EP0674518A1 - Application de la lamotrigine dans le traitement de lesions neurologiques liees a des traumatismes - Google Patents
Application de la lamotrigine dans le traitement de lesions neurologiques liees a des traumatismesInfo
- Publication number
- EP0674518A1 EP0674518A1 EP94902802A EP94902802A EP0674518A1 EP 0674518 A1 EP0674518 A1 EP 0674518A1 EP 94902802 A EP94902802 A EP 94902802A EP 94902802 A EP94902802 A EP 94902802A EP 0674518 A1 EP0674518 A1 EP 0674518A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- treatment
- lamotrigine
- neurological lesions
- spinal
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Definitions
- the present invention relates to a new therapeutic application of lamotrigine or the pharmaceutically acceptable salts of this compound.
- Lamotrigine and the pharmaceutically acceptable salts of this compound are described as anticonvulsants and antiepileptics in particular in patent EP 247892.
- this compound can also be used in the treatment of neurological lesions linked to traumas and, in particular, to spinal, cranial or cranio-spinal traumas.
- lamotrigine decreases the neurological deficit of the animals (paraplegia) linked to the lesion of the spinal cord as well as the histopathological lesions (necrosis of the cord). This reduction is generally equal to or greater than 5%.
- a) preparation of the animal the rabbits are injected intramuscularly with 5 mg of valium® and 1/16 mg of atropine. 30 minutes later, an isotonic saline infusion is set up and the rabbits are anesthetized by injection 40 mg / kg slow intravenous injection of Nesdonal®. We then put in place a cardioscope because the animal may present, especially during re-injections of Nesdonal®, lasting apnea with bradycardia.
- PES somesthesic evoked potentials
- the trauma is carried out by inflating the balloon of a Fogarty French 3 probe placed in the spinal canal in the extradural position. For this, we perform a low lumbar laminectomy. The opening of the yellow ligament allows the passage of the probe up to the level of the first lumbar vertebra and the operating wound is closed. A new PES is recorded to ensure that there is no functional lesion during the passage of the probe. The lesion is then carried out by inflating the balloon with variable amounts of air (0.2; 0.4 and 0.55 ml of air) then the probe is removed. A new PES is performed just after the trauma and is compared (amplitudes and latencies) to the reference PES.
- the product is injected intraperitoneally once a day for 5 days, at doses between 1 and 8 mg / kg.
- a spinal cord block is taken comprising the injured level which is placed in 10% formalin. A week later, the cord is extracted from the block (this fixation period seems necessary to avoid post-mortem injury). A hemorrhagic area visible to the naked eye shows the level of trauma. Staged histological sections specify the extent of the lesions.
- lamotrigine makes it possible to decrease the neurological deficit linked to the lesion of the spinal cord, to protect the sensitive neurological pathways and to decrease the necrotic hemorrhagic zone within the gray substance of the spinal cord. These decreases are generally equal to or greater than 5%.
- lamotrigine improves the neurological score of animals that have suffered a head trauma and reduces necrotic lesions. This reduction is generally equal to or greater than 5%.
- salts As pharmaceutically acceptable salts, mention may in particular be made of addition salts with mineral acids such as hydrochloride, sulfate, nitrate, phosphate or organic salts such as acetate, propionate, succinate, oxalate, benzoate, fumarate. maleate, methanesulfonate, isethionate, theophillin-acetate, salicylate, phenolphthalinate, methylene-bis- ⁇ -oxynaphtoate or substitution derivatives of these derivatives.
- mineral acids such as hydrochloride, sulfate, nitrate, phosphate or organic salts such as acetate, propionate, succinate, oxalate, benzoate, fumarate. maleate, methanesulfonate, isethionate, theophillin-acetate, salicylate, phenolphthalinate, methylene-bis- ⁇ -oxynaphtoate or substitution derivatives of these derivatives.
- the medicaments consist of at least lamotrigine in free form or in the form of an addition salt with a pharmaceutically acceptable acid, in the pure state or in the form of a composition in which it is associated with any other pharmaceutical product. compatible, possibly inert or physiologically active.
- the medicaments according to the invention can be used orally or parenterally.
- compositions for oral administration tablets, pills, powders (gelatin capsules, cachets) or granules can be used.
- the active principle according to the invention is mixed with one or more inert diluents, such as starch, cellulose, sucrose, lactose or silica, under a stream of argon.
- these compositions can also include substances other than thinners, for example one or more lubricants such as magnesium stearate or talc, a colorant, a coating (dragees) or a varnish.
- compositions for oral administration there can be used pharmaceutically acceptable solutions, suspensions, emulsions, syrups and elixirs containing diluents .
- inert such as water, ethanol, glycerol, vegetable oils or paraffin oil.
- These compositions can include substances other than diluents, for example wetting, sweetening, thickening, flavoring or stabilizing products.
- the sterile compositions for parenteral administration can preferably be aqueous or non-aqueous solutions, suspensions or emulsions.
- solvent or vehicle water, propylene glycol, polyethylene glycol, vegetable oils, in particular olive oil, injectable organic esters, for example ethyl oleate or other organic solvents can be used. suitable.
- These compositions can also contain adjuvants, in particular wetting agents, isotonizers, emulsifiers, dispersants and stabilizers. Sterilization can be done in several ways, for example by aseptic filtration, by incorporating sterilizing agents into the composition, by irradiation or by heating. They can also be prepared in the form of sterile solid compositions which can be dissolved at the time of use in sterile water or any other sterile injectable medium.
- the doses depend on the desired effect, on the duration of the treatment and on the route of administration used; they are generally between 50 and 800 mg per day by the oral route for an adult with unit doses ranging from 25 to 200 mg of active substance and between 25 and 600 mg per day by the intravenous route for an adult with unit doses ranging from 12.5 to 200 mg of active substance.
- the doctor will determine the appropriate dosage based on age, weight and all other factors specific to the subject to be treated.
- Example A illustrate medicaments according to the invention:
- Tablets containing 50 mg of active product having the following composition are prepared according to the usual technique:
- capsules containing 50 mg of active product having the following composition are prepared:
- a solution for injection containing 10 mg of active product having the following composition is prepared:
- the invention also relates to the process for the preparation of medicaments useful in the treatment of neurological lesions linked to traumas and, in particular, to spinal, cranial or craniospinal traumas, consisting in mixing the lamotrigine or the pharmaceutically acceptable salts of this compound. with one or more compatible and pharmaceutically acceptable diluents and / or adjuvants.
- the invention also relates to a method of treatment of a mammal and, in particular, of a man presenting with neurological lesions linked to traumas and, in particular, to spinal, cranial or craniospinal traumas, comprising the administration of an effective amount of lamotrigine or the pharmaceutically acceptable salts of this compound.
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Data Exchanges In Wide-Area Networks (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9215148 | 1992-12-16 | ||
FR9215148A FR2699077B1 (fr) | 1992-12-16 | 1992-12-16 | Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes. |
PCT/FR1993/001227 WO1994013296A1 (fr) | 1992-12-16 | 1993-12-10 | Application de la lamotrigine dans le traitement de lesions neurologiques liees a des traumatismes |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0674518A1 true EP0674518A1 (fr) | 1995-10-04 |
Family
ID=9436652
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94902018A Ceased EP0674520A1 (fr) | 1992-12-16 | 1993-12-10 | Application de la carbamazepine et de l'oxcarbazepine dans le traitement de lesions neurologiques liees a des traumatismes |
EP94902019A Expired - Lifetime EP0674512B1 (fr) | 1992-12-16 | 1993-12-10 | Application du riluzole dans le traitement de lesions neurologiques liees a des traumatismes |
EP94902802A Withdrawn EP0674518A1 (fr) | 1992-12-16 | 1993-12-10 | Application de la lamotrigine dans le traitement de lesions neurologiques liees a des traumatismes |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94902018A Ceased EP0674520A1 (fr) | 1992-12-16 | 1993-12-10 | Application de la carbamazepine et de l'oxcarbazepine dans le traitement de lesions neurologiques liees a des traumatismes |
EP94902019A Expired - Lifetime EP0674512B1 (fr) | 1992-12-16 | 1993-12-10 | Application du riluzole dans le traitement de lesions neurologiques liees a des traumatismes |
Country Status (23)
Country | Link |
---|---|
US (1) | US5830907A (sk) |
EP (3) | EP0674520A1 (sk) |
JP (3) | JPH08504428A (sk) |
KR (3) | KR950703965A (sk) |
AT (1) | ATE164067T1 (sk) |
AU (3) | AU678795B2 (sk) |
CA (3) | CA2151603A1 (sk) |
CZ (3) | CZ154795A3 (sk) |
DE (1) | DE69317578T2 (sk) |
DK (1) | DK0674512T3 (sk) |
ES (1) | ES2113635T3 (sk) |
FR (1) | FR2699077B1 (sk) |
GR (1) | GR3026403T3 (sk) |
HU (3) | HUT71839A (sk) |
IL (3) | IL108053A0 (sk) |
MX (3) | MX9307883A (sk) |
NO (3) | NO952228D0 (sk) |
PL (3) | PL309348A1 (sk) |
RU (1) | RU2142800C1 (sk) |
SK (3) | SK78795A3 (sk) |
UA (1) | UA41906C2 (sk) |
WO (3) | WO1994013288A1 (sk) |
ZA (3) | ZA939400B (sk) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2700117B1 (fr) * | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens. |
GB9424766D0 (en) * | 1994-12-07 | 1995-02-08 | Wellcome Found | Pharmaceutical composition |
FR2733684B1 (fr) | 1995-05-03 | 1997-05-30 | Cird Galderma | Utilisation de retinoides dans une composition cosmetique ou pour la fabrication d'une composition pharmaceutique |
GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
US20020022056A1 (en) | 1997-02-14 | 2002-02-21 | Burkhard Schlutermann | Oxacarbazepine film-coated tablets |
CO4920215A1 (es) * | 1997-02-14 | 2000-05-29 | Novartis Ag | Tabletas de oxacarbazepina recubiertas de una pelicula y metodo para la produccion de estas formulaciones |
EP1369421B1 (en) * | 1997-09-05 | 2004-11-03 | Glaxo Group Limited | Pharmaceutical compositions comprising 2,3-Diaryl-pyrazolo[1,5-B]pyridazine derivatives |
GB9808015D0 (en) * | 1998-04-15 | 1998-06-17 | United Medical And Dental Scho | Protection of the nervous system from the effects of inflammatory disease |
US6150423A (en) * | 1998-10-15 | 2000-11-21 | Phoenix Scientific, Inc. | Propofol-based anesthetic and method of making same |
FR2787028B1 (fr) * | 1998-12-15 | 2002-10-18 | Aventis Pharma Sa | Utilisation du riluzole dans le traitement des traumatismes acoustiques |
US6239156B1 (en) * | 1999-04-29 | 2001-05-29 | Centre National De La Recherche Scientifique Cnrs | Method for the prevention of ischemic spinal cord injury caused by aortic crossclamping |
GB9925962D0 (en) * | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
GB9930058D0 (en) | 1999-12-20 | 2000-02-09 | Novartis Ag | Organic compounds |
US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
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Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0059987B1 (en) * | 1979-06-01 | 1985-08-14 | The Wellcome Foundation Limited | Alpha-cyano-alpha-((n-guanidino)-imino) toluenes |
US4431641A (en) * | 1980-10-17 | 1984-02-14 | Ciba-Geigy Corporation | Pharmaceutical compositions having antiepileptic and antineuralgic action |
FR2492258A1 (fr) * | 1980-10-17 | 1982-04-23 | Pharmindustrie | Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole |
GB8613183D0 (en) * | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
US4826860A (en) * | 1987-03-16 | 1989-05-02 | Warner-Lambert Company | Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents |
US4918090A (en) * | 1988-01-25 | 1990-04-17 | Warner-Lambert Company | Substituted 2-aminbenzothiazoles and derivatives useful as cerebrovascular agents |
US5240948A (en) * | 1989-12-13 | 1993-08-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | 3-(3-alkylthiopropyl)benzothiazoline derivatives, their preparation and the medicament containing them |
GB9012312D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
KR100246083B1 (ko) * | 1991-02-08 | 2000-03-15 | 버틀러 그레고리 비. | 신경전달물질의 방출조절물질인 치환 구아니딘류 및 그것의 유도체와 그들을 함유하는 약학 조성물 |
FR2688138B1 (fr) * | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
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1992
- 1992-12-16 FR FR9215148A patent/FR2699077B1/fr not_active Expired - Fee Related
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1993
- 1993-12-10 KR KR1019950702458A patent/KR950703965A/ko not_active Application Discontinuation
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- 1993-12-10 CA CA002151603A patent/CA2151603A1/fr not_active Abandoned
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- 1993-12-10 CA CA002151601A patent/CA2151601A1/fr not_active Abandoned
- 1993-12-10 PL PL93309347A patent/PL309347A1/xx unknown
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- 1993-12-10 KR KR1019950702460A patent/KR100298808B1/ko not_active IP Right Cessation
- 1993-12-10 DK DK94902019.2T patent/DK0674512T3/da active
- 1993-12-10 JP JP6513879A patent/JPH08504429A/ja active Pending
- 1993-12-10 HU HU9501751A patent/HU217133B/hu not_active IP Right Cessation
- 1993-12-10 SK SK785-95A patent/SK78595A3/sk unknown
- 1993-12-10 UA UA95062798A patent/UA41906C2/uk unknown
- 1993-12-10 WO PCT/FR1993/001228 patent/WO1994013298A1/fr not_active Application Discontinuation
- 1993-12-10 PL PL93309346A patent/PL309346A1/xx unknown
- 1993-12-10 CZ CZ951545A patent/CZ284420B6/cs not_active IP Right Cessation
- 1993-12-10 JP JP51388094A patent/JP3712239B2/ja not_active Expired - Fee Related
- 1993-12-10 KR KR1019950702459A patent/KR950703968A/ko not_active Application Discontinuation
- 1993-12-10 WO PCT/FR1993/001227 patent/WO1994013296A1/fr not_active Application Discontinuation
- 1993-12-10 RU RU95114405A patent/RU2142800C1/ru not_active IP Right Cessation
- 1993-12-10 AU AU57020/94A patent/AU5702094A/en not_active Abandoned
- 1993-12-10 EP EP94902019A patent/EP0674512B1/fr not_active Expired - Lifetime
- 1993-12-10 EP EP94902802A patent/EP0674518A1/fr not_active Withdrawn
- 1993-12-10 AU AU56539/94A patent/AU5653994A/en not_active Abandoned
- 1993-12-10 CA CA002151604A patent/CA2151604C/fr not_active Expired - Fee Related
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- 1993-12-13 MX MX9307884A patent/MX9307884A/es unknown
- 1993-12-15 ZA ZA939400A patent/ZA939400B/xx unknown
- 1993-12-15 ZA ZA939399A patent/ZA939399B/xx unknown
- 1993-12-15 ZA ZA939401A patent/ZA939401B/xx unknown
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- 1993-12-16 IL IL10805193A patent/IL108051A/en not_active IP Right Cessation
- 1993-12-16 IL IL10805293A patent/IL108052A0/xx unknown
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1995
- 1995-06-06 NO NO952228A patent/NO952228D0/no unknown
- 1995-06-06 NO NO952230A patent/NO307027B1/no not_active IP Right Cessation
- 1995-06-06 NO NO952229A patent/NO952229D0/no unknown
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1998
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Non-Patent Citations (1)
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