EP0761198B1 - Katheter für die perkutane enterale Ernährung - Google Patents

Katheter für die perkutane enterale Ernährung Download PDF

Info

Publication number
EP0761198B1
EP0761198B1 EP96114109A EP96114109A EP0761198B1 EP 0761198 B1 EP0761198 B1 EP 0761198B1 EP 96114109 A EP96114109 A EP 96114109A EP 96114109 A EP96114109 A EP 96114109A EP 0761198 B1 EP0761198 B1 EP 0761198B1
Authority
EP
European Patent Office
Prior art keywords
catheter
connector part
duct
catheter tube
bulb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP96114109A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0761198A1 (de
Inventor
Rüdiger Ufermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius SE and Co KGaA
Original Assignee
Fresenius SE and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius SE and Co KGaA filed Critical Fresenius SE and Co KGaA
Publication of EP0761198A1 publication Critical patent/EP0761198A1/de
Application granted granted Critical
Publication of EP0761198B1 publication Critical patent/EP0761198B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J15/00Feeding-tubes for therapeutic purposes
    • A61J15/0015Gastrostomy feeding-tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J15/00Feeding-tubes for therapeutic purposes
    • A61J15/0026Parts, details or accessories for feeding-tubes
    • A61J15/003Means for fixing the tube inside the body, e.g. balloons, retaining means
    • A61J15/0034Retainers adjacent to a body opening to prevent that the tube slips through, e.g. bolsters
    • A61J15/0038Retainers adjacent to a body opening to prevent that the tube slips through, e.g. bolsters expandable, e.g. umbrella type
    • A61J15/0042Retainers adjacent to a body opening to prevent that the tube slips through, e.g. bolsters expandable, e.g. umbrella type inflatable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J15/00Feeding-tubes for therapeutic purposes
    • A61J15/0026Parts, details or accessories for feeding-tubes
    • A61J15/0053Means for fixing the tube outside of the body, e.g. by a special shape, by fixing it to the skin
    • A61J15/0065Fixing means and tube being one part
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J15/00Feeding-tubes for therapeutic purposes
    • A61J15/0026Parts, details or accessories for feeding-tubes
    • A61J15/0092Valves on feeding tubes

Definitions

  • the invention relates to a catheter for percutaneous enteral nutrition.
  • Gastrostomy probes for enteral nutrition are known to use of a balloon are secured against slipping out. After the introduction of the Catheter through the stoma into the stomach, the balloon is filled with air from the outside or filled with a liquid. This causes the balloon to expand and closes the stoma from the inside. A movable locking ring that fits on the Probe tube is pulled up, supports the catheter from the outside Abdominal wall.
  • US-A-4,701,163 describes such a catheter for percutaneous enteral Nutrition.
  • the catheter has a catheter tube attached to its proximal end with a connector part for connecting a transfer device or a bladder syringe.
  • the one enveloping the catheter tube The balloon stands in via a channel with a connector Flow connection that protrudes laterally from the connector part.
  • To the A pump or the like can be connected to the connector Fill the balloon with air or a liquid.
  • a valve element in the feed channel switched is to prevent that Filling medium emerges from the balloon.
  • a catheter for percutaneous enteral nutrition which has several connectors for connecting a transfer device and a filling element is also off known from US-A-4,642,092.
  • the invention is based, a relatively simple task to create catheters for percutaneous enteral nutrition, whose support body can have a low overall height.
  • the connector part is for connecting one Filling device, for example a pump or the like., In the support body integrated.
  • the connector part is in one piece with the support body Closure element made of a pierceable, self-sealing material formed, which closes the channel for supplying the filling medium.
  • the Connector part forms in the catheter according to the invention as it were Closure element. It can be made of the same or a different material than the support body are made of a different material Connector part connected to the support body by gluing or welding is.
  • the support body and the connector part preferably consist of same material, especially silicone, so that the support body together can be inexpensively manufactured with the connector part in the injection molding process.
  • the connector part can be designed as a short projecting connector that does not appear disruptive.
  • the wall of the connector part is easy with a Pierce the needle. After removing the needle, the connector part seals the Channel for supplying the medium from airtight or liquid-tight.
  • the connector part is a cylindrical body into which the channel to Feeding the filling medium extends.
  • the connector part is preferred Part of a flexible tab made of a plate-shaped element protrudes, which can be placed on the abdominal wall. The channel to The filling medium then extends through the connector part the tab, the plate-shaped element and the wall of the Catheter tube right into the balloon. That of the plate-shaped element protruding tab can be easily gripped by hand to fill the medium inject.
  • the Connector part not only a means for feeding a filling medium, but also provides a captive secured to the plate-shaped element Closure element, with which the channel for feeding the nutrient solution can be closed tightly.
  • the balloon is advantageously through an annular space in the wall of the Catheter tube formed.
  • the catheter tube can be used as an injection molded part a wall slotted in the axial direction, the distal end of the outer tube wall with the distal end of the inner Hose wall is glued or welded.
  • a tubular body from the catheter tube elastic material to put on at its upper and lower edges the catheter tube is glued or welded.
  • the catheter tube is provided with a plurality of balloons arranged one above the other, which each extend over part of the length of the catheter tube.
  • Each balloon is via a channel with a separate connector part connected so that the balloons are filled individually with the filling medium can.
  • either one or the other balloon filled can also be provided only in an annular space, which differs from the extends the lower edge of the support plate to the lip valve. If in the Annually air is blown, only the part of the catheter tube expands balloon-like that protrudes into the gastric lumen. The other part has in Stoma channel a sealing function.
  • the connector parts are advantageously on the plate-shaped element of the support body appropriate.
  • one of the connector parts can be an integral part of the Be tab to a closure element for the channel for feeding the To get nutrient solution.
  • Outer wall of the balloon made of two superimposed layers different material, with the inner layer of one flexible, sealing material and the outer layer of a harder Material than the inner layer is made of.
  • the harder outer skin gives that Balloon the necessary stability and resistance. This will reduce the service life extended.
  • the two layers are preferably not flat with one another connected, but only at their upper and lower edges glued or welded so that they move against each other can.
  • To ensure the necessary flexibility is advantageously between the inner and outer layers of the Balloon outer wall a gel-like, evenly distributed mass locked in.
  • the support body has the entire surface on the abdominal wall advantageously projecting elements on its underside, in particular Pimples on.
  • the catheter according to the invention is preferably a suitable for that Connector part of the support body attachable adapter piece provided to the a filling element, e.g. a pump or syringe can be connected.
  • a filling element e.g. a pump or syringe
  • the adapter piece is integrated with a cannula, which the connector part at Attaching the adapter piece to create a flow connection between the balloon and the filler that can be connected to the adapter pierces. Since the cannula is integrated into the adapter piece, Avoid injuries.
  • the arrangement consisting of the catheter and the adapter piece comprises in an advantageous embodiment still a rod-shaped stylet, the front the catheter is inserted into the catheter tube. This gives the catheter tube the necessary for insertion Stability.
  • the catheter has a circular disc shape on the abdominal wall of the Patient support plate 1, from which a catheter tube 2 extends.
  • Channel 3 of the catheter tube for supplying a nutrient solution in the gastric lumen is at its distal end with a lip valve 4 closed, the two extending from the distal end of the tube Has lips 5.5 ', which lie close together.
  • the lip valve 4 allows a liquid flow from the catheter tube 2 into the Gastric lumen, however, reverse fluid flow is not possible.
  • the circular disc-shaped support plate 1 and the catheter tube 2 with the Lip valve 4 consist of a flexible material, preferably silicone. Numerous knobs 30 are provided on the underside of the support plate 1.
  • a filling medium e.g. Air or a liquid
  • Reference numeral 7 designates the circumferential adhesive point at which the lower one End of the outer tube wall of the slit in the axial direction Catheter tube forming the annulus with the inner one Hose wall is glued.
  • a cylindrical Molded connector part 9 which consists of a pierceable, self-sealing Material, preferably the same material, e.g. Silicone like that Support plate, the tab and the catheter tube.
  • a cylindrical shaft 10 is formed, which in a channel 11 opens, which is through the tab 8 and the hose wall 12 of the Catheter extends into the annular space 6.
  • a cylindrical recess 24 provided to which the channel 3 of the catheter tube 2 for feeding a nutrient solution.
  • the inside diameter of the recess 24 corresponds to the outer diameter of the molded on the tab 8 Connector part 9, so that this to close the filling opening in the Recess can be inserted.
  • the catheter arrangement further comprises an adapter piece 13 for the connection a syringe to inflate the balloon.
  • One end piece of the adapter piece 13 is a Luer lock connector 14 with a funnel-shaped recess 15 and an external thread 16, while the other end piece with a cylindrical recess 17 is provided so that the adapter piece 13 fit onto the cylindrical connector part 9 of the catheter 1 leaves.
  • the catheter-side connector part 9 and the recess 17 of the adapter piece 13 can also be conical.
  • a pointed cannula 19 used, which extends into the cylinder space 17 and a Flow connection between the conical recess 15 and the produces cylindrical recess 17.
  • the adapter piece 13 is opened the connector part 9 attached to the catheter, the cannula 19 Connector part 9 pierces and into the connector shaft 10 of the tab 8 penetrates.
  • a conventional syringe is attached to the Luer lock connector 14 or a hose line connected to an air pump. Then the Balloon filled with air and the adapter piece 13 is pulled off again, whereby the opening in the connector part 9 closes again in a self-sealing manner.
  • the Adapter piece 13 can also be in a syringe or in the connecting part Pump be integrated.
  • the Catheter arrangement still a stylet 20, which consists of a round with a External thread 20 'provided rod 21 with a handle 22.
  • the rod 21 of the stylet has a cylindrical one Paragraph 23, which with the stylet inserted in the recess 24 in Center of the support plate 1 sits.
  • the channel 3 of the catheter tube 2 to Feeding the nutrient solution is provided with an internal thread 25.
  • FIG. 3 shows the distal end piece of the catheter tube 31 of another Embodiment of the catheter
  • Fig. 4 shows the catheter in plan view shows.
  • the catheter differs from that with reference to that in FIG the fig. 1 and 2 embodiments described in that Catheter tube are formed two superimposed balloons that can be inflated individually and an individual adjustment of the shaft length allow.
  • Figs. 3 and 4 are the parts of the catheter that correspond to the parts of the Embodiment according to FIGS. 1 and 2 correspond with the same Provide reference numerals.
  • the two annular spaces 6 ', 6 "of the balloons are in each case via a channel in the hose wall which cannot be seen in FIG. 3 12 connected to a connector part.
  • the lower annular space 6 stands with Connector part 9 on the tab 8 of the catheter in connection.
  • Connector part 9 is a second connector part 26 on the support plate provided (Fig. 4).
  • the outer wall of the balloon consists of two superimposed layers 27, 28 of different materials.
  • the inner layer 27 consists of a flexible sealing material and the outer layer 28 of a harder material than the inner layer.
  • the the two layers are not flat with one another in the region of the annular space connected.
  • a gel-like material 29 is between the layers 27, 28 included to increase flexibility.
  • the harder outer skin gives the balloon the necessary stability and resistance.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96114109A 1995-09-12 1996-09-04 Katheter für die perkutane enterale Ernährung Expired - Lifetime EP0761198B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19533749A DE19533749A1 (de) 1995-09-12 1995-09-12 Stoma-Gastrostomiesonde mit flacher Rückhalteplatte und optionaler variabler Schaftlänge
DE19533749 1995-09-12

Publications (2)

Publication Number Publication Date
EP0761198A1 EP0761198A1 (de) 1997-03-12
EP0761198B1 true EP0761198B1 (de) 2001-12-12

Family

ID=7771946

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96114109A Expired - Lifetime EP0761198B1 (de) 1995-09-12 1996-09-04 Katheter für die perkutane enterale Ernährung

Country Status (7)

Country Link
EP (1) EP0761198B1 (no)
AT (1) ATE210419T1 (no)
DE (2) DE19533749A1 (no)
DK (1) DK0761198T3 (no)
ES (1) ES2165949T3 (no)
NO (1) NO311331B1 (no)
PT (1) PT761198E (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10055281B4 (de) * 2000-11-08 2004-12-23 Fresenius Kabi Deutschland Gmbh Adapter für eine PEG-Sonde
DE10131152B4 (de) * 2001-04-30 2004-05-27 Nutricia Healthcare S.A. Medizinisches Ballon-Button-System

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102342A (en) * 1975-12-29 1978-07-25 Taichiro Akiyama Valved device
WO1990012611A1 (en) * 1989-04-21 1990-11-01 Ash Medical Systems, Inc. Non-intravascular infusion access device
WO1992019314A1 (en) * 1991-05-03 1992-11-12 Bierman Steven F Sideport connector for catheterization system
US5267969A (en) * 1992-10-08 1993-12-07 Abbott Laboratories External retaining device for feeding tube or the like
JP3073019B2 (ja) * 1993-01-07 2000-08-07 メディカル・イノヴェーションズ・コーポレーション 胃瘻形成術用カテーテル・システム

Also Published As

Publication number Publication date
NO963590D0 (no) 1996-08-28
DE59608419D1 (de) 2002-01-24
ES2165949T3 (es) 2002-04-01
ATE210419T1 (de) 2001-12-15
NO311331B1 (no) 2001-11-19
PT761198E (pt) 2002-05-31
DE19533749A1 (de) 1997-03-13
NO963590L (no) 1997-03-13
DK0761198T3 (da) 2002-03-18
EP0761198A1 (de) 1997-03-12

Similar Documents

Publication Publication Date Title
DE102006053219B4 (de) Tropfkammer für ein Infusionsgerät und Infusionsgerät mit einer Tropfkammer sowie Anordnung bestehend aus einem Infusionsbehältnis und einem Infusionsgerät
DE60013092T2 (de) Ballonkatheter für den Magen mit verbesserter Ballonorientierung
DE68916960T2 (de) Einen ballon aufweisendes instrument zum kontinuierlichen injizieren einer medizinischen flüssigkeit.
EP2355888A1 (de) Konnektor mit membran zum anschluss einer spritze an ein behältnis oder eine schlauchleitung
DE1675448A1 (de) Einweg-Durchflussventil
DE2238722B2 (de) Katheter
WO1995029661A1 (de) Einstückige appliziervorrichtung zur kontaminationsfreien verabreichung von arzneimitteln (zytostatika)
DE2735086A1 (de) Katheter zur untersuchung oder behandlung eines blutgefaesses, nebst geraet zum einsatz des katheters
EP1331962B1 (de) Adapter für eine peg-sonde
DE3919740A1 (de) Geraet zum einsetzen einer suprapubischen blasenfistel
DE102009004461A1 (de) Infusionsbesteck mit integriertem 3-Wege-Hahn zur Infusionsvorbereitung und Zuspritzung (Chamber Spike vented/not vented)
EP0824929B1 (de) Katheter für die perkutane enterale Ernährung
EP1331912B1 (de) Adapter für eine peg-sonde
DE10139644B4 (de) Montageteil für einen Adapter einer PEG-Sonde und Adapter für eine PEG-Sonde mit einem derartigen Montageteil
EP0761198B1 (de) Katheter für die perkutane enterale Ernährung
DE2918326A1 (de) Mit einer kunststoffkanuele verbundenes anschlusstueck
DE3140192A1 (de) Katheter
DE3731590C1 (en) Medical probe
WO2003039383A1 (de) Mandrin für einen katheter, längenmesser zur bestimmung der stomalänge und set zur enteralen ernährung
DE1541237B2 (de) Trokar
DE102006001255A1 (de) Kathetervorrichtung
EP3595610A1 (de) Entnahmekappe für einen behälter
DE2106266C2 (de) Mehrwegeventil, das zum Anschluß an eine Kanülenbaugruppe bestimmt ist
DE10051593C2 (de) PEG-Sonden-Adapter
DE7812248U1 (de) Injektionsventil zum Einsetzen in die Verbindung zwischen einer Injektionsspritze und einer Leitungsbahn für Infusionslösungen

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

17P Request for examination filed

Effective date: 19970715

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

17Q First examination report despatched

Effective date: 20001103

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

RBV Designated contracting states (corrected)

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

REF Corresponds to:

Ref document number: 210419

Country of ref document: AT

Date of ref document: 20011215

Kind code of ref document: T

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: GERMAN

REF Corresponds to:

Ref document number: 59608419

Country of ref document: DE

Date of ref document: 20020124

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 20020225

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2165949

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20020306

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20020400973

Country of ref document: GR

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20020814

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20020822

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20020826

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20020904

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20020916

Year of fee payment: 7

Ref country code: FR

Payment date: 20020916

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20020918

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20020919

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20020920

Year of fee payment: 7

Ref country code: FI

Payment date: 20020920

Year of fee payment: 7

Ref country code: CH

Payment date: 20020920

Year of fee payment: 7

Ref country code: BE

Payment date: 20020920

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 20020923

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20020926

Year of fee payment: 7

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20021116

Year of fee payment: 7

26N No opposition filed
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030904

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030904

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030904

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030904

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030904

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030905

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030905

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030930

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030930

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030930

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030930

BERE Be: lapsed

Owner name: *FRESENIUS A.G.

Effective date: 20030930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040401

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040402

GBPC Gb: european patent ceased through non-payment of renewal fee
EUG Se: european patent has lapsed
REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040528

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee

Effective date: 20040401

REG Reference to a national code

Ref country code: PT

Ref legal event code: MM4A

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040331

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20030905

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050904