EP0544657A1 - Procede permettant d'obtenir des particules de dimension uniforme a partir de composes insolubles - Google Patents

Procede permettant d'obtenir des particules de dimension uniforme a partir de composes insolubles

Info

Publication number
EP0544657A1
EP0544657A1 EP90912514A EP90912514A EP0544657A1 EP 0544657 A1 EP0544657 A1 EP 0544657A1 EP 90912514 A EP90912514 A EP 90912514A EP 90912514 A EP90912514 A EP 90912514A EP 0544657 A1 EP0544657 A1 EP 0544657A1
Authority
EP
European Patent Office
Prior art keywords
particles
solution
solvent
compound
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP90912514A
Other languages
German (de)
English (en)
Other versions
EP0544657A4 (en
Inventor
Michael R. Violante
Harry W. Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25675878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0544657(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Rochester filed Critical University of Rochester
Publication of EP0544657A1 publication Critical patent/EP0544657A1/fr
Publication of EP0544657A4 publication Critical patent/EP0544657A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F7/00—Compounds of aluminium
    • C01F7/02—Aluminium oxide; Aluminium hydroxide; Aluminates
    • C01F7/34—Preparation of aluminium hydroxide by precipitation from solutions containing aluminium salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Abstract

Le présent procédé permet de fabriquer des particules de dimension uniforme à partir de composés solides. Premièrement, un composé solide approprié est dissous dans un solvant approprié. On fait infuser un liquide de précipitation qui provoque une suspension de particules non agrégées ayant un diamètre moyen sensiblement uniforme. Les particules sont ensuite séparées du solvant. Selon le composé solide et selon la dimension de particules souhaitée, les paramètres de température, de rapport non-solvant/solvant, de vitesse d'infusion, de vitesse d'agitation, et de volume peuvent être modifiés. Le liquide de précipitation peut être aqueux ou non aqueux, selon la solubilité relative du composé et selon le véhicule de suspension souhaité.
EP19900912514 1984-05-21 1990-08-21 Method for making uniformly-sized particles from insoluble compounds Withdrawn EP0544657A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61272584A 1984-05-21 1984-05-21
CA002089075A CA2089075A1 (fr) 1984-05-21 1990-08-21 Methode servant a fabriquer des particules de grosseur uniforme a partir de composes insolubles

Publications (2)

Publication Number Publication Date
EP0544657A1 true EP0544657A1 (fr) 1993-06-09
EP0544657A4 EP0544657A4 (en) 1993-08-04

Family

ID=25675878

Family Applications (2)

Application Number Title Priority Date Filing Date
EP85201206A Expired - Lifetime EP0169618B2 (fr) 1984-05-21 1985-05-21 Méthode pour obtenir des particules à dimensions uniformes de matières organiques insolubles dans l'eau
EP19900912514 Withdrawn EP0544657A4 (en) 1984-05-21 1990-08-21 Method for making uniformly-sized particles from insoluble compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP85201206A Expired - Lifetime EP0169618B2 (fr) 1984-05-21 1985-05-21 Méthode pour obtenir des particules à dimensions uniformes de matières organiques insolubles dans l'eau

Country Status (7)

Country Link
EP (2) EP0169618B2 (fr)
JP (1) JPH072209B2 (fr)
KR (1) KR930701346A (fr)
AU (1) AU579166B2 (fr)
CA (2) CA1282405C (fr)
PT (1) PT80494B (fr)
WO (1) WO1992003380A1 (fr)

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US4606939A (en) * 1983-06-22 1986-08-19 The Ohio State University Research Foundation Small particle formation
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
US4783484A (en) * 1984-10-05 1988-11-08 University Of Rochester Particulate composition and use thereof as antimicrobial agent
NL194638C (nl) * 1986-12-19 2002-10-04 Novartis Ag Hydrosol die vaste deeltjes van een farmaceutisch actieve stof bevat en farmaceutisch preparaat dat deze hydrosol bevat.
DK181988A (da) * 1988-03-30 1989-10-01 Dumex Ltd As Thiocarbamidsyreester til brug som terapeutikum samt praeparat til behandling af alkoholmisbrug
SE464743B (sv) * 1989-06-21 1991-06-10 Ytkemiska Inst Foerfarande foer framstaellning av laekemedelspartiklar
DE3936053A1 (de) * 1989-10-28 1991-05-02 Basf Ag Verfahren zur verbesserung der bioverfuegbarkeit von pharmazeutischen wirkstoffen mit peptidbindungen
US6350462B1 (en) * 1990-12-26 2002-02-26 Olympus Optical Co., Ltd. Hollow porous ceramic carrier for embedding in patient for sustained medicament release and method of preparation thereof
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
MX9201782A (es) * 1991-04-19 1992-10-01 Sandoz Ag Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
AU2317592A (en) * 1991-07-05 1993-02-11 University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
DE69309056T2 (de) * 1992-06-10 1997-09-18 Nanosystems Llc Oberflaechenmodifizierte nsaid nanopartikeln
DE4329446A1 (de) * 1993-09-01 1995-03-02 Basf Ag Verfahren zur Herstellung von feinteiligen Farb- oder Wirkstoffzubereitungen
SE9403846D0 (sv) * 1994-11-09 1994-11-09 Univ Ohio State Res Found Small particle formation
SE9501384D0 (sv) 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US6048550A (en) * 1996-10-03 2000-04-11 Chan; Daniel C. F. Hydrophilic microparticles and methods to prepare same
EP1369111A1 (fr) * 1996-10-03 2003-12-10 Hermes Biosciences, Inc. Microparticules hydrophiles et leurs procédés de préparation
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
IL130715A (en) * 1997-02-05 2003-07-31 Merck & Co Inc Form i of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoro-methyl-1,4-dihydro-2h-3,1-benzoxazin-2-one and a process for preparing the crystalline form of said compound
SE9701956D0 (sv) 1997-05-23 1997-05-23 Astra Ab New composition of matter
DE19856432A1 (de) 1998-12-08 2000-06-15 Basf Ag Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen
US6447806B1 (en) 1999-02-25 2002-09-10 Novartis Ag Pharmaceutical compositions comprised of stabilized peptide particles
GB9925934D0 (en) * 1999-11-03 1999-12-29 Glaxo Group Ltd Novel apparatus and process
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
JP4376518B2 (ja) * 2000-12-22 2009-12-02 バクスター・インターナショナル・インコーポレイテッド サブミクロン粒子の懸濁物を調製する方法
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
AU2002337692B2 (en) 2001-09-26 2007-09-13 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
JP2006511499A (ja) * 2002-05-13 2006-04-06 ファルマシア コーポレイション 安定な無定形セレコキシブ複合物およびその製法
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
JP4326197B2 (ja) * 2002-08-30 2009-09-02 独立行政法人科学技術振興機構 顔料ナノ粒子の新規な製造方法
US7511079B2 (en) 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
US8022054B2 (en) 2005-11-28 2011-09-20 Marinus Pharmaceuticals Liquid ganaxolone formulations and methods for the making and use thereof
AU2007325628A1 (en) 2006-11-28 2008-06-05 Marinus Pharmaceuticals Nanoparticulate formulations and methods for the making and use thereof
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
WO2009073517A2 (fr) * 2007-11-30 2009-06-11 Indevus Pharmaceuticals, Inc. Compositions et procédés de traitement du cancer de la vessie
JPWO2015137289A1 (ja) * 2014-03-10 2017-04-06 国立大学法人 東京大学 水分散性非晶質粒子及びその調製方法
KR20180082457A (ko) 2015-10-16 2018-07-18 마리누스 파마슈티컬스 인코포레이티드 나노입자들을 포함하는 주사용 뉴로스테로이드 제제들
WO2018031748A1 (fr) 2016-08-11 2018-02-15 Ovid Therapeutics Inc. Methodes et compositions pour le traitement de troubles épileptiques
US10391105B2 (en) 2016-09-09 2019-08-27 Marinus Pharmaceuticals Inc. Methods of treating certain depressive disorders and delirium tremens
WO2020118142A1 (fr) 2018-12-07 2020-06-11 Marinus Pharmaceuticals, Inc. Ganaxolone destiné à être utilisé dans la prophylaxie et le traitement de la dépression post-partum
MX2022001553A (es) 2019-08-05 2022-04-18 Marinus Pharmaceuticals Inc Ganaxolona para su uso en el tratamiento del estado epileptico.
WO2021113834A1 (fr) 2019-12-06 2021-06-10 Marinus Pharmaceuticals, Inc. Ganaxolone destinée à être utilisée dans le traitement du complexe de la sclérose tubéreuse

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB899667A (en) * 1960-04-19 1962-06-27 Glaxo Lab Ltd Crystalline griseofulvin
EP0147767A2 (fr) * 1983-12-30 1985-07-10 Hoechst Aktiengesellschaft Préparations d'anthelmintiques peu hydrosolubles et procédé de leur fabrication
US4997454A (en) * 1984-05-21 1991-03-05 The University Of Rochester Method for making uniformly-sized particles from insoluble compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3887692A (en) * 1972-07-10 1975-06-03 Armour Pharma Microspherical basic aluminum halides and method of making same
DE2348334C2 (de) * 1973-09-26 1982-11-11 Boehringer Mannheim Gmbh, 6800 Mannheim Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs
US4606939A (en) * 1983-06-22 1986-08-19 The Ohio State University Research Foundation Small particle formation
US4670461A (en) * 1984-04-26 1987-06-02 The United States Of America As Represented By The Department Of Health And Human Services Formaldehyde derivatives of mitindomide
US4783484A (en) * 1984-10-05 1988-11-08 University Of Rochester Particulate composition and use thereof as antimicrobial agent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB899667A (en) * 1960-04-19 1962-06-27 Glaxo Lab Ltd Crystalline griseofulvin
EP0147767A2 (fr) * 1983-12-30 1985-07-10 Hoechst Aktiengesellschaft Préparations d'anthelmintiques peu hydrosolubles et procédé de leur fabrication
US4997454A (en) * 1984-05-21 1991-03-05 The University Of Rochester Method for making uniformly-sized particles from insoluble compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9203380A1 *

Also Published As

Publication number Publication date
AU579166B2 (en) 1988-11-17
EP0169618B2 (fr) 1993-11-10
JPS6227032A (ja) 1987-02-05
EP0544657A4 (en) 1993-08-04
CA1282405C (fr) 1991-04-02
EP0169618A2 (fr) 1986-01-29
JPH072209B2 (ja) 1995-01-18
CA2089075A1 (fr) 1992-02-22
EP0169618B1 (fr) 1990-08-29
PT80494A (en) 1985-11-22
PT80494B (pt) 1987-08-19
EP0169618A3 (en) 1988-07-27
KR930701346A (ko) 1993-06-11
WO1992003380A1 (fr) 1992-03-05
AU4501285A (en) 1987-01-22

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