or nutrient formulation before administration.
  • the film is preferably mechanically peelable, detachable, severable, pierceable or at least partially, separable and / or severable by suction and / or soluble in saliva.
  • the sealing film does not dissolve in the transport liquid.
  • the film has lines of weakness, preferably predetermined separation points or predetermined breaking points.
  • the closure film preferably consists of aluminum or an aluminum-plastic film laminate, single- or multi-layer plastic films or plastic film laminates.
  • the production of the optionally multi-layer films is known and is preferably carried out by (co) extrusion, melt casting, laminating, lyophilization, crystallization, optionally with the addition of polymers, weaving or pressing of fibrous material.
  • Fibrous material can be obtained by a method described in US 4855326, the corresponding disclosure being introduced for reference.
  • the lines of weakness of the closure film can preferably divide the film into segments of the same size and be arranged radially from the center of the film.
  • the line of weakness can also be arranged in a circle on the outer edge of the closure film, the line of weakness being interrupted for a preferably short piece, so that when the drinking straw is opened, the closing film initially remains connected to the drinking straw in this area and from there if necessary, can be completely removed by pulling it off.
  • the sealing film can also be used to remove the film residues, a pulling aid connected to the sealing film, e.g. B. in the form of a tab or a nipple.
  • the lines of weakness can preferably be applied in line with the film production by perforation or scoring into the film material used, preferably before being separated into the sealing films.
  • the straw opening can additionally be provided with a cap.
  • the other drinking straw opening can also be provided with the above-mentioned closure film and / or cap.
  • the active ingredient, vitamin and / or nutrient formulation is preferably solid or pasty.
  • a multiparticulate active substance, vitamin and / or nutrient formulation is preferred, the particles of the multiparticulate formulation preferably having a diameter of 50-1500 ⁇ m.
  • the active ingredients, vitamins and / or nutrients per se or the active ingredient, vitamin and / or nutrient formulations as a whole can be insoluble or at least partially soluble in the transport liquid.
  • the active ingredients, vitamins or nutrients or their formulations are soluble in the transport liquid, they are dissolved by the transport liquid flowing past and taken away in dissolved form. If, on the other hand, the active substances, vitamins or nutrients or their formulations are insoluble in the transport liquid, they are suspended in the transport liquid flowing past and carried along in suspended form with the transport liquid. Multiparticulate formulations are preferably used for this.
  • the particles should be so small and light that they can be transported by the transport liquid.
  • the adhesion of the particles to each other or to the straw walls should be as small as possible, which can be achieved by suitable surface treatment of the particles if necessary.
  • active ingredients preferably therapeutic active ingredients, vitamins and nutrients, all orally administrable substances can be used in the form of a suitable formulation.
  • the drinking straw preferably contains a precisely determined dose of these substances, which is sufficient for a single administration.
  • the locking device is preferably designed as a plug, the cross section of which is preferably adapted to the cross section of the drinking straw.
  • the loose plug can also have a larger cross section, provided that this plug can be pressed together to a cross section corresponding to the inner cross section of the drinking straw.
  • the blocking device can be permanently fixed in the drinking straw or arranged to be movable.
  • the plug can be permanently fixed in the drinking straw, for example by the plug being fixed, for example, by narrowing the drinking straw or by the plug being glued into the drinking straw.
  • the plug is preferably fixed by constriction of the drinking straw.
  • the stopper can also be movable between two stops by the transport liquid.
  • the drinking straw is narrowed by these stops, the narrowings being designed in such a way that the plug-like blocking device, but not the formulation particles which are insoluble in the transport liquid, are thereby retained.
  • the plug preferably consists of filter material, particularly preferably of non-woven material or pressed fiber material.
  • a membrane fixed in the drinking straw is also preferred as the blocking device, the cross section of the membrane preferably being adapted to the cross section of the drinking straw and the membrane preferably being glued into the drinking straw.
  • the membrane is preferably made of synthetic material.
  • Also preferred as a blocking device is a grid fixed in the drinking straw, the mesh diameter of which is smaller than the diameter of the smallest formulation particle.
  • the cross section of the grid is preferably matched to the cross section of the drinking straw and the grid is preferably fixed in the drinking straw by constrictions of the drinking straw or glued into the drinking straw.
  • the grid is preferably made of synthetic material.
  • a constriction of the drinking straw which is designed in such a way that even the smallest formulation particles are retained, is also suitable as a blocking device.
  • the blocking device must not reduce the flow of the transport liquid to such an extent that a solid, insoluble active substance, vitamin and / or nutrient formulation can no longer be taken along.
  • the drinking straw can be rigid or flexible, angled straight or angled, preferably reversibly angled.
  • the drinking straw is preferably made of a synthetic material. At least the possibly existing area in which the drinking straw can be reversibly bent is preferably made of an elastic, synthetic material or a synthetic material that is plastically deformable at a temperature below its softening point.
  • the area in which the drinking straw can be reversibly angled is preferably designed like an accordion.
  • the inside diameter of the drinking straw should preferably be at least 3 mm, so that a sufficient amount of transport liquid can be drawn through the drinking straw to transport the formulation.
  • An inner diameter of 4-15 mm is preferred, very particularly preferably 5-10 mm.
  • the drinking straw preferably has a round, oval, rectangular or square cross section and preferably has a smooth inside.
  • the drinking straw opening, which faces the formulation and is closed according to the invention, is preferably designed as a mouthpiece, particularly preferably corrugated, while the drinking straw opening, which faces the locking device, is preferably designed as a connection piece to a reservoir of the transport liquid.
  • the drinking straw preferably has a marking to identify the mouth part and / or to indicate the direction of suction of the transport liquid. This marking makes handling easier.
  • the sealing film can also serve as a marking.
  • At least the part of the drinking straw containing the formulation is transparent and / or colored.
  • a transparent drinking straw the absorption of the active ingredient, vitamin and / or nutrient formulation can be observed, while the use of an opaque colored drinking straw offers the possibility of masking the administration of an active ingredient, vitamin and / or nutrient formulation ,
  • Another object of the invention is also a kit consisting of the dosage form according to the invention and a physiologically harmless, optionally active substance, nutrient and / or vitamin-containing transport liquid.
  • An aqueous liquid is preferably suitable as the transport liquid, with water, lemonade, fruit juice without pulp, tea or coffee being particularly preferred.
  • Another object of the invention is a method for producing the dosage form according to the invention, in which the blocking device is inserted into the drinking straw, the formulation is introduced into the drinking straw through the drinking straw opening and at least the drinking straw opening facing the formulation is provided with the closure film.
  • Another object of the invention is a method for producing the dosage form according to the invention, in which the one drinking straw opening is provided with the closure film and the formulation and the blocking device are successively introduced into the drinking straw through the remaining drinking straw opening are and if necessary this drinking straw opening is provided with a further closure device.
  • a method for producing the dosage form according to the invention is preferred in which at least the end of the drinking straw provided with the sealing film is provided with a removable cap.
  • Figure 1 shows a dosage form according to the invention with a removed
  • Figure 2 shows a further dosage form according to the invention with a removed cap in side view.
  • Figures 3a and 3b show a dosage form according to the invention in the
  • the dosage form shown in Figure 1 comprises a drinking straw (1) which has two openings (6, 10) and a plug fixed in the drinking straw as a blocking device (2), a film with lines of weakness as a closing device (3) and one between the blocking device and sealing film contained in the drinking straw formulation (4).
  • the drinking straw (1) can be provided with a cap (5).
  • the drinking straw (1) has a round cross section and is straight.
  • the plug (2) serving as a blocking device consists of filter material and is permeable to air and the transport liquid, but impermeable to the formulation.
  • the plug is cylindrical and has a round cross-section, the diameter of the plug being matched to the inside diameter of the drinking straw.
  • the plug is permanently fixed in the drinking straw.
  • the formulation (4) is in the form of spherical particles.
  • the film (3) serving as a sealing device is impermeable to the formulation before administration, but is destroyed before the formulation is removed.
  • the sealing film (3) can be protected with the help of a removable cap (5).
  • the inside diameter of the cap is adapted to the outside diameter of the drinking straw (1) so that the cap can be placed on the drinking straw.
  • the dosage form shown in FIG. 2 essentially corresponds to the dosage form shown in FIG. 1.
  • a stopper (2) that can be moved by the transport liquid between two stops (8, 9) is used as a blocking device (2).
  • the formulation particle is smaller than the inside diameter of the drinking straw at the point of the stop (8), so that the formulation particles can pass through this point.
  • the drinking straw opening (6) of the dosage form shown in FIG. 3a comprising a drinking straw (1) which is closed with a film (3).
  • the film closure has lines of weakness (7), which run radially outwards, along which the film can be easily severed.
  • the drinking straw opening (6) of the dosage form shown in FIG. 3b comprises a drinking straw (1).
  • the parts of the film (3) which are separate from one another and still adhere to the drinking straw (1) can be folded away and thus open the way for the formulation (4).

Abstract

La présente invention concerne une forme d'administration orale de substances actives, de vitamines et/ou de substances nutritives. Cette forme d'administration comprend une paille dont le dispositif de fermeture se présente sous forme d'un film amovible et/ou destructible comprenant des lignes de rupture. La présente invention concerne également un ensemble composé de ladite forme d'administration et d'un liquide de transport.
PCT/EP2003/006532 2002-06-24 2003-06-20 Paille permettant d'administrer des substances actives, des vitamines et/ou des substances nutritives WO2004000264A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003278969A AU2003278969A1 (en) 2002-06-24 2003-06-20 Drinking straw for administering active substances, vitamins, and/or nutrients

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2002128179 DE10228179A1 (de) 2002-06-24 2002-06-24 Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen
DE10228179.3 2002-06-24

Publications (1)

Publication Number Publication Date
WO2004000264A1 true WO2004000264A1 (fr) 2003-12-31

Family

ID=29761360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/006532 WO2004000264A1 (fr) 2002-06-24 2003-06-20 Paille permettant d'administrer des substances actives, des vitamines et/ou des substances nutritives

Country Status (3)

Country Link
AU (1) AU2003278969A1 (fr)
DE (1) DE10228179A1 (fr)
WO (1) WO2004000264A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006069920A1 (fr) * 2004-12-23 2006-07-06 Grünenthal GmbH Formes galeniques a liberation rapide pour antibiotiques
US8147874B2 (en) 2006-12-14 2012-04-03 Gruenenthal Gmbh Coated pellets
US8747900B2 (en) 2005-04-25 2014-06-10 Gruenenthal Gmbh Dosage form with improved release of cefuroximaxetil
CN110169918A (zh) * 2018-02-21 2019-08-27 Ds技术有限公司 用于服用活性物质的吸管

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005004257A1 (de) * 2005-01-28 2006-08-24 Grünenthal GmbH Verfahren zur Herstellung eines Trinkhalms mit Controller

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383503A1 (fr) * 1989-02-17 1990-08-22 Eli Lilly And Company Dispositif pour administrer des médicaments par voie orale
US6096003A (en) * 1996-10-18 2000-08-01 Alza Corporation Closure system for an active agent delivery device
US6210713B1 (en) * 1995-07-21 2001-04-03 Alza Corporation Oral delivery of discrete units

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US38871A (en) * 1863-06-09 Improvement in labels or tags
US4581013A (en) * 1982-04-19 1986-04-08 Jane C. A. Hayes Doser for orally administering medicine
US5718681A (en) * 1996-01-11 1998-02-17 Christopher E. Manning Medication delivery straw
US6217545B1 (en) * 1999-02-08 2001-04-17 Porex Technologies Corp. Filter with varying density which is responsive to fluid flow
US6283294B1 (en) * 1999-09-01 2001-09-04 Biogaia Biologics Ab Enclosed living cell dispensing tube
GB2366178A (en) * 2000-09-02 2002-03-06 Dan Drake Flavouring device for a liquid
DE20017686U1 (de) * 2000-10-12 2001-02-22 Schneickert Thomas Trinkhalm mit Füllung
JP2004512907A (ja) * 2000-11-03 2004-04-30 リカバリー　ファーマシューティカルズ　インコーポレーティッド 禁煙用の装置および方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383503A1 (fr) * 1989-02-17 1990-08-22 Eli Lilly And Company Dispositif pour administrer des médicaments par voie orale
US6210713B1 (en) * 1995-07-21 2001-04-03 Alza Corporation Oral delivery of discrete units
US6096003A (en) * 1996-10-18 2000-08-01 Alza Corporation Closure system for an active agent delivery device

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006069920A1 (fr) * 2004-12-23 2006-07-06 Grünenthal GmbH Formes galeniques a liberation rapide pour antibiotiques
CN101123961B (zh) * 2004-12-23 2012-10-03 格吕伦塔尔有限公司 快速释放的抗生素剂型
US8361506B2 (en) 2004-12-23 2013-01-29 Gruenenthal Gmbh Fast release dosage forms for antibiotics
US8747900B2 (en) 2005-04-25 2014-06-10 Gruenenthal Gmbh Dosage form with improved release of cefuroximaxetil
US8147874B2 (en) 2006-12-14 2012-04-03 Gruenenthal Gmbh Coated pellets
CN110169918A (zh) * 2018-02-21 2019-08-27 Ds技术有限公司 用于服用活性物质的吸管
EP3530256A1 (fr) * 2018-02-21 2019-08-28 DS-Technology GmbH Paille pour boisson destinée à l'administration d'une substance active

Also Published As

Publication number Publication date
AU2003278969A1 (en) 2004-01-06
DE10228179A1 (de) 2004-01-22

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