EP0992288B1 - Mechanique d'éjection d'embouts de pipette - Google Patents

Mechanique d'éjection d'embouts de pipette Download PDF

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Publication number
EP0992288B1
EP0992288B1 EP99114892A EP99114892A EP0992288B1 EP 0992288 B1 EP0992288 B1 EP 0992288B1 EP 99114892 A EP99114892 A EP 99114892A EP 99114892 A EP99114892 A EP 99114892A EP 0992288 B1 EP0992288 B1 EP 0992288B1
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EP
European Patent Office
Prior art keywords
ejection
pipetting system
guide
pipetting
ejection element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP99114892A
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German (de)
English (en)
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EP0992288A2 (fr
EP0992288A3 (fr
Inventor
Jens Wilmer
Ernst Tennstedt
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Eppendorf SE
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Eppendorf SE
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Publication of EP0992288A3 publication Critical patent/EP0992288A3/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means

Definitions

  • the invention relates to a pipetting system with a pipetting device and at least one pipette tip detachably secured thereto.
  • Such pipetting systems are used primarily in the laboratory for metering fluid quantities. These are sucked into pipette tips and ejected from them.
  • piston are arranged displaceably in a cylinder.
  • the piston and cylinder are integrated into the pipetting device and communicate with the pipette tip so that metering of the fluid is mediated via an air cushion.
  • the piston and cylinder are integrated into the tip and act directly on the aspirated fluid.
  • Such pipette tips are also referred to as syringes.
  • Piston-less systems may in particular comprise a pipette tip with a balloon-like end portion, which expands to suck in liquid and is compressed for ejection.
  • the pipette tip is releasably connected to the pipetting device so that it can be exchanged for a fresh pipette tip after use, thereby avoiding contamination at subsequent dosages.
  • Single-use pipette tips are inexpensively available in plastic.
  • the pipetting devices have a mounting boss for attaching pipette tips. For the most part, this is a conical projection onto which a pipette tip clamped with a conical receptacle. This can be done without touching the pipette tip by attaching the attachment lug on a pipette tip, which is available in a holder.
  • a pipette with a tip remover which has a lever mechanism to facilitate the use by reducing the ejection force.
  • This lever mechanism protrudes laterally from a pipette housing and is to be pressed manually. It may have a gear rotatably articulated to an actuator arm for the pipette tip in a vertical plane. Further, the inner edge of the gear meshes with a rack on the side of the elongated housing.
  • a hollow push rod is arranged on the side of the housing, which meshes with a thread on its inside with the outer side of the gear.
  • the gear moves down and simultaneously carries the actuator arm and ejector sleeve, forcing a pipette tip off a mounting cone.
  • the push rod lays exactly twice as long as the actuator arm and is on the push rod applied force half as large as the force applied to press the pipette tip force.
  • This system is structurally complex and allows only a single gear ratio of 1: 2, so that it is limited in applicability.
  • the present invention seeks to provide a pipetting system with a discharge device, which allows other ratios and constructive simplifications in addition to the aforementioned.
  • the pipetting system according to the invention is an alternative to the known pipette with tip remover, which opens both the known ratio and other ratios and thus increased freedom of design and extended applications due to the traction mechanism, pressure-medium transmission or joint transmission. Also, in a pipetting system according to the invention, gear ratios are possible which vary during tip ejection. In addition, the pipetting system opens up the possibility of structural simplifications.
  • the drive device and the discharge element can have mutually cross-end portions and the transmission have a rotatably mounted on the end portion of the discharge element pulley and a rope which is fixed at one end with respect to the fastener and the other end is fixed to the end portion of the drive device.
  • a drive rod and the ejection element are aligned parallel to each other.
  • the discharge element moves only over half of this path.
  • a force is available at the discharge element for releasing the pipette tip, which force is approximately twice as large as the force applied for the drive movement.
  • Other translation ratios can be achieved when multiple pulleys are mounted on the discharge element. This transmission allows structurally particularly simple solutions.
  • the transmission has a first piston connected to the drive device, which is displaceable in a first cylinder and a second piston connected to the discharge element, which is displaceable in a second cylinder, wherein the two cylinders communicate with each other, this communicating cylinder system is sealed to the environment and filled with hydraulic fluid and the first piston has a smaller cross-sectional area than the second piston.
  • a displacement of the first piston over a certain distance causes a displacement of the second piston over a smaller distance, wherein the ratio of the distances is inversely proportional to the ratio of the cross-sectional areas of the two pistons.
  • the force exerted by the second piston on the drop element and thus on the pipette tip is greater than the force exerted by the drive rod on the first piston, the ratio of these forces being proportional to the ratio of the cross-sectional areas of the two pistons.
  • the transmission has a first bellows connected to the drive device and a second bellows connected to the discharge element, wherein the bellows are communicatively connected to each other, this communicating bellows system is filled with hydraulic fluid and the first bellows a smaller cross-section than the second Bellows has.
  • the transmission has a first joint rod which is articulated to the drive means and a second joint rod which is articulated to the discharge element, wherein the two joint rods are hinged at the other end and are guided in the articulation region along a positionally fixed with respect to the fastener guide comprising a first guide portion, the distance of which increases from a common axis of the drive movement and the discharge element in the direction of the drive means to the discharge element and which is arranged so that the articulation region is movable along this first guide portion upon release of a pipette tip.
  • the discharge element is a discharge rod. This can in turn with at least one further element of a discharge device be connected.
  • the fastener may be a mounting boss, a mounting receptacle or the like.
  • the invention can be used with all types of pipetting systems, in particular piston and direct displacement systems, single stroke and dispensing systems, hand and stationary systems, manual and power driven systems, and single and multiple channel systems ,
  • a hand pipetting system according to the invention has a hand pipetting device 1 with a housing 2 and a housing shaft 3, which has a fastening attachment in the form of an attachment cone 4 at the lower end.
  • an operating knob 6 out.
  • a piston By axially pressing the operating knob 6, a piston can be moved in a cylinder in the housing 2 between two stops.
  • the cylinder is connected via a channel with an opening at the lower end of the attachment cone 4.
  • an air column By moving the piston, an air column is moved in the channel. After pressing the piston 6, this can spring-assisted return to its original position, wherein the air column can suck liquid into the pipette tip 5. Pressing the actuating button 6 again causes an ejection of the liquid from the pipette tip 5.
  • the pipetting device on a discharge device 7. This has a displaceably arranged on the housing shaft 3 discharge sleeve 8 with a lateral projection 9 at the upper edge within the housing 2.
  • a discharge button 11th To operate the discharge sleeve 8 is located on a longitudinal side in the housing 2 a parallel to the housing shaft 3 drive rod 10, by means of a discharge button 11th is actuated, which protrudes above the housing 2.
  • the lower end of the drive rod 10 is connected via a gear 12 with the upper end of a discharge rod 13, which is also parallel to the housing shaft 3.
  • the lower end of the discharge rod 13 is in turn assigned to the lateral projection 9 of the discharge sleeve 8.
  • the transmission 12 is a traction, pressure medium or joint transmission. It has a reduction. As a result, upon actuation of the ejection device 7, the displacement of the ejection button 11 is greater than the displacement of the ejection sleeve 8, but exceeds the force exerted by the ejection sleeve 8 on the upper edge of the pipette tip 5 force exerted on the ejection button 11 force. Fixed pipette tips 5 can thus be more easily detached from the pipetting device 1.
  • Fig. 2 and 3 show an embodiment of the transmission as a traction mechanism 12 '.
  • a guide block 14 is provided at the lower end portion of the drive rod 10, in which an axially directed guide groove 15 is formed, which has a lateral opening 16.
  • Adjacent to the guide block 14, the drive rod 10 has an axial guide bore 17.
  • the discharge bar 13 is guided by a transverse housing wall 18.
  • the discharge rod 13 carries below the housing wall 18 a ring 19, which secures against pulling upwards.
  • a compression spring 21 is guided on the discharge rod 13, which is supported at one end on the housing wall 18 and the other end to a further ring 21 which sits on the discharge rod 13.
  • the discharge rod 13 carries a bearing block 22. This is pushed onto the discharge rod 13 and secured by means of rings 23, 24 on the discharge rod 13. The discharge rod 13 protrudes with its upper end into the guide bore 17 and the bearing block 22 is guided in the guide groove 15 of the guide block 14. Above the bearing block 22, a compression spring 25 is guided on the discharge rod 13, which is supported at one end to the ring 24 and the other end to a step 26 between the guide groove 15 and guide bore 17.
  • a guide roller 28 is mounted on a protruding from the opening 16 journal 27 of the bearing block 22, a guide roller 28 is mounted.
  • the deflection roller 28 has a groove 29 on the circumference.
  • a cable 30 is placed around the deflection roller 28 and guided in the groove 29.
  • the rope 30 may in particular be a steel or wire rope. It extends approximately over half of the circumference of the guide roller 28. At one end it is defined below the bearing block 22 in the housing 2 and thus with respect to a Aufsteckkonus 4 for a pipette tip 5. At the other end it is defined below the guide roller 28 at 32 on the guide block 14.
  • the determination on the housing 2 for example, by means of a loop which sits on a pin.
  • the attachment to the guide block 14 takes place, for example by means of a rope-resistant ball or other thickening, which is pushed from the side into a receptacle having a passage for the cable 30.
  • the bearing block 22 has a bearing pin 27 concentric ring 33 which secures the guide roller 28 with a bead 34 on the inner circumference and prevents the rope 30 from slipping out of the groove 29.
  • the rim 33 has through holes through which the ends of the cable 30 are guided to the outside.
  • the transmission 12 When unactuated ejection button 11, the transmission 12 'assumes the drawn arrangement. If the ejection button 11 is actuated, the drive rod 10 with the guide block 14 pulls down the end of the cable 30 fixed thereto. The rope 30 is pulled over the guide roller 28 and at the same time the guide roller 28 and thus the bearing block 22 and the discharge rod 13 down. This traction mechanism 12 'causes thereby the discharge rod 13 is moved to a discharge path, which is only half as large as the displacement distance of the drive rod 10. On the other hand, the discharge force exerted by the discharge rod 13 is twice as large as the force applied to the discharge button 11. The lower end of the discharge rod 13 can thus exert an increased force on a pipette tip 5 directly or via a discharge sleeve 8.
  • the spring 20 pushes the traction mechanism gear 12 'in the drawn starting position.
  • the spring 25 pushes the drive rod 10 with respect to the discharge rod 13 in the starting position and thus compensates for the differences in the displacements of the drive rod 10 and discharge rod 13, so that the cable 30 is held under tension.
  • the pressure medium piston gearing 12 "shown in FIG. 4 can also be used in a pipetting system according to FIG. 1.
  • the drive rod 10 is connected to a first piston 33. This is arranged axially displaceable in a cylinder 34.
  • the drive rod 10, which is also the drive rod of the piston 33, is sealingly guided through the upper opening of the cylinder 34.
  • an O-ring 35 is supported on an inner shoulder of the cylinder 34 and pressed by means of a screw ring 36 between the cylinder 34 and 10 discharge rod, similar to a stuffing box seal.
  • the maximum diameter D 1 of the piston 32 is significantly smaller than the inner diameter of the cylinder 34.
  • a second piston 37 which is guided into the other end of the cylinder 34.
  • another O-ring 38 which is pressed by means of a union nut 39 sealingly against the outer periphery of the piston 37.
  • the outer diameter D 2 of the piston 37 corresponds approximately to the inner diameter of the portion of the cylinder 34 in which it is displaceable.
  • the guided on the discharge rod 13 spring is supported at one end on the transverse housing wall 18 and the other end on a shoulder 40 on the underside of the piston 37 from.
  • the transmission 12 '' is shown in non-actuated arrangement.
  • a tip ejection is pressed on the ejection button 11, so that the piston 33 dips deeper into the cylinder 34.
  • hydraulic fluid is displaced and the piston 37 is moved against the action of the spring 20 down so that the discharge rod 13 entrains the discharge sleeve 8 and ultimately the pipette tip 5 pushes off the attachment cone 4.
  • a pipette system according to FIG. 1 can also be equipped with a pressure-medium bellows transmission 12 '''according to FIGS. 5 and 6.
  • This has a first bellows 42 which is frontally connected to the drive rod 10 so that it can be compressed by this. Further, it has a second bellows 43, the frontally connected to the discharge rod 13, so that it moves axially during deployment.
  • the two bellows 42, 43 are connected to each other via a short tube section 44, so that their interiors communicate with each other.
  • a radially directed groove 45 in which a transverse housing wall 18 engages.
  • This has a laterally open slot 46 for insertion of the hose portion 44th
  • the bellows 42, 43 and the hose portion 44 are filled with a hydraulic fluid 41 or other suitable fluid. They have a circular cross-section, wherein the bellows 42 may have an approximately half the diameter (D1), as the bellows 43 (D 2 ).
  • the bellows 42, 43 may be made of an elastic material so as to be unaffected in an effort to adopt the initial shape shown in FIG. But it is also possible to achieve this initial shape by means of an additional spring device.
  • the bellows 42 can be compressed by moving the drive rod 10 in the arrow direction, wherein the hydraulic fluid 41 is displaced into the bellows 43 and this expands.
  • the arrangement according to FIG. 6 is achieved, in which the bellows 42 is compressed to the maximum and the bellows 43 is maximally expanded.
  • the compression travel Y of the bellows 42 is significantly greater than the expansion Z of the bellows 43.
  • the bellows 43 pushes with a much greater discharge force (F 2 ) on the discharge bar 13, as is introduced via the drive rod 10 in the bellows 42 (F 1 ).
  • the pipetting system according to FIG. 1 can advantageously also be equipped with a joint gear 12 IV according to FIG. 7.
  • the drive rod 10 and the discharge bar 13 are guided coaxially in axial guides 47, 48 of the housing.
  • At the lower end of the drive rod 10 are at 49 two first hinge rods 50, 50 'articulated.
  • a guide 55, 55 'formed with a certain contour This moves away in a first guide portion 56, 56 'from the aforementioned axis and is in a second guide portion 57, 57' parallel to this axis.
  • the rollers 54, 54 ' may initially be located within the guide 47. As soon as the rollers 54, 54 'reach the region of the guide 55, 55', they follow the contour of the first guide section 56, 56 'and move away from one another. This situation is shown in FIG. As a result, during the movement of the rollers 54, 54 'over the first guide portion 56, 56', the discharge bar 13 is displaced a shorter distance than the drive rod 10. On the other hand, the discharge bar 13 can exert a greater force on a discharge sleeve 8 than on the drive rod 10 is exercised.
  • the pipette tip 5 is advantageously pressed off the attachment cone 4, while the rollers 54, 54 'along of the guide section 56, 56 'are moved.
  • the movement of the discharge rod 13 in turn corresponds to the movement of the drive rod 10, as a result of which a pipette tip 5 can already be accelerated.
  • the first guide portion 56, 56 ' can be a force-boosting translation of z. B. 3.5: 1 can be achieved.
  • the transmission ratio is 1: 1.
  • a joint gear with appropriate function can also be realized by the drive rod 10 and the discharge bar 13 are only two pivot rods 50, 52 connected to each other and only on one side of the common axis of movement of the drive rod 10 and the discharge rod 13, a guide 55 is formed with the various sections 56, 57 (or 58, 59). One of the guide 55 opposite wall 60 can then be aligned with the boundaries of the guides 47, 48. As a result, a space-saving design is possible.
  • joint gear according to FIG. 7 to 9 can cooperate with a spring device which act on the discharge rod 13 counteracting direction of actuation in order to return it to a starting position.

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Claims (26)

  1. Système de pipette, comportant
    - un dispositif de pipette (1) et au moins une pointe de pipette (5) fixée à lui de façon démontable,
    - au moins un élément de fixation (4) sur le dispositif de pipette (1), sur lequel la pointe de pipette (5) est fixée,
    - un dispositif de rejet (7) sur le dispositif de pipette (1) qui présente un organe de rejet (13) mobile axialement sous forme d'une tige de rejet (13) associée à une saillie (9) latérale d'une douille de rejet (8), pour libérer la pointe de pipette (5) de l'élément de fixation (4) en cas de mouvement axial de l'organe de rejet (13), et un dispositif d'entraînement (10, 11) comportant une tige d'entraînement (10), disposée parallèlement à un corps de boîtier (2), pour entraîner le mouvement axial de l'organe de rejet (13), et
    - un mécanisme à moyen de traction, un mécanisme à moyen de compression ou un mécanisme à articulation transmettant un mouvement d'entraînement, sensiblement axial, du dispositif d'entraînement (10; 11) en un mouvement axial de l'organe de rejet (13), mécanisme par lequel l'extrémité inférieure de la tige d'entraînement (10) est reliée à l'extrémité supérieure de la tige de rejet (13), mécanisme avec lequel la tige de rejet (13) peut être déplacé axialement, au moins lorsque la pointe de pipette (5) est libérée de l'élément de fixation (4), sur une course plus petite que le mouvement sensiblement axial d'entraînement ne parcourt, et la force de rejet, dépassant une force pour le mouvement sensiblement axial d'entraînement, peut être exercée sur la pointe de pipette (5).
  2. Système de pipette suivant la revendication 1, dans le cas duquel un dispositif de ressort (20) agissant contre le mouvement axial en cas de libération de la pointe de pipette (5) est appliqué.
  3. Système de pipette suivant la revendication 2, dans le cas duquel le dispositif de ressort (20) est un ressort de compression agissant entre une butée d'appui (18) montée fixe par rapport à l'organe de fixation (5) et un contre-palier (21) de la tige de rejet (13).
  4. Système de pipette suivant l'une des revendications 1 à 3, dans le cas duquel le dispositif d'entraînement présente une tige d'entraînement (10) mobile axialement et/ou un bouton de rejet (11) actionnable manuellement.
  5. Système de pipette suivant l'une des revendications 1 à 4, dans le cas duquel le dispositif d'entraînement (10, 11) et l'organe de rejet (13) ont des parties d'extrémité dépassant l'un sur l'autre, et le mécanisme (12') présente une poulie de renvoi (28), montée tournante sur la partie d'extrémité de l'élément de rejet (13), et un câble (30), qui, à une extrémité, est monté fixe par rapport à l'élément de fixation (4) et, à l'autre extrémité, est monté fixe sur la partie d'extrémité du dispositif d'entraînement (10).
  6. Système de pipette suivant la revendication 5, dans le cas duquel la partie d'extrémité de l'organe d'entraînement (10, 11) et l'organe de rejet (13) sont guidés de façon télescopique l'un par rapport à l'autre.
  7. Système de pipette suivant la revendication 5 ou 6, dans le cas duquel, à la partie d'extrémité de l'organe de rejet (13), est fixé un bloc de palier (22) contre lequel la poulie de renvoi (28) est montée tournante, la partie d'extrémité de l'organe d'entraînement (10, 11) présente un bloc de guidage (14) comportant une rainure de guidage (15), recevant le bloc de palier (22), et comportant une ouverture latérale (16) d'où dépasse la poulie de renvoi (28).
  8. Système de pipette suivant la revendication 7, dans le cas duquel une extrémité de l'organe de rejet (13) dépassant du bloc de palier (22) est guidée dans un alésage de guidage (17),en limite de la rainure de guidage (15), de la partie d'extrémité du dispositif d'entraînement (10, 11).
  9. Système de pipette suivant l'une des revendications 5 à 8, dans le cas duquel, entre le dispositif d'entraînement (10, 11) et l'organe de rejet (13), est disposé un autre dispositif de guidage (25) qui s'oppose au dépassement de la partie d'extrémité.
  10. Système de pipette suivant l'une des revendications 7 à 9, dans le cas duquel l'autre dispositif de guidage (25) est un ressort de compression (25) disposé entre le bloc de palier (22) et un seuil (26), entre la rainure de guidage (15) et l'alésage de guidage (17).
  11. Système de pipette suivant l'une des revendications 1 à 4, dans le cas duquel le mécanisme (12") présente un premier piston (33) relié au dispositif d'entraînement (10, 11), piston qui peut coulisser dans un cylindre (34), le mécanisme (12") présente un deuxième piston (37), relié à l'organe de rejet (13) et qui peut coulisser dans un cylindre (34), les deux cylindres (34) communiquant entre eux, ce système de communication des cylindres étant rendu étanche par rapport à l'environnement et étant rempli de fluide hydraulique (41), et le premier piston (33) présentant une surface de section plus petite que le deuxième piston (37).
  12. Système de pipette suivant la revendication 11, dans le cas duquel les deux pistons (33, 37) sont disposés dans un unique cylindre (34).
  13. Système de pipette suivant la revendication 11 ou 12, dans le cas duquel une tige d'entraînement (10, 13) du premier piston (33) et/ou du deuxième piston (37) est guidée de façon étanche dans une ouverture d'introduction du cylindre (34).
  14. Système de pipette suivant l'une des revendications 1 à 4, dans le cas duquel le mécanisme (12'") présente un premier soufflet à plis (42) relié au dispositif d'entraînement et le mécanisme (12'") présente un deuxième soufflet à plis (43) relié au dispositif de rejet (13), soufflets à plis qui sont reliés de manière à communiquer ensemble, le système de soufflets à plis communiquant étant rempli de liquide hydraulique (41), et le premier soufflet à plis (42) présentant une section plus petite que le deuxième soufflet à plis (43).
  15. Système de pipette suivant la revendication 14, dans le cas duquel les deux soufflets à plis (42, 43) sont reliés entre eux par une partie de tuyau flexible (44).
  16. Système de pipette suivant la revendication 15, dans le cas duquel, entre les soufflets à plis (42, 43), une cannelure radiale (46), dans laquelle pénètre une paroi de boîtier comportant une ouverture (46) qui reçoit la partie de tuyau flexible (44), entoure la partie de tuyau flexible (44).
  17. Système de pipette suivant l'une des revendications 1 à 4, dans le cas duquel le mécanisme (12IV) présente une première barre d'articulation (50) qui s'articule sur le dispositif d'entraînement (10, 11), le mécanisme (12IV) présente une deuxième barre d'articulation (52) qui s'articule sur l'organe de rejet (13), les deux barres d'articulation (50, 52) étant articulées entre elles à leur autre extrémité et étant guidées, dans la zone d'articulation, le long d'un guidage (55) qui présente une première partie de guidage (56) dont la distance d'un axe commun du mouvement d'entraînement et de l'organe de rejet (13) augmente , dans la direction du dispositif de commande (10, 11) vers l'organe de rejet (13), et qui est disposée de telle façon que la zone d'articulation (53) puisse se déplacer le long de cette première partie de guidage (56) lorsque la pointe de pipette (5) est libérée.
  18. Système de pipette suivant la revendication 17, dans le cas duquel, dans la zone d'articulation (53) des deux barres d'articulation (50, 52), est montée tournante une poulie (54), qui peut rouler contre le guidage (55).
  19. Système de pipette suivant la revendication 17 ou 18, dans le cas duquel le guidage (55) présente, contre la première partie de guidage (56), une deuxième partie de guidage (57) à une distance constante de l'axe de l'organe de rejet (13).
  20. Système de pipette suivant l'une des revendications 17 à 19, dans le cas duquel le guidage (55) présente, en limite de la première partie de guidage (56) ou de la partie de rejet (57), une autre partie de guidage (58, 59) dont la distance de l'axe de l'organe de rejet (13) diminue dans la direction du dispositif de commande (10, 11) vers l'organe de rejet (13).
  21. Système de pipette suivant l'une des revendications 17 à 20, dans le cas duquel des barres d'articulation (50, 52; 50', 52") articulées l'une à l'autre et des guidages (55, 55') sont disposés symétriquement par rapport à l'axe de l'organe de rejet (13).
  22. Système de pipette suivant l'une des revendications 1 à 21, qui présente un dispositif manuel de pipette ou un dispositif stationnaire de pipette.
  23. Système de pipette suivant l'une des revendications 1 à 22, qui est un système à un canal ou un système à plusieurs canaux.
  24. Système de pipette suivant une des revendications 1 à 23 qui présente un dispositif de rejet (7) entraîné manuellement, électriquement ou autrement.
  25. Système de pipette suivant la revendication 24, dans le cas duquel le dispositif d'entraînement comporte une tige d'entraînement avec un bouton de rejet (11) actionnable manuellement ou un entraînement à moteur linéaire.
  26. Système de pipette suivant une des revendications 1 à 24, dans le cas duquel le siège de pipette (5) est fixé à l'élément de fixation avec une force de serrage d'au moins 0,5 N, de préférence de 0,5 N à 80 N, force qui peut être surmontée par le dispositif de rejet (7).
EP99114892A 1998-10-06 1999-07-30 Mechanique d'éjection d'embouts de pipette Expired - Lifetime EP0992288B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19845950 1998-10-06
DE19845950A DE19845950C1 (de) 1998-10-06 1998-10-06 Pipettiersystem mit einer Pipettiervorrichtung und mindestens einer daran lösbar befestigten Pipettenspitze

Publications (3)

Publication Number Publication Date
EP0992288A2 EP0992288A2 (fr) 2000-04-12
EP0992288A3 EP0992288A3 (fr) 2002-07-03
EP0992288B1 true EP0992288B1 (fr) 2007-03-07

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EP99114892A Expired - Lifetime EP0992288B1 (fr) 1998-10-06 1999-07-30 Mechanique d'éjection d'embouts de pipette

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EP (1) EP0992288B1 (fr)
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EP2210667A1 (fr) 2009-01-19 2010-07-28 Eppendorf Ag Pipette avec éjecteur de pointe
EP3680016A1 (fr) 2019-01-08 2020-07-15 Eppendorf AG Pipette destinée à une utilisation avec une pointe de pipette
EP3680017A1 (fr) 2019-01-08 2020-07-15 Eppendorf AG Pipette destinée à une utilisation avec une pointe de pipette

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Publication number Priority date Publication date Assignee Title
EP2210667A1 (fr) 2009-01-19 2010-07-28 Eppendorf Ag Pipette avec éjecteur de pointe
EP3680016A1 (fr) 2019-01-08 2020-07-15 Eppendorf AG Pipette destinée à une utilisation avec une pointe de pipette
EP3680017A1 (fr) 2019-01-08 2020-07-15 Eppendorf AG Pipette destinée à une utilisation avec une pointe de pipette
US11426720B2 (en) 2019-01-08 2022-08-30 Eppendorf Ag Pipette for use with a pipette tip
US11554367B2 (en) 2019-01-08 2023-01-17 Eppendorf Ag Pipette for use with a pipette tip

Also Published As

Publication number Publication date
DE59914234D1 (de) 2007-04-19
JP2000107613A (ja) 2000-04-18
DE19845950C1 (de) 2000-03-23
JP4484985B2 (ja) 2010-06-16
US6199435B1 (en) 2001-03-13
EP0992288A2 (fr) 2000-04-12
EP0992288A3 (fr) 2002-07-03

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