EP0695575B1 - Procédé et dispositif de fabrication de systèmes dispersés, en particulier des onguents, crèmes, suspensions, émulsions, gels ou pâtes - Google Patents
Procédé et dispositif de fabrication de systèmes dispersés, en particulier des onguents, crèmes, suspensions, émulsions, gels ou pâtes Download PDFInfo
- Publication number
- EP0695575B1 EP0695575B1 EP95111721A EP95111721A EP0695575B1 EP 0695575 B1 EP0695575 B1 EP 0695575B1 EP 95111721 A EP95111721 A EP 95111721A EP 95111721 A EP95111721 A EP 95111721A EP 0695575 B1 EP0695575 B1 EP 0695575B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- bag
- pressing
- ribs
- contents
- pressing plates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/18—Controlling escape of air from containers or receptacles during filling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/55—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being contained in a flexible bag submitted to periodical deformation
Definitions
- the invention relates to a method for producing disperse Systems, especially of ointments, creams, suspensions, emulsions, Gels or pastes and devices for carrying them out steps of this procedure.
- Disperse systems such as ointments, creams, suspensions, emulsions, So far, gels or pastes have mainly been mixed by stirring of the individual components of the mixture.
- the stirring method has considerable disadvantages. It is time consuming and remains in the stirrers noticeable proportion of the mix on the walls of the device and the stirring tools back.
- the mixing process can be practical do not take place in the absence of air, and heating or cooling of the mix can be unfavorable because of the existing Heat transfer conditions in the devices only take place relatively slowly.
- US-A-3,332,670 describes a mixing device which has a hand-operated scooter, with which the mix in a bag from a Position is moved to another position in which the Bag walls through the profiled roller on changing Digits are squeezed together.
- FR-A-2.152.618 also describes a similar mixing device, in which a bag of mixed material is purely pressurized is subjected to pressure here by two driven plunger is generated.
- the invention has for its object a method and To create devices with significant savings Time and energy a lossless production of disperse Allow systems.
- the object is achieved by a method with the procedural steps apparent from the main claim solved.
- the pressure on the bag and its contents Walking can be done in different ways, whereby it must be ensured that the components of the mixture the pressure influence in the observed free volume of the Bag can dodge.
- the method can be advantageously perform with a facility that is for the individual Method steps devices designed according to the invention has, in particular a device for walking the with Mix components filled bag, which advantageously in a rigid frame at least a pair of interacting fulling plates with profiled Surface are slidably mounted parallel to each other on their mutually facing surfaces with predominantly across edge-free arched in the direction of displacement Ribs are provided, between which flat grooves are formed are.
- the walking device can be easily adapt to different blending quantities, whereby expediently arranged the interchangeable flex plates and also as exchangeable plates with different profiles on the can be formed both plate surfaces.
- the whale boards can also use height-adjustable ribs for adjustment have different blending amounts.
- the fulling plates can be profiled Surfaces made of a highly heat-conductive metallic Material manufactured and, if desired, heatable or coolable be trained.
- the back and forth movement of the whale plates can be motorized using conventional gears or smaller devices can also be effected by hand.
- the disperse mass formed can quickly and residue-free into a tube body after the milling process contribute.
- the introduction of a pasty mixture into a tube body with the bag or with a subsequent trigger of the bag is from the applicant's German patent 39 27 996 known.
- the contents of the bag can be placed in dispensing containers expressed like tubes and the bag with a new mixture can be filled for processing.
- Fig. 1 shows part of a leg of a stationary device frame 10, on the inside with a distance and parallel to each other two rails 11 and 12 for ball-bearing Wheels 13 are attached.
- the impellers of which two are shown individually, several are on an upper one Carriage 14 and flying on a lower carriage 15 stored.
- the two slides 14 and 15 are used for interchangeable recording from a whale plate 16 or 17 and are about gear parts, not shown, for example via a simple endless chain drive, with each other in terms of drive so coupled that they are always opposite to each other Carry out a reciprocating motion as arrows 19 Show.
- the drive can be motor or manual.
- the limit two walk plates 16 and 17 arranged parallel to one another a walking gap 18 between them and point to their the Walk gap 18 bounding sides on a corrugated surface, formed by flat arched ribs 20, which are formed by grooves 21 are separated from each other and which are preferably transverse to the Direction of displacement of the flex plates 16 and 17 run. Between the end face of the ribs 20 is the fulling gap 18 on narrowest.
- the opposite direction of displacement of the two Walk plates 16 and 17 are indicated by arrows 22 and 23.
- the walking gap 18 there is one with the components a disperse mixture of filled, laid flat tubular flexible plastic bag 25.
- the walking gap 18 delimiting Surfaces of the two fulling plates 16 and 17 is the Plastic bag 25 with its contents rolled and intense drummed, so that in a short time an intimately mixed Mass is created.
- Both flex plates 16 and 17 are designed as indexable inserts and on both sides with a different profile Mistake.
- the inactive upper side of the fulling plate in FIG. 2 16 and lower side of the fulling plate 17 are with narrower, more corrugated transverse ribs 20 'and accordingly intermediate grooves 21 'formed as the active here Sides of the whale panels.
- the walk plates made of aluminum or the ribs 20 'can have channels 28 for insertion of cartridge heaters or to carry a liquid Heating or coolant may be provided, as in Fig. 2 on the Walk plate 17 is shown.
- Fig. 1 shows another flex plate 24, the Surfaces of the fulling plates also have an irregular profile, for example, changing with their direction, width and depth Grooves 26 and accordingly vary in width Ribs 27 may be provided, which during the flexing process on the Walkgut not only forces in the directions of movement of the walking plates, but also reinforces power components that are directed at an angle be exercised. This allows the mixing process further intensify and accelerate.
- FIG. 3a and 3b show two fulling plates 16 'and 17', the are provided with height-adjustable ribs 20 '.
- the height adjustable Ribs 20 'thus allow the adjustment of the walking gap.
- FIG. 4a to 4e show further devices for walking of a bag 125.
- a fulling plate 110 is shown, with the help of the bag 125 on a base plate 111 is rolled.
- the flex plate 110 is provided with ribs 120 provided that cause the contents of the bag to pass through.
- Fig. 4b (not covered by the device claims) shows a flexible walk mat 112, which is also included Walk ribs 113 is provided. The mat 112 is wrapped and the bag 125 'interposed and tumbled.
- the 4c to 4e show an elastic flex tube 115, which provided on the inside with a number of ribs 116 is.
- the tube 115 is then flattened and moved over a base plate 117 (Fig. 4d). By Rolling the bag 125 '' is the content of the Ribs 116 thoroughly milled. The tube 115 can also are moved mechanically, as can be seen from Fig. 4e.
- machine 130 has a drive belt 131, which Pipe 115 set in rotation. That is on the other pages Pipe 115 passed through rollers 132. The direction of the conveyor belt 131 can be reversible.
- the pouch can be placed in a pouch filled with a suitably tempered liquid and tumbled together with the latter using one of the flexing devices shown.
- the additional bag can also be simply rolled through parallel to the bag with the mix and in the process deliver its temperature to the mix.
- an additional bag can also be used for volume compensation in the case of an unadjustable flexing device and only a small amount of a disperse system to be produced.
- Emulsification time now instead of approx. 15 minutes only 15 seconds. Subsequent stirring (see above) is not required and it can be instant, lossless Filling takes place (insert the mixing bag with its contents into the tube in about 15 seconds). Easy in-process and final inspection. Are there wax-like components (e.g. Cera flava), they are made by heating the whole The mixture melted. Thereafter, according to the invention Dispersing, suspending, emulsifying in one operation and homogenizing. The extremely high dispersion performance of the Devices according to the invention also allow simultaneous very rapid cooling of the mixture to 25 ° C. temperature-sensitive Mix components are preferably added later incorporated; equally crystallizing.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Bag Frames (AREA)
- Fluid-Damping Devices (AREA)
- Basic Packing Technique (AREA)
Claims (19)
- Procédé de fabrication de systèmes dispersés, en particulier de pommades, crèmes, suspensions, émulsions, gels ou pâtes, au moyen d'un dispositif, caractérisé par les étapes de procédé suivantes :a) introduction des ingrédients du mélange dans une poche souple en réservant un volume vide ;b) fermeture de l'extrémité ouverte de la poche après évacuation de l'air se trouvant dans la poche ;c) sollicitation en pression de la poche et de son contenu en des endroits alternés et dans des directions alternées par foulage de la poche, de préférence transversalement à son axe longitudinal, le contenu de la poche étant trituré entre les surfaces intérieures de la poche, lesquelles sont déplacées dans des directions opposées l'une par rapport à l'autre.
- Procédé selon la revendication 1, caractérisé en ce que le remplissage de la poche est limité à 50 % au maximum du volume de la poche.
- Procédé selon la revendication 1, caractérisé en ce que la fermeture de l'extrémité ouverte de la poche s'effectue par soudage de la poche fabriquée au moins partiellement en matériau soudable ou par nouage.
- Procédé selon la revendication 1, caractérisé en ce que l'évacuation de l'air hors de la poche s'effectue en plongeant verticalement la poche remplie dans du liquide et en fermant au-dessous de la surface du liquide ou en aplatissant la poche de bas en haut, de préférence en maintenant la poche verticalement.
- Procédé selon la revendication 1, caractérisé en ce que l'évacuation de l'air hors de la poche s'effectue par aplatissement.
- Procédé selon la revendication 1, caractérisé en ce que la sollicitation en pression de la poche et de son contenu par foulage s'effectue au choixau moyen d'une plaque de foulage, avec laquelle la poche est roulée sur un support de préférence pourvu d'une surface adhérente,ou au moyen d'un tapis de foulage dans lequel la poche est insérée,ou au moyen d'un tube élastique de foulage qui peut être comprimé à plat et dans lequel la poche est insérée,ou au moyen de surfaces profilées mobiles en sens contraire les unes par rapport aux autres, entre lesquelles la poche est insérée.
- Procédé selon la revendication 1 ou 6, caractérisé en ce que, à l'issue de la sollicitation en pression, la poche est divisée en poches portionnées fermées individuelles au moyen d'un dispositif de séparation-soudage.
- Procédé selon l'une des revendications 1 à 7, caractérisé en ce que, après la sollicitation en pression de la poche et de son contenu, le mélange fini, dans la poche ou sans poche, est introduit dans un récipient de stockage ou de prélèvement.
- Procédé selon l'une des revendications 1 à 8, caractérisé en ce qu'il est réalisable à de multiples reprises à température ambiante.
- Procédé selon l'une des revendications 1 à 9, caractérisé en ce qu'il peut être mis en oeuvre pour fabriquer de petites quantités de systèmes dispersés ou, dans des installations de traitement, pour fabriquer de grandes quantités de systèmes dispersés.
- Procédé selon la revendication 10, caractérisé en ce que différents systèmes dispersés peuvent être fabriqués parallèlement les uns aux autres dans des installations de traitement.
- Dispositif pour la mise en oeuvre d'étapes du procédé selon l'une des revendications 1 à 11, caractérisé en ce qu'il comporte un dispositif pour le foulage de la poche (25), dans lequel au moins une paire de plaques de foulage (16, 17) à surfaces profilées coopérant entre elles sont logées dans un cadre fixe (10) de manière parallèle et mobile dans des directions mutuellement opposées, lesdites plaques de foulage étant pourvues, sur leurs surfaces en vis-à-vis, de nervures bombées sans arête (20, 20') qui s'étendent pour l'essentiel transversalement à la direction de déplacement (19, 20, 23) et entre lesquelles sont ménagées des rainures (21, 21').
- Dispositif selon la revendication 12, caractérisé en ce que les rainures (26) et donc les nervures (27) des plaques de foulage (24) ont des sections transversales alternées et/ou des directions alternées.
- Dispositif selon la revendication 12 ou 13, caractérisé en ce que les plaques de foulage (16, 17) sont disposées de manière échangeable dans des chariots mobiles (14, 15) et sont pourvues, des deux côtés, de profilages différents.
- Dispositif selon l'une des revendications 12 à 14, caractérisé en ce que les plaques de foulage (16, 17, 24) sont fabriquées avec leurs surfaces profilées en un matériau métallique.
- Dispositif selon l'une des revendications 12 à 15, caractérisé en ce que l'écartement des plaques de foulage (16, 17) et la hauteur des nervures (27) sont réglables.
- Dispositif pour la mise en oeuvre d'étapes du procédé selon l'une des revendications 1 à 11, caractérisé en ce qu'il comporte un tube élastique (115) pourvu de nervures de foulage sur le côté intérieur et dans lequel la poche (125'') peut être insérée.
- Dispositif selon la revendication 7, caractérisé en ce que le tube de foulage peut être actionné par une machine, une rotation permanente du tube s'effectuant en même temps qu'une pression est exercée soit dans une direction soit dans des directions alternées.
- Dispositif selon l'une des revendications 12 à 16 ou 18, caractérisé en ce qu'au moins une plaque de foulage est conçue pour être chauffée ou refroidie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4426421A DE4426421A1 (de) | 1994-07-26 | 1994-07-26 | Verfahren und Vorrichtung zur Herstellung disperser Systeme, insbesondere Salben, Cremes, Suspensionen, Emulsionen, Gele oder Pasten |
DE4426421 | 1994-07-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0695575A2 EP0695575A2 (fr) | 1996-02-07 |
EP0695575A3 EP0695575A3 (fr) | 1996-03-27 |
EP0695575B1 true EP0695575B1 (fr) | 2002-01-09 |
Family
ID=6524160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95111721A Expired - Lifetime EP0695575B1 (fr) | 1994-07-26 | 1995-07-25 | Procédé et dispositif de fabrication de systèmes dispersés, en particulier des onguents, crèmes, suspensions, émulsions, gels ou pâtes |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0695575B1 (fr) |
AT (1) | ATE211656T1 (fr) |
DE (2) | DE4426421A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7614781B2 (en) | 2002-11-20 | 2009-11-10 | Conopco, Inc. | Apparatus and method for mixing components |
EP2429486B1 (fr) | 2009-05-11 | 2017-08-23 | Teoxane | Procédé de préparation d'un gel réticulé |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19616823C2 (de) * | 1996-04-26 | 2000-04-20 | Murjahn Amphibolin Werke | Verfahren zum Abtönen von pulverförmigen Produkten mit Pigmenten |
SE507614C2 (sv) * | 1996-12-19 | 1998-06-29 | Tetra Laval Holdings & Finance | Metod och anordning för att vibrera en i en aseptisk påse innesluten vätska |
GB9819897D0 (en) * | 1998-09-11 | 1998-11-04 | Seward Limited | Devices for blending materials |
GB9922682D0 (en) * | 1999-09-25 | 1999-11-24 | Rogers Christopher R | Mixing apparatus and method |
US7377686B2 (en) * | 2003-09-04 | 2008-05-27 | Millipore Corporation | Disposable mixing system |
US8518069B2 (en) | 2005-09-07 | 2013-08-27 | Cabochon Aesthetics, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US9358033B2 (en) | 2005-09-07 | 2016-06-07 | Ulthera, Inc. | Fluid-jet dissection system and method for reducing the appearance of cellulite |
US9011473B2 (en) | 2005-09-07 | 2015-04-21 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US10548659B2 (en) | 2006-01-17 | 2020-02-04 | Ulthera, Inc. | High pressure pre-burst for improved fluid delivery |
US9486274B2 (en) | 2005-09-07 | 2016-11-08 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US7885793B2 (en) | 2007-05-22 | 2011-02-08 | International Business Machines Corporation | Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution |
US8439940B2 (en) | 2010-12-22 | 2013-05-14 | Cabochon Aesthetics, Inc. | Dissection handpiece with aspiration means for reducing the appearance of cellulite |
US8167280B2 (en) | 2009-03-23 | 2012-05-01 | Cabochon Aesthetics, Inc. | Bubble generator having disposable bubble cartridges |
US11096708B2 (en) | 2009-08-07 | 2021-08-24 | Ulthera, Inc. | Devices and methods for performing subcutaneous surgery |
US9358064B2 (en) | 2009-08-07 | 2016-06-07 | Ulthera, Inc. | Handpiece and methods for performing subcutaneous surgery |
DK2951452T3 (en) * | 2013-02-01 | 2016-11-28 | Asociación Centro De Investigación Coop En Biomateriales Cic Biomagune | Non-intrusive agitator |
US20140322396A1 (en) * | 2013-04-30 | 2014-10-30 | J.R. Simplot Company | System and method for packaging a frozen product |
FR3026622B1 (fr) * | 2014-10-07 | 2016-12-30 | Laboratoires M&L | Systeme de fabrication d'un produit cosmetique par melange a partir de plusieurs unites de conditionnement a usage unique. |
FR3090398B1 (fr) | 2018-12-21 | 2021-06-25 | Seb Sa | Appareil de fabrication, machine à mélange et/ou dispositif de réception pour la fabrication d’une composition à partir d’un mélange de formulations |
FR3090407B1 (fr) | 2018-12-21 | 2020-12-04 | Seb Sa | Appareil de fabrication, machine à mélange et/ou dispositif de réception pour la fabrication d’une composition à partir d’un mélange de formulations |
FR3090396B1 (fr) | 2018-12-21 | 2023-03-31 | Seb Sa | Appareil de fabrication, machine à mélange et/ou dispositif de réception pour la fabrication d’une composition à partir d’un mélange de formulations |
FR3090399B1 (fr) * | 2018-12-21 | 2021-09-17 | Seb Sa | Appareil de fabrication, machine à mélange et/ou dispositif de réception pour la fabrication d’une composition à partir d’un mélange de formulations |
FR3090397B1 (fr) | 2018-12-21 | 2021-09-17 | Seb Sa | Appareil de fabrication, machine à mélange et/ou dispositif de réception pour la fabrication d’une composition à partir d’un mélange de formulations |
GB2586567B (en) * | 2019-03-01 | 2023-10-18 | Asymptote Ltd | Closed tissue disaggregation and cryopreservation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3332670A (en) * | 1964-12-15 | 1967-07-25 | Tra Can Inc | Blending device |
US3543966A (en) * | 1968-10-16 | 1970-12-01 | Mattel Inc | Mixing and dispensing device |
BE788274A (fr) * | 1971-09-06 | 1973-02-28 | Unilever Nv | Dispositifs servant a melanger des matieres |
FR2541623B1 (fr) * | 1983-02-25 | 1985-06-21 | Roth Sa Freres | Sac auto-expansible par une mousse de polyurethane avec dispositif de melange par barbotage d'air |
US5238303A (en) * | 1989-01-18 | 1993-08-24 | Dixon James D | Method of and apparatus for mixing of fluent materials enclosed in a bag |
DE3927996C1 (fr) * | 1989-08-24 | 1991-01-24 | Heinz 7417 Pfullingen De Hartmann | |
DE4014051A1 (de) * | 1990-05-02 | 1991-11-07 | Schreiber Hans | Verfahren und vorrichtung zum mischen von wenigstens zwei materialkomponenten, insbesondere von zahnaerztlichen abdruckmaterialien |
-
1994
- 1994-07-26 DE DE4426421A patent/DE4426421A1/de not_active Withdrawn
-
1995
- 1995-07-25 EP EP95111721A patent/EP0695575B1/fr not_active Expired - Lifetime
- 1995-07-25 DE DE59509985T patent/DE59509985D1/de not_active Expired - Lifetime
- 1995-07-25 AT AT95111721T patent/ATE211656T1/de not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7614781B2 (en) | 2002-11-20 | 2009-11-10 | Conopco, Inc. | Apparatus and method for mixing components |
EP2429486B1 (fr) | 2009-05-11 | 2017-08-23 | Teoxane | Procédé de préparation d'un gel réticulé |
Also Published As
Publication number | Publication date |
---|---|
EP0695575A2 (fr) | 1996-02-07 |
ATE211656T1 (de) | 2002-01-15 |
DE4426421A1 (de) | 1996-02-01 |
DE59509985D1 (de) | 2002-02-14 |
EP0695575A3 (fr) | 1996-03-27 |
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