EP0336960A4 - Entgiftungszusatz für nahrungsmittel. - Google Patents

Entgiftungszusatz für nahrungsmittel.

Info

Publication number
EP0336960A4
EP0336960A4 EP19880910286 EP88910286A EP0336960A4 EP 0336960 A4 EP0336960 A4 EP 0336960A4 EP 19880910286 EP19880910286 EP 19880910286 EP 88910286 A EP88910286 A EP 88910286A EP 0336960 A4 EP0336960 A4 EP 0336960A4
Authority
EP
European Patent Office
Prior art keywords
acid
sugar
lyxose
fucose
arabitol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19880910286
Other languages
English (en)
French (fr)
Other versions
EP0336960A1 (de
Inventor
Joseph A Haklitch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0336960A1 publication Critical patent/EP0336960A1/de
Publication of EP0336960A4 publication Critical patent/EP0336960A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Definitions

  • This invention relates to food supplements which have the effect of ameliorating the effects of the ingestion of alcoholic beverages.
  • 2,321,113 appears to recommend a mixture of one-third ascorbic acid, one third D-glucose and one-third of a mixture of Japanese peppermint oil, eucalyptus oil, and aniseed oil as a sobering mixture but does not appear to quantify any result.
  • One object of the invention is to provide a substance, a food supplement, which has a rapid sobering effect or which reduces post drunkenness discomfort or both.
  • Another object is to provide such a supplement, which is inexpensive to make and use, is readily manufactured and packaged, has long shelf life, and does not have a disagreeable taste.
  • Another object is to provide such a substance in a form which can be dissolved in readily-available liquids, fruit juice or plain water, so that it can be ingested by an alcohol drinker at the place where he or she has been drinking.
  • a food supplement which converts the alcohol in the ingester's stomach into a different substance, which utilizes body chemistry to reduce blood alcohol to carbon dioxide and urea and which crosses the brain-blood barrier to restore neuro- receptor and neuro-transmitter equilibrium.
  • a material that provides those results It detoxifies alcohol in the stomach and blood in thirty minutes or less, and it restores normal motor function and sensory functions in seconds after being ingested.
  • the material that provides those actions is a combination of one or more of four "pure" sugars with one or more of a number of amino acids.
  • the sugars are L-fructose, L-mannitol, L-sorbitol and D ( + )glucose.
  • the term "pure” as applied to sugar herein means crystalline purity, 99 percent pure. The requirement for high purity is based upon both a need for purity and the fact that the character of impurities is unknown and some can negate the arabitol, D(+) fucose, L(-) fucose, D(-) lyxose, L(+) lyxose, and L(-) lyxose.
  • the term "pure” as applied to sugar herein means crystalline purity, 99 percent pure.
  • the requirement for high purity is based upon both a need for purity and the fact that the character of impurities is unknown and some can negate the effectiveness of the sugar or the amino acids.
  • the amino acids are gluta ine, lysine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glycine, histidine, leucine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and taurine.
  • the amino acids may be those found in common foodstuffs such as orange juice, clam chowder, soy bean soup, sheep milk, and others, but for uniform and more predictable result it is preferred that the amino acid be incorporated in pure crystalline form having optical density of 20 degrees or less.
  • the degree of drunkenness to be overcome and the amount required in the practice of the invention depends in part on the amount of alcohol that was ingested. There is a level of alcohol intake below which the drinker does not require the invention. In terms of amount of sugar, that level is about 2.5 grams. More than 6 grams of sugar may produce the adverse side effects listed above and is not required to produce the sobering effect. Thus the range of sugar per serving is about 2.5 to 6 grams. When prepackaged, 2.5 to 3 grams per package is preferred. A drinker who needs more than 3 grams, may be given two packages.
  • acetylsalicylic acid induces the production of the enzymes which convert ethanol to acetaldehyde by stimulating production of alcohol dehydrogenase in the liver in the volatilization reaction:
  • the acetaldehyde is converted to acetic acid by the stimulation of the enzyme acetaldehyde dehydrogenase.
  • the acetic acid is further converted to a (2) carbon metabolite (CO2) by the enzyme carboxylase.
  • CO2 carbon metabolite
  • the addition of the acetylsalicylic acid apparently produces, by conjugation, an abundance of carb ⁇ xylase to accelerate conversion of the acetic acid to CO2.
  • the invention is not concerned with the specifics of the process and relies only on the fact the that alcohol in the blood and stomach can be eliminated as a consequence of ingestion of the ingredients of the inventive supplement.
  • the reaction with alcohol which has not left the stomach is described as follows, using fructose as the example:
  • amino acids listed above have been found to be effective in combination with the listed sugars. Amino acids not in that list have not been found to be effective. In terms of quantity required for effectiveness with sugar in the range 2.5 to 6 grams, the amino acids arginine, tryptophan and tyrosine have been found to be effective in the range 25 to 3000 milligrams. The others appear to be effective in the range from 25 to 50 milligrams. The three amino acids which are effective over the greatest range: arginine, tryptophan, and tyrosine, are preferred over the other amino acids. The smaller number represents the minimum amount for reasonable effectiveness, and the upper amount represents the quantity above which the desired effect tends not to be increased.
  • the preferred form of the invention is a combination of any one or more of the listed sugars and any one or more of the listed amino acids in a quantity such that for each measure of the sugar between 2.5 and 6 grams there is an accumulation of effective amounts to a total of about 480 milligrams or more.
  • the sugar and amino acid combination be provided in powdered rather than in capsule or pill form to minimize the possibility of choking by an inebriated user.
  • the lower limit for observable beneficial result is very low, five to ten milligrams of amino acid. However, tests indicate that at least 480 milligrams is required to insure restoration of motor and sensory functions to very inebriated subjects.
  • the preferred range of ingredients is 2.5 to 6 grams of pure form of one or more of the sugars listed above together with 480 to 3000 milligrams of pure, or foodstuff form, of one or more of the amino acids listed above. Within the list of amino acids, arginine, tryptophan, and tyrosine are preferred.
  • Example 1 The combination of 3 grams of pure sugar selected from, or consisting of a combination of sugars from, the group consisting of zylitol, D(+) galactose, D(+) lactose, D(+) xylose, dulcitol, wyo-insoitol, L(-) fructose, D(-) mannitol, sorbitol, D(+) glucose, D(+) arabinose, D(-) arabinose, celloboise, D(+) maltose, D(+) raffinose, L(+)rhamnose, D(+) melibiose, D(-) ribose, adonitol, D(+) arabitol, L(-) arabitol, D(+) fucose, L(-) fucose, D(-) lyxose, L(+) lyxose, and L(-)
  • lysine arginine, asparagine, aspartic acid, cysteine, glutamic acid, glycine, histidine, leucine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and taurine.
  • Example 2 The combination of 3 grams of pure sugar selected from, or consisting of a combination of sugars from, the group consisting of zylitol, D(+) galactose, D(+) lactose, D(+) xylose, dulcitol, wyo-insoitol, L(-) fructose, D(-) mannitol.
  • sorbitol D(+) glucose, D(+) arabinose, D(-) arabinose, celloboise, D(+) maltose, D(+) raffinose, L(+)rhamnose, D(+) elibiose, D(-) ribose, adonitol, D(+) arabitol, L(-) arabitol, D(+) fucose, L(-) fucose, D(-) lyxose, L(+) lyxose, and L(-) lyxose with 480 to 3000 milligrams of pure, crystalline amino acid consisting of any combination of, or any one of, the group of amino acids consisting of arginine, tryptophan, and tyrosine.
  • Example 3 The combination of 3 grams of pure sugar selected from, or consisting of a combination of sugars from, the group consisting of zylitol, D(+) galactose, D(+) lactose, D(+) xylose, dulcitol, wyo-insoitol, L(-) fructose, D(-) mannitol, sorbitol, D(+) glucose, D(+) arabinose, D(-) arabinose, celloboise, D(+) maltose, D(+) raffinose, L(+)rhamnose, D(+) melibiose, D(-) ribose, adonitol, D(+) arabitol, L(-) arabitol, D(+) fucose, L(-) fucose, D(-) lyxose, L(+) lyxose, and L(-)
  • Example 4 The combination of 3 grams of pure sugar selected from, or consisting of a combination of sugars from, the group consisting of zylitol, D(+) galactose, D(+) lactose, D(+) xylose, dulcitol, wyo-insoitol, L(-) fructose, D(-) mannitol, sorbitol, D(+) glucose, D(+) arabinose, D(-) arabinose, celloboise, D(+) maltose, D(+) raffinose, L(+)rhamnose, D(+) melibiose, D(-) ribose, adonitol, D(+) arabitol, L(-) arabitol, D(+) fucose, L(-) fucose, D(-) lyxose, L(+) lyxose, and L(-)
  • asparagine aspartic acid, cysteine, glutamic acid, glycine, histidine, leucine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and taurine.
  • acetylsalicylic acid is added at the rate of about three to six grains for each 2.5 to 3 grams of sugar. Also, the addition of acetylsalicylic acid has the added advantage that the resulting mixture also helps overcome the discomfort that is often experienced while overcoming alcohol intoxication. The addition of the acetylsalicylic acid to the basic mixture of the invention results in a product which is useful as a remedy for the after effects of alcohol intoxication even if ingested after the ingester is no longer intoxicated.
  • acetylsalicylic acid is added for each 2.5 grams of sugar up to a maximum of 12 grains of the acid.
  • all or a part of the amino acid may be added in the form of a fruit juice or other foodstuff which is rich in one or more of the operative amino acids.
  • Citric acid is an alternative to acetylsalicylic acid as a potentiator of the volatilization of alcohol.
  • the minimum amount for effectiveness is about ten percent by weight of the amount of sugar.
  • the inclusion of citric acid rather than acetylsalicylic acid has the advantage that the upper permissible limit is established by taste rather than by some deleterious effect.
  • Acetylsalicylic acid and citric acid may be combined such that the product includes an amount of acetylsalicylic acid which equals approximately 0.025 to 0.06 grains for each milligram in which the amount of acetic acid is less than 100 milligrams per gram of sugar.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Seasonings (AREA)
EP19880910286 1987-10-19 1988-10-13 Entgiftungszusatz für nahrungsmittel. Withdrawn EP0336960A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US109597 1980-01-04
US10959787A 1987-10-19 1987-10-19
US23930388A 1988-09-01 1988-09-01
US239303 1988-09-01

Publications (2)

Publication Number Publication Date
EP0336960A1 EP0336960A1 (de) 1989-10-18
EP0336960A4 true EP0336960A4 (de) 1990-02-20

Family

ID=26807138

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19880910286 Withdrawn EP0336960A4 (de) 1987-10-19 1988-10-13 Entgiftungszusatz für nahrungsmittel.

Country Status (2)

Country Link
EP (1) EP0336960A4 (de)
WO (1) WO1989004165A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294520B1 (en) * 1989-03-27 2001-09-25 Albert T. Naito Material for passage through the blood-brain barrier
GB9215768D0 (en) * 1992-07-24 1992-09-09 Agricultural & Food Res Repression of virulent gene expression
KR970008105B1 (ko) * 1993-06-28 1997-05-21 주식회사 미원 L-아스파테이트 또는 아스파라긴을 유효성분으로 함유하는 알콜성 장해 보호제 및 그의 제조방법
GB9402950D0 (en) * 1994-02-16 1994-04-06 Univ Leeds Innovations Ltd Sports drink
DE4416429A1 (de) * 1994-05-10 1995-11-16 Hoechst Ag Süßungsmittel mit verbessertem saccharoseähnlichem Geschmack sowie Verfahren zu dessen Herstellung und dessen Verwendung
US5798371A (en) * 1995-01-13 1998-08-25 Komissarova; Irina Alexeevna Pharmaceutical composition endowed with an antialcoholic and nootropic effect
GB9715340D0 (en) * 1997-07-22 1997-09-24 Cerestar Holding Bv Beverages for enhanced physical performance
DE19755367C2 (de) * 1997-12-12 2001-03-22 Afting Ernst Guenter Pharmazeutische Zusammensetzung enthaltend D-Galaktose und ihre Verwendung
WO2000071145A1 (en) * 1999-05-24 2000-11-30 Hee Jung Kim Composition for recovering from a hangover and for preventing brain cell damage
RU2191582C2 (ru) * 2000-04-05 2002-10-27 Хазанов Вениамин Абрамович Фармацевтические композиции на основе нестероидных противовоспалительных средств
WO2005089774A1 (en) * 2004-03-18 2005-09-29 Tanabe Seiyaku Co., Ltd. D-ribose for improving depression-like symptoms
RU2358723C1 (ru) * 2008-01-31 2009-06-20 Андрей Александрович Иващенко Средство, обладающее антипохмельным действием, биологически активная добавка, фармацевтическая композиция, лекарственное средство и способ получения
RU2396076C1 (ru) * 2009-01-29 2010-08-10 Андрей Александрович Иващенко Средство, уменьшающее степень острой алкогольной интоксикации (опьянения) и обладающее антипохмельным действием, биологически активная добавка, фармацевтическая композиция, лекарственное средство и способ получения
EP2992078B1 (de) 2013-04-29 2019-06-12 Chigurupati, Harsha Verminderte toxizität in alkoholischen getränken
CA2929338A1 (en) * 2013-11-06 2015-05-14 Salim JARROUJ Composition and method for increasing the rate of alcohol metabolism and preventing hangover symptoms
WO2016203499A1 (en) 2015-06-19 2016-12-22 Chigurupati Harsha Synergistic beverage composition
EP3668328A4 (de) 2017-08-18 2021-04-14 Calwood Nutritionals, LLC Zusammensetzungen und verfahren zur erhöhung der muskelmasse und der stärke, behandlung der haut, verminderung der abnutzung und des abbaus durch alterung und belastung und verbesserung der regeneration von stress wie training und trauma

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0087068A1 (de) * 1982-02-12 1983-08-31 Thomas Moses Dr. Beck Nahrungsergänzungsmittel

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115572A (en) * 1977-02-03 1978-09-19 American Cyanamid Company Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma
GB1587697A (en) * 1978-02-10 1981-04-08 Honey Bee Corp Acidified beverage of whole milk
US4432975A (en) * 1981-04-13 1984-02-21 Icn Pharmaceuticals, Inc. Process for introducing vitamin B-12 into the bloodstream
US4582705A (en) * 1982-07-12 1986-04-15 Leonard Primes Composition for detoxification
JPS6150917A (ja) * 1984-08-20 1986-03-13 Ajinomoto Co Inc 抗アルコ−ル性肝障害組成物
US4647453A (en) * 1984-10-18 1987-03-03 Peritain, Ltd. Treatment for tissue degenerative inflammatory disease
IT1177384B (it) * 1984-12-12 1987-08-26 Boeehringer Biochemia Robin Sp Prodotti dietetici granulari a base di amminoacidi e procedimento per la loro preparazione

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0087068A1 (de) * 1982-02-12 1983-08-31 Thomas Moses Dr. Beck Nahrungsergänzungsmittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8904165A1 *

Also Published As

Publication number Publication date
WO1989004165A1 (en) 1989-05-18
EP0336960A1 (de) 1989-10-18

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