GB2586567B - Closed tissue disaggregation and cryopreservation - Google Patents

Closed tissue disaggregation and cryopreservation Download PDF

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Publication number
GB2586567B
GB2586567B GB1902763.0A GB201902763A GB2586567B GB 2586567 B GB2586567 B GB 2586567B GB 201902763 A GB201902763 A GB 201902763A GB 2586567 B GB2586567 B GB 2586567B
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GB
United Kingdom
Prior art keywords
cryopreservation
tissue disaggregation
closed tissue
closed
disaggregation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1902763.0A
Other versions
GB2586567A (en
GB201902763D0 (en
Inventor
John Morris George
Lamb Stephen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asymptote Ltd
Original Assignee
Asymptote Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asymptote Ltd filed Critical Asymptote Ltd
Priority to GB1902763.0A priority Critical patent/GB2586567B/en
Publication of GB201902763D0 publication Critical patent/GB201902763D0/en
Priority to PCT/EP2020/000053 priority patent/WO2020177920A2/en
Priority to US17/433,463 priority patent/US20220145234A1/en
Priority to CA3128778A priority patent/CA3128778A1/en
Priority to KR1020217027460A priority patent/KR20210135233A/en
Priority to EP20726700.6A priority patent/EP3931299A2/en
Priority to CN202080017908.7A priority patent/CN113508284A/en
Priority to JP2021551820A priority patent/JP2022522793A/en
Priority to AU2020230753A priority patent/AU2020230753A1/en
Publication of GB2586567A publication Critical patent/GB2586567A/en
Application granted granted Critical
Publication of GB2586567B publication Critical patent/GB2586567B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/08—Apparatus for tissue disaggregation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/55—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being contained in a flexible bag submitted to periodical deformation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F35/92—Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C1/00—Crushing or disintegrating by reciprocating members
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/33—Disintegrators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/20—Heating; Cooling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2866—Grinding or homogeneising

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
GB1902763.0A 2019-03-01 2019-03-01 Closed tissue disaggregation and cryopreservation Active GB2586567B (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GB1902763.0A GB2586567B (en) 2019-03-01 2019-03-01 Closed tissue disaggregation and cryopreservation
CN202080017908.7A CN113508284A (en) 2019-03-01 2020-02-28 Closed tissue dissociation and cryopreservation
US17/433,463 US20220145234A1 (en) 2019-03-01 2020-02-28 Closed Tissue Disaggregation and Cryopreservation
CA3128778A CA3128778A1 (en) 2019-03-01 2020-02-28 Closed tissue disaggregation and cryopreservation
KR1020217027460A KR20210135233A (en) 2019-03-01 2020-02-28 Closed tissue degradation and cryopreservation
EP20726700.6A EP3931299A2 (en) 2019-03-01 2020-02-28 Closed tissue disaggregation and cryopreservation
PCT/EP2020/000053 WO2020177920A2 (en) 2019-03-01 2020-02-28 Closed tissue disaggregation and cryopreservation
JP2021551820A JP2022522793A (en) 2019-03-01 2020-02-28 Closed tissue separation and freezing
AU2020230753A AU2020230753A1 (en) 2019-03-01 2020-02-28 Closed tissue disaggregation and cryopreservation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1902763.0A GB2586567B (en) 2019-03-01 2019-03-01 Closed tissue disaggregation and cryopreservation

Publications (3)

Publication Number Publication Date
GB201902763D0 GB201902763D0 (en) 2019-04-17
GB2586567A GB2586567A (en) 2021-03-03
GB2586567B true GB2586567B (en) 2023-10-18

Family

ID=66377406

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1902763.0A Active GB2586567B (en) 2019-03-01 2019-03-01 Closed tissue disaggregation and cryopreservation

Country Status (1)

Country Link
GB (1) GB2586567B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4426421A1 (en) * 1994-07-26 1996-02-01 Heinz Hartmann Process and device for the production of disperse systems, in particular ointments, creams, suspensions, emulsions, gels or pastes
EP0968760A1 (en) * 1998-07-01 2000-01-05 Interlab Mixer for preparating microbiological analysis and/or test samples
US20170172173A1 (en) * 2014-02-14 2017-06-22 Cedra S.A. Thermoregulated device for modifying the consistency of a composition and method for operating the device
WO2018130845A1 (en) * 2017-01-13 2018-07-19 Cellular Therapeutics Ltd Aseptic tissue processing method, kit and device
WO2018185467A1 (en) * 2017-04-07 2018-10-11 Asymptote Ltd Cryopreservation apparatus and methods

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4426421A1 (en) * 1994-07-26 1996-02-01 Heinz Hartmann Process and device for the production of disperse systems, in particular ointments, creams, suspensions, emulsions, gels or pastes
EP0968760A1 (en) * 1998-07-01 2000-01-05 Interlab Mixer for preparating microbiological analysis and/or test samples
US20170172173A1 (en) * 2014-02-14 2017-06-22 Cedra S.A. Thermoregulated device for modifying the consistency of a composition and method for operating the device
WO2018130845A1 (en) * 2017-01-13 2018-07-19 Cellular Therapeutics Ltd Aseptic tissue processing method, kit and device
WO2018185467A1 (en) * 2017-04-07 2018-10-11 Asymptote Ltd Cryopreservation apparatus and methods

Also Published As

Publication number Publication date
GB2586567A (en) 2021-03-03
GB201902763D0 (en) 2019-04-17

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