EP0845983A2 - Composition pharmaceutique a proprietes trypanocides - Google Patents

Composition pharmaceutique a proprietes trypanocides

Info

Publication number
EP0845983A2
EP0845983A2 EP96929285A EP96929285A EP0845983A2 EP 0845983 A2 EP0845983 A2 EP 0845983A2 EP 96929285 A EP96929285 A EP 96929285A EP 96929285 A EP96929285 A EP 96929285A EP 0845983 A2 EP0845983 A2 EP 0845983A2
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical preparation
preparation according
water
weight
volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP96929285A
Other languages
German (de)
English (en)
Inventor
Alain Jacques Bourdichon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atarost Allgem Tierarzneimittelfabrik Dr Ulrich
Original Assignee
Atarost Allgem Tierarzneimittelfabrik Dr Ulrich Bourdichon Alain Jacques Boehmer Nachf & Co GmbH
Bourdichon Alain Jacques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atarost Allgem Tierarzneimittelfabrik Dr Ulrich Bourdichon Alain Jacques Boehmer Nachf & Co GmbH, Bourdichon Alain Jacques filed Critical Atarost Allgem Tierarzneimittelfabrik Dr Ulrich Bourdichon Alain Jacques Boehmer Nachf & Co GmbH
Publication of EP0845983A2 publication Critical patent/EP0845983A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds

Definitions

  • the invention relates to a pharmaceutical preparation with trypanozid properties for the veterinary field, in the form of an aqueous solution, the diminazenediacetate (4,4'-diamidinodiazobenzenediacetamidoacetate) and pentamidine (4,4 '- (pentamethylendioxy) ) -dibenzamidine) as trypanozide active ingredients, phenazone (1,2-dihydro-l, 5-dimethyl-2-phenyl-3H-pyrazol-3-one) as antipyretic and analgesic component as well as glycerin.
  • Arsenic preparations and trypan dyes are known as chemotherapeutic agents, but due to their arsenic
  • a preparation for the treatment of such infections in animals is a trypanozide based on diminazen powder.
  • Other commercially available trypanozides are also only available in powder form.
  • the powdered form of the medicament is extremely disadvantageous, since the powdered preparations cannot be added to the feed and they therefore have to be mixed with water in order to prepare an injection solution. It is not possible to prepare a sterile solution from the powdery preparations, since the active substances crystallize out of the solution after a short time, so that the effectiveness of the preparation is quickly lost. Such solutions are therefore not adequately storable and transportable.
  • the injection solution must therefore be prepared shortly before the injection, but this is very dangerous due to the generally available water, since it can generally contain bacteria, viruses and germs which cause additional infections in the animals, so that the animals are very heavily burdened by an additional infection.
  • a complete solution of the solids is not achieved, so that the solution for injection has a poor effectiveness.
  • the currently known powdery trypanozides thus represent a risk of additional infections or contamination, at the same time that There is a risk of underdosing of the therapeutic agent, so that the chemotherapy may have to be repeated, which naturally increases the risk potential for infections or the like.
  • aqueous solutions of diminazene diacetate which contain castor oil as a solubilizer.
  • the invention is therefore based on the object of providing a solution of a pharmaceutical preparation of the type mentioned at the outset which is stable even at high temperatures.
  • the invention provides to create a pharmaceutical preparation with trypanozid properties in the form of an aqueous solution which contains the following substances: - Diminazene di-aceturate
  • Diminazene diacetate and pentamidine are trypanoicidal active ingredients which have a different spectrum of activity and thus complement one another in their action, so that almost all types of blood parasites are detected. In addition, resistances are advantageously avoided by the combination.
  • the poor water solubility of diminazene diacetate is compensated for by the combination of the two trypanozidic active substances according to the invention, since pentamidine, which is water soluble, acts as a solubilizer.
  • the phenazone also brings about better solubility of the diminazene di-aceturate, in addition to its action as an analgesic, which advantageously alleviates pain and fever conditions in the animals which are caused by the injection or the infection.
  • Glycerin and the water-soluble cellulose ether serve as emulsifiers.
  • a stable aqueous solution can be obtained according to the combination of all of the aforementioned substances.
  • the stability of the preparation according to the invention is advantageously so great that it can also be heated to 70 ° C. over a long period of time without any signs of decomposition occurring.
  • Methyl-cellulose is preferably used as the water-soluble cellulose ether, although other cellulose ethers, such as, for. B. hydroxy-ethyl cellulose or hydroxypropyl cellulose or their mixed forms are suitable.
  • the water used is preferably water which is physiologically, ie. H. in terms of pH and osmolality.
  • the water is pH neutral and isotonic. It also has a saline content of 0.9 + 0.3%.
  • aqueous solution is obtained as a preparation which can be stored without any problems since the active ingredient cannot crystallize out. In addition, there is no risk of an additional infection since it can be produced under sterile conditions.
  • Babesiosis (Babesia bigemina, Babesia motasi, Babesia canis and other Babesia) Theileria annulata.
  • the preparation according to the invention is combined with a further antipyretic substance and / or a pain reliever.
  • a further antipyretic substance and / or a pain reliever.
  • Lidocaine, procaine or their derivatives are preferably used. If necessary, acetylsalicylic acid can also be used as a fever and pain reliever.
  • the preparation according to the invention contains isometadium hydrochloride from the group of the phenathridines as a further biocidal active ingredient.
  • Methyl cellulose physiologically adjusted water 66.5 vol.-3
  • composition in% by weight of the active ingredients is preferably:
  • Methyl cellulose 1.6% physiologically adjusted water 78.4%.
  • the preparation according to the invention has the advantage that, based on the volume, the active substance content can be doubled compared to the prior art.
  • a particular advantage is that a single injection, which is necessary for chemotherapy, also provides three-month protection against reinfections.
  • a preferred embodiment of the pharmaceutical preparation is produced by the biocidal active ingredients, the intended activity-reducing agents.
  • water Emulsifier mixture can be mixed.
  • the emulsifier / water mixture which is composed of glycerol 20% by volume, methyl cellulose 1.6% by volume and physiological water 78.4% by volume, is then added to the active substances.
  • the ready-to-use preparation can be filled sterile filtered.

Abstract

Cette composition pharmaceutique à propriétés trypanocides utile en médecine vétérinaire sous forme d'une solution aqueuse contient du diminazène-diacéturate, de la pentamidine, du phénazone, de la glycérine et un éther de cellulose soluble dans l'eau.
EP96929285A 1995-08-21 1996-08-20 Composition pharmaceutique a proprietes trypanocides Ceased EP0845983A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1995130708 DE19530708C2 (de) 1995-08-21 1995-08-21 Pharmazeutisches Präparat mit trypanoziden Eigenschaften
DE19530708 1995-08-21
PCT/EP1996/003657 WO1997006769A2 (fr) 1995-08-21 1996-08-20 Composition pharmaceutique a proprietes trypanocides

Publications (1)

Publication Number Publication Date
EP0845983A2 true EP0845983A2 (fr) 1998-06-10

Family

ID=7769997

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96929285A Ceased EP0845983A2 (fr) 1995-08-21 1996-08-20 Composition pharmaceutique a proprietes trypanocides

Country Status (7)

Country Link
EP (1) EP0845983A2 (fr)
AP (1) AP827A (fr)
AU (1) AU6875096A (fr)
DE (1) DE19530708C2 (fr)
EA (1) EA199800218A1 (fr)
OA (1) OA10665A (fr)
WO (1) WO1997006769A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE29618094U1 (de) * 1996-10-18 1998-02-12 Bourdichon Alain Jaques Pharmazeutisches Präparat
DE19853937A1 (de) * 1998-11-24 2000-05-25 Chambord Ltd Pharmazeutisches Präparat
DE10325672A1 (de) * 2003-06-03 2004-12-23 Tropmed Gmbh Pharmazeutisches Präparat zur Behandlung von parasitären Tropenkrankheiten
CN105168121A (zh) * 2015-08-28 2015-12-23 重庆布尔动物药业有限公司 兽用复方三氮脒注射液及其制备方法
RU2638433C1 (ru) * 2016-12-15 2017-12-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Горский государственный аграрный университет" Способ повышения лечебной эффективности Диминазина-70 при пироплазмозе крупного рогатого скота
RU2638444C1 (ru) * 2016-12-15 2017-12-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Горский государственный аграрный университет" Способ повышения лечебной эффективности пироплазмоза крупного рогатого скота Неозидином-М в сочетании с лазеропунктурой

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4309415C2 (de) * 1993-03-19 1996-11-07 Alain Jaques Bourdichon Pharmazeutisches Präparat

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9706769A3 *

Also Published As

Publication number Publication date
AU6875096A (en) 1997-03-12
EA199800218A1 (ru) 1998-12-24
AP827A (en) 2000-04-28
OA10665A (en) 2002-09-25
DE19530708C2 (de) 1999-01-07
AP9801196A0 (en) 1998-03-31
WO1997006769A2 (fr) 1997-02-27
DE19530708A1 (de) 1997-02-27
WO1997006769A3 (fr) 1997-05-09

Similar Documents

Publication Publication Date Title
DE19782320B4 (de) Insektizidkombination gegen Flöhe und Zecken von Säugern, insbesondere von Hunden und Katzen
DE19781981B3 (de) Neue Pestizidkombination
EP0117888B2 (fr) Compositions liquides de dihydropyridines, leur préparation et application thérapeutique
DE3612538C2 (fr)
DE69818093T2 (de) Langwirkende, injizierbare, formulierungen enthaltend rizinusöl
DE60310377T2 (de) Lang wirksame, parasiten-abtötende zubereitung enthaltend eine salicylanilid verbindung, eine polymere verbindung und mindestens eine weitere parasiten-abtötende verbindung
DE602005002495T2 (de) Injizierbare Formulierung mit Natriumdiclofenac, Beta-Cyclodextrin und einem Polysorbat
DE69923471T2 (de) Injizierbare propofol-formulierungen
EP0240829A2 (fr) Agent carcinostatique
DE69917248T2 (de) Topische antiseptische zusammensetzungen und verfahren
WO1997006769A2 (fr) Composition pharmaceutique a proprietes trypanocides
DE19780396B3 (de) Direkt auf die Haut aufzubringende Lösung zur Parasitenbekämpfung bei Rindern und Schafen
DE3619426A1 (de) Mittel zur erhoehung der widerstandskraft gegen erkaeltungskrankheiten bei patienten mit eingeschraenkter lungenfunktion
EP1001756B1 (fr) Compositions a effet synergique pour lutter selectivement contre les tissus tumoraux
EP1833499B1 (fr) Agent homeopathique de prophylaxie contre des maladies causees par des parasites
EP2136816B1 (fr) Oléyl-phosphocholine
EP0817623A1 (fr) Medicaments pour le traitement selectif des tissus affectes par des tumeurs
DE69910738T2 (de) Fungizide zusammensetzung enthaltend ein n-benzoyl-n&#39;-phenyl-harnstoff derivat
DE60315597T2 (de) Haloacetamidobenzoesäure derivate und deren verwendung zur behandlung von parasitären erkrankungen
DE4309415C2 (de) Pharmazeutisches Präparat
EP3275430A1 (fr) Solution de curcumine pour infusion intraveineuse
WO1996012504A1 (fr) Formulation du type &#39;huile dans l&#39;eau&#39; pour application locale
DE2314387C3 (de) Arzneimittel zur Behandlung bösartiger Neubildungen
DE3030314A1 (de) Arzneimittel auf sulfonamidbasis
DE19854139A1 (de) Pharmazeutisches Präparat mit trypanoziden und blutschizontoziden Eigenschaften

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19980223

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): BE DE FR GB IE

AX Request for extension of the european patent

Free format text: LT PAYMENT 980223

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ATAROST ALLGEM. TIERARZNEIMITTELFABRIK DR. ULRICH

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BOURDICHON, ALAIN JACQUES

17Q First examination report despatched

Effective date: 20010629

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 31/655 A, 7A 61K 31/155 B, 7A 61K 31/245 B, 7A 61K 47/38 B, 7A 61K 47/26 B, 7A 61K 31/655 J, 7A 61K 31:155 J, 7A 61K 31:245 J

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20021118