EP0328859A1 - Vorrichtung zum Abwaschen eines Reaktionsgefässes und/oder der Aussenfläche eines Reagenzkugelkörpers - Google Patents

Vorrichtung zum Abwaschen eines Reaktionsgefässes und/oder der Aussenfläche eines Reagenzkugelkörpers Download PDF

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Publication number
EP0328859A1
EP0328859A1 EP89100103A EP89100103A EP0328859A1 EP 0328859 A1 EP0328859 A1 EP 0328859A1 EP 89100103 A EP89100103 A EP 89100103A EP 89100103 A EP89100103 A EP 89100103A EP 0328859 A1 EP0328859 A1 EP 0328859A1
Authority
EP
European Patent Office
Prior art keywords
tube
suction mouth
washing
suction
jacket
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP89100103A
Other languages
German (de)
English (en)
French (fr)
Inventor
Wolf Dieter Dr. Rer.Nat. Engel
Johann Dr. Rer.Nat. Karl
Friedrich Stäbler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH, Boehringer Mannheim GmbH filed Critical Roche Diagnostics GmbH
Publication of EP0328859A1 publication Critical patent/EP0328859A1/de
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se

Definitions

  • the invention relates to a device according to the preamble of claim 1.
  • a device was previously used which allows the liquid to be sucked out of the reaction vessel through a tube and also makes it possible to introduce a washing liquid into the reagent vessel via a supply channel after suction, the amount of washing liquid flowing in via electrodes connected to a liquid level sensor connected, can be regulated automatically.
  • the lower end of the tube the opening width of which corresponds to the diameter of the tube, served as the suction mouth of the device.
  • the previously used device was pressed against the bottom of the reaction vessel by a spring attached to the upper end of the device. So that the liquid could be sucked off when the tube was placed on the floor, the lower end of the tube, which acts as a suction mouth, was notched in two opposite positions.
  • test tubes containing reagent spheres with reagent-coated inner walls are also possible.
  • the previously used devices for suction and washing are not well suited, since their suction mouth rests on the top of the reagent sphere and as soon as the liquid level drops below the height of the suction mouth, suction the liquid surrounding the reagent ball body is not possible.
  • the object of the invention is therefore to provide a device according to the preamble of claim 1, which enables complete removal of the liquid and thorough washing of the surfaces in the same automatic analyzer both for reaction vessels with reagent-coated inner surfaces and also for reaction vessels which contain a reagent spherical body .
  • the tube of the device according to the invention is shortened by comparison with that of a device according to the prior art at its suction-mouth end by the diameter of the reagent ball body and has a funnel-shaped suction mouth, the diameter of which is preferably at least as large as the diameter of the reagent ball body.
  • the device according to the invention is introduced into the reaction vessel before or after the addition of a sample dissolved in a liquid and, if present, is applied to the reagent ball body via the spring. If the reaction vessel does not contain a reagent ball body, the device is immersed approximately as deep into the tube as if a reagent ball body were present, i.e. the suction mouth of the device is not seated on the bottom of the reaction vessel. After a reaction time, the liquid is sucked off via the suction mouth of the tube and the washing liquid is then filled into the tube via the feed channel. The addition of washing liquid is interrupted as soon as the liquid level in the tube touches the two electrodes.
  • the device according to the invention is preferably designed according to claim 2 and particularly preferably according to claim 3.
  • the funnel shape of the suction mouth is by an outdoors Attachment attached to the end of the tube. This is preferably attached to the free end of the tube according to claim 5.
  • an embodiment according to claim 6 is preferably provided.
  • the device according to the exemplary embodiment has a suction mouth 2, the inner surface 18 of which is concavely curved in the axial section and is delimited by an attachment 22 plugged onto the free end 20 of the tube 6.
  • the outer surface of the tube 6 and a jacket 8 enclosing the tube 6 at an axial distance from its suction opening 2 with a radial distance delimit a washing liquid supply channel 10 which opens into an interior 26 of a head part 24.
  • the tube 6 passes through this interior space 26.
  • the interior space 26 of the head part 24 can be connected to a washing liquid supply device via a further tube 28.
  • In the end of the jacket 8 facing the suction mouth 2 there are holes 12 through which the washing liquid emerges from the washing liquid supply channel 10.
  • Two electrodes 14 and 16 guided through the head part 24 can be connected to an electrical liquid level sensor. Up to exposed end sections 30, 32, they are surrounded by insulating material jackets 34, 36. A spring 4 enclosing the upper end of the tube 6 presses the head part 24 towards the bottom of a reaction vessel.
  • a spherical body coated with bovine serum albumin and a conjugate of CEA (carcino embryonic antigen) and peroxidase was placed in a reaction vessel which was also coated with bovine serum albumin and CEA peroxidase.
  • CEA carcino embryonic antigen
  • the color reaction is carried out in such a way that 500 ml of a reagent consisting of ABTS (2,2'-azino-di- [3-ethylbenzthiazolinesulfonic acid (6)] - diammonium salt and sodium perborate) are added, and after 45 minutes the absorbance at 422 nm was determined.
  • a reagent consisting of ABTS (2,2'-azino-di- [3-ethylbenzthiazolinesulfonic acid (6)] - diammonium salt and sodium perborate
  • TSH-Enzymuntest® TSH thyroid stimulating hormone
  • the tube wall being coated.
  • the tube contained no reagent spheres.
  • the solutions, coated tubes and standards used come from the Enzyme Test @ TSH (Boehringer Mannheim GmbH, order number 736083). The determination is carried out in accordance with the manufacturer's instructions.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Cleaning In General (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP89100103A 1988-01-08 1989-01-04 Vorrichtung zum Abwaschen eines Reaktionsgefässes und/oder der Aussenfläche eines Reagenzkugelkörpers Ceased EP0328859A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3800379 1988-01-08
DE3800379A DE3800379A1 (de) 1988-01-08 1988-01-08 Vorrichtung zum abwaschen der innenflaeche eines reaktionsgefaesses und/oder der aussenflaeche eines reagenzkugelkoerpers

Publications (1)

Publication Number Publication Date
EP0328859A1 true EP0328859A1 (de) 1989-08-23

Family

ID=6344972

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89100103A Ceased EP0328859A1 (de) 1988-01-08 1989-01-04 Vorrichtung zum Abwaschen eines Reaktionsgefässes und/oder der Aussenfläche eines Reagenzkugelkörpers

Country Status (4)

Country Link
US (1) US4913179A (ja)
EP (1) EP0328859A1 (ja)
JP (1) JPH01223353A (ja)
DE (1) DE3800379A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016980A1 (en) * 1990-05-08 1991-11-14 Source Scientific Systems, Inc. Apparatus for washing magnetic particles in a vessel with a bottom pull
WO1991016979A2 (en) * 1990-05-08 1991-11-14 Source Scientific Systems, Inc. Laboratory washing device with swirling current
DE19626234A1 (de) * 1996-06-29 1998-01-02 Innova Gmbh Vorrichtung zur kontaminationsfreien Zu- und Abfuhr von Flüssigkeiten
CN113502887A (zh) * 2021-07-30 2021-10-15 九牧厨卫股份有限公司 一种带自清洁功能的喷射检测喷头及马桶

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT391097B (de) * 1987-11-17 1990-08-10 Prolic Sa Reinigungsvorrichtung fuer kuevetten
CA1319920C (en) * 1988-10-07 1993-07-06 Akira Suzuki Roller bottle filling and harvesting system
US5185269A (en) * 1990-02-13 1993-02-09 Source Scientific Systems, Inc. Immunobead aspirator and method of use
US5807359A (en) * 1993-06-08 1998-09-15 Bemis Manufacturing Company Medical suction system
US6244311B1 (en) 1994-12-29 2001-06-12 Bemis Manufacturing Company Method and apparatus for removing and disposing of body fluids
US6358232B1 (en) 1994-12-29 2002-03-19 Bemis Manufacturing Company Method and apparatus for removing and disposing of body fluids
US5730938A (en) * 1995-08-09 1998-03-24 Bio-Chem Laboratory Systems, Inc. Chemistry analyzer
JP2001514732A (ja) * 1995-09-21 2001-09-11 パストゥール サノフィ ダイアグノスティクス 反応容器を洗浄するための手段及び方法
US5866186A (en) * 1996-06-05 1999-02-02 Bazan; Alberto Method and apparatus for withdrawing and diluting fluid in a bag in a box container and for rinsing the bag
JP3419431B2 (ja) * 1996-08-21 2003-06-23 日本電子株式会社 生化学自動分析装置における洗浄装置
EP1024893A1 (en) * 1997-01-17 2000-08-09 Smithkline Beecham Corporation Apparatus and process for arraying beads
US5783938A (en) * 1997-02-24 1998-07-21 Contamination Studies Laboratories, Inc. Method and apparatus for the quantitative measurement of the corrosivity effect of residues present on the surface of electronic circuit assemblies
DE19930980A1 (de) * 1999-07-05 2001-01-11 Roche Diagnostics Gmbh System zum Waschen von Gefäßen und/oder Partikeln, die sich in Gefäßen befinden
US7585292B2 (en) * 2000-03-28 2009-09-08 Bemis Manufacturing Company Medical suction apparatus and draining of same
WO2001072350A1 (en) * 2000-03-28 2001-10-04 Bemis Manufacturing Company Medical suction apparatus and methods for draining same
US7674248B2 (en) * 2000-03-28 2010-03-09 Bemis Manufacturing Company Medical suction apparatus and methods for draining same
WO2002055134A2 (en) 2001-01-12 2002-07-18 Bemis Mfg Co Method and apparatus for disposing of bodily fluids from a container
US20050101922A1 (en) * 2003-11-07 2005-05-12 Bemis Manufacturing Company Suction canister and drainage of same
US7658198B2 (en) * 2004-11-12 2010-02-09 Distek Inc. Washing system for dissolution vessels and the like
EP1877805B1 (en) * 2005-05-06 2020-12-23 Instrumentation Laboratory Company Telescoping closed-tube sampling assembly
EP2019321A1 (en) * 2006-05-17 2009-01-28 Olympus Corporation Cleaning equipment and automatic analyzer
DE102010040681A1 (de) * 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Unterdruckgreifer zur Handhabung von Wirkstoff-Beads mit vorzugsweise konkaver Bead-Kontaktfläche
KR20130024529A (ko) * 2011-08-31 2013-03-08 삼성전기주식회사 공기 분사 장치
CN103658087B (zh) * 2013-12-06 2016-05-04 桂林电子科技大学 全自动高效酶标卧式洗板机
TWI552808B (zh) * 2015-06-09 2016-10-11 緯創資通股份有限公司 吸管尖

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1942201A1 (de) * 1968-08-20 1970-07-30 Vickers Ltd Vorrichtung zum Entfeuchten und Spuelen von Behaeltern,wie Reagenzglaesern
FR2277630A1 (fr) * 1974-07-10 1976-02-06 Abbott Lab Appareil combine de lavage et d'aspiration
FR2354555A1 (fr) * 1976-06-08 1978-01-06 Technicon Instr Pipette pour aspirer des liquides pour l'analyse d'echantillons
US4341568A (en) * 1980-06-27 1982-07-27 Beckman Instruments, Inc. Method and apparatus for washing objects
EP0209353A1 (en) * 1985-07-17 1987-01-21 Hybritech Incorporated An improved apparatus for washing beads

Family Cites Families (10)

* Cited by examiner, † Cited by third party
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SE371983B (ja) * 1972-09-22 1974-12-09 Tetra Pak Int
JPS52115017A (en) * 1976-03-24 1977-09-27 Ansei Kogyo:Kk Simultaneous locking and unlocking device for automotive door lock
JPS5860258A (ja) * 1981-10-06 1983-04-09 Eisai Co Ltd 生化学的検査用洗浄装置
JPS58125865A (ja) * 1982-01-22 1983-07-27 Sanyo Electric Co Ltd 感光装置
DE3216604A1 (de) * 1982-05-04 1983-11-10 Seitz Enzinger Noll Maschinenbau Ag, 6800 Mannheim Fuellelement fuer gefaess-fuellmaschinen zum abfuellen stiller oder kohlensaeurehaltiger fluessigkeiten
EP0109762A3 (en) * 1982-10-19 1985-07-24 Vickers Plc Device for use in a bottle filling head
SE449218B (sv) * 1985-02-12 1987-04-13 Suni Kas Oy Anordning for fyllning av behallarartade fyllningsobjekt, sasom flaskor, med vetska
DE3511078A1 (de) * 1985-03-27 1986-10-09 Krones Ag Hermann Kronseder Maschinenfabrik, 8402 Neutraubling Verfahren und vorrichtung zum reinigen einer gefaessfuellmaschine, insbesondere einer vakuumfuellmaschine
JPS61234356A (ja) * 1985-04-10 1986-10-18 Toray Fuji Baionikusu Kk 自動洗浄ノズル
US4685480A (en) * 1985-08-30 1987-08-11 Abbott Laboratories Combined washer and aspirator

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1942201A1 (de) * 1968-08-20 1970-07-30 Vickers Ltd Vorrichtung zum Entfeuchten und Spuelen von Behaeltern,wie Reagenzglaesern
FR2277630A1 (fr) * 1974-07-10 1976-02-06 Abbott Lab Appareil combine de lavage et d'aspiration
FR2354555A1 (fr) * 1976-06-08 1978-01-06 Technicon Instr Pipette pour aspirer des liquides pour l'analyse d'echantillons
US4341568A (en) * 1980-06-27 1982-07-27 Beckman Instruments, Inc. Method and apparatus for washing objects
EP0209353A1 (en) * 1985-07-17 1987-01-21 Hybritech Incorporated An improved apparatus for washing beads

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016980A1 (en) * 1990-05-08 1991-11-14 Source Scientific Systems, Inc. Apparatus for washing magnetic particles in a vessel with a bottom pull
WO1991016979A2 (en) * 1990-05-08 1991-11-14 Source Scientific Systems, Inc. Laboratory washing device with swirling current
WO1991016979A3 (en) * 1990-05-08 1992-03-19 Source Scient Systems Inc Laboratory washing device with swirling current
DE19626234A1 (de) * 1996-06-29 1998-01-02 Innova Gmbh Vorrichtung zur kontaminationsfreien Zu- und Abfuhr von Flüssigkeiten
WO1998000718A1 (de) * 1996-06-29 1998-01-08 November Ag Novus Medicatus Bertling Gesellschaft Für Molekulare Medizin Vorrichtung zur kontaminationsfreien zu- und abfuhr von flüssigkeit
US6379624B1 (en) 1996-06-29 2002-04-30 November Aktiengesellschaft Gesellschaft Fur Molekulare Medizin Device for the contamination-free delivery and discharge of liquid
CN113502887A (zh) * 2021-07-30 2021-10-15 九牧厨卫股份有限公司 一种带自清洁功能的喷射检测喷头及马桶
CN113502887B (zh) * 2021-07-30 2022-06-14 九牧厨卫股份有限公司 一种带自清洁功能的喷射检测喷头及马桶

Also Published As

Publication number Publication date
US4913179A (en) 1990-04-03
JPH01223353A (ja) 1989-09-06
DE3800379A1 (de) 1989-07-20

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