EP1434607A1 - Osteophile implantate - Google Patents
Osteophile implantateInfo
- Publication number
- EP1434607A1 EP1434607A1 EP02764480A EP02764480A EP1434607A1 EP 1434607 A1 EP1434607 A1 EP 1434607A1 EP 02764480 A EP02764480 A EP 02764480A EP 02764480 A EP02764480 A EP 02764480A EP 1434607 A1 EP1434607 A1 EP 1434607A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- implant
- range
- titanium
- hydroxylated
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0037—Details of the shape
- A61C2008/0046—Textured surface, e.g. roughness, microstructure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
- A61C8/0015—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating being a conversion layer, e.g. oxide layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0095—Packages or dispensers for prostheses or other implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2803—Bones for mandibular reconstruction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30838—Microstructures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/3084—Nanostructures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/3085—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/30906—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth shot- sand- or grit-blasted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/30925—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth etched
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Definitions
- the present invention relates to osteophilic implants which are used for insertion into bones and which have significantly improved osteointegration properties, and to methods for their production.
- Implants which are used for insertion into bones, such as, for example, hip or knee prostheses or pins to be screwed into the jaw for the construction of artificial teeth, are known per se.
- Such implants are preferably made of titanium or titanium-based alloys, e.g. Titanium / zirconium alloys, which may additionally contain niobium, tantalum or other tissue-compatible metallic additives.
- a key property of such implants is their osteointegration time, that is, the time it takes for the bone substance to have sufficient strength and to be permanently bonded to the implant surface, that is, integrated.
- How firmly the implant is anchored in the bone can be determined with mechanical measurements, namely by measuring the force, be it as tension, pressure, shear or torque, which are necessary to pull the implant anchored in the bone out of its anchoring or unscrew it, ie to bring about an adhesion break between the surface of the implant and the bone substance connected to it.
- mechanical measurements namely by measuring the force, be it as tension, pressure, shear or torque, which are necessary to pull the implant anchored in the bone out of its anchoring or unscrew it, ie to bring about an adhesion break between the surface of the implant and the bone substance connected to it.
- Such measurement methods are known per se and are described, for example, in Brunski, Clinical Materials, Vol. 10, 1992, pp. 153-201. Measurements have shown that titanium implants with a smooth surface structure anchor themselves insufficiently in the bone, while implants with a roughened surface result in a noticeably improved bone-implant bond in terms of tensile strength.
- a macroroughness is applied to the implant surface in a first step by means of sandblasting and this is then superimposed with a microroughness by means of treatment in an acid bath.
- the implant surface is roughened, for example, by means of sandblasting and then treated with an etching agent, for example with hydrofluoric acid or a hydrochloric acid / sulfuric acid mixture.
- the surface thus provided with a defined roughness is then washed with water and solvents and subjected to a sterilization treatment.
- a hydroxylated surface can only develop its full effect if it is in the “hydrophilic” state, that is, if it is not covered with volatile hydrocarbons and other compounds, such as sulfur dioxide or nitrogen monoxide, which are present in the air Other impurities can also get onto the implant surface at any stage of the manufacturing process, for example in the cleaning process, if the implant is treated with organic solvents such as methanol or acetone
- a hydroxylated and hydrophilic surface for example of titanium or a titanium Tan alloy has biologically active properties or can be described as biologically active.
- a hydroxylated and hydrophilic implant surface grows together with the bone substance to form a strong bond much faster than an identical hydroxylated but non-hydrophilic surface. The production of a hydroxylated and at the same time hydrophilic implant surface is described in WO 0044305 (PCT / EP00 / 00619).
- a contamination-free, hydroxylated surface has a high surface energy, which means that volatile hydrocarbons and other contaminants that occur in unpurified air are quickly adsorbed. Initially, for example, the adsorbed hydrocarbons form a monomolecular layer (monolayer) on the hydroxylated surface, whereby the hydrophilic character of the surface is lost. However, the longer the implant is exposed to the air, the thicker the contamination layer.
- a clean hydroxylated surface made of titanium is hydrophilic and has a contact angle of less than 50 ° when wetted with water, while a contaminated hydroxylated surface has a contact angle of over 70 ° and is referred to as hydrophobic.
- the hydroxylated and hydrophilic surface and thus also its biological activity, can be maintained largely unchanged if this surface is sealed in a covering in such a way that contact of the surface with compounds which can impair the hydrophilic character of the implant surface is prevented becomes.
- the covering is broken open, which is necessary shortly before the implantation, contact of the implant surface with the atmospheric outside air and thus a reduction in the hydrophilic character of the implant surface cannot be prevented.
- There is therefore a need to convert the hydroxylated and hydrophilic implant To produce or treat the surface in such a way that its hydrophilic character is largely retained over an extended period of time even in contact with the atmospheric outside air.
- a hydroxylated but contaminated, ie contaminated, hydrophobic implant surface acquires a hydrophilic character when this surface is treated with high-energy ultraviolet radiation (UV rays).
- UV rays high-energy ultraviolet radiation
- the stability of the hydrophilic character of a hydroxylated and hydrophilic implant surface obtained with acid etching increases significantly when treated in the hydrophilic state with high-energy ultraviolet radiation.
- the present invention relates to an osteophilic implant with a particularly roughened, hydroxylated and hydrophilic surface, this implant preferably consisting of titanium or a titanium alloy and being suitable for implantation in bones, characterized in that the implant in the hydroxylated state with high-energy ultraviolet radiation was treated.
- this implant preferably consisting of titanium or a titanium alloy and being suitable for implantation in bones, characterized in that the implant in the hydroxylated state with high-energy ultraviolet radiation was treated.
- other materials for example other metals and ceramics, are also conceivable.
- implant in the hydroxylated state denotes both an implant which has been produced with a hydroxylated surface but whose surface has a hydrophobic character, and also an implant with a hydroxylated and hydrophilic surface.
- the implant according to the invention shows a significantly increased stability against the loss of the hydrophilic character and thus improved osteointegration properties.
- the present invention also relates to methods for producing an osteophilic implant with a roughened, hydroxylated and hydrophilic surface in particular, wherein this implant preferably consists of titanium or a titanium alloy and is suitable for implantation in bone, characterized in that the implant is in the hydroxylated state treated with high-energy ultraviolet radiation.
- the implants according to the invention preferably consist of a titanium alloy, preferably of a titanium / zirconium alloy, which may additionally contain niobium, tantalum or other tissue-compatible metallic additives. Other suitable materials can also be used in the context of the invention. These implants are preferably used as hip or knee prostheses or as pins to be screwed into the jaw for building artificial teeth. Such implants, their nature and the metallic materials used for their production are known per se and are described, for example, in J. Black, G. Hastings, Handbook of Biomaterials Properties, pages 135-200, Chapman & Hall, London, 1998.
- the structural and functional anchoring for example a dental implant, in the bone is usually achieved by attaching a macro roughness, such as a screw thread or a recess. Formations in the surface and / or optionally an additional microroughness is achieved, the microroughness being applied to the surface either in an additive process by means of plasma technology or in a subtractive process by chemical etching.
- a macro roughness such as a screw thread or of depressions in the surface and, if appropriate, an additional micro roughness is known per se.
- the procedure is preferably as described in EP 0 388 576 or in WO 0044305 (PCT / EP00 / 00619).
- the implant obtained in this way can then be treated according to the invention with high-energy ultraviolet radiation.
- the implant surface according to the invention preferably has a macro roughness in the range from 5 ⁇ m to 100 ⁇ m (in each case peak to valley), in particular in the range from 20 ⁇ m to 40 ⁇ m and a superimposed micro roughness in the range from 0.5 ⁇ m to 20 ⁇ m, in particular in the range from 0.5 ⁇ m to 10 ⁇ m, in particular approximately 2 .mu.m.
- the macro-roughness of the implant surface is generated by sandblasting with corundum grains with an average grain size in the range of 0.25-0.5 mm, after which the micro-roughness can be achieved by treatment with an aqueous hydrochloric acid / sulfuric acid mixture in the ratio of HC1: H 2 S0: H 2 0 of 2 : 1: 1 at a temperature in the range of 80 ° C to about 110 ° C for about five minutes.
- the surface-structured titanium parts washed thoroughly with pure water until neutral, if necessary treated with alcohol, acetone or another organic solvent or disinfectant, and dried in hot air.
- a hydrophilic implant surface is obtained if, after the acid bath, the implant surface is washed thoroughly with neutral water and dried in an atmosphere which is inert to the hydrophilic surface and the implant is kept in an inert atmosphere.
- a hydrophobic implant surface is obtained when treated with alcohol, acetone or another organic solvent or a disinfectant and when dried in hot atmospheric air.
- the "pure" water used for washing is preferably multiply distilled water or water produced by inverse osmosis, which is preferably in an inert atmosphere, i.e. e.g. was produced under reduced pressure, in a nitrogen or inert gas atmosphere. Furthermore, the pure water has an electrical resistance of at least 2 Moh cm (electrical resistance> 2 Mohm cm) and a total organic carbon (TOC) content of at most 10 ppb ( ⁇ 10 ppb).
- the implant is treated in the hydroxylated state with high-energy ultraviolet radiation.
- the high-energy ultraviolet radiation (UV radiation) causes the implant surface to become hydrophilic and the impurities on the surface to be removed.
- the high-energy UV radiation used is UV radiation with a wavelength in the range from 150 nm to 300 nm, preferably in the range from 170 nm to 260 nm, and in particular UV radiation in the range of the absorption maximum of acid. Material, that is with a wavelength of about 184.9nm and in the range of the absorption maximum of ozone, that is with a wavelength of about 253.7nm.
- Wavelengths in this range promote the simultaneous formation or decay of ozone and are able to break high-energy chemical bonds, such as the ethylenic carbon-carbon double bond. Wavelengths in the ranges mentioned are generated by so-called xenon radiators, which are commercially available.
- the distance of the implant surface to be treated from the UV source is kept small, for example in the range of approximately 1 mm.
- the duration of the UV treatment depends on the type and thickness of the contamination layer and can easily be determined or optimized by a person skilled in the art. In general, the irradiation time is in the range from 1 minute to 15 minutes.
- the treatment according to the invention of a hydrophilic (and thus already relatively clean) surface also results in a cleaner product compared to the treatment of a contaminated surface.
- XPS X-ray excited Photoelectron Specroscopy
- AES Auger Electron Spectroscopy
- An implant surface such as that which occurs immediately after acid etching and is hydroxylated and hydrophilic, has a wetting angle with water of less than 50 ° ( ⁇ 50 °) when the water drop penetrates the surface or less than 20 ° ( ⁇ 20 °) in the case of the regressing drop, and has a remarkable biological activity.
- Chen whose hydrophilic character remains in contact with the atmospheric outside air according to the invention over a prolonged period of time.
- the hydroxylated and hydrophilic implant surface obtained according to the invention preferably contains at most 20 atomic% carbon, measured by spectroscopic methods such as XPS or AES or other spectroscopic methods known per se.
- the implant obtained is preferably stored in a casing filled with gases which are inert to the implant surface.
- gases which are inert to the implant surface.
- gases which are inert gases are for example nitrogen, oxygen or noble gas, such as e.g. Argon.
- the casing is preferably impermeable to gases and liquids.
- Compounds that can impair the biological activity of the implant surface include, as already mentioned, methanol, ethanol, acetone and related ketones, as well as numerous other organic compounds, or carbon dioxide.
- the covering can, if appropriate, be partially or completely filled with pure water, which may optionally contain additives, at least such an amount of water being present that the roughened implant surface is kept moist or wetted.
- Suitable additives are, for example, monovalent alkali cations, such as Na + or K + , with corresponding anions in the form of inorganic salts, such as, for example, sodium chloride, potassium chloride, sodium or potassium chlorate, sodium or potassium nitrate, sodium or potassium phosphate or a mixture of such salts.
- Divalent cations in the form of water-soluble inorganic salts can also be added.
- Suitable cations are in particular Mg +2 , Ca +2 , Sr +2 and / or Mn +2 in the form of the chlorides or their mixtures.
- Suitable anions are also phosphate and phosphonate anions, which in each case also include monoorthophosphate anions and diorthophosphate anions or monoorthophosphonate anions and diorthophosphonate anions, in combination with the cations mentioned.
- Cations and anions which are already present in the body fluid are preferred, in particular in the respective physiological concentration and at a physiological acid value (pH value) in the range from preferably 4 to 9 and preferably at an acid value in the range from 6 to 8.
- Preferred cations are Na + , K + , Mg +2 and Ca +2 .
- the preferred anion is Cl " .
- the total amount of the cations or anions mentioned is in each case in the range from about 50 mEq / 1 to 250 mEq / 1, preferably about 100 mEq / 1 to 200 mEq / 1 and preferably about 150 mEq / 1 1.
- Eq / 1 means (formula) equivalent weight or Eq / 1 corresponds to the atomic weight of the formula unit divided by the valency.
- MEq / 1 means milliequivalents per liter.
- the gas- and liquid-tight envelope is preferably a welded ampoule made of glass, metal, a synthetic polymer. lymeren or another gas- and liquid-tight material or consists of a combination of these materials.
- the metal is preferably in the form of a thin metal foil, it being possible for polymeric materials and metallic foils, but also glass, to be combined with one another in a manner known per se to form suitable packaging.
- a particular advantage of the present invention is that packaging of the implant in a gas- and liquid-tight envelope, as described above, can be dispensed with if the implant within a useful period following the treatment according to the invention with UV rays Time period, for example within an hour, is implanted.
- the implant surface treated according to the invention surprisingly retains its hydrophilic character largely unchanged during this time even in contact with atmospheric air.
- Suitable comparatively compact UV devices are available today and can be easily installed in the doctor's office. It is therefore sufficient to pack an implant provided with a roughened but hydrophobic surface, the manufacture of which has been described above and is known per se, in a dust-free manner.
- the operating physician can treat the implant provided with a hydrophobic surface with the UV rays according to the invention immediately before the implantation in the UV device, a sterile (sterilized) implant with a hydroxylated and hydrophilic surface being obtained.
- This hydroxylated and hydrophilic state of the implant surface, and thus also its biological activity, is thus largely retained until the implantation.
- the present invention also relates to a method for implanting an osteophilic implant with a roughened hydroxylated and hydrophilic surface, whereby this implant consists of titanium or a titanium alloy and is suitable for implantation in bones, characterized in that the implant is treated in the hydroxylated state with high-energy ultraviolet radiation and immediately after this treatment implanted in the bone.
- this implant consists of titanium or a titanium alloy and is suitable for implantation in bones, characterized in that the implant is treated in the hydroxylated state with high-energy ultraviolet radiation and immediately after this treatment implanted in the bone.
- a common form of a dental implant in the form of a screw 4 mm in diameter and 10 mm in length was produced.
- the raw form was obtained by machining and turning the cylindrical blank in a manner known per se.
- the surface to be used in the bones was provided with a macroroughness by sandblasting with a grain of the average grain size 0.25-0.5 mm.
- the roughened surface that is to say the macroroughness, was then treated with an aqueous hydrochloric acid / sulfuric acid mixture with a ratio of HC1: H 2 S0 4 : H 2 0 of 2: 1: 1 at a temperature of 95 ° C.
- the low-carbon state of the surfaces of the samples according to test b) remained practically unchanged over a period of at least one day.
- the implants according to experiments a) and b) were implanted in the upper jaw of a mini pig.
- the anchorage in the bone was measured as the loosening torque of the screw implanted in the upper jaw of the mini-pig. The results obtained are shown in Table 1.
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dentistry (AREA)
- Ceramic Engineering (AREA)
- Materials For Medical Uses (AREA)
- Dental Prosthetics (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH18732001 | 2001-10-11 | ||
CH187301 | 2001-10-11 | ||
PCT/CH2002/000561 WO2003030957A1 (de) | 2001-10-11 | 2002-10-11 | Osteophile implantate |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1434607A1 true EP1434607A1 (de) | 2004-07-07 |
Family
ID=4566608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02764480A Withdrawn EP1434607A1 (de) | 2001-10-11 | 2002-10-11 | Osteophile implantate |
Country Status (7)
Country | Link |
---|---|
US (1) | US20040210309A1 (ja) |
EP (1) | EP1434607A1 (ja) |
JP (1) | JP2005505352A (ja) |
CN (1) | CN100366300C (ja) |
AU (1) | AU2002328762B2 (ja) |
HK (1) | HK1071526A1 (ja) |
WO (1) | WO2003030957A1 (ja) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610067B2 (en) * | 2000-05-01 | 2003-08-26 | Arthrosurface, Incorporated | System and method for joint resurface repair |
EP2314257B9 (en) * | 2000-05-01 | 2013-02-27 | ArthroSurface, Inc. | System for joint resurface repair |
US8177841B2 (en) | 2000-05-01 | 2012-05-15 | Arthrosurface Inc. | System and method for joint resurface repair |
US7678151B2 (en) | 2000-05-01 | 2010-03-16 | Ek Steven W | System and method for joint resurface repair |
US7163541B2 (en) | 2002-12-03 | 2007-01-16 | Arthrosurface Incorporated | Tibial resurfacing system |
WO2010096826A1 (en) * | 2002-06-04 | 2010-08-26 | Arthrosurface Incorporated | Nanorough alloy substrate |
US7901408B2 (en) | 2002-12-03 | 2011-03-08 | Arthrosurface, Inc. | System and method for retrograde procedure |
US8388624B2 (en) | 2003-02-24 | 2013-03-05 | Arthrosurface Incorporated | Trochlear resurfacing system and method |
US7951163B2 (en) | 2003-11-20 | 2011-05-31 | Arthrosurface, Inc. | Retrograde excision system and apparatus |
CA2593182A1 (en) | 2003-11-20 | 2006-07-13 | Arthrosurface, Inc. | System and method for retrograde procedure |
AU2004293042A1 (en) | 2003-11-20 | 2005-06-09 | Arthrosurface, Inc. | Retrograde delivery of resurfacing devices |
EP1765201A4 (en) | 2004-06-28 | 2013-01-23 | Arthrosurface Inc | SYSTEM FOR THE BENDING AREA |
US7828853B2 (en) | 2004-11-22 | 2010-11-09 | Arthrosurface, Inc. | Articular surface implant and delivery system |
JP4907643B2 (ja) * | 2005-03-07 | 2012-04-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 医療用インプラント |
US8562685B2 (en) | 2005-05-06 | 2013-10-22 | Titan Spine, Llc | Spinal implant and integration plate for optimizing vertebral endplate contact load-bearing edges |
US8758442B2 (en) | 2005-05-06 | 2014-06-24 | Titan Spine, Llc | Composite implants having integration surfaces composed of a regular repeating pattern |
US8585767B2 (en) | 2005-05-06 | 2013-11-19 | Titan Spine, Llc | Endplate-preserving spinal implant with an integration plate having durable connectors |
US8545568B2 (en) | 2005-05-06 | 2013-10-01 | Titan Spine, Llc | Method of using instruments and interbody spinal implants to enhance distraction |
US8585765B2 (en) | 2005-05-06 | 2013-11-19 | Titan Spine, Llc | Endplate-preserving spinal implant having a raised expulsion-resistant edge |
US8585766B2 (en) | 2005-05-06 | 2013-11-19 | Titan Spine, Llc | Endplate-preserving spinal implant with an integration plate having durable connectors |
US8435302B2 (en) | 2005-05-06 | 2013-05-07 | Titan Spine, Llc | Instruments and interbody spinal implants enhancing disc space distraction |
US20120312779A1 (en) | 2005-05-06 | 2012-12-13 | Titian Spine, LLC | Methods for manufacturing implants having integration surfaces |
US8403991B2 (en) | 2005-05-06 | 2013-03-26 | Titan Spine Llc | Implant with critical ratio of load bearing surface area to central opening area |
US8758443B2 (en) | 2005-05-06 | 2014-06-24 | Titan Spine, Llc | Implants with integration surfaces having regular repeating surface patterns |
US8617248B2 (en) | 2005-05-06 | 2013-12-31 | Titan Spine, Llc | Spinal implant having variable ratios of the integration surface area to the axial passage area |
US11096796B2 (en) | 2005-05-06 | 2021-08-24 | Titan Spine, Llc | Interbody spinal implant having a roughened surface topography on one or more internal surfaces |
US9125756B2 (en) | 2005-05-06 | 2015-09-08 | Titan Spine, Llc | Processes for producing regular repeating patterns on surfaces of interbody devices |
US8992622B2 (en) | 2005-05-06 | 2015-03-31 | Titan Spine, Llc | Interbody spinal implant having a roughened surface topography |
US9168147B2 (en) | 2005-05-06 | 2015-10-27 | Titan Spine, Llc | Self-deploying locking screw retention device |
US8562684B2 (en) | 2005-05-06 | 2013-10-22 | Titan Spine, Llc | Endplate-preserving spinal implant with an integration plate having a roughened surface topography |
US8814939B2 (en) | 2005-05-06 | 2014-08-26 | Titan Spine, Llc | Implants having three distinct surfaces |
US8262737B2 (en) | 2005-05-06 | 2012-09-11 | Titan Spine, Llc | Composite interbody spinal implant having openings of predetermined size and shape |
US8480749B2 (en) | 2005-05-06 | 2013-07-09 | Titan Spine, Llc | Friction fit and vertebral endplate-preserving spinal implant |
US8551176B2 (en) | 2005-05-06 | 2013-10-08 | Titan Spine, Llc | Spinal implant having a passage for enhancing contact between bone graft material and cortical endplate bone |
US8591590B2 (en) | 2005-05-06 | 2013-11-26 | Titan Spine, Llc | Spinal implant having a transverse aperture |
EP1941052B1 (en) * | 2005-09-20 | 2013-12-18 | The Regents of the University of California | Method for regenerating hydrophilic and osteophilic surfaces of an implant |
CN100385039C (zh) * | 2005-10-24 | 2008-04-30 | 深圳清华大学研究院 | 一种医用金属表面生物活性纳米复合层制备方法 |
ATE516769T1 (de) * | 2006-02-28 | 2011-08-15 | Straumann Holding Ag | Einteiliges implantat mit hydroxylierter kontaktoberfläche für weiches gewebe |
EP2160998B1 (en) | 2006-02-28 | 2012-04-04 | Straumann Holding AG | Two-part implant with a hydroxylated soft tissue contact surface |
ATE519447T1 (de) * | 2006-02-28 | 2011-08-15 | Straumann Holding Ag | Aufbau mit hydroxylierter oberfläche |
EP1847278A1 (de) * | 2006-04-13 | 2007-10-24 | Camlog Biotechnologies AG | Bio-auflösende Salzbeschichtungen von Implantaten zum Schutz vor organischen Verunreinigungen |
DE102006033547A1 (de) * | 2006-07-20 | 2008-01-24 | Dieter Keller | Implantat |
US8101198B2 (en) | 2006-07-26 | 2012-01-24 | The Regents Of The University Of California | Osteogenic enhancer composition |
US8057843B2 (en) * | 2006-08-22 | 2011-11-15 | Thommen Medical Ag | Implant, in particular dental implant |
JP2010505849A (ja) * | 2006-10-06 | 2010-02-25 | ユニバーシティ オブ バージニア パテント ファウンデーション | 糖尿病性創傷治癒に有用な方法および組成物 |
CA2686814A1 (en) | 2006-12-11 | 2008-06-19 | Arthrosurface Incorporated | Retrograde resection apparatus and method |
US8671572B2 (en) * | 2006-12-22 | 2014-03-18 | Thommen Medical Ag | Method for the production of a dental implant |
DE102007007865A1 (de) | 2007-02-14 | 2008-08-21 | Jennissen, Herbert, Prof. Dr. | Verfahren zur Herstellung von lagerfähigen Implantaten mit einer ultrahydrophilen Oberfläche |
WO2008143219A1 (ja) * | 2007-05-18 | 2008-11-27 | National University Corporation Okayama University | 生体親和性インプラントの製造方法 |
JP5806466B2 (ja) | 2008-01-28 | 2015-11-10 | バイオメット・3アイ・エルエルシー | 親水性を向上させたインプラント表面 |
WO2009111481A1 (en) | 2008-03-03 | 2009-09-11 | Arthrosurface Incorporated | Bone resurfacing system and method |
CH699079A1 (de) * | 2008-07-04 | 2010-01-15 | Arik Zucker | Anordnung, bestehend aus einem Stent und einer Verpackung. |
US10945743B2 (en) | 2009-04-17 | 2021-03-16 | Arthrosurface Incorporated | Glenoid repair system and methods of use thereof |
WO2010121250A1 (en) | 2009-04-17 | 2010-10-21 | Arthrosurface Incorporated | Glenoid resurfacing system and method |
CA2759027C (en) | 2009-04-17 | 2020-02-25 | Arthrosurface Incorporated | Glenoid resurfacing system and method |
CA2792048A1 (en) | 2010-03-05 | 2011-09-09 | Arthrosurface Incorporated | Tibial resurfacing system and method |
WO2011113568A1 (en) | 2010-03-15 | 2011-09-22 | Nobel Biocare Services Ag | Surface treatment method |
US8641418B2 (en) | 2010-03-29 | 2014-02-04 | Biomet 3I, Llc | Titanium nano-scale etching on an implant surface |
KR101174837B1 (ko) * | 2010-05-31 | 2012-08-17 | 주식회사 메가젠임플란트 | 골유착 증진을 위한 자외선 광조사기 및 이를 이용한 치과용 임플란트 표면 개질방법 |
CN203169336U (zh) * | 2010-05-31 | 2013-09-04 | 美加真种植有限公司 | 用于牙植入物的表面处理装置 |
CN101880874B (zh) * | 2010-07-12 | 2011-11-16 | 西安交通大学 | 改善医用钛或钛合金表面亲水性的方法 |
ES2352635B1 (es) * | 2010-09-16 | 2011-12-29 | Biotechnology Institute, I Mas D, S.L. | Implante con calcio en su superficie, y método de modificación de la superficie de un implante para dotar a dicha superficie de calcio. |
US9066716B2 (en) | 2011-03-30 | 2015-06-30 | Arthrosurface Incorporated | Suture coil and suture sheath for tissue repair |
US8992619B2 (en) | 2011-11-01 | 2015-03-31 | Titan Spine, Llc | Microstructured implant surfaces |
CN102492950A (zh) * | 2011-12-16 | 2012-06-13 | 南京理工大学 | 具有优异生物摩擦学性能的仿生多尺度结构表面及制备方法 |
US20130165982A1 (en) | 2011-12-22 | 2013-06-27 | Arthrosurface Incorporated | System and Method for Bone Fixation |
KR101196171B1 (ko) | 2011-12-27 | 2012-11-01 | 오스템임플란트 주식회사 | 골형성 증진 효과가 있는 친수성 표면을 가진 치과용 임플란트의 제조방법 |
KR101213355B1 (ko) * | 2011-12-27 | 2012-12-18 | 오스템임플란트 주식회사 | 초기 안정성이 증진된 치과용 임플란트 및 그 제조 방법 |
KR20140125764A (ko) * | 2012-01-19 | 2014-10-29 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 보철기기의 연조직 결합 및 밀봉을 향상시키기 위한 방법 |
ES2671740T3 (es) | 2012-03-20 | 2018-06-08 | Biomet 3I, Llc | Superficie de tratamiento para una superficie de implante |
CA2880825C (en) * | 2012-03-20 | 2021-03-16 | Titan Spine, Llc | Friction-fit spinal endplate and endplate-preserving method |
KR101248785B1 (ko) | 2012-04-30 | 2013-04-03 | 오스템임플란트 주식회사 | 초친수성을 갖는 티타늄 임플란트, 그 표면처리 및 보관 방법 |
WO2013180237A1 (ja) * | 2012-05-30 | 2013-12-05 | 京セラメディカル株式会社 | 歯科インプラント |
DE112013003358T5 (de) | 2012-07-03 | 2015-03-19 | Arthrosurface, Inc. | System und Verfahren für Gelenkoberflächenersatz und -reparatur |
JP5616405B2 (ja) | 2012-08-13 | 2014-10-29 | 学校法人愛知学院 | 生体親和性に優れたインプラント材料の処理方法 |
EP2716261A1 (en) | 2012-10-02 | 2014-04-09 | Titan Spine, LLC | Implants with self-deploying anchors |
US9498349B2 (en) | 2012-10-09 | 2016-11-22 | Titan Spine, Llc | Expandable spinal implant with expansion wedge and anchor |
US20140277483A1 (en) * | 2013-03-14 | 2014-09-18 | Titan Spine, Llc | Surface and subsurface chemistry of an integration surface |
KR101343817B1 (ko) | 2013-03-22 | 2013-12-20 | 주식회사 디오 | 치과용 임플란트 픽스춰 포장용기 |
US9492200B2 (en) | 2013-04-16 | 2016-11-15 | Arthrosurface Incorporated | Suture system and method |
CN105916678B (zh) * | 2014-01-16 | 2018-08-17 | 学校法人冲绳科学技术大学院大学学园 | 由选定尺寸的纳米颗粒制成的分级氧化的钽多孔膜的设计和组装及其牙科和生物医疗植入物应用 |
US9615935B2 (en) | 2014-01-30 | 2017-04-11 | Titan Spine, Llc | Thermally activated shape memory spring assemblies for implant expansion |
US10624748B2 (en) | 2014-03-07 | 2020-04-21 | Arthrosurface Incorporated | System and method for repairing articular surfaces |
US9931219B2 (en) | 2014-03-07 | 2018-04-03 | Arthrosurface Incorporated | Implant and anchor assembly |
US11607319B2 (en) | 2014-03-07 | 2023-03-21 | Arthrosurface Incorporated | System and method for repairing articular surfaces |
CN104083801B (zh) * | 2014-07-25 | 2017-05-10 | 林野 | 一种使牙种植体粗化表面具有亲水性的方法 |
TW201632342A (zh) * | 2015-03-13 | 2016-09-16 | 優克材料科技股份有限公司 | 三維列印方法 |
EP3294351B1 (en) * | 2015-05-11 | 2022-03-23 | Nova Plasma Ltd | Method for preparing a silicone implant using plasma processing |
CN105125304A (zh) * | 2015-08-19 | 2015-12-09 | 周正 | 种植体亲水活化仪以及活化方法 |
EA201891821A1 (ru) * | 2016-02-12 | 2019-01-31 | Нано Бриджинг Молекьюлз Са | Усовершенствованная обработка имплантатов соединениями фосфоновых кислот |
WO2018081283A1 (en) * | 2016-10-27 | 2018-05-03 | The Penn State Research Foundaiton | Implantable medical devices having hydrophilic surfaces |
CN110753560B (zh) | 2017-04-11 | 2022-07-26 | 斯特劳曼控股公司 | 牙科植入物 |
US11160663B2 (en) | 2017-08-04 | 2021-11-02 | Arthrosurface Incorporated | Multicomponent articular surface implant |
GB2609338B (en) | 2019-03-12 | 2023-06-14 | Arthrosurface Inc | Humeral and glenoid articular surface implant systems and methods |
KR20230104201A (ko) | 2020-11-02 | 2023-07-07 | 인스티투트 스트라우만 아게 | 치과 임플란트 |
CN114343894A (zh) * | 2022-02-17 | 2022-04-15 | 北京冠美口腔医院管理有限公司 | 一种牙科种植体骨结合率加速器 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4073999A (en) * | 1975-05-09 | 1978-02-14 | Minnesota Mining And Manufacturing Company | Porous ceramic or metallic coatings and articles |
US4065816A (en) * | 1975-05-22 | 1978-01-03 | Philip Nicholas Sawyer | Surgical method of using a sterile packaged prosthesis |
US4207286A (en) * | 1978-03-16 | 1980-06-10 | Biophysics Research & Consulting Corporation | Seeded gas plasma sterilization method |
US4377010A (en) * | 1978-11-08 | 1983-03-22 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Biocompatible material comprising a base polymer bulk graft polymerized with an ethylenically unsaturated carboxylic acid |
JPS56161054A (en) * | 1980-05-15 | 1981-12-11 | Ushio Electric Inc | Sterilizing method |
US4448750A (en) * | 1981-06-05 | 1984-05-15 | Fuesting Michael L | Sterilization method |
SE447445B (sv) * | 1984-12-27 | 1986-11-17 | Branemark Per Ingvar | Steril forpackning for artificiella implantat samt sett for forpackning |
US5071351A (en) * | 1986-07-02 | 1991-12-10 | Collagen Corporation | Dental implant system |
FR2610512B1 (fr) * | 1987-02-06 | 1997-01-24 | Cuilleron J | Procede et moyens d'ancrage d'elements d'implants visses dans les tissus osseux et les elements d'implants obtenus |
US5188800A (en) * | 1988-06-03 | 1993-02-23 | Implant Innovations, Inc. | Dental implant system |
DE58905636D1 (de) * | 1989-03-23 | 1993-10-21 | Straumann Inst Ag | Metallisches Implantat. |
JP2930619B2 (ja) * | 1989-10-30 | 1999-08-03 | 春幸 川原 | チタンもしくはチタン基合金製生体修復部材及びその表面処理法 |
US5213619A (en) * | 1989-11-30 | 1993-05-25 | Jackson David P | Processes for cleaning, sterilizing, and implanting materials using high energy dense fluids |
US5380547A (en) * | 1991-12-06 | 1995-01-10 | Higgins; Joel C. | Method for manufacturing titanium-containing orthopedic implant devices |
SE500657C2 (sv) * | 1992-12-07 | 1994-08-01 | Nobelpharma Ab | Metod och anordning för preparering av implantatytor med användning av gasurladdningsplasma |
US6312668B2 (en) * | 1993-12-06 | 2001-11-06 | 3M Innovative Properties Company | Optionally crosslinkable coatings, compositions and methods of use |
JPH07284527A (ja) * | 1994-04-18 | 1995-10-31 | Ishikawajima Harima Heavy Ind Co Ltd | 生体用金属およびその使用法 |
US6491723B1 (en) * | 1996-02-27 | 2002-12-10 | Implant Innovations, Inc. | Implant surface preparation method |
JPH08289927A (ja) * | 1995-04-21 | 1996-11-05 | Nikon Corp | 骨内インプラント及びその製造方法 |
JPH09231821A (ja) * | 1995-12-22 | 1997-09-05 | Toto Ltd | 照明器具及び照度維持方法 |
AU2612797A (en) * | 1996-02-09 | 1997-08-28 | Institut Straumann Ag | Pin or screw-like securing device for osteosynthesis |
ES2113834B1 (es) * | 1996-11-12 | 1999-01-01 | Univ Vigo | Metodo de mejora de la osteointegracion de implantes de fijacion osea. |
SE9701647D0 (sv) * | 1997-04-30 | 1997-04-30 | Nobel Biocare Ab | Calcium-phonsphate coated implant element |
DE59711225D1 (de) * | 1997-06-10 | 2004-02-19 | Straumann Inst Ag | Binäre titan-zirkon-legierung für chirurgische implantate sowie herstellungsverfahren |
US6045581A (en) * | 1997-12-12 | 2000-04-04 | Sulzer Orthopedics Inc. | Implantable prosthesis having textured bearing surfaces |
US6214049B1 (en) * | 1999-01-14 | 2001-04-10 | Comfort Biomedical, Inc. | Method and apparatus for augmentating osteointegration of prosthetic implant devices |
WO1999030632A1 (en) * | 1997-12-18 | 1999-06-24 | Comfort Biomedical, Inc. | Bone augmentation for prosthetic implants and the like |
JP2000093812A (ja) * | 1998-09-25 | 2000-04-04 | Kyodo Printing Co Ltd | 光触媒体の製造と使用方法 |
DE69924749T2 (de) * | 1998-11-20 | 2006-04-27 | The University Of Connecticut, Farmington | Generisch integrierte implantierbare Potentiostatfernmeßanordnung für elektrochemische Fühler |
US6379741B1 (en) * | 1998-11-30 | 2002-04-30 | The Regents Of The University Of California | Plasma-assisted surface modification of polymers for medical device applications |
EP1140239B1 (en) * | 1998-12-14 | 2004-07-14 | Osteotech, Inc., | Bone graft made of bone particles |
EP1023910A1 (en) * | 1999-01-29 | 2000-08-02 | Institut Straumann AG | Preparation of osteophilic surfaces for metallic prosthetic devices anchorable to bone |
WO2000044305A1 (de) * | 1999-01-29 | 2000-08-03 | Institut Straumann Ag | Osteophile implantate |
JP3072373B1 (ja) * | 1999-07-05 | 2000-07-31 | 工業技術院長 | 汚濁物質、雑菌付着抑制機能および耐酸性を有する人工歯根ならびに製造方法 |
GB9920547D0 (en) * | 1999-08-31 | 1999-11-03 | Destiny Pharma Ltd | Coated implant |
US6893462B2 (en) * | 2000-01-11 | 2005-05-17 | Regeneration Technologies, Inc. | Soft and calcified tissue implants |
EP1134303B1 (en) * | 2000-03-13 | 2010-06-09 | Canon Kabushiki Kaisha | Thin film production process |
JP2001332216A (ja) * | 2000-03-14 | 2001-11-30 | Toshiba Lighting & Technology Corp | 放電ランプ、光照射装置、殺菌装置、液体処理装置および空気清浄装置 |
US6183255B1 (en) * | 2000-03-27 | 2001-02-06 | Yoshiki Oshida | Titanium material implants |
US6599448B1 (en) * | 2000-05-10 | 2003-07-29 | Hydromer, Inc. | Radio-opaque polymeric compositions |
US6558621B1 (en) * | 2000-06-23 | 2003-05-06 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Removal of biologically active organic contaminants using atomic oxygen |
US6684648B2 (en) * | 2000-07-26 | 2004-02-03 | Fakieh Research & Development Center | Apparatus for the production of freshwater from extremely hot and humid air |
CH694935A5 (de) * | 2000-07-26 | 2005-09-30 | Straumann Holding Ag | Oberflaechenmodifizierte Implantate. |
US6752831B2 (en) * | 2000-12-08 | 2004-06-22 | Osteotech, Inc. | Biocompatible osteogenic band for repair of spinal disorders |
US6620332B2 (en) * | 2001-01-25 | 2003-09-16 | Tecomet, Inc. | Method for making a mesh-and-plate surgical implant |
US7018418B2 (en) * | 2001-01-25 | 2006-03-28 | Tecomet, Inc. | Textured surface having undercut micro recesses in a surface |
US20020120333A1 (en) * | 2001-01-31 | 2002-08-29 | Keogh James R. | Method for coating medical device surfaces |
JP4790917B2 (ja) * | 2001-02-23 | 2011-10-12 | 独立行政法人科学技術振興機構 | 人工椎体 |
AU2002305201A1 (en) * | 2001-04-19 | 2002-11-05 | Case Western Reserve University | Fabrication of a polymeric prosthetic implant |
RU2286801C2 (ru) * | 2001-05-01 | 2006-11-10 | Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук | Двухфазные биоадгезионные композиции, абсорбирующие воду |
US6444318B1 (en) * | 2001-07-17 | 2002-09-03 | Surmodics, Inc. | Self assembling monolayer compositions |
WO2003070289A1 (fr) * | 2002-02-19 | 2003-08-28 | Kabushiki Kaisha Kobe Seiko Sho | Element d'articulation artificielle realise en materiau polymere |
US7879107B2 (en) * | 2002-02-20 | 2011-02-01 | The Cleveland Clinic Foundation | Composition and method for inducing bone growth and healing |
CA2476653C (en) * | 2002-02-21 | 2009-01-27 | Encelle, Inc. | Cross-linked bioactive hydrogel matrices |
US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
US20040167632A1 (en) * | 2003-02-24 | 2004-08-26 | Depuy Products, Inc. | Metallic implants having roughened surfaces and methods for producing the same |
-
2002
- 2002-10-11 AU AU2002328762A patent/AU2002328762B2/en not_active Ceased
- 2002-10-11 US US10/492,131 patent/US20040210309A1/en not_active Abandoned
- 2002-10-11 WO PCT/CH2002/000561 patent/WO2003030957A1/de active Application Filing
- 2002-10-11 CN CNB028202457A patent/CN100366300C/zh not_active Expired - Fee Related
- 2002-10-11 JP JP2003533988A patent/JP2005505352A/ja active Pending
- 2002-10-11 EP EP02764480A patent/EP1434607A1/de not_active Withdrawn
-
2005
- 2005-05-24 HK HK05104360A patent/HK1071526A1/xx not_active IP Right Cessation
Non-Patent Citations (1)
Title |
---|
See references of WO03030957A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU2002328762B2 (en) | 2007-08-23 |
JP2005505352A (ja) | 2005-02-24 |
US20040210309A1 (en) | 2004-10-21 |
CN100366300C (zh) | 2008-02-06 |
HK1071526A1 (en) | 2005-07-22 |
WO2003030957A1 (de) | 2003-04-17 |
CN1568200A (zh) | 2005-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1434607A1 (de) | Osteophile implantate | |
EP1150620B1 (de) | Osteophile implantate | |
EP2004248B1 (de) | Bio-auflösende salzbeschichtungen von implantaten zum schutz vor organischen verunreinigungen | |
EP2054093B1 (de) | Implantat, insbesondere dentalimplantat | |
DE60118738T2 (de) | Poröses orthopädisches silikon-implantat | |
DE69326352T2 (de) | Verfahren zur behandlung eines metallischen chirurgischen implantats. | |
CH695985A5 (de) | Oberflächenmodifizierte Implantate. | |
CH694935A5 (de) | Oberflaechenmodifizierte Implantate. | |
WO2007088013A1 (de) | Verfahren zur herstellung eines metallkörpers sowie metallkörper | |
EP2189170A1 (de) | Verfahren zur Herstellung einer korrosionshemmenden Beschichtung auf einem Implantat aus einer biokorrodierbaren Magnesiumlegierung sowie nach dem Verfahren hergestelltes Implantat | |
DE4311772A1 (de) | Verfahren zur Herstellung von gewebefreundlichen Implantaten, einsetzbar für die Knochenchirurgie, aus mindestens 98 Gew.-% Titan enthaltenden Metallen, aus Titan und/oder titanhaltigen Mikrolegierungen sowie ihre Verwendung | |
EP1941950A1 (de) | Verfahren zur Herstellung poröser Oberflächen auf Metallkomponenten | |
DE112015002155T5 (de) | Osteosynthetisches Implantat | |
EP2323705B1 (de) | Implantat und verfahren zu seiner herstellung sowie deren verwendung | |
EP2206526A2 (de) | Implantat und Verfahren zur Herstellung desselben | |
DE60301796T2 (de) | Osteointegrierende grenzfläche für implantierbare prothese und methode zu deren herstellung | |
DE69434831T2 (de) | Verfahren zur behandlung eines implantates aus titan oder titanlegierung | |
DE102012210804B4 (de) | Verfahren zur Erzeugung einer bakteriziden Schicht auf einem Grundkörper aus Titan oder einer Titanbasislegierung | |
DE102004021739B4 (de) | Metallimplantat mit Oberflächenbeschichtung | |
EP4072606B1 (de) | Implantat, implantatkomponente und verfahren zu deren herstellung | |
DE10158302A1 (de) | Beschichtung von implantierbaren Metallkörpern mit bioaktiven Materialien | |
AT524312B1 (de) | Verfahren zur Herstellung eines oberflächenmodifizierten Metallimplantats | |
DE68905550T2 (de) | Entzuendungshemmendes oxydierendes mittel, verfahren zur herstellung und sonstige anwendungen. | |
WO1998052489A1 (de) | Biokompatible barrieremembran | |
EP1293219A1 (de) | Biomedizinisches Erzeugnis mit einem eine Nickel-Titan-Legierung enthaltenden Substrat und einer Calciumphosphat enthaltenden überdeckenden Schicht |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20040315 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SIMPSON, JAMES, P. Inventor name: DENZER, ALAIN, J. |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: STRAUMANN HOLDING AG |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20120613 |