EP0572816B1 - Procédé et dispositif de compactage de comprimés à deux couches sur une presse à table tournante avec deux postes - Google Patents

Procédé et dispositif de compactage de comprimés à deux couches sur une presse à table tournante avec deux postes Download PDF

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Publication number
EP0572816B1
EP0572816B1 EP93107324A EP93107324A EP0572816B1 EP 0572816 B1 EP0572816 B1 EP 0572816B1 EP 93107324 A EP93107324 A EP 93107324A EP 93107324 A EP93107324 A EP 93107324A EP 0572816 B1 EP0572816 B1 EP 0572816B1
Authority
EP
European Patent Office
Prior art keywords
station
layer
discharge
die
pressing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP93107324A
Other languages
German (de)
English (en)
Other versions
EP0572816A1 (fr
Inventor
Jürgen Ing. Grad. Hinzpeter
Ingo Schmidt
Helmut Brommrowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fette GmbH
Original Assignee
Wilhelm Fette GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wilhelm Fette GmbH filed Critical Wilhelm Fette GmbH
Publication of EP0572816A1 publication Critical patent/EP0572816A1/fr
Application granted granted Critical
Publication of EP0572816B1 publication Critical patent/EP0572816B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B30PRESSES
    • B30BPRESSES IN GENERAL
    • B30B11/00Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/005Control arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B30PRESSES
    • B30BPRESSES IN GENERAL
    • B30B11/00Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B30B11/085Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable for multi-layer articles

Definitions

  • the invention relates to a method for pressing two-layer tablets in a double rotary press according to the preamble of claim 1.
  • Rotary presses for the production of tablets from a wide variety of substances and for a wide variety of applications are generally known.
  • a die plate which is usually driven about a vertical axis, has dies arranged on a circle, to which pairs of press rams that are synchronous with the plate are assigned.
  • the press rams are actuated by control cams and pressure rollers.
  • the lower punch of a pair forms the bottom of a mold cavity, its height in the die dictating the dosage. This is followed by pressing opposing rams in a pressing station towards one another and compressing the tablet material to a desired thickness (web height).
  • the press station usually has a pre-printing and a main printing station.
  • the lower punches controlled by the ejector curve, push the tablet out of the die at a certain point on the machine, while the opposite row of punches (upper punch) gradually moves away from the die plate.
  • a stripper can strip the ejected compacts from the die plate and feed them to a discharge channel.
  • a discharge switch can be assigned to the discharge channel, which optionally directs the incoming tablets towards a test station.
  • a device of this type has become known from GB-A-952006.
  • the first layers are compressed more in the intermediate sampling station before the sampling than during normal production. It is assumed that during the manufacture of the two-layer tablet the first layer can only be "pressed” and must not yet have the hardness of the final tablet. Otherwise, the two layers could not be joined by press molding.
  • the final thickness or web height of the two-layer tablet is reached in the second pressing station, in which the tablet is given the desired tightness or hardness. If the first layer is removed in its normal state, it is relatively soft, so that material is rubbed off or crumbled off, particularly in the case of automatic removal. Therefore, in the method according to the invention, the first layer is compressed noticeably more than during normal production, so that the first layer has a consistency comparable to the usual tablet and can be treated accordingly. It is therefore readily possible to automatically remove the compressed first layer in the same way as is known and customary for finished tablets in rotary presses of the type mentioned, so that they can be fed to an automatic test method.
  • the invention has for its object to provide a method for pressing two-layer tablets in a double rotary press, in which it is prevented that residues remain in the die holes after ejection and detachable or rubbed material accumulates on the die plate and in the rest of the machine when the second layer is also filled during sampling.
  • the second layers are also still filled in, ie the second filling device remains in operation even during the sampling. It is only necessary to ensure that the compacts representing the second layer are led into a bad channel, from where they can be returned to the starting material by suitable recycling measures.
  • the invention therefore provides that the second layers are also increasingly compressed during the sampling.
  • the method has the advantage that it enables a sample to be taken fully automatically within a short time, for example within 10 seconds, with extremely little uncompressed material being able to collect on the die plate, on the tablet scraper or in the tablet outlet.
  • the previous effort to operate the filling device in front of the second press station is no longer applicable.
  • an intermediate removal station is required, in which the compacts consisting of only one layer can be removed and fed to a testing device.
  • a device provides that the intermediate removal station has an adjustable ejector curve segment, a stripping device and a discharge switch and that the discharge switch directs incoming single-layer compacts either into a bad channel or to the test station.
  • the discharge switch is directed towards the bad channel as long as the curve segment in the press station and the curve segment for the ejector have not reached the new position for sampling.
  • the control curves of the first and, if necessary, the second press station are adjusted synchronously. This produces some two-layer compacts with increased compression. These will also be led into the bad channel through a discharge switch in the removal station.
  • An impermissible pressure load on the machine can be avoided by means of pressure limitation measures that are generally known in connection with tabletting machines or by adjusting the compression parameters (web heights).
  • the curve segment for the first ejector station is expediently operated by an electromechanical drive adjusted, for example a spindle drive or the like.
  • a rotary press 10 for the production of two-layer tablets is indicated in FIG. 1.
  • the supply of tablet material is not shown.
  • the finished two-layer tablets reach an automatic dedusting and deburring device 14 via a conveyor path 12.
  • the finished tablets pass from the device 14 a conveyor path 16 to a filling device 18.
  • the rotary press 10 is assigned an automatic test device 20, which in particular checks the weight of the tablets.
  • a branch 22, which leads to the testing device 20, is branched off from the conveying path 16. From time to time, tablets are branched off and subjected to an automatic check.
  • a further conveyor path 24 shown in dashed lines can be seen in FIG. 1. This is intended to indicate that the first layer of a two-layer tablet is also removed from the press 10 and fed to the testing device 20.
  • a conveyor path 26 is indicated by dashed lines. The second layer of a two-layer tablet is to be fed to the testing device 20 via it.
  • the operation of the devices shown is controlled by an operating computer 28 via a control cabinet 30.
  • FIG. 2 The basic structure of the rotary press 10 according to FIG. 1 is shown in FIG. 2.
  • Tablet material for the first layer is fed to a first filling station 32, in which the material is dispensed in a metered manner into die bores in a die plate.
  • the first layer is compressed in a pre-compression station 34 and in one second compression station 36 fully compresses the first layer.
  • the main printing station 36 is followed by an ejection station 38, which is however out of operation when producing a two-layer tablet.
  • the material for the second layer is metered in a second filling station 42, and a second pre-pressing station 44 compresses the two layers in a first process, while a second pre-pressing station 46 the final one Compression concerned.
  • a second ejection station 48 the finished two-layer compacts are removed from the rotating die plate and removed in a removal station 50, from where they are then fed to the dedusting and deburring device 14, as described with reference to FIG. 1.
  • the discharge stations 40 and 50 are assigned discharge switches which can be pivoted between two positions.
  • the discharge switch assigned to the intermediate removal station 40 directs the single-layer compacts either to a bad channel, not shown, or to the testing device 20.
  • the discharge switch 50 of the removal station 50 either directs the compacts to the device 14 or also into a bad channel.
  • a die plate 52 which is driven to rotate about a vertical axis, has a row of continuous die holes 54 arranged on a circle.
  • a pair of press rams 56, 54 is assigned to each die hole 54.
  • the upper ram 56 are axially movable in a disk 58 which is driven synchronously with the die plate 52.
  • the lower press rams 54 are axially movably mounted in a disk 60, which also rotates synchronously.
  • the axial position of the rams 53 and 56 is determined by control cams with which the rear ends of the rams 53, 56 cooperate.
  • the first filling station 32 contains a filling device 62 (not described in more detail), which is arranged above the disk 52 and fills tablet material, for example in powder form, into the passing die holes 54.
  • the filling depth is determined by the position of the lower press rams 53, which first run along a fixed cam segment 66 to form a movable cam segment 68, which can be actuated with the aid of an electromechanical adjusting device 70 (not described in more detail).
  • the cam segment 68 delimits the end position of the lower press rams 53, which gradually release the die holes 54 along the cam segment 66. By adjusting the curve segment 68 can therefore the filling depth and thus the dosage can be determined.
  • the actual pre-pressing device 34 is formed by pre-pressure rollers 70, 72 which specify the extent to which the filling in the die holes 54 is pressed together.
  • the height of the compact obtained in this way is also referred to as the web height.
  • the final web height is also determined in the main press station 36 by adjustable main pressure rollers 74, 76.
  • FIG. 3 shows the state of sampling for the first layer of a two-layer tablet.
  • a second layer is filled into the matrix holes on the first layer in a similar manner as described above and pressed together in the same way as was explained for the first layer.
  • a curve segment 78 is adjusted by means of an electromechanical adjusting device 80 so that the lower ram 53 are moved upwards, while the upper ram 56 with the help curve segment 80a can also move upwards.
  • the single-layer compacts 82 are ejected up to the surface of the die plate 52 and can be deflected to the side with the aid of a scraper 84 in the direction of the intermediate removal station 40.
  • a similar ejection station is provided in the removal station 50.
  • the operation of a rotary press for producing a two-layer tablet is known. It should therefore not be explained further.
  • the sampling for the first layer is explained below with reference to FIG. 4.
  • the start for the start of sampling is indicated in FIG. 4.
  • the pressing stations 34, 36 and 44, 46 are set with the help of the pressure rollers so that the desired web heights for the first layer and the double layer are achieved.
  • the switch in the intermediate removal station is in a position in which it forwards compacts to the testing device 20.
  • the switch of the intermediate removal station is also inoperative.
  • the switch in the removal station 50 is switched so that it deflects the two-layer compacts towards the dedusting and deburring device 14.
  • the web heights in the first and the second press stations 40, 50 are brought to a lower value in a temporal connection, which is done by correspondingly adjusting the pressure rollers in the press stations.
  • the switches of the intermediate and main removal station are switched towards the bad channel.
  • the adjusting device 80 begins to adjust the curve segment 78 in the ejection station 38 into a position as shown in FIG. 3.
  • the switch in the intermediate removal station is switched over so that the ejected single-layer compacts can reach the testing device 20 via the transport path 24.
  • the switch in the intermediate sampling station is switched back towards the bad channel.
  • the curve segment 78 is moved back again, so that the removal of single-layer compacts is ended.
  • the ejection station 36 has reached its original position again, the web heights are brought back to the original value by adjustment in the pressing stations.
  • the drain switch in the main removal station which, as mentioned, was previously switched continuously towards the bad channel, becomes again switched so that the two-layer compacts can again reach the device 14 via the normal transport route 12.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Sorting Of Articles (AREA)

Claims (5)

  1. Procédé de pressage, sur une presse rotative double, de comprimés comportant deux couches, selon lequel:
       le matériau en poudre est comprimé, couche par couche, dans des trous de matrice (54) d'un disque de matrice rotatif (52), au moyen de poinçons de presse (56, 59) tournant en synchronisme, et les ébauches à deux couches sont ensuite, dans une station d'évacuation (50), éjectées puis évacuées,
       et, dans un but de contrôle, après le pressage, des ébauches de la première couche sont prélevées dans une station intermédiaire d'évacuation (40), ou bien des ébauches terminées, à deux couches, sont prélevées dans la station d'évacuation (50), et sont envoyées à une station de contrôle (18), étant entendu qu'avant le prélèvement des échantillons, les premières couches sont comprimées, dans la station intermédiaire d'évacuation (40), plus fortement que pendant la fabrication normale,
       caractérisé en ce que, pendant le prélèvement d'échantillons, les deuxièmes couches sont, de même, comprimées plus fortement, et les deuxièmes couches, comprimées à leur tour, sont, au plus tard après évacuation des ébauches à une couche dans la station d'évacuation (50), envoyées à un canal de refus ou, de même, à la station de contrôle (18).
  2. Dispositif de pressage de comprimés à deux couches sur une presse rotative double, comportant un disque de matrice (52) entraîné en rotation autour d'un axe vertical et présentant des trous de matrice (54), et comportant des poinçons de presse (56, 59) tournant avec le disque de matrice (52),
       étant entendu que, sur le disque de matrice (52), sont disposés, dans le sens de la rotation, une première station de remplissage (32), une première station de pressage (34, 36), une deuxième station de remplissage (42), une deuxième station de pressage (44, 46), une station d'éjection (48) et une station d'évacuation (50), étant entendu, de plus, que les poinçons de presse (56, 59) sont actionnés, sur leur face opposée au disque de matrice (52), par des galets de pression (70 à 76), qui sont montés de façon à pouvoir coulisser vers les poinçons de presse (56, 59) ou s'en éloigner,
       et étant entendu qu'une station intermédiaire d'évacuation (40) comprend un segment de came mobile formant éjecteur (78) et un dispositif racleur (84),
       caractérisé en ce que la station intermédiaire d'évacuation (40) présente un aiguillage d'évacuation qui fait dévier, à volonté, les ébauches de la première couche (82), qui arrivent, soit vers un canal de refus, soit vers une station de contrôle (20),
       en ce que les galets de pression (70 à 76) de la première station de pressage (34, 36) et de la deuxième station de pressage (44, 46) sont réglés en étant coordonnés dans le temps, ou synchronisés,
       et en ce que, avant le déplacement des galets de pression (70 à 76) de la première station de pressage (34, 36), l'aiguillage d'évacuation est orienté dans la direction du canal de refus.
  3. Dispositif suivant la revendication 2, caractérisé en ce que le segment de came mobile formant éjecteur de la station intermédiaire d'évacuation (40) est déplacé en vue d'une éjection seulement après que les galets de pression de la première station de pressage (34, 36) ont été déplacés jusque dans leur nouvelle position pour comprimer la première couche.
  4. Dispositif suivant l'une des revendications 2 ou 3, caractérisé en ce que l'aiguillage d'évacuation est orienté vers la station de contrôle (20) seulement après que les galets de pression de la première station de pressage (34, 36) ont atteint leur nouvelle position, produisant une compression plus forte.
  5. Dispositif suivant l'une des revendications 2 à 4, caractérisé en ce que le segment de came mobile (78) formant éjecteur de la station d'éjection (48) est déplacé au moyen d'un dispositif électromécanique (80).
EP93107324A 1992-06-02 1993-05-06 Procédé et dispositif de compactage de comprimés à deux couches sur une presse à table tournante avec deux postes Expired - Lifetime EP0572816B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4218122 1992-06-02
DE4218122A DE4218122C1 (de) 1992-06-02 1992-06-02 Verfahren zum Pressen von Zweischichttabletten in einer Doppelrundläuferpresse und Vorrichtung zur Durchführung des Verfahrens

Publications (2)

Publication Number Publication Date
EP0572816A1 EP0572816A1 (fr) 1993-12-08
EP0572816B1 true EP0572816B1 (fr) 1996-04-17

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Application Number Title Priority Date Filing Date
EP93107324A Expired - Lifetime EP0572816B1 (fr) 1992-06-02 1993-05-06 Procédé et dispositif de compactage de comprimés à deux couches sur une presse à table tournante avec deux postes

Country Status (3)

Country Link
US (1) US5350548A (fr)
EP (1) EP0572816B1 (fr)
DE (2) DE4218122C1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2707213B1 (fr) 2011-05-10 2020-02-26 Fette Compacting GmbH Presse à plateau tournant et procédé permettant de faire fonctionner une presse à plateau tournant

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WO1996004128A1 (fr) * 1994-08-03 1996-02-15 Voss Gunter M Procede de fabrication de comprimes enrobes
IT1274883B (it) * 1994-08-05 1997-07-25 Ima Spa Dispositivo di dosaggio in macchine comprimitrici per la realizzazionedi compresse.
DE19855328A1 (de) * 1998-12-01 2000-06-08 Henkel Kgaa Tablettenpresse
KR100463775B1 (ko) * 2000-12-04 2004-12-29 가부시키가이샤 무라타 세이사쿠쇼 분말 공급 장치 및 분말 성형 장치
JP3780842B2 (ja) * 2000-12-04 2006-05-31 株式会社村田製作所 粉末成形装置及び粉末成形方法
JPWO2002090098A1 (ja) * 2001-05-07 2004-08-19 株式会社菊水製作所 回転式圧縮成型機
WO2003018302A1 (fr) * 2001-08-30 2003-03-06 Sanwa Kagaku Kenkyusho Co., Ltd Dispositif de fabrication d'articles moules et article moule pouvant etre fabrique par ce dispositif
US7122143B2 (en) 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
US6767200B2 (en) * 2001-09-28 2004-07-27 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
ITBO20020452A1 (it) * 2002-07-15 2004-01-15 Ima Spa Macchina comprimitrice
DE102005007790B4 (de) 2005-02-19 2007-06-28 Fette Gmbh Verfahren und Vorrichtung zur Versuchspressung von Mehrschichttabletten oder Manteltabletten
DE102005021923C5 (de) * 2005-05-12 2014-03-13 Fette Compacting Gmbh Verfahren zum Betrieb einer Rundläuferpresse und Rundläuferpresse
WO2008016183A1 (fr) * 2006-08-04 2008-02-07 Brother Kogyo Kabushiki Kaisha Appareil de formation d'image
DE102007061081B4 (de) 2007-12-14 2010-04-08 Fette Gmbh Verfahren zum Prüfen von Mehrschichttabletten
PL2110231T3 (pl) * 2008-04-18 2021-09-06 Korsch Ag Obrotowa prasa do tabletek
DE102008046422B3 (de) * 2008-09-09 2009-11-12 Fette Gmbh Verfahren zum Prüfen von Mehrschichttabletten in einer Mehrfachrundläuferpresse
DE102011101287B4 (de) * 2011-05-10 2013-11-14 Fette Compacting Gmbh Abstreifeinrichtung für eine Rundläuferpresse, Rundläuferpresse und Verfahren zum Betreiben einer Rundläuferpresse
CN102794922B (zh) * 2011-05-26 2014-11-26 许祥熙 金刚石节块自动冷压机
CN103372994A (zh) * 2012-04-25 2013-10-30 北京翰林航宇科技发展有限公司 具有三套压轮结构的压片机
EP4010181A4 (fr) * 2019-08-07 2023-10-18 Scitech Centre Échantillonnage de comprimés bicouches

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Publication number Priority date Publication date Assignee Title
EP2707213B1 (fr) 2011-05-10 2020-02-26 Fette Compacting GmbH Presse à plateau tournant et procédé permettant de faire fonctionner une presse à plateau tournant

Also Published As

Publication number Publication date
DE59302232D1 (de) 1996-05-23
EP0572816A1 (fr) 1993-12-08
US5350548A (en) 1994-09-27
DE4218122C1 (de) 1994-01-20

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