EP0611357A1 - Abgabevorrichtung für konservierungsmittelfreie sterile flüssigkeit. - Google Patents

Abgabevorrichtung für konservierungsmittelfreie sterile flüssigkeit.

Info

Publication number
EP0611357A1
EP0611357A1 EP92921558A EP92921558A EP0611357A1 EP 0611357 A1 EP0611357 A1 EP 0611357A1 EP 92921558 A EP92921558 A EP 92921558A EP 92921558 A EP92921558 A EP 92921558A EP 0611357 A1 EP0611357 A1 EP 0611357A1
Authority
EP
European Patent Office
Prior art keywords
valve
hydrophobic membrane
fluid dispensing
dispensing system
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP92921558A
Other languages
English (en)
French (fr)
Other versions
EP0611357B1 (de
Inventor
Stevem R Bystrom
Jesus F Martinez
Peter W Chan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JSP Partners LP
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0611357A1 publication Critical patent/EP0611357A1/de
Application granted granted Critical
Publication of EP0611357B1 publication Critical patent/EP0611357B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0062—Outlet valves actuated by the pressure of the fluid to be sprayed
    • B05B11/0075—Two outlet valves being placed in a delivery conduit, one downstream the other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/04—Deformable containers producing the flow, e.g. squeeze bottles
    • B05B11/047—Deformable containers producing the flow, e.g. squeeze bottles characterised by the outlet or venting means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K15/00—Check valves
    • F16K15/14—Check valves with flexible valve members
    • F16K15/144—Check valves with flexible valve members the closure elements being fixed along all or a part of their periphery
    • F16K15/147—Check valves with flexible valve members the closure elements being fixed along all or a part of their periphery the closure elements having specially formed slits or being of an elongated easily collapsible form
    • F16K15/1472—Check valves with flexible valve members the closure elements being fixed along all or a part of their periphery the closure elements having specially formed slits or being of an elongated easily collapsible form the closure elements being fixed onto an internally extending mount
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/7722—Line condition change responsive valves
    • Y10T137/7837—Direct response valves [i.e., check valve type]
    • Y10T137/7838—Plural
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/7722—Line condition change responsive valves
    • Y10T137/7837—Direct response valves [i.e., check valve type]
    • Y10T137/7879—Resilient material valve
    • Y10T137/788—Having expansible port
    • Y10T137/7882—Having exit lip

Definitions

  • the present invention relates to a fluid dispensing system specifically designed to deliver multidose sterile, .or homogenized and pasteurized, chemical preservative, antibacterial or antimicrobial additive free (hereinafter known collectively as "preservative free”) solutions. More, specifically, the present invention is directed to a fluid dispensing system with a dual self-sealing valve system to dispense multidose sterile solutions in a dropwise form.
  • the dual self-sealing valve system and hydrophobic air filter protects the solutions from contamination after multidose dispensing without the use of preservatives.
  • OTC over-the-counter
  • prescription preparations such as ophthalmic pharmaceutical, contact lens solutions, drop- administrated medicines for the ear or nose, and some consumer health care liquid solutions, such as creams, gels and lotions, must be kept sterile to prevent contamination from bacteria or other microbes.
  • the conventional means of preventing such contamination is to add a preservative or other antibacterial agent to the solution during packaging.
  • preservatives include benzalkoniu chloride, methyl parabens, propyl parabens, thimerosal and chlorobutanol.
  • Commonly used antibacterial agents include saline formulations. While these preservatives keep the enclosed solution sterile, the bottle itself may harbor
  • SUBSTITUTE SHEET external bacterial or microbial growth which is carried along with the outflow of fluids.
  • the preservatives themselves are often toxic, not just to bacteria or microbes, but also to the cells which are being treated by the bottled solution.
  • the preservatives used in most eye drops can disrupt the corneal epithelium, irritate conjunctival tissues and cause allergic reactions. Because of this toxicity level, continued use can cause more long-term problems than the solutions solve.
  • squeezable dispensing bottles containing saline formulations in the dispensing liquids may be provided with nozzles including filter membranes which are permeable to the dispensed liquid as well as being permeable to the air which must be aspirated through the nozzle to replace the dispensed liquid and reinflate or re-expand the container.
  • the filter membrane must be impermeable to bacteria in order to prevent the aspirated air from carrying bacteria into contact with the stored solution, and contaminating the solution due to repeated dispensing.
  • filter membrane materials which are sufficiently hydrophilic to permit permeation of the saline solution often permit retention of the saline solution on the filter so that the retained solution increases the resistance of the filter to passage of the aspirating air.
  • the partially obstructed flow of aspirating air not only retards the re-expansion of the squeezed bottle wall, but also impedes repeated squeezing of the bottle when large quantities of the solution must be dispensed.
  • portions of the filter are treated to repel the solution and improve air passage, the solution can sometimes leach the treating composition from the filter.
  • consumer food products such as milk and dairy products, must be kept refrigerated to reduce the contamination and/or action of bacteria or other microbes.
  • Container contamination can also be the result of particulate matter being drawn back into the container with the liquid in the dropper tip that has not been delivered as a drop. Over several drop deliveries, for example, in dusty conditions, a significant accumulation of dust in the container is possible.
  • U.S. Patent No. 4,938,389 describes a dispenser including a filter assembly having a hydrophobic filter and a hydrophilic filter in tandem with the hydrophobic filter located near the dispensing tip.
  • U.S. Patent No. 3,760,987 describes a snap assembled dispensing package and cover made up of a container which has a tapered shank on its discharge end and a piercing device, snappably connected to the container, which also serves as a conduit for dispensing the medicament.
  • the dispensing package further contains an air filter and a solution filter.
  • BSTITUTE SHEET drop dispenser with a single hydrophobic and microporous antibacterial filter that provide a barrier to the ingress of bacteria and for permitting the egress of sterile liquid.
  • U.S. Patent No. 4,533,068 describes sterile solution delivery and venting devices including a positive acting, normally closed check valve which opens to express solution from the package when squeezing pressure is applied and which automatically closes when the pressure is released.
  • a hydrophobic filter is included to sterilize the replacement air which enters the package upon release of the squeezing pressure.
  • U.S. Patent No. 2,684,789 describes seal cap and dispensing nozzle for tubes or bottles having a self-closing dispensing valve.
  • U.S. Patent No. 3,176,883 describes a fluid dispenser of the squeeze bottle type having an air vent post extending to the side of the dropper tip and directly above the lip of the container.
  • Another object of the present invention is to provide a multidose fluid dispensing bottle which can be used to dispense medicine solutions, which do not contain preservatives, in substantially uniform drops.
  • a preservative free sterile solution dispensing system to eliminate the need of using preservatives in ophthalmic, pharmaceutical, contact lens solutions, consumer health care liquids and consumer food product solutions.
  • the fluid dispensing system for dispensing sterile preservative free solution comprises a container having an outer and an inner surface.
  • the container further has a reservoir compartment for storing sterile solution and a tip compartment adapted to dispense the sterile solutions.
  • a dual self-sealing valve dispensing assembly is sealed by an adhesive, mechanical compression, ultrasonic sealing, gasket, encapsulation or other commonly known methods, to the inside surface of the tip compartment and comprises a hydrophobic membrane assembly having a membrane housing.
  • the membrane housing is constructed of a thermoplastic material, such as polyethylene, polypropylene, polystyrene, ethylene-vinyl acetate or a combination thereof.
  • a hydrophobic membrane support is connected to the membrane housing.
  • the hydrophobic membrane support has a top surface and a bottom surface.
  • the hydrophobic membrane support further has a central fluid channel to allow the solution to pass through.
  • the hydrophobic membrane support is also generally constructed of a thermoplastic material such as polyethylene, polypropylene, polystyrene, ethylene-vinyl acetate or a combination thereof.
  • a hydrophobic membrane is hermetically sealed to the bottom surface of the hydrophobic membrane support separating the reservoir compartment from the tip compartment.
  • the membrane further connects to a central solution flow port which in turn is in communication with the fluid channel in the hydrophobic membrane support to allow the solution to pass through.
  • the hydrophobic membrane is constructed of a hydrophobic polymer, such as polyfluoroethylene, including TEFLON*, polyolefins or a combination thereof.
  • a passageway for ingress of air from outside the container through the membrane is provided in the hydrophobic membrane support.
  • the dual self-sealing valve dispensing assembly further comprises a valve assembly, which in turn, comprises a valve housing support with a top and a bottom surface.
  • the bottom surface of the valve housing support further connects to the top surface of the hydrophobic membrane support; a first self-sealing valve is hermetically sealed to the bottom surface of the housing support; a second self-sealing valve is hermetically sealed to the top surface of the valve housing support and in series with the first self-sealing valve wherein an outlet of the first valve opens to an inlet of the second valve to allow the solution to pass through; and a system outlet from which solution from an outlet of the second valve passes through.
  • Figure 1 is a perspective cross-sectional view of a preservative free sterile fluid dispensing system of the present invention.
  • the preservative free fluid dispensing system 10 is provided with a container 12 having an outer surface 14 and an inner surface 16.
  • the container 12 is provided with means to temporarily reduce its volume, typically by providing that at least part of the container is elastically deformable. Thus, pressure on a deformable portion of the container will force the fluid contained therein out of the container when it is appropriately oriented.
  • the container 12 can be a standard dispersing bottles with removable tip, e.g., low density polypropylene such as those made by Wheaton Plastics, Melville, N.J.
  • the container 12 further has a reservoir compartment 18 for storing sterile solution 20 and a tip compartment 22 adapted to dispense the sterile solution 20.
  • a dual self-sealing valve dispensing assembly 24 is sealed to the inside surface 16 of the container 12.
  • the dual self-sealing valve dispensing assembly 24 has a membrane housing 26 to which hydrophobic membrane support 27 with a top surface 28 and a bottom surface 30 is attached.
  • the hydrophobic membrane support 27 further has a central fluid channel 32 for the solution 20 to pass through.
  • a hydrophobic membrane 34 is hermetically sealed to the bottom surface 30 of the hydrophobic membrane support 27, separating the reservoir compartment 18 from the tip compartment 22 except at a central solution flow port 38 which is in communication with the fluid channel 32 of the hydrophobic membrane support to allow the solution 20 to
  • the hydrophobic membrane support 27 also has a passageway 40 (comprising an inflow 3, side port 9 and channel 11 discussed below) for ingress of air from outside the container 12 through the membrane 34.
  • the hydrophobic membrane 34 has pore openings from 0.01 to 1 micron, and preferably about 0.2 to 0.24 micron, in flat sheet configuration.
  • Such hydrophobic membranes are readily available commercially and can be fabricated from any suitable hydrophobic polymer, such as tetrafluoroethylene, polyolefins, including polyethylene and polypropylene or a mixture thereof.
  • the hydrophobic membrane is a laminated tetrafluoroethylene (e.g. TEFLON ® , a trademark of E.I.
  • the dual self-sealing valve dispensing assembly 24 further has a valve assembly 42 comprising a valve housing 44 with a top surface 46 and a bottom surface 48 and sealed by gasket to the top surface 28 of the hydrophobic membrane support 27.
  • a first self-sealing valve 56 is hermetically sealed to the bottom surface 48 of the valve support 44.
  • a second self-sealing valve 58 is similarly hermetically sealed to the top surface 46 of the valve housing support 44 and in series with the first self-sealing valve 56 wherein the outlet 60 of the first valve opens to an inlet 62 of the second valve to allow solution to pass through.
  • Solution 20 after passing through the outlet 64 of the second self-sealing valve 58, then dispenses to the outside of the container 12 via system o ⁇ ⁇ let 66.
  • the first and second self-sealing valves used are generally of the duckbill type and are normally closed during storage.
  • the self-sealing valves used in the preferred embodiment are of the duckbill type, model X60Z9 and can be obtained from Vernay Laboratories, Inc.
  • the outlet 64 from the second self-sealing valve opens to a system outlet 66 from which the solution 20 is dispensed.
  • elements 26 are similarly hermetically sealed to the top surface 46 of the valve housing support 44 and in series with the first self-s
  • bottle 12 After assembly, during a dispensing cycle, bottle 12 is squeezed in an inverted position with sterile solution 20 flowing from the reservoir compartment, through the central solution flow port 38, and percolate through hydrophobic membrane 73, channel 32 in the center of hydrophobic membrane support 27, through the first self-sealing valve 56 and outlet 60 of same, through inlet 62 and outlet 64 of second self- sealing valve 58 and finally out through system outlet 66 of container 12.
  • the system outlet 66 is of a dimension of only about 0.020 to about 0.050 inches.
  • the cap further is provided with antislip knurls 74 which are threaded together by means of threads 76.
  • the cap 70 can be rendered
  • an antibacterial agent such as salts of common heavy metal oxides, including oxides of silver, gold or copper.
  • a 5% aqueous solution of food grade blue dye was prepared from a stock concentrate.
  • Fifteen double duckbill self-sealing valve dispensing assemblies in their normally closed position were connected in parallel on a tubing set testing fixture. The entire tubing set was primed with the dye solution and the dual double duckbill self-sealing valve assemblies connected to each of the parallel tubing arms.
  • a calibrated pressure gauge connected to the tubing assembly was used to monitor the hydraulic pressure continuously for 24 hours. After 24 hours exposure to a pressure of 20 mm Hg, no retrograde migration of dye was detected past the first or second duckbill valve by direct observation and by colorimetric determination.
  • Example 3 The same conditions as in Example 3 except that the hydrophobic membrane discs in all fifteen double duckbill valve assemblies were immersed in water at room temperature for 24 hours. The ability of the hydrophobic membrane discs to filter air entering the bottle was similar to the results obtained with the hydrophobic membrane never exposed to water.
  • each bottle was set in an upright position and the cap removed and examined for the presence of water inside the cap well. In each of the assemblies no water was found.
  • the bayonet in the screw-on bottle cap coacting with the mating surface on the dispensing tip hermetically sealed the outlet channel on the dispensing tip assembly.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Food Science & Technology (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Closures For Containers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Packages (AREA)
  • Nozzles (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • External Artificial Organs (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP19920921558 1991-11-15 1992-10-09 Abgabevorrichtung für konservierungsmittelfreie sterile flüssigkeit Expired - Lifetime EP0611357B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US792989 1991-11-15
US07/792,989 US5310094A (en) 1991-11-15 1991-11-15 Preservative free sterile fluid dispensing system
PCT/US1992/008619 WO1993010015A1 (en) 1991-11-15 1992-10-09 Preservative free sterile fluid dispensing system

Publications (2)

Publication Number Publication Date
EP0611357A1 true EP0611357A1 (de) 1994-08-24
EP0611357B1 EP0611357B1 (de) 1996-08-28

Family

ID=25158734

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920921558 Expired - Lifetime EP0611357B1 (de) 1991-11-15 1992-10-09 Abgabevorrichtung für konservierungsmittelfreie sterile flüssigkeit

Country Status (15)

Country Link
US (1) US5310094A (de)
EP (1) EP0611357B1 (de)
JP (1) JPH07502238A (de)
AT (1) ATE141886T1 (de)
AU (1) AU666882B2 (de)
BR (1) BR9206933A (de)
CA (1) CA2122629A1 (de)
DE (1) DE69213248T2 (de)
DK (1) DK0611357T3 (de)
ES (1) ES2094373T3 (de)
FI (1) FI942229A (de)
GR (1) GR3021824T3 (de)
HU (1) HU214638B (de)
NO (1) NO941766L (de)
WO (1) WO1993010015A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8425926B2 (en) 2003-07-16 2013-04-23 Yongxing Qiu Antimicrobial medical devices
US10806628B2 (en) 2012-07-26 2020-10-20 Allergan, Inc. Dual cap system for container-closures to maintain tip sterility during shelf storage

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5373972A (en) * 1991-11-15 1994-12-20 Jsp Partners, L.P. Preservative-free sterile fluid dispensing system
US5819730A (en) * 1993-06-09 1998-10-13 Glaxo Wellcome Australia Ltd. Device for administering pharmaceutical substances
ATE168553T1 (de) * 1993-06-25 1998-08-15 Alcon Cusi S A Neue verwendung von polymeren membranen zum ausgeben von pharmazeutischen lösungen, die quarternäre, als konserviermittel dienende ammoniumverbindungen enthalten und entsprechender dosierbehälter
ES2064286B1 (es) * 1993-06-25 1995-09-01 Cusi Lab Nueva aplicacion de membranas polimericas en la dispensacion de soluciones farmaceuticas que contienen compuestos de amonio cuaternario como conservadores y envase dosificador correspondiente.
DE19627228A1 (de) * 1996-07-05 1998-01-08 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
FR2769595B1 (fr) 1997-10-10 1999-11-19 Oreal Tete de distribution a reprise d'air amelioree, et ensemble de conditionnement et de distribution equipe d'une telle tete
NL1010749C2 (nl) 1998-12-07 2000-06-08 V O F Pharmasept Houder voor het gedoseerd en in hoofdzaak kiemvrij afgeven van een vloeistof.
US6089260A (en) * 1999-09-10 2000-07-18 S. C. Johnson & Son, Inc. Nested duckbill check valves
JP4010005B2 (ja) 2000-02-29 2007-11-21 ニプロ株式会社 薬液注入器の注入速度調整装置
US20040234321A1 (en) 2001-04-25 2004-11-25 Breidenbach Diane C. Dual cosmetic container
US6488427B1 (en) 2000-02-29 2002-12-03 Diane C. Breidenbach Cosmetic applicator
US6685059B2 (en) * 2000-09-29 2004-02-03 Pepsico, Inc. Brewed iced tea or non-carbonated drink dispenser
DE10200519A1 (de) * 2002-01-09 2003-07-10 Neomed Holding Sa Luxemburg Lu Ventil
EP1505006A4 (de) * 2002-05-10 2011-04-06 Santen Pharmaceutical Co Ltd Kappe zur verhinderung von kontaminierung
CA2495582C (en) 2002-08-13 2016-07-12 Medical Instill Technologies, Inc. Container and valve assembly for storing and dispensing substances, and related method
JP2006521887A (ja) * 2003-03-31 2006-09-28 ニック ジェイ マニーシス 多数回投与液体分配組立体
US6913244B1 (en) * 2003-05-02 2005-07-05 Gordon Edgar Atkinson Urinary slide valve
US7845517B2 (en) * 2003-12-10 2010-12-07 Medical Instill Technologies Inc. Container and one-way valve assembly for storing and dispensing substances, and related method
DE102004027734A1 (de) 2004-06-07 2005-12-22 Filtertek B.V., Newcastle West Vorrichtung zur Verbindung eines Beatmungsgerätes mit dem Patienten
US7673653B2 (en) 2004-06-17 2010-03-09 Filtertek Inc. Check valve
DE202004009721U1 (de) * 2004-06-21 2004-08-26 Filtertek B.V. Vorrichtung zur Abgabe von Flüssigkeiten in Form von Tropfen
FR2872137B1 (fr) * 2004-06-24 2009-01-23 Thea Sa Lab Recipient pour le conditionnement d'un liquide a distributeur goutte a goutte, a deformation reversible par admission d'air
FR2886926B1 (fr) * 2005-06-10 2007-08-31 Rexam Dispensing Systems Sas Dispositif de filtration de l'air pour pompe de produit liquide ou semi-liquide
CA2513181C (en) * 2005-07-25 2012-03-13 Gotohti.Com Inc. Antibacterial foam generator
US20100108712A1 (en) * 2005-09-30 2010-05-06 Manesis Nick J Multi-dose liquid dispensing assembly
US7775398B2 (en) * 2005-10-26 2010-08-17 Medical Instill Technologies, Inc. Container and one-way valve assembly for storing and dispensing substances, and related method
WO2007104327A1 (de) * 2006-03-14 2007-09-20 Seaquist-Löffler Kunststoffwerk Gmbh Abgabevorrichtung für ein fliessfähiges medium sowie spendervorrichtung mit einer solchen abgabevorrichtung
US20080039807A1 (en) * 2006-08-08 2008-02-14 Jerrold Scott Pine Ophthalmic Drug Dispensing Tip
JP5122270B2 (ja) * 2007-12-28 2013-01-16 株式会社吉野工業所 液体注出容器
FR2929249B1 (fr) 2008-03-27 2012-02-17 Rexam Pharma La Verpilliere Dispositif de distribution de liquide contenu dans un reservoir
FR2934572A1 (fr) * 2008-07-31 2010-02-05 Thea Lab Embout pour flacon de conditionnement de liquide a distribuer goutte a goutte.
EP2253352A1 (de) * 2009-05-21 2010-11-24 Debiotech S.A. Passiver Flüssigkeitsflussregler
GB2474520B (en) 2009-10-19 2015-08-26 London & General Packaging Ltd Spray dispenser
US8512313B2 (en) * 2009-11-03 2013-08-20 Advanced Urological Products Urinary flow control valve with pressure sealing
FR2963326B1 (fr) 2010-07-30 2012-09-07 Rexam Healthcare La Verpillier Embout et recipient de distribution de liquide
NL2006543C2 (en) * 2011-04-05 2012-10-08 Rexam Airspray Nv Foam-forming assembly and squeeze foamer.
FR2980378B1 (fr) * 2011-09-22 2016-02-26 Rexam Healthcare La Verpillier Dispositif de distribution de liquide sous forme de gouttes
JP5695544B2 (ja) * 2011-10-31 2015-04-08 株式会社吉野工業所 フィルタ付き注出容器
CA2893809C (en) 2012-12-05 2017-11-28 Bracco Imaging S.P.A. Validation techniques for fluid delivery systems
US20150014363A1 (en) * 2013-07-12 2015-01-15 Gojo Industries, Inc. Air-vented liquid dispensers and refill units therefor
JP2016538203A (ja) * 2013-08-14 2016-12-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 高圧抽出カプセル
US9648992B2 (en) 2013-12-19 2017-05-16 Gojo Industries, Inc. Pumps with vents to vent inverted containers and refill units having non-collapsing containers
US10160590B2 (en) 2014-02-24 2018-12-25 Gojo Industries, Inc. Vented non-collapsing containers, dispensers and refill units having vented non-collapsing containers
WO2016018974A1 (en) 2014-07-30 2016-02-04 Gojo Industries, Inc. Vented refill units and dispensers having vented refill units
USD795631S1 (en) 2015-05-01 2017-08-29 The Baby Barista Company Apparatus for preparing ingredients for a baby bottle
WO2016179052A1 (en) 2015-05-01 2016-11-10 The Baby Barista Company Apparatus and method for preparing ingredients for a baby bottle using a concentrated solution
HUE049878T2 (hu) 2016-01-22 2020-11-30 Baxter Int Eljárás és gép steril oldatos termékzacskók elõállítására
RU2732111C2 (ru) 2016-01-22 2020-09-11 Бакстер Интернэшнл Инк. Мешок для стерильного раствора продукта
CN105771076A (zh) * 2016-03-24 2016-07-20 无锡圣马科技有限公司 儿童保险鼻喷
DE102016108873B4 (de) * 2016-05-13 2018-01-25 Gerresheimer Regensburg Gmbh Vorrichtung zum Aufbewahren und dosierten Abgeben eines sterilen Fluids
FR3052446B1 (fr) * 2016-06-10 2018-07-13 Karine Courtin Dispositif de distribution de produit fluide
SG11201811247PA (en) * 2016-06-24 2019-01-30 Castrol Ltd Fluid distribution and dispensing system
EP3427839B1 (de) * 2017-07-13 2020-12-02 Aptar Radolfzell GmbH Flüssigkeitsspender mit belüfteter flasche und austragkopf hierfür
IT201800020839A1 (it) * 2018-12-21 2020-06-21 Paolo Gobbi Frattini S R L Erogatore goccia a goccia ad uso multiplo per prodotto liquido sterile, particolarmente per collirio o altro prodotto medicinale o dispositivo medico
US10945881B1 (en) * 2019-12-19 2021-03-16 Paolo Gobbi Frattini S.R.L. Plural-use drop-by-drop dispenser for sterile liquid product, particularly for collyrium or other medicinal product or medical device
CN116172866B (zh) * 2023-04-24 2023-07-18 张家港众辉医用塑料科技有限公司 具有阻菌及无残液功能的滴液器及其使用方法

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2594318A (en) * 1947-03-19 1952-04-29 Jesse D Langdon Valved coupling
US2761833A (en) * 1951-12-26 1956-09-04 Samuel I Ward Liquid treating apparatus
US2783091A (en) * 1955-06-10 1957-02-26 Stratafoam Corp Foam-dispensing package
US3034731A (en) * 1959-03-04 1962-05-15 R E Chapin Mfg Works Inc Back flow preventing valve assembly
US3176883A (en) * 1963-04-15 1965-04-06 Jr George B Davis Fluid dispenser
US3365240A (en) * 1967-05-04 1968-01-23 Gordon Mack Valve control for discharge of finely divided material from vacuum to atmosphere
US3572375A (en) * 1967-06-02 1971-03-23 David Rosenberg Twin valve t-connector
ES419697A1 (es) * 1972-10-18 1976-03-16 Ivanov Mantchev Dispositivo tapon valvular para botellas y recipientes si- milares.
DE2405687A1 (de) * 1974-02-06 1975-08-07 Jakob Westermeier Automatischer tubenverschluss
AR207395A1 (es) * 1976-01-16 1976-09-30 Ferrante J Mejoras en envases dosificadores de productos granulados pulverulentos etc
FR2364168A1 (fr) * 1976-09-10 1978-04-07 Workum Donald Dispositif de pulverisation
US4139469A (en) * 1977-01-21 1979-02-13 Altex Scientific, Inc. Fluid control mechanism
FR2419873A1 (fr) * 1978-03-16 1979-10-12 Normos Norbert Tete d'evacuation - sans bouchon - de type nouveau, adaptable notamment sur des tubes souples en plastique ou metal
FR2422569A1 (fr) * 1978-04-14 1979-11-09 Roussel Uclaf Distributeur de liquide sterile
GB2048827A (en) * 1979-05-04 1980-12-17 Chappell A Metering device
US4349134A (en) * 1980-09-09 1982-09-14 Ahk Alkohol Handelskontor Gmbh Valved, resilient-walled container for safely dispensing flammable liquids
FR2494603A1 (fr) * 1980-11-26 1982-05-28 Normos Norbert Dispositif de pulverisation de fluides
US4533068A (en) * 1981-08-17 1985-08-06 Health Care Concepts, Inc. Sterile solution delivery and venting devices
US4432496A (en) * 1981-12-08 1984-02-21 Toyo Seikan Kaisha, Ltd. Foam liquid dispensing device
US4475274A (en) * 1982-07-07 1984-10-09 Hunt-Wesson Foods, Inc. Method of making and installing a pouring fitment
DK148704C (da) * 1983-01-04 1986-04-01 Coloplast As Tilbageloebsventil til en pose til opsamling af flydende kropssekreter
DE3305898A1 (de) * 1983-02-19 1984-08-23 Günter 7535 Königsbach-Stein Hirsch Fluessigkeitsspender
FR2543920A1 (fr) * 1983-04-11 1984-10-12 Dore Pierre Dispositif d'obturation de flacon ou bouteille deformable a capsule auto-etanche a clapet
US4728006A (en) * 1984-04-27 1988-03-01 The Procter & Gamble Company Flexible container including self-sealing dispensing valve to provide automatic shut-off and leak resistant inverted storage
US4676407A (en) * 1985-03-20 1987-06-30 Risdon Corporation Mounting cap with extended sleeve
NL8600111A (nl) * 1986-01-20 1987-08-17 Bernardus Johannes Josephus Au Stop voor een houder, zoals een fles en een daarop aansluitbare pomp voor het afzuigen resp. inpersen van gasvormig medium uit resp. in de houder.
FR2597551B1 (fr) * 1986-04-16 1993-11-12 Alpha Systemes Pompe distributrice jetable pour des produits liquides ou pateux
EP0280669A1 (de) * 1987-02-24 1988-08-31 Erik Bottger Gerät zur Ausgabe von Creme oder pastosen Massen aus einem Behälter
US4785978A (en) * 1987-03-02 1988-11-22 Japan Crown Cork Co., Ltd. Container closure provided with automatic opening-closing mechanism
US4842165A (en) * 1987-08-28 1989-06-27 The Procter & Gamble Company Resilient squeeze bottle package for dispensing viscous products without belching
US5183184A (en) * 1988-10-07 1993-02-02 Ryder International Corporation Liquid dispenser nozzle assembly
US5025957A (en) * 1988-10-07 1991-06-25 Ryder International Corp. Liquid dispenser nozzle assembly
US4938389A (en) * 1988-11-03 1990-07-03 Eye Research Institute Of Retina Foundation Filter bottle
US4978036A (en) * 1988-11-15 1990-12-18 Koller Enterprises, Inc. Dispensing valve
GB9011455D0 (en) * 1989-06-01 1990-07-11 Pall Corp Contamination-resistant dispensing and metering device
GB2234965A (en) * 1989-08-08 1991-02-20 Kenneth Simon Aylett Moore Container closure
US4953588A (en) * 1989-08-16 1990-09-04 Mueller Co. Dual check valve
ES2057844T3 (es) * 1990-02-16 1994-10-16 Sterisol Ab Valvula de distribucion de un fluido.
DE4008442A1 (de) * 1990-03-16 1991-09-19 Detlef Dr Schierstedt Selbstverschliessendes verschlusssystem fuer fluessige und halbfeste zubereitungen
FR2660877B1 (fr) * 1990-04-13 1992-07-31 Oreal Ensemble de distribution d'au moins un produit liquide ou sous forme de creme.
CA2043521A1 (en) * 1990-05-31 1991-12-01 Vlado I. Matkovich Contamination-resistant dispensing and metering device
US5074440A (en) * 1990-07-16 1991-12-24 Alcon Laboratories, Inc. Container for dispensing preservative-free preparations
DE4027539A1 (de) * 1990-08-31 1992-03-05 Kautex Werke Gmbh Quetschflasche mit innenbeutel
CA2025105A1 (en) * 1990-09-11 1992-03-12 Garth T. Webb Device for storing and dispensing sterile liquids
JPH075135B2 (ja) * 1990-10-12 1995-01-25 株式会社フローレックス 接着剤容器
US5154325A (en) * 1991-01-09 1992-10-13 Ryder International Corporation Solution delivery nozzle and system with antimicrobial features
FR2671538A1 (fr) * 1991-01-11 1992-07-17 Saint Laurent Parfums Yves Dispositif distributeur et doseur de produit.
US5238153A (en) * 1991-02-19 1993-08-24 Pilkington Visioncare Inc. Dispenser for dispersing sterile solutions
DE4119634A1 (de) * 1991-06-14 1992-12-17 Gerd Hermann Ventil fuer einen quetschbehaelter
GB9122319D0 (en) * 1991-10-19 1991-12-04 Coda Plastics Ltd Fluid dispensing closure
US5373972A (en) * 1991-11-15 1994-12-20 Jsp Partners, L.P. Preservative-free sterile fluid dispensing system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9310015A1 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8425926B2 (en) 2003-07-16 2013-04-23 Yongxing Qiu Antimicrobial medical devices
US10806628B2 (en) 2012-07-26 2020-10-20 Allergan, Inc. Dual cap system for container-closures to maintain tip sterility during shelf storage

Also Published As

Publication number Publication date
DE69213248D1 (de) 1996-10-02
FI942229A0 (fi) 1994-05-13
JPH07502238A (ja) 1995-03-09
AU2774792A (en) 1993-06-15
HUT68257A (en) 1995-06-28
EP0611357B1 (de) 1996-08-28
ATE141886T1 (de) 1996-09-15
HU214638B (hu) 1998-04-28
FI942229A (fi) 1994-05-13
NO941766D0 (no) 1994-05-11
DE69213248T2 (de) 1997-04-03
CA2122629A1 (en) 1993-05-27
DK0611357T3 (de) 1997-02-24
WO1993010015A1 (en) 1993-05-27
HU9401345D0 (en) 1994-08-29
US5310094A (en) 1994-05-10
ES2094373T3 (es) 1997-01-16
NO941766L (no) 1994-07-13
GR3021824T3 (en) 1997-02-28
AU666882B2 (en) 1996-02-29
BR9206933A (pt) 1995-05-02

Similar Documents

Publication Publication Date Title
US5310094A (en) Preservative free sterile fluid dispensing system
US5373972A (en) Preservative-free sterile fluid dispensing system
US4533068A (en) Sterile solution delivery and venting devices
US4463880A (en) Medicine drop dispenser with anti-bacterial filter
US5265770A (en) Contamination-resistant dispensing and metering device
CA1340719C (en) Liquid dispenser nozzle assembly
US5219101A (en) Contamination-resistant dispensing and metering drop forming device
US5431310A (en) Liquid dispenser nozzle assembly
JPH05500937A (ja) 防腐剤を含まない製剤を小出しするための容器
JPS60502089A (ja) インラインフイルタ−
JPH04312462A (ja) ディスペンサ
US4473094A (en) Air inlet
EP0459498B1 (de) Kontaminationsbeständige Verteilungs- und Dosierungsvorrichtung
EP0401022B1 (de) Vorrichtung zur injektionsfreien Verabreichung und Dosierung einer Flüssigkeit
JPS59150514A (ja) 手持ち型液体濾過分配装置
CA1195300A (en) Sterile solution delivery and venting devices
JPS5878661A (ja) 無菌溶液放出及び通気装置

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19940506

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: JSP PARTNERS L.P.

17Q First examination report despatched

Effective date: 19951123

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

REF Corresponds to:

Ref document number: 141886

Country of ref document: AT

Date of ref document: 19960915

Kind code of ref document: T

REF Corresponds to:

Ref document number: 69213248

Country of ref document: DE

Date of ref document: 19961002

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: 69619

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19961030

Year of fee payment: 5

Ref country code: DE

Payment date: 19961030

Year of fee payment: 5

Ref country code: AT

Payment date: 19961030

Year of fee payment: 5

ET Fr: translation filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 19961031

Year of fee payment: 5

Ref country code: SE

Payment date: 19961031

Year of fee payment: 5

Ref country code: NL

Payment date: 19961031

Year of fee payment: 5

Ref country code: ES

Payment date: 19961031

Year of fee payment: 5

Ref country code: DK

Payment date: 19961031

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 19961113

Year of fee payment: 5

ITF It: translation for a ep patent filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 19961126

Year of fee payment: 5

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: ABREMA AGENCE BREVETS & MARQUES GANGUILLET & HUMPH

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2094373

Country of ref document: ES

Kind code of ref document: T3

REG Reference to a national code

Ref country code: GR

Ref legal event code: FG4A

Free format text: 3021824

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 19970203

Year of fee payment: 5

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: MC

Payment date: 19970428

Year of fee payment: 5

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 19970908

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 19970911

Year of fee payment: 6

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971009

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971009

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971009

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971009

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971010

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971010

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971031

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971031

Ref country code: FR

Free format text: THE PATENT HAS BEEN ANNULLED BY A DECISION OF A NATIONAL AUTHORITY

Effective date: 19971031

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971031

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19971031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19980430

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19980501

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 19971009

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee

Effective date: 19980501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19980701

EUG Se: european patent has lapsed

Ref document number: 92921558.0

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19981031

BERE Be: lapsed

Owner name: JSP PARTNERS L.P.

Effective date: 19981031

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 19981113

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 20051009