EP0521460A1 - Pointe de transfert et prélèvement - Google Patents

Pointe de transfert et prélèvement Download PDF

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Publication number
EP0521460A1
EP0521460A1 EP19920111057 EP92111057A EP0521460A1 EP 0521460 A1 EP0521460 A1 EP 0521460A1 EP 19920111057 EP19920111057 EP 19920111057 EP 92111057 A EP92111057 A EP 92111057A EP 0521460 A1 EP0521460 A1 EP 0521460A1
Authority
EP
European Patent Office
Prior art keywords
flow
channel
piercing
shut
flow channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19920111057
Other languages
German (de)
English (en)
Other versions
EP0521460B1 (fr
Inventor
Von Brand Axel
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Individual
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0521460A1 publication Critical patent/EP0521460A1/fr
Application granted granted Critical
Publication of EP0521460B1 publication Critical patent/EP0521460B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096Combination of a vial and a syringe for transferring or mixing their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2013Piercing means having two piercing ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2058Connecting means having multiple connecting ports
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2058Connecting means having multiple connecting ports
    • A61J1/2062Connecting means having multiple connecting ports with directional valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068Venting means
    • A61J1/2072Venting means for internal venting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068Venting means
    • A61J1/2075Venting means for external venting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079Filtering means
    • A61J1/2082Filtering means for gas filtration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079Filtering means
    • A61J1/2086Filtering means for fluid filtration

Definitions

  • the invention relates to a device, in particular for medical purposes, with a carrier plate and, connected thereto, diametrically arranged piercing spikes, through which two flow channels are guided.
  • a device is referred to in technical terminology, for example, as a transfer spike or transfer device.
  • the field of application for the present invention is in particular medical technology.
  • a first container holding the liquid in particular a bottle or a bag
  • a second Container in particular a container for receiving a substance to be dissolved, in particular a bottle or a bag.
  • the medical device with the piercing spikes is inserted into the sealing plugs, each of which seals the two containers and is made of rubber or the like, i.e. the sealing plugs are pierced by means of the piercing spikes, so that a flow connection is created between the two containers via one of the two flow channels, while the other flow channel serves to equalize the pressure between the two containers.
  • the liquid-receiving container is held upward, so that the liquid can pass into the container to be dissolved, the air in this container flows through the ventilation channel into the empty container.
  • the device with the emptied container was separated from the now filled container and the dissolved substance was removed by means of a syringe provided with a cannula.
  • the plug of the container had to be pierced by the cannula.
  • the additional cannula with protective cap and separate packaging means that additional effort is required to remove the dissolved substance from the container.
  • Additional manipulations using a separate cannula and inserting the same into the rubber stopper of the container deliver additional particles and fragments of the dissolved substance.
  • the same cannula is used for the patient that was previously used to pierce the rubber stopper of the container.
  • a device which has two piercing mandrels into which the two flow channels are integrated, this device consisting entirely of plastic.
  • a device which has four Has piercing mandrels, with two piercing mandrels arranged diametrically to each other being assigned a flow channel for the liquid transfer or the venting.
  • the spikes consist of metal, so that the spikes are cannulas.
  • the device has a shut-off element cooperating with one of the flow channels, which releases the flow through the flow channel in an open position and blocks the flow through the flow channel in a blocking position, a liquid removal channel of the device in in the blocking position Flow connection with a section of the flow channel open to a piercing tip, and the liquid removal channel opens into a connecting piece.
  • the mixing of different liquids that is to say at a point in time at which a connection of the two containers through two flow channels is no longer necessary, at least one flow channel of the shut-off element, wherein the shut-off element in the locked position establishes a flow connection between a section of the flow channel that is open to a puncture tip and a liquid removal channel of the device, through which the dissolved liquid can then be removed.
  • the liquid removal channel itself opens into a connection piece, which is designed in particular as a connection canoe, for syringes or transfer systems. It goes without saying that the liquid extraction channel can also open into several connecting pieces.
  • the advantage of the invention is therefore that a separate cannula with the problem of additional particles by pushing through the rubber stopper is not necessary. This saves additional packaging, disposal, handling and costs. At the same time, the invention precludes the user from using the same cannula for the rubber stopper as for the patient.
  • shut-off element interacts only with one flow channel
  • the other flow channel remains open in the locked position of the shut-off element.
  • a backflow of the dissolved liquid from the container located at the top when the dissolved liquid is removed into the empty container below is excluded because the air in this container cannot flow out because of the section of the flow channel which is closed by the shut-off element and is assigned to the empty container.
  • shut-off element also interacts with the other flow channel, the shut-off element opening the flow through the other flow channel in the open position and blocking the flow through the other flow channel in the blocking position, with an outward position in the blocking position open ventilation channel of the device in flow connection with a section of the other flow channel open to a puncture syringe of the associated piercing mandrel.
  • the shut-off element can thus completely shut off the sections of the two flow channels opening into the lower, empty container and it takes place via the channel sections of the two flow channels assigned to the upper container holding the dissolved substance, as well as the liquid removal channel and the ventilation channel emptying container instead.
  • the device expediently has two diametrically arranged piercing mandrels.
  • the outlet openings of the one flow channel in the area of the piercing tip of the one piercing mandrel should be arranged at a distance from the piercing tip of the other piercing mandrel, and the outlet openings of the other flow channel should be arranged in the area of the piercing tip of the other piercing mandrel and spaced from the piercing tip of the one piercing mandrel.
  • the liquid When the substance is dissolved, the liquid enters the flow channel from the upper container, whose outlet opening facing this container is lower, while the air from the lower container passes into the upper container through the outlet opening of the other flow channel located further up.
  • the device should be connected to the two containers in such a way that after the substance has been loosened, i.e. before the dissolved substance has been removed, the liquid removal channel is assigned to the section of the flow channel whose outlet opening is lower than the outlet opening of the associated other flow channel.
  • the piercing mandrels should extend perpendicular to the plane of the carrier plate, which is usually the main plane thereof.
  • the shut-off element is designed as a slide element which is slidably mounted in the carrier plate, the slide element having two through bores which form channel sections of the two flow channels in the open position of the slide element, and furthermore the slide element forms the liquid removal channel and has the ventilation channel, which in the blocking position come into flow connection with the flow channel sections of a piercing mandrel.
  • the sections of the flow channels leading to the lower, empty container are blocked in the blocking position of the blocking element and the liquid is withdrawn from the upper container or its container Ventilation exclusively via the channel sections of the two flow channels assigned to the upper container and the liquid extraction channel and the ventilation channel.
  • a special embodiment of the invention provides that the slide element assumes its blocking position in the inserted position. If it is assumed that a syringe for removing the dissolved liquid is primarily connected to the connecting piece of the slide element and the connecting piece is oriented in the sliding direction of the slide element, the transfer of the slide element into its locked position can be accomplished by a pronounced insertion movement of the syringe into the connecting piece .
  • a second embodiment of the inventive principle described at the outset provides that the shut-off element is designed as a tap with two T passages, with a first and a second outlet of the respective passage in the open position of the tap being in flow connection with one of the flow channels of the piercing mandrels and the third The outlet is closed by the carrier plate, and in the blocking position of the tap the first outlet of the respective passage is closed by the carrier plate and the second and the third outlet of the respective passage are in flow communication with the channel section of a piercing mandrel and the liquid extraction channel or the ventilation channel.
  • the connection between the container to be emptied and the liquid extraction channel or the ventilation channel is effected by turning the valve into its locked position.
  • the tap has two T-passages, but in principle it would be sufficient to provide one T-passageway which can be brought into operative connection with the flow channel serving for the removal of liquid, while the other passage is straight could be so that it blocks the associated flow channel when the valve is in the blocking position and thus does not allow ventilation of the container from which the dissolved substance can be removed.
  • the dissolved substance would have to be removed from the assigned container against increasing negative pressure. A pressure equalization would be possible after removing the syringe from the connector after swiveling the container downwards beforehand.
  • a third embodiment of the principle of the invention described in the introduction provides that a valve is integrated in the liquid removal channel, in particular a lip valve, which allows a flow through the liquid removal channel to the connecting piece when a negative pressure is applied to the connecting piece side.
  • the liquid extraction channel is integrated into the shut-off element, which is also designed as a slide element, and when the slide element is in the blocking position, this interrupts the passage through the assigned flow channel, so that a flow path from the other section of this flow channel through the liquid removal channel and thus when a negative pressure is applied through the valve is possible is.
  • the valve closes off the assigned flow channel in the area of the connecting piece.
  • one of the flow channels has a branch which opens into a connecting piece which receives a conical extension of a Syringe or other disposable system is used, the device wall forming the flow channel at the level of the connecting piece on the opposite side thereof having a shoulder arranged substantially perpendicular to the flow path, which the approach introduced into the connecting piece contacts, such that the approach to the flow path shuts off a channel section and a flow connection between the flow path to the other Channel section and the syringe / disposable system opens, the connector being closed by a cap when the syringe is removed.
  • a basic, preferred embodiment provides that a filter is integrated in those configurations in which there is a liquid extraction channel and / or a ventilation channel.
  • Figures 1a, 1b and 1c illustrate the problem underlying the invention.
  • a substance in a first container, the bottle 1 is to be dissolved using a liquid in the second container, the bottle 2, in the present case water, and the dissolved substance is then removed from the bottle 1 by means of the device 3 according to the invention.
  • Figure 1a shows the device 3 in a highly simplified representation. It has a carrier plate 4, in which a shut-off element 5 designed as a slide is located in the region of the carrier plate 4 is shown in dashed lines, is displaceable in the direction of the double arrows B.
  • the carrier plate 4 On the top and underside, the carrier plate 4 has two piercing mandrels 6 and 7 or 8 and 9 in the form of metal cannulas, the long piercing mandrel 6 being aligned with the short piercing mandrel 8 and the short piercing mandrel 7 being aligned with the long piercing mandrel 9 and thus also the flow channels formed by the piercing mandrels 6 to 9, which cannot be removed from this FIG.
  • the shut-off element 5 also has two through bores 10 and 11, which are aligned with the flow channels of the piercing pins 6 and 8 or 7 and 9 in the extended position of the shut-off element representing the open position. Furthermore, the shut-off element 5 is provided with a liquid removal channel 12 and a ventilation channel 13 which, when the position representing the blocking position of the shut-off element 5 is inserted, come into connection with the section of the flow channel of the piercing mandrel 6 or the piercing mandrel 7 and the flow channel sections of the piercing mandrels 8 and 9 shut off.
  • the arrangement described so far works as follows:
  • the shut-off element 5 When the shut-off element 5 is in the open position, the bottle 1 with its bottle neck is inserted into a receptacle sleeve 14 connected to one side of the carrier plate 4, the piercing pins 8 and 9 penetrating a rubber stopper, not shown, of the bottle 1 on the other side of the carrier plate 4 is the receiving sleeve 15, the other bottle 2 is inserted with its bottle neck and the piercing pins 6 and 7 penetrate the rubber sealing plug of this bottle 2, which is not shown in more detail.
  • the shut-off element 5 When the bottles 1 and 2 are plugged in, the shut-off element 5 is in its open position , This initial situation is shown in Figure 1a.
  • the bottle 2 containing the water is held upwards, so that the water can pass through the short piercing mandrel 7, the through hole 11 and the piercing mandrel 9 into the lower bottle 1 containing the substance to be dissolved, while the bottle 1 corresponds to the filling state of the bottle in this air through the piercing mandrel B, the through hole 10 and the long piercing mandrel 6 into the bottle 2.
  • the syringe attachment 17 of a dispensing syringe 18, which is only partially shown, is inserted into a connecting piece 16 in fluid communication with the liquid channel 12, the shut-off element being due to the insertion movement 5 is immediately transferred to the locked position.
  • This state is shown in the illustration in FIG. 1b.
  • the liquid removal channel 12 is thus in flow connection with the piercing mandrel B, while the ventilation channel 13 is connected to the piercing mandrel 9.
  • the carrier plate 4 with the two bottles 1 and 2 is pivoted about the longitudinal axis of the dispensing syringe 18 by 180 °, so that the bottle 1, which is in water contains dissolved substance, is arranged above, and the empty bottle 2 below.
  • the withdrawal syringe 18 is pulled out, the liquid containing the substance can be removed from the bottle 1 through the short piercing mandrel B and the liquid removal channel 12, and air can enter the bottle 1 through the ventilation channel 13 and the long piercing mandrel 9. This state is shown in Figure 1c.
  • the disposable syringe 18 is to be replaced by another one, this can be done, for example, by moving the arrangement into the position according to FIG. 1b before removing the syringe and pivoting the position of FIG. 1c back after the next syringe has been attached.
  • FIGS. 2a and 2b show a modified design of the device 3 according to the invention using a shut-off element 5 designed as a slide.
  • the device 3 consists entirely of plastic.
  • Two diametrically arranged piercing pins 19 and 20 are connected directly to the carrier plate 4, through which the two flow channels 21 and 22 are guided. These flow channels 21 are in the open position shown in FIG. 2a and 22 in flow connection with the through bores 10 and 11 of the shut-off element 5.
  • the piercing mandrel 19 is inserted into the bottle 1 and the piercing mandrel 20 into the bottle 2, so that after the bottle 2 is upward is pivoted, the water can flow from the bottle 2 into the bottle 1 containing the substance to be dissolved.
  • the shut-off element 5 is moved into its locked position and then the arrangement is pivoted through 180 °, so that the bottle 1 containing the water and the substance is arranged at the top.
  • the position of the shut-off element 5 in this end position is shown in FIG. 2b, according to which in the area of the piercing mandrel 19 the flow channel 21 is in fluid communication with the liquid extraction channel 12 over the short channel length and the long channel length of the flow channel 22 via the ventilation channel 13 in the surrounding atmosphere lies.
  • a liquid filter 23 integrated into the shut-off element 5 is provided, and accordingly an air filter 24 in the transition area between the ventilation channel 13 and the assigned section of the flow channel 22.
  • the liquid removal channel 12 opens into a connecting piece 25 for the Withdrawal syringe 18, further into a connecting piece 26 for a transfer system, not shown, which can be connected to the device 3 and thus to the overall arrangement.
  • the connecting pieces 25 and 26 can optionally be closed by means of caps 27.
  • Two locking elements 28 and 29 arranged on the shut-off element 5 serve to fix the shut-off element in its open position or locked position, in that one of the locking elements 28 and 29 respectively engages in a recess 30 in the carrier plate.
  • the device 3 in accordance with the embodiment described above, has two piercing pins 19 and 20, but there the shut-off element 5 is designed as a tap with two T passages 31 and 32.
  • Each T passage 31 and 32 thus has three outputs 33, 34 and 35, respectively.
  • the bore sections of the T passages 31 and 32 located between the outlets 33 and 34 connect them to the flow channels 21 and 22, respectively, so that when the piercing pins 19 are inserted into the bottles 1 and 2, respectively or 20 overflow the water in the bottle 2 into the bottle 1 and thus can dissolve the substance therein.
  • the device 3 is shown in the relevant position of the shut-off element 5 in Figures 3a and 3c. To remove the dissolved substance, it is then only necessary to move the shut-off element 5 into the locked position and to pivot the arrangement by 180 ° in total.
  • the blocking position is shown in FIGS. 3b and 3d, according to which the shut-off element 5 is rotated by 90 ° and thus a flow connection is formed between the section of the flow channel 21 assigned to the piercing mandrel 19 via the outlets 35 and 33 to the liquid removal channel 12.
  • the device 3 again has the two piercing pins 19 and 20, with the flow channels 21 and 22.
  • the shut-off element 5 designed as a slide is exclusively assigned to one flow channel, namely the flow channel 21.
  • the essentially rotationally symmetrical shut-off element 5, which opens directly into the connecting piece 16 for the dispensing syringe 18, has a projection 36 on the side of the flow channel 21 facing the spike 20, which in the open position of the shut-off element 5 extends as far from the partition 37 between the two flow channels 21 and 22 arranged away is that the flow channels 21 and 22 can be flowed through unhindered when dissolving the substance.
  • a lip valve 38 integrated into the shut-off element 5 and pointing towards the connecting piece 16 prevents water from entering the connecting piece 16 when the water is passed over to dissolve the substance.
  • the dispensing syringe 18 is inserted with the syringe attachment 17 into the connecting piece 16, the shut-off element 5 being moved in the direction of the dividing wall 37 during the insertion movement until the projection 36 abuts the dividing wall 37 and the Closes passage through the flow channel 22 in the area of the piercing mandrel 20.
  • a liquid filter 23 is integrated in the shut-off element 5.
  • An anti-rotation device is not shown between the shut-off element 5 and a device attachment 40 serving to guide it.
  • the carrier plate 4 extends essentially perpendicular to the plane of the drawing. Since in this embodiment no separate ventilation duct 13 is provided in the shut-off element 5, the device 3 is particularly suitable for non-rigid containers, for example plastic bags.
  • FIGS. 5a and 5b also have two piercing pins 19 and 20 with two flow channels 21 and 22 corresponding to those according to FIGS. 4a and 4b.
  • About half the length of the flow channel 22 opens into the connecting piece 16, which is closed with a cap.
  • the partition 37 has on the side facing the connecting piece 16 at the level of the connecting piece 16 a shoulder arranged substantially perpendicular to the flow path.
  • the syringe attachment 17 of the withdrawal syringe 18 contacts via an arc of its Front ring the above paragraph 41, with simultaneous sealing of the syringe neck 17 to the neck 16, so that the flow path is blocked by the area associated with the piercing mandrel 20 of the flow channel 21. While the liquid can flow unhindered through the piercing pins 19 and 20 when the dispensing syringe 18 is not inserted or when the connecting piece 16 is closed, while venting through the piercing pins at the same time, as shown in FIG Flow channel 21 are removed.
  • the carrier plate 4 extends perpendicular to the plane of the drawing.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
EP19920111057 1991-07-04 1992-06-30 Pointe de transfert et prélèvement Expired - Lifetime EP0521460B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4122221 1991-07-04
DE19914122221 DE4122221A1 (de) 1991-07-04 1991-07-04 Transfer- und entnahmespike

Publications (2)

Publication Number Publication Date
EP0521460A1 true EP0521460A1 (fr) 1993-01-07
EP0521460B1 EP0521460B1 (fr) 1995-09-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920111057 Expired - Lifetime EP0521460B1 (fr) 1991-07-04 1992-06-30 Pointe de transfert et prélèvement

Country Status (3)

Country Link
EP (1) EP0521460B1 (fr)
AT (1) ATE127679T1 (fr)
DE (2) DE4122221A1 (fr)

Cited By (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013785A1 (fr) * 1993-11-16 1995-05-26 Christian Eichler Systeme de transvasement a usage medical ou pharmaceutique, par exemple pour transvaser une substance dans une solution
WO1996029113A1 (fr) * 1995-03-20 1996-09-26 Medimop Medical Projects Ltd. Dispositif de regulation de fluide
WO1997020536A1 (fr) * 1995-12-06 1997-06-12 Gabriel Meyer Dispositif pour la preparation d'une solution medicamenteuse reconstituee a partir de deux composants
WO1999026581A1 (fr) * 1997-11-24 1999-06-03 Eurospital S.P.A. Dispositif de transfert de fluide connectant deux recipients medicaux dans un systeme ferme
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AT519623A1 (de) * 2017-02-08 2018-08-15 Hubertus Goller Ges M B H Mischvorrichtung
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WO1995013785A1 (fr) * 1993-11-16 1995-05-26 Christian Eichler Systeme de transvasement a usage medical ou pharmaceutique, par exemple pour transvaser une substance dans une solution
WO1996029113A1 (fr) * 1995-03-20 1996-09-26 Medimop Medical Projects Ltd. Dispositif de regulation de fluide
WO1997020536A1 (fr) * 1995-12-06 1997-06-12 Gabriel Meyer Dispositif pour la preparation d'une solution medicamenteuse reconstituee a partir de deux composants
WO1999026581A1 (fr) * 1997-11-24 1999-06-03 Eurospital S.P.A. Dispositif de transfert de fluide connectant deux recipients medicaux dans un systeme ferme
FR2850015A1 (fr) * 2003-01-22 2004-07-23 Rvp Finance Dispositif pour le transfert d'un liquide entre deux recipients
US7491197B2 (en) 2003-03-06 2009-02-17 Csl Behring Gmbh Fluid transfer device
AU2004200893B9 (en) * 2003-03-06 2010-04-15 Csl Behring Gmbh Transfer Device, in Particular for Medical Fluids
AU2004200893B2 (en) * 2003-03-06 2010-03-11 Csl Behring Gmbh Transfer Device, in Particular for Medical Fluids
US7294122B2 (en) 2003-07-17 2007-11-13 Nipro Corporation Transfer needle
EP1498097A3 (fr) * 2003-07-17 2005-02-16 Nipro Corporation Aiguille de transfert
US8066688B2 (en) 2004-04-29 2011-11-29 Medimop Medical Projects Ltd. Liquid drug medical device
WO2005105014A3 (fr) * 2004-04-29 2005-12-01 Medimop Medical Projects Ltd Dispositifs medicaux pour medicaments liquides et dispositif d'enlevement de protection d'aiguille
WO2005105014A2 (fr) * 2004-04-29 2005-11-10 Medimop Medical Projects Ltd Dispositifs medicaux pour medicaments liquides et dispositif d'enlevement de protection d'aiguille
US8021325B2 (en) 2004-04-29 2011-09-20 Medimop Medical Projects Ltd. Liquid drug medical device
WO2005120431A1 (fr) * 2004-05-03 2005-12-22 Sedat Seringue pour interventions medicales et necessaire de reconstitution de substances extemporanees comportant une telle seringue
FR2869533A1 (fr) * 2004-05-03 2005-11-04 Sedat Sa Seringue pour interventions medicales et necessaire de reconstitution de substances extemporanees comportant une telle seringue
US7896849B2 (en) 2004-05-03 2011-03-01 Sedat Syringe for medical interventions and kit for reconstituting extemporaneous substances
US8070739B2 (en) 2005-08-11 2011-12-06 Medimop Medical Projects Ltd. Liquid drug transfer devices for failsafe correct snap fitting onto medicinal vials
US8435210B2 (en) 2007-04-17 2013-05-07 Medimop Medical Projects Ltd. Fluid control device with manually depressed actuator
US8317743B2 (en) 2007-09-18 2012-11-27 Medimop Medical Projects Ltd. Medicament mixing and injection apparatus
US8016809B2 (en) 2007-09-25 2011-09-13 Medimop Medical Projects Ltd. Liquid drug delivery devices for use with syringes with widened distal tips
USD641080S1 (en) 2009-03-31 2011-07-05 Medimop Medical Projects Ltd. Medical device having syringe port with locking mechanism
EP2419071A2 (fr) * 2009-04-14 2012-02-22 Yukon Medical, LLC Dispositif de transfert de fluide
EP2419071A4 (fr) * 2009-04-14 2014-11-05 Yukon Medical Llc Dispositif de transfert de fluide
USD616984S1 (en) 2009-07-02 2010-06-01 Medimop Medical Projects Ltd. Vial adapter having side windows
USD630732S1 (en) 2009-09-29 2011-01-11 Medimop Medical Projects Ltd. Vial adapter with female connector
US8998875B2 (en) 2009-10-01 2015-04-07 Medimop Medical Projects Ltd. Vial assemblage with vial and pre-attached fluid transfer device
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US8979792B2 (en) 2009-11-12 2015-03-17 Medimop Medical Projects Ltd. Inline liquid drug medical devices with linear displaceable sliding flow control member
WO2011058548A1 (fr) * 2009-11-12 2011-05-19 Medimop Medical Projects Ltd Dispositifs médicaux en ligne pour médicament liquide comprenant un élément de commande d'écoulement coulissant à déplacement linéaire
US9132063B2 (en) 2009-11-12 2015-09-15 Medimop Medical Projects Ltd. Inline liquid drug medical devices with linear displaceable sliding flow control member
US8608723B2 (en) 2009-11-12 2013-12-17 Medimop Medical Projects Ltd. Fluid transfer devices with sealing arrangement
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US8753325B2 (en) 2010-02-24 2014-06-17 Medimop Medical Projects, Ltd. Liquid drug transfer device with vented vial adapter
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US8852145B2 (en) 2010-11-14 2014-10-07 Medimop Medical Projects, Ltd. Inline liquid drug medical device having rotary flow control member
US8752598B2 (en) 2011-04-17 2014-06-17 Medimop Medical Projects Ltd. Liquid drug transfer assembly
US8905994B1 (en) 2011-10-11 2014-12-09 Medimop Medical Projects, Ltd. Valve assembly for use with liquid container and drug vial
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
USD674088S1 (en) 2012-02-13 2013-01-08 Medimop Medical Projects Ltd. Vial adapter
US9283324B2 (en) 2012-04-05 2016-03-15 Medimop Medical Projects, Ltd Fluid transfer devices having cartridge port with cartridge ejection arrangement
US9795536B2 (en) 2012-08-26 2017-10-24 Medimop Medical Projects, Ltd. Liquid drug transfer devices employing manual rotation for dual flow communication step actuations
US10299990B2 (en) 2012-08-26 2019-05-28 West Pharma. Services IL, Ltd. Liquid drug transfer devices
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US9339438B2 (en) 2012-09-13 2016-05-17 Medimop Medical Projects Ltd. Telescopic female drug vial adapter
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US9801786B2 (en) 2013-04-14 2017-10-31 Medimop Medical Projects Ltd. Drug container closure for mounting on open-topped drug container to form drug reconstitution assemblage for use with needleless syringe
US9943463B2 (en) 2013-05-10 2018-04-17 West Pharma. Services IL, Ltd. Medical devices including vial adapter with inline dry drug module
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
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US10688295B2 (en) 2013-08-07 2020-06-23 West Pharma. Services IL, Ltd. Liquid transfer devices for use with infusion liquid containers
USD794183S1 (en) 2014-03-19 2017-08-08 Medimop Medical Projects Ltd. Dual ended liquid transfer spike
DE102014213948B4 (de) 2014-07-17 2021-09-23 B. Braun Melsungen Aktiengesellschaft Fluidverbindungssystem für medizinische Zwecke
DE102014213948A1 (de) 2014-07-17 2016-01-21 B. Braun Melsungen Ag Fluidverbindungssystem für medizinische Zwecke
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US10285907B2 (en) 2015-01-05 2019-05-14 West Pharma. Services IL, Ltd. Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
US10278897B2 (en) 2015-11-25 2019-05-07 West Pharma. Services IL, Ltd. Dual vial adapter assemblage including drug vial adapter with self-sealing access valve
US10420927B2 (en) 2015-12-04 2019-09-24 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10765604B2 (en) 2016-05-24 2020-09-08 West Pharma. Services IL, Ltd. Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
US10806667B2 (en) 2016-06-06 2020-10-20 West Pharma. Services IL, Ltd. Fluid transfer devices for filling drug pump cartridges with liquid drug contents
US10806671B2 (en) 2016-08-21 2020-10-20 West Pharma. Services IL, Ltd. Syringe assembly
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US10772798B2 (en) 2016-12-06 2020-09-15 West Pharma Services Il, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
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Also Published As

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EP0521460B1 (fr) 1995-09-13
DE59203648D1 (de) 1995-10-19
DE4122221A1 (de) 1993-03-18
ATE127679T1 (de) 1995-09-15

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