CA2025105A1 - Device for storing and dispensing sterile liquids - Google Patents

Device for storing and dispensing sterile liquids

Info

Publication number
CA2025105A1
CA2025105A1 CA 2025105 CA2025105A CA2025105A1 CA 2025105 A1 CA2025105 A1 CA 2025105A1 CA 2025105 CA2025105 CA 2025105 CA 2025105 A CA2025105 A CA 2025105A CA 2025105 A1 CA2025105 A1 CA 2025105A1
Authority
CA
Canada
Prior art keywords
container
outlet
valve
housing
filter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2025105
Other languages
French (fr)
Inventor
Garth T. Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA 2025105 priority Critical patent/CA2025105A1/en
Priority to EP91904141A priority patent/EP0548078A1/en
Priority to PCT/CA1991/000056 priority patent/WO1992004004A1/en
Priority to CA002091358A priority patent/CA2091358C/en
Priority to AU72455/91A priority patent/AU651086B2/en
Publication of CA2025105A1 publication Critical patent/CA2025105A1/en
Priority to US08/336,272 priority patent/US5507417A/en
Abandoned legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00Closures with filling and discharging, or with discharging, devices
    • B65D47/04Closures with discharging devices other than pumps
    • B65D47/20Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2093Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure slide valve type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/086Container, accessories or devices therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/022Filtration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005Components or details
    • B05B11/0037Containers
    • B05B11/0039Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005Components or details
    • B05B11/0037Containers
    • B05B11/0039Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/1443Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/145Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/1443Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/1456Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/1468Containers characterised by specific material properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Closures For Containers (AREA)

Abstract

DEVICE FOR STORING AND DISPENSING STERILE LIQUIDS
ABSTRACT OF THE DISCLOSURE
Various means are used to produce and dispense sterile saline for use by contact lens wearers. The present invention provides a simple, portable device for storing and dispensing sterile saline which comprises a resilient hollow container having a first outlet, a housing removably mounted on said container and having a second outlet and a passage communicating between said first and second outlet, a liquid-sterilizing filter mounted in said housing in said passage, and valve means for alternately opening and closing said second outlet, whereby pressure applied to said container forces a liquid stored in said container through said filter and out said second outlet when said valve is in an open position.

Description

2~`2510~
DEVICE FOR STORING AND DISPENSING STERILE LIOUIDS

BACKGROUND OF THE INVENTION

The invention relates to the field of devices for sterilizing liquids, and more particularly to devices for storing and sterilizing saline for ophthalmic purposes, and particularly for contact lens applications.
Sterile saline is required by contact lens wearers for use as a rinse solution, for rinsing the lens prior to inserting the lens in the eye, and also for soaking the lens during the cleaning and disinfecting process.
Sterilization of the saline is generally accomplished using heat, ultra-violet light, or filtration. The saline which has been sterilized in bulk is then stored in plastic squeeze bottles with the addition of chemicals to preserve the sterility.
Sterilized saline has also been marketed in aerosol cans, which provide sterile storage without the need for chemical agents.
This is accomplished due to the positive pressure within the container which keeps contaminants out. However, the expense and environmental problems associated with aerosol containers make this a less desirable alternative.
There is therefore a need for a simple and portable device for storing and dispensing sterile saline.
SUMMARY OF THE INVENTION

The present invention provides a simple, portable 2~25~
device for storing and dispensing sterile saline which comprises a resilient hollow container having a first outlet, a housing removably mounted on said container and having a second outlet and a passage communicating between said first and second outlet, a liquid-sterilizing filter mounted in said housing in said passage, and valve means for alternately opening and closing said second outlet, whereby pressure applied to said container forces a liquid stored in said container through said filter and out said second outlet when said valve is in an open position.
BRIEF DESCRIPTION OF THE DRAWINGS

In drawings which illustrate a preferred embodiment of the invention:
Fig. 1 is a vertical cross-sectional view of the invention with the valve in the closed position;
Fig. 2 is a detail of the view of invention shown in Figure 1, but with the valve in the open position;
Fig. 3 is a horizontal cross-sectional viPw of the invention taken along lines 3-3 of Figure 2;
Fig. 4 is a horizontal cross-sectional view of the invention taken along lines 4-4 of Figure 2; and Fig. 5 is a detail of a second embodiment of the invention in vertical cross-section.

2Q2~ ~rj;

DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT

Referring to Figure 1, the device of the invention is designated generally as 1. It consists of a resilient squeeze bottle container 3 having hollow interior 2, and a valve and filter housing 5. The squeeze bottle portion 3 is manufactured of a flexible plastic such as a polyethylene or PET, which has sufficient resiliency and memory to return to its original shape after being squeezed. ~he housing 5 is constructed of a rigid plastic such as a polycarbonate. The housing comprises a base 7, body 9 and cover 11. Container 3 has a circular neck 13 forming open mouth 14 and provided with screw threads 15 on its exterior surface which mate with complementary screw threads 17 on the interior surface of circular extension 19 of base 7. Base 7 has a circular flange 21 which has a snap fit connection with circular lip 23 of body 9.
Mounted in the valve and filter housing 5 between base 7 and body 9 is a circular micro-filter 25. Filter 25 is chosen with a mesh sufficiently fine to be useful for the sterilizing function of the invention. A filter having a .2 micron rating is suitable. Such filters are manufactured by Pall Ultrafine Filtration Corporation under the trade-mark ULTIPOR. The filter 25 is sealed in place between base 7 and body 9 by two rubber O-rings 27. To provide rigidity to the filter 25, it is also supported by two plastic inserts 29 located above and below the filter body and having radial ar~s 30 such that the radius of insert 29 is slightly less than that of filter 25. Inserts 29 could also form part of base 7 and body 9.

~2~05 A valve 31 is provided in base 7 to permit air to enter container 3 after liquid is expelled. It consists of a small opening 33 and a pivoting, inwardly opening flap 35 on the interior surface of flange 21, shown in an open position in Figure 1 and a closed position in Figure 2. When the container 3 is squeezed to expel liquid, flap 35 closes opening 33, and when pressure on container 3 is released, flap 35 opens to allow air to enter container 3 in the direction of arrow B, and to allow container 3 to return to its original volume. The same function could be achieved by a plurality of smaller openings.
Alternatively, an accordion type of container could replace a squeeze bottle for container 3 which would obviate the necessity for valve 31.
Housing 9 has a hollow cylindrical portion 36 which forms a lower opening 38 and is provided with outlet port 37.
Opening 38 is circular but for shoulder 40 which extends into opening 38. Port 37 is alternately opened or closed by rubber valve 39. Valve 39 has a sloping, rounded lower face 41 which ends in a circular lip 43 which seals against the interior surface of cylinder 36. Shoulder 40 has a sloping upper surface 44 which conforms to face 41 to seal port 37 when the valve 39 is in the lower position.
Valve 39 is biassed to its lower, closed position by spring 46, one end of which is held on cylindrical base 48 attached to cover 11, and the other end of which is held on a cylindrical extension 50 of base 52 of valve 39. Cover 11 ~s screwed into housing 9 by screw threads 51. This permits cover 11 to be removed leaving valve 39 in place. Alternatively, cover 202510~
11 can be permanently fixed by an adhesive.
In operation, the hollow interior 2 of container 3 is filled with non-sterile saline and valve and filter housing 9 is then screwed into place. In a rest position, valve 39 closes port 537 due to the action of spring 46. When the user squeezes container 3, flap 35 closes and saline is forced through filter 25 in the direction of arrow A, thereby sterilizing it. Valve 39 moves upwardly opening port 37 and the sterile saline is dispensed from port 37 in the direction of arrow C. When pressure 10on container 3 is released, valve 39 returns to its closed position, closing port 37, and flap 35 opens to permit air to enter to return container 3 to its original shape.
A second embodiment shown in Figure 5 permits valve 39 to be locked in a closed position for transport. In this 15embodiment cover 11 in turn is provided with opening 60 provided with screw threads 62 into which a knob 64 is screwed by screw threads 66 on disk 68. Attached to the lower surface 69 of disk 68 is a rod 70 with bulbous lower end 72. Rubber valve 74 has a hollow interior 76 into which rod 70 extends, and a flat lower 20face 78 which seats against shoulder 80 of outlet port 82. Valve 74 is sufficiently resilient in this embodiment, due to the flexing action of its walls, to open and close outlet port 82 in response to the squeezing of container 3 when rod 70 is with-drawn. However valve 74 is locked against opening when rod 70 is 25screwed tightly against the lower interior surface of valve 74 by rotation of knob 64. In this embodiment, valve 74 could be replaced by a rubber diaphragm stretched across the interior chamber 88 of body 9, and adapted to seal against outlet 82 when 202~

pressure is released and open outlet 82 when pressure is applied.
In this variation, shoulder 80 would be generally perpendicular to the walls of chamber 88. Also, to improve the flexibility of valve 74, holes could be provided in disk 68 to permit air to flow between the interior 76 of the valve and the atmosphere.
Figure 5 also shows a second embodiment of base 7 in which the cylindrical flange 19 of base 7 screws into the interior surface of neck 13 of container 3, and a centrally located shield 84 attached to base 7 guards the filter against damage when the container 3 is removed from housin~ 9. Passage-ways 86 permit passage of the liquid around shield 84.
As will be apparent to those skilled in the art, various modifications and adaptations of the structure above described may be made without departing from the spirit of the invention, the scope of which is to be construed in accordance with the accompanying claims.

Claims (12)

1. A device for storing and dispensing a sterile liquid comprising:
a) an expandable and contractible hollow container having a first outlet;
b) a housing removably mounted on said container and having a second outlet and a passage communicating between said first and second outlets;
c) a liquid-sterilizing filter mounted in said housing in said passage; and d) first valve means for alternately opening and closing said second outlet;
whereby pressure applied to said container causes said container to contract and forces a liquid stored in said container through said filter and out said second outlet when said valve is in an open position.
2. The device of claim 1 wherein said expandable container is adapted to be contracted by squeezing by the hands of a user.
3. The device of claims 1 or 2 wherein said container comprises air inlet means communicating between said hollow interior of said container and the exterior of said container, said air inlet means further comprising second, one-way valve means adapted to permit flow of air into said container but preventing flow of air out of said container through said valve.
4. The device of claim 1 wherein said first valve means comprises a resilient sealing surface biassed in a direction to seal against said second outlet and adapted to be movable to open said second outlet upon application of pressure against said surface.
5. The device of claim 1 wherein said filter has a mesh having rating of .2 microns or less.
6. The device of claim 1 wherein said housing comprises a hollow cylindrical chamber, and said first valve means is mounted for reciprocal motion in said chamber.
7. The device of claim 6 wherein said first valve is biassed by means of a spring mounted in said chamber.
8. The device of claim 1 wherein said housing is mounted coaxially on said container and said filter is mounted coaxially between said housing and said container.
9. The device of claim 1 wherein said filter extends perpendicu-larly to the direction of fluid flow in said passage.
10. The device of claim 9 wherein said filter extends completely across said passage.
11. The device of claim 1 wherein said container is a plastic squeeze bottle.
12. The device of claim 11 wherein said first outlet is circular and said housing is mounted on said container by screw threads.
CA 2025105 1990-09-11 1990-09-11 Device for storing and dispensing sterile liquids Abandoned CA2025105A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA 2025105 CA2025105A1 (en) 1990-09-11 1990-09-11 Device for storing and dispensing sterile liquids
EP91904141A EP0548078A1 (en) 1990-09-11 1991-02-22 Device for storing and dispensing sterile liquids
PCT/CA1991/000056 WO1992004004A1 (en) 1990-09-11 1991-02-22 Device for storing and dispensing sterile liquids
CA002091358A CA2091358C (en) 1990-09-11 1991-02-22 Device for storing and dispensing sterile liquids
AU72455/91A AU651086B2 (en) 1990-09-11 1991-02-22 Device for storing and dispensing sterile liquids
US08/336,272 US5507417A (en) 1990-09-11 1994-11-08 Device for storing and dispensing sterile liquids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2025105 CA2025105A1 (en) 1990-09-11 1990-09-11 Device for storing and dispensing sterile liquids

Publications (1)

Publication Number Publication Date
CA2025105A1 true CA2025105A1 (en) 1992-03-12

Family

ID=4145949

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2025105 Abandoned CA2025105A1 (en) 1990-09-11 1990-09-11 Device for storing and dispensing sterile liquids

Country Status (4)

Country Link
EP (1) EP0548078A1 (en)
AU (1) AU651086B2 (en)
CA (1) CA2025105A1 (en)
WO (1) WO1992004004A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5373972A (en) * 1991-11-15 1994-12-20 Jsp Partners, L.P. Preservative-free sterile fluid dispensing system
US5310094A (en) * 1991-11-15 1994-05-10 Jsp Partners, L.P. Preservative free sterile fluid dispensing system
EP0631770B1 (en) * 1993-06-25 1998-07-22 Alcon Cusi, S.A. New use of polymeric membranes in the dispensing of pharmaceutical solutions that contain quaternary ammonium compounds as preservatives and corresponding dose dispensor
CA2102589C (en) * 1993-11-05 2003-02-11 Garth T. Webb Method and apparatus for removing air locks within manually operated micro-filtration devices
US5611464A (en) * 1995-05-30 1997-03-18 Ciba Geigy Corporation Container for preserving media in the tip of a solution dispenser
NZ308677A (en) * 1995-05-31 1997-09-22 Christopher James Cranshaw Flexible, free standing, fluid dispensing apparatus with a fluid exit which allows for air drawback
US20050135972A1 (en) 1997-08-11 2005-06-23 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US6045759A (en) 1997-08-11 2000-04-04 Ventana Medical Systems Fluid dispenser
US6093574A (en) 1997-08-11 2000-07-25 Ventana Medical Systems Method and apparatus for rinsing a microscope slide
US20020110494A1 (en) * 2000-01-14 2002-08-15 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US8137619B2 (en) 1997-08-11 2012-03-20 Ventana Medical Systems, Inc. Memory management method and apparatus for automated biological reaction system
US6745763B2 (en) * 1998-10-27 2004-06-08 Garth T. Webb Vaporizing device for administering sterile medication
US7378058B2 (en) 2002-01-30 2008-05-27 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
DE102004048503A1 (en) * 2004-10-05 2006-04-13 Thilo Schleip Contact lens wetting device for human eye, has sprayers which apply solution to contact lens in eye, for wetting lens, where spraying output of sprayers are adjusted with respect to delivered volume of absorbency of eye
CN103649760B (en) 2011-06-01 2015-09-09 文塔纳医疗系统公司 There is the knockout of filter element
DE102012025414A1 (en) 2012-12-20 2014-06-26 Meadwestvaco Calmar Gmbh Manually operated dispenser for media

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Publication number Priority date Publication date Assignee Title
US3149758A (en) * 1961-11-01 1964-09-22 Millipore Filter Corp Combination filter and flow divider for gas and liquid
GB1000248A (en) * 1962-05-03 1965-08-04 Robert Carl Crisafi Disposable device for sterilizing solutions by filtration
GB2021429B (en) * 1978-04-14 1982-08-11 Roussel Lab Ltd Dispensers for sterile liquids
US4533068A (en) * 1981-08-17 1985-08-06 Health Care Concepts, Inc. Sterile solution delivery and venting devices
DE3146343A1 (en) * 1981-11-23 1983-10-20 PROAQUA - PROVITA AG, 1700 Fribourg Sterile-sealed container and method of producing it
US4463880A (en) * 1982-04-30 1984-08-07 The Regents Of The University Of California Medicine drop dispenser with anti-bacterial filter
DE3628197A1 (en) * 1986-08-20 1988-02-25 Streitenberg Hubert Dr Med Container for liquid medicaments
US5025957A (en) * 1988-10-07 1991-06-25 Ryder International Corp. Liquid dispenser nozzle assembly

Also Published As

Publication number Publication date
AU651086B2 (en) 1994-07-14
WO1992004004A1 (en) 1992-03-19
EP0548078A1 (en) 1993-06-30
AU7245591A (en) 1992-03-30

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