EP0299211B1 - DHP-Manteltablette - Google Patents
DHP-Manteltablette Download PDFInfo
- Publication number
- EP0299211B1 EP0299211B1 EP88109420A EP88109420A EP0299211B1 EP 0299211 B1 EP0299211 B1 EP 0299211B1 EP 88109420 A EP88109420 A EP 88109420A EP 88109420 A EP88109420 A EP 88109420A EP 0299211 B1 EP0299211 B1 EP 0299211B1
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- EP
- European Patent Office
- Prior art keywords
- core
- active compound
- atoms
- coated
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 C*1(*)/C=C/[C@](*)CNCC=C1 Chemical compound C*1(*)/C=C/[C@](*)CNCC=C1 0.000 description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Definitions
- the invention relates to solid pharmaceutical preparations with a long-lasting effect for dihydropyridines in the form of a coated tablet and to processes for their preparation.
- Hypertension For the treatment of diseases that require long-term treatment, such as Hypertension is desirable to keep the frequency of taking medication as low as possible. This is not only more pleasant for the patient, but also increases the safety of treatment by reducing the disadvantages of irregular intakes and leading to a uniform active substance concentration-time profile in the body. This also minimizes the risk of undesirable over- or underdosing.
- Particularly preferred active ingredients are nifedipine, nitrendipine, nimodipine and nisoldipine.
- the coated tablets according to the invention preferably contain a total of preferably 1 to 200 mg, in particular 10 to 150 mg, of at least one active ingredient from the dihydropyridines class.
- the quick-release core of the coated tablet preferably contains the active ingredient in amorphous form or in finely ground or micronized crystalline form.
- the release rate is preferably by the addition of water-soluble Auxiliaries and influenced by changing the particle size distribution of the active ingredient.
- Rapid-release tablet cores are preferably those cores which release 75% of the dihydropyridine active ingredient in one hour, preferably in 30 minutes.
- the fast-releasing core contains amorphous dihydropyridine
- this is preferably dissolved together with water-soluble polymers such as polyvinylpyrrolidone, methyl cellulose, hydroxypropyl cellulose or hydroxypropyl methyl cellulose in organic solvent. It is expedient to use 2 to 10 parts by weight, in particular 3 to 8 parts by weight, of the water-soluble polymers to 1 part by weight of dihydropyridine and to produce corresponding coprecipitates therefrom.
- dihydropyridine crystals with a maximum average grain size of approximately 25 ⁇ m, in particular a maximum average grain size of approximately 15 ⁇ m, are preferably used.
- the grain size is determined by the Cilas method (lit .: A. Buerkholz et al, Part. Charact. 1, 1984, 153-160, "Laser defraction spectrometers / experience in particle size analysis”.).
- This quick-release core is produced by customary methods (cf. DE-OS 3 415 128 and DE-OS 3 142 853 or Brit. Pat. 1 579 818).
- the shell of the tablet contains 10 to 99%, preferably 20 to 90% of the total shell weight of hydrophilic gel-forming polymers.
- modified starch or cellulose-like substances such as e.g. Methyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose and sodium carboxymethyl cellulose are suitable.
- Hydroxypropyl cellulose (HPC) may be mentioned as particularly preferred (see: Hagers Handbook of Pharmaceutical Practice, Volume 7, Part B, (1977) 130-141).
- HPC-L low viscosity of approx. 6-10 mPa.s
- HPC-M medium viscosity of approx. 150 mPa.s
- HPC-H high viscosity of approx. 1000-4000 mPa.s.
- the release rate can be controlled via the different viscosity grades, the release rate increasing when low-viscosity grades are used and slowing down when using high-viscosity grades.
- part of the active ingredient in the form of an outer layer of the coated tablet may be applied as an initial dose using the known techniques and auxiliary substances.
- galenical measures such as the coating of the core with an enteric layer, the use of flavors and aromas and lubricants and conventional auxiliaries which are familiar to the galenic expert can of course also be used and used in the coated tablet according to the invention.
- the coated tablet according to the invention differs from the previously known coated tablets in that the coat contains the active ingredient in a slowly releasing form and the core contains the active ingredient in a rapidly releasing form.
- Multilayer tablets based on casein matrices have been described in the prior art which contain two or three layers, each of which in turn can contain active ingredients (cf. US Pat. No. 3,184,386).
- the tablets described therein contain a rapidly releasing preparation in the outer casing, the core primarily having the function of not making the surface of the outer active substance-containing layer relevant for the release too small.
- this patent does not contain any indication that the core of the preparation contains the active ingredient in a rapidly releasing form. Rather, both the middle shell and the core are described in the examples as slow release forms.
- Chem. Abs. 104 (1986) No. 174662y describes nifedipine preparations which initially ensure rapid release of the active ingredient (initial dose), which is then combined with a delayed release of active ingredient (maintenance dose). Such formulations allow rapid release of active ingredient to achieve an effective plasma level, which is then maintained by the delayed delivery of the second dose of active ingredient. This principle only ensures that effective levels are reached quickly after ingestion. However, after this it is not possible to achieve higher active levels with a single administration at a desired later point in time. Only through the formulation according to the invention can it be ensured that an increased active ingredient level is made available at a certain point in time even after a long period after application.
- the principle of the coated tablet according to the invention avoids the previously usual disadvantages of normal prolonged-release tablets and also of previously known multilayer or coated tablets or of preparation forms which are based on the osmotic principle. In particular, it is avoided that the rate of release of the active ingredient becomes ever lower towards the end of the dissolution of the tablets and thus the plasma level drops.
- the release rate of normal prolonged-release tablets which is reduced by reducing the volume of the tablet, is more than compensated for by the rapid release effect of the core of the coated tablet according to the invention.
- a complete release of the active ingredient is achieved compared to osmotic systems.
- the formulation according to the invention differs from all previously known retardation principles for solid dosage forms.
- Another advantage is the rapid flooding of the active ingredient after application avoiding a delay phase as well as the simple manufacturing technology.
- coated tablet according to the invention is particularly suitable for those active ingredients which are in the lower gastrointestinal region, e.g. B. in the colon, show a high absorption rate, is particularly useful.
- the preparation according to the invention can ensure increased bioavailability for such active substances.
- the preparations according to the invention are prepared by customary methods, for example by the following process:
- the active ingredient and the other auxiliaries for the core are mixed and granulated by conventional methods by adding an aqueous binder solution, for. B. in a planetary mixer, a high-speed mixer or a fluidized bed granulator.
- the granules obtained are dried, preferably in a fluidized bed dryer, then sieved and mixed with magnesium stearate and then pressed into tablets.
- the preparation can also be carried out by pressing the constituents directly, where appropriate the core obtained by customary methods, for. B. can be provided in a paint kettle with a layer of paint.
- the granules are produced by customary methods, preferably in a fluidized bed granulator by spraying an aqueous suspension which contains the active ingredient and a binder onto the solid components, which are then dried, sieved and washed with a lubricant such as, for. B.
- a lubricant such as, for. B.
- Magnesium stearate can be mixed.
- the casing is pressed onto the core on commercially available casing tablet presses (e.g. press coaters from Kilian or Manesty). If necessary, the tablet can then be coated with a lacquer, where appropriate, light stabilizers, taste improvers or an initial dose of the active ingredient can be introduced into this lacquer layer, the amount of the active ingredient introduced in this way being a maximum of 20% of the total amount of the ready-to-use formulation.
- a lacquer where appropriate, light stabilizers, taste improvers or an initial dose of the active ingredient can be introduced into this lacquer layer, the amount of the active ingredient introduced in this way being a maximum of 20% of the total amount of the ready-to-use formulation.
- the present invention enables the patient to have to apply the medication only once a day, which is a safer and more pleasant type of treatment, particularly in the case of continuous therapy.
- the curves in FIG. 1 show the principle of the jacket which slowly releases over a few hours and the core which subsequently releases rapidly.
- 50 g of crystalline nifedipine (average grain size 5 ⁇ m) are mixed with 388 g of milk sugar and 150 g of corn starch, granulated in a paste of 10 g of starch and 140 g of hot water and then dried. The granules are sieved and mixed with 50 g of microcrystalline cellulose and 2 g of magnesium stearate. This mixture is compressed into 65 mg tablets with a diameter of 6 mm. The cores are coated with an organic solution of hydroxypropylmethyl cellulose phthalate resistant to gastric juice. The coated tablet weighs 72 mg
- 250 g nifedipine are mixed with 400 g milk sugar, 16 g colloidal silicon dioxide, 700 g hydroxypropyl cellulose type M, 1747 g hydroxypropyl cellulose type L and 320 g citric acid and granulated in a fluidized bed granulator with a solution of 20 g hydroxypropyl cellulose type L.
- the dried and sieved granules are mixed with 27 g magnesium stearate.
- This coated granulate and the cores described under A) are compressed on a coated tablet press to 420 mg heavy coated tablets with a diameter of 10 mm.
- the tablets are then varnished red with a varnish dispersion of hydroxypropylmethyl cellulose, polyethylene glycol, titanium dioxide and iron oxide.
- 400 g milk sugar are mixed with 17 g colloidal silicon dioxide, 2196 g hydroxypropyl cellulose type L, 250 g hydroxypropyl cellulose type M and 320 g citric acid and granulated in a fluidized bed granulator with an aqueous suspension of 250 g nifedipine and 20 g hydroxypropyl cellulose type L.
- the dried granules are sieved and mixed with 27 g magnesium stearate.
- This coated granulate and the cores described under A) are compressed on a coated tablet press to 420 mg heavy coated tablets with a diameter of 10 mm.
- the tablets are then coated with a hydroxy dispersion propylmethylcellulose, polyethylene glycol, titanium dioxide and iron oxide painted red.
- crystalline nifedipine (average grain size 8 ⁇ m) are mixed with 291 g of milk sugar, 162.5 g of corn starch and granulated with a paste of 7.5 g of corn starch in 100 g of hot water. The granules are dried, sieved and then mixed with 1.5 g of magnesium stearate and 37.5 g of microcrystalline cellulose. This mixture is pressed into 55 mg cores with a diameter of 5.5 mm.
- 400 g of milk sugar are mixed with 17 g of colloidal silicon dioxide, 1105 g of HPC type L, 443 g of HPC type M and 202 g of citric acid and granulated with an aqueous suspension consisting of 250 g of nifedipine and 16 g of HPC type L.
- the granules are dried and sieved and mixed with 17 g of magnesium stearate.
- This tablet granulate and the cores are used to produce jacket tablets with a weight of 300 mg and a diameter of 9 mm.
- the tablets are then coated according to example 1.
- the cores are coated with an organic solution of hydroxypropylmethyl cellulose phthalate resistant to gastric juice.
- the coated tablets weigh 60 mg.
- 250 g of nifedipine are mixed with 400 g of milk sugar, 17 g of colloidal silicon dioxide, 1155 g of HPC type L, 343 g of HPC type M and 202 g of citric acid and granulated with an aqueous solution of 16 g of HPC type L.
- the granules are dried, sieved and mixed with 17 g magnesium stearate.
- This tablet granulate and the cores are used to produce jacket tablets with a weight of 300 mg and a diameter of 9 mm.
- the tablets are then coated according to example 1.
- the coated granules are produced analogously to Example 1.
- 200 g of nifedipine are mixed with 350 g of milk sugar, 17 g of colloidal silicon dioxide, 1105 g of HPC type L, 443 g of HPC type M and 202 g of citric acid and granulated with an aqueous solution of 16 g of HPC type L.
- the granules are dried and sieved and mixed with 12 g of magnesium stearate.
- Sheath tablets with a weight of 290 mg are pressed from these shell granules and the cores.
- crystalline nifedipine (average grain size 10 ⁇ m) are mixed with 600 g of milk sugar and 228 g of corn starch and granulated with a paste of 20 g of starch and 320 g of water and then dried.
- the granules are sieved and mixed with 2 g of magnesium stearate and pressed into 90 mg tablets with a diameter of 7 mm.
- the cores are coated with an organic solution of hydroxypropylmethyl cellulose phthalate. The coated tablets weigh 97 mg.
- 250 g of nifedipine are mixed with 400 g of milk sugar, 16 g of colloidal silicon dioxide and granulated with a solution of 16 g of type L hydroxypropyl cellulose in water.
- the dried and sifted Granules are mixed with 900 g hydroxypropyl cellulose type M, 2387 g hydroxypropyl cellulose type L, 400 g citric acid and 61 g magnesium stearate.
- coated granules and the cores described under A) are pressed on a coated tablet press to give tablets weighing 540 mg and a diameter of 11 mm.
- the tablets are then varnished red with a varnish dispersion of hydroxypropylmethyl cellulose, polyethylene glycol, titanium dioxide and iron oxide.
- 100 g of crystalline nifedipine (average grain size 4 ⁇ m) are mixed with 241 g of milk sugar and 162.5 g of corn starch and granulated with a paste of 7.5 g of corn starch in 100 g of water.
- the dried granules are sieved, mixed with 1.5 g of magnesium stearate and 37.5 g of Avicel and pressed into 55 mg tablets with a diameter of 5.5 mm.
- nifedipine 500 g are mixed with 335 g of milk sugar, 16 g of colloidal silicon dioxide and granulated with a solution of 33 g of type L hydroxypropyl cellulose in water.
- the dried granules are sieved and mixed with 443 g of hydroxypropyl cellulose type M, 1105 g of hydroxypropyl cellulose type L and 18 g of magnesium stearate.
- coated granules and the cores described under A) are compressed on a coated tablet press to give tablets weighing 300 mg and a diameter of 9 mm.
- the tablets are then varnished red with a varnish dispersion of hydroxypropylmethyl cellulose, polyethylene glycol, titanium dioxide and iron oxide.
- jacket tablets are produced: Total weight: 550mg Format: ⁇ 10 mm
- jacket tablets are produced: Total weight: 293 mg Format: ⁇ 9 mm
- jacket tablets are produced: Total weight: 557 mg Format: ⁇ 10 mm
- the preparation is carried out according to Example 8, instead of 100 g nifedipine and 241 g milk sugar, now 200 g nimodipine and 141 g milk sugar are used.
- the painting is also carried out analogously to Example 8, but without the use of red iron oxide.
- the preparation is carried out analogously to Example 8, with 50 g of nifedipine, 150 g of nisoldipine and 141 g of lactose being used instead of 100 g of nifedipine and 241 g of lactose.
- the preparation is carried out analogously to Example 8, but instead of 500 g of nifedipine 200 g nifedipine and 300 g nisoldipine can now be used. At the same time, instead of 443 g HPC-M and 1105 g HPC-L, 518 g HPC-M and 1030 g HPC-L are used.
- 50 g nifedipine (average particle diameter 5 ⁇ m) are mixed with 170 g lactose and 173.5 g corn starch. This mixture is granulated with an aqueous paste of 5 g corn starch. After drying and sieving, 1.5 g of magnesium stearate, 50 g of Plasdone XL and 50 g of Avicel are added and the granules are pressed into tablets with a diameter of 5 mm and a weight of 50 mg.
- 1,101 g of type L hydroxypropyl cellulose, 755 g of type M hydroxypropyl cellulose and 341 g of lactose are mixed with 16 g of colloidal silica gel and then granulated with an aqueous suspension of 250 g of nifedipine and 20 g of type L hydroxypropyl cellulose.
- the granules are dried, sieved and mixed with 17 g of magnesium stearate, compressed into tablets with a weight of 300 mg, which have a tablet diameter of 9 mm.
- the tablets are then coated with an aqueous suspension of hydroxypropylmethyl cellulose, polyethylene glycol, titanium dioxide and red iron oxide (light stabilizer).
- nifedipine with an average particle diameter of 5 ⁇ m 100 g of nifedipine with an average particle diameter of 5 ⁇ m are mixed with 160 g of lactose and 148.8 g of corn starch and then granulated with an aqueous paste of 5 g of corn starch. After drying and sieving, 1.3 g of magnesium stearate, 50 g of Plasdone XL and 34.9 g of Avicel are added and the granules obtained are pressed into 50 mg tablets with a diameter of 5 mm.
- 1,010 g of type L hydroxypropyl cellulose and 628 g of type M hydroxypropyl cellulose are mixed with 289 g of lactose and 16 g of colloidal silica gel and granulated with an aqueous suspension of 500 g of nifedipine and 40 g of type L HPC. After drying and sieving, the granules are mixed with 17 g of magnesium stearate and pressed into tablets with a weight of 300 mg and a diameter of 9 mm. The tablets obtained are then coated with an aqueous suspension of hydroxypropylmethyl cellulose, polyethylene glycol, titanium dioxide and red iron oxide (light protection).
- 150 g nifedipine (particle size 5 ⁇ m) are mixed with 130 g lactose and 124 g corn starch and granulated with an aqueous paste of 5 g corn starch. After drying and sieving, 1 g of magnesium stearate, 50 g of Plasdone XL and 40 g of Avicel are added and the granules are pressed into 50 mg cores with a diameter of 5 mm.
- nitrendipine (average particle diameter 5 ⁇ m) are mixed with 4 g of lactose, 5 g of cross-linked PVPP and 12.3 g of microcrystalline cellulose and then with an aqueous Granulated solution of 1.8 g PVP and 0.8 g sodium lauryl sulfate. After drying and sieving, 0.1 g of magnesium stearate is added and the mixture is compressed into tablet cores with a weight of 42 mg and a diameter of 5 mm.
- nitrendipine (average particle diameter 5 ⁇ m) are mixed with 15 g of cross-linked PVPP and 7.2 g of microcrystalline cellulose.
- the mixture is granulated with an aqueous solution of 1.8 g of PVP and 0.9 g of sodium lauryl sulfate, then dried and sieved and mixed with 0.1 g of magnesium stearate. Then compressed to 45 mg tablet cores with a diameter of 5 mm.
- 4 g of crystalline nisoldipine with an average particle diameter of 5 ⁇ m are mixed with 8 g of lactose, 15 g of cross-linked PVPP and 12.3 g of microcrystalline cellulose and this mixture is granulated with an aqueous solution of 1.8 g of PVP and 0.8 g of sodium lauryl sulfate.
- the dried and sieved granules are mixed with 0.1 g magnesium stearate and compressed to 42 mg tablet cores with a diameter of 5 mm.
- the tablet cores are produced as in Example 20.
- the cores are produced in accordance with Example 20 A).
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT88109420T ATE75142T1 (de) | 1987-06-24 | 1988-06-14 | Dhp-manteltablette. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3720757 | 1987-06-24 | ||
DE19873720757 DE3720757A1 (de) | 1987-06-24 | 1987-06-24 | Dhp-manteltablette |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0299211A1 EP0299211A1 (de) | 1989-01-18 |
EP0299211B1 true EP0299211B1 (de) | 1992-04-22 |
Family
ID=6330136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP88109420A Expired - Lifetime EP0299211B1 (de) | 1987-06-24 | 1988-06-14 | DHP-Manteltablette |
Country Status (10)
Country | Link |
---|---|
US (1) | US4892741A (fi) |
EP (1) | EP0299211B1 (fi) |
JP (2) | JPH0611699B2 (fi) |
AT (1) | ATE75142T1 (fi) |
CA (1) | CA1309951C (fi) |
DE (2) | DE3720757A1 (fi) |
ES (1) | ES2051800T3 (fi) |
GR (1) | GR3004448T3 (fi) |
IE (1) | IE60352B1 (fi) |
IL (1) | IL86827A (fi) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9993432B2 (en) | 2008-11-27 | 2018-06-12 | Bayer Intellectual Property Gmbh | Pharmaceutical dosage form comprising nifedipine or nisoldipine and an angiotensin II antagonist and/or a diuretic |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2618073B1 (fr) * | 1987-07-16 | 1990-09-07 | Pf Medicament | Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation |
US5032406A (en) * | 1989-02-21 | 1991-07-16 | Norwich Eaton Pharmaceuticals, Inc. | Dual-action tablet |
FI93924C (fi) * | 1991-09-17 | 1995-06-26 | Martti Lauri Antero Marvola | Menetelmä säädellysti lääkeainetta vapauttavan valmisteen valmistamiseksi |
EP0546593B1 (en) * | 1991-10-30 | 1997-09-03 | Glaxo Group Limited | Multi-layered compositions containing histamine or serotonin antagonists |
DE4201179A1 (de) * | 1992-01-17 | 1993-07-22 | Alfatec Pharma Gmbh | Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung |
DE4201173C2 (de) * | 1992-01-17 | 1998-10-29 | Alfatec Pharma Gmbh | Akutarzneimittel in Form von Dihydropyridinderivaten enthaltenden Pellets und ihre Herstellung |
AU3949093A (en) * | 1992-03-31 | 1993-11-08 | Benzon Pharma A/S | A pharmaceutical formulation |
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US5662933A (en) * | 1993-09-09 | 1997-09-02 | Edward Mendell Co., Inc. | Controlled release formulation (albuterol) |
US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
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US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
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US20060263428A1 (en) * | 1993-09-20 | 2006-11-23 | Eugenio Cefali | Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics |
US6210714B1 (en) * | 1993-11-23 | 2001-04-03 | Euro-Celtique S.A. | Immediate release tablet cores of acetaminophen having sustained-release coating |
US5500227A (en) * | 1993-11-23 | 1996-03-19 | Euro-Celtique, S.A. | Immediate release tablet cores of insoluble drugs having sustained-release coating |
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US6156343A (en) * | 1994-12-27 | 2000-12-05 | Akzo Nobel N.V. | Controlled release preparation |
SI9500173B (sl) * | 1995-05-19 | 2002-02-28 | Lek, | Trofazna farmacevtska oblika s konstantnim in kontroliranim sproščanjem amorfne učinkovine za enkrat dnevno aplikacijo |
JP3220373B2 (ja) * | 1995-11-28 | 2001-10-22 | バイエル薬品株式会社 | 持続性ニフエジピン製剤 |
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US6093420A (en) | 1996-07-08 | 2000-07-25 | Edward Mendell Co., Inc. | Sustained release matrix for high-dose insoluble drugs |
US5837379A (en) * | 1997-01-31 | 1998-11-17 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
US5922352A (en) * | 1997-01-31 | 1999-07-13 | Andrx Pharmaceuticals, Inc. | Once daily calcium channel blocker tablet having a delayed release core |
DE19747261A1 (de) * | 1997-10-25 | 1999-04-29 | Bayer Ag | Osmotisches Arzneimittelfreisetzungssystem |
US6056977A (en) * | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
US6485748B1 (en) | 1997-12-12 | 2002-11-26 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
DE19842753A1 (de) | 1998-09-18 | 2000-03-23 | Bayer Ag | Agitationsunabhängige pharmazeutische Retardzubereitungen und Verfahren zu ihrer Herstellung |
US6602521B1 (en) * | 1998-09-29 | 2003-08-05 | Impax Pharmaceuticals, Inc. | Multiplex drug delivery system suitable for oral administration |
WO2000020033A1 (fr) * | 1998-10-05 | 2000-04-13 | Eisai Co., Ltd. | Comprimes se delitant immediatement dans la cavite buccale |
US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
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US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
JP3893058B2 (ja) | 1999-09-30 | 2007-03-14 | ペンウェスト ファーマシューティカルズ カンパニー | 高度に可溶性の薬物のための徐放性マトリックス系 |
US6500462B1 (en) * | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
US6627223B2 (en) * | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
DE10031043A1 (de) | 2000-06-26 | 2002-02-14 | Bayer Ag | Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung |
JP4637338B2 (ja) * | 2000-09-22 | 2011-02-23 | 大塚製薬株式会社 | シロスタゾール有核錠 |
US6344215B1 (en) | 2000-10-27 | 2002-02-05 | Eurand America, Inc. | Methylphenidate modified release formulations |
US6932861B2 (en) * | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
IL155959A0 (en) | 2000-11-28 | 2003-12-23 | Fmc Corp | Edible pga (propylene glycol alginate) coating composition |
GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
US20050175687A1 (en) * | 2001-01-30 | 2005-08-11 | Mcallister Stephen M. | Pharmaceutical formulations |
ATE330586T1 (de) * | 2001-03-14 | 2006-07-15 | Pfizer Prod Inc | Pharmazeutische tablette und eine verfahren zu deren herstellung |
US20030143272A1 (en) * | 2001-03-14 | 2003-07-31 | Waterman Kenneth C. | Pharmaceutical tablet and process for making thereof |
JP4817562B2 (ja) * | 2001-09-26 | 2011-11-16 | 東和薬品株式会社 | 長時間持続型ニフエジピン有核錠 |
US9358214B2 (en) * | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
EP2266590A3 (en) | 2002-02-22 | 2011-04-20 | Shire LLC | Active agent delivery sytems and methods for protecting and administering active agents |
WO2003080057A1 (fr) * | 2002-03-27 | 2003-10-02 | Bayer Aktiengesellschaft | Comprime-noyau de taille reduite contenant de la nifedipine |
US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
MXPA05007883A (es) * | 2003-01-29 | 2005-09-21 | Takeda Pharmaceutical | Proceso para producir una preparacion recubierta. |
CA2519208A1 (en) * | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | Controlled release composition |
JP4933033B2 (ja) * | 2003-03-17 | 2012-05-16 | 武田薬品工業株式会社 | 放出制御組成物 |
DK1615626T3 (da) * | 2003-04-24 | 2010-02-08 | Jagotec Ag | Tablet med farvet kerne |
TW200526274A (en) * | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
JP4575654B2 (ja) * | 2003-09-05 | 2010-11-04 | エスエス製薬株式会社 | 溶解性と流動性を改善した医薬組成物 |
WO2005025507A2 (en) * | 2003-09-10 | 2005-03-24 | Synta Phamaceuticals Corp. | Dihydropyridine compounds for treating or preventing metabolic disorders |
JP2005187339A (ja) * | 2003-12-24 | 2005-07-14 | Iwaki Seiyaku Co Ltd | 耐光性塩酸テルビナフィンフィルムコート錠 |
US20050163847A1 (en) * | 2004-01-21 | 2005-07-28 | Andrx Pharmaceuticals, Llc | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and an antiulcerative drug |
US20060024368A1 (en) * | 2004-07-30 | 2006-02-02 | Reza Fassihi | Compressed composite delivery system for release-rate modulation of bioactives |
US20060134212A1 (en) * | 2004-09-02 | 2006-06-22 | Forest Laboratories, Inc. | Lercanidipine immediate release compositions |
US20060165789A1 (en) * | 2004-09-09 | 2006-07-27 | Forest Laboratories, Inc. | Lercanidipine modified release compositions |
US20060165788A1 (en) * | 2004-09-09 | 2006-07-27 | Wattanaporn Abramowitz | Lercanidipine pH dependent pulsatile release compositions |
US8747895B2 (en) * | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
JP4681843B2 (ja) * | 2004-09-30 | 2011-05-11 | 日本臓器製薬株式会社 | 固形医薬製剤 |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
NZ728442A (en) | 2004-10-21 | 2018-05-25 | Adare Pharmaceuticals Inc | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US20060105038A1 (en) * | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
KR100683232B1 (ko) * | 2005-01-18 | 2007-02-15 | 한림제약(주) | 니솔디핀의 경구용 제제 및 그를 제조하는 방법 |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
DE102005031577A1 (de) * | 2005-07-06 | 2007-01-11 | Bayer Healthcare Ag | Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten |
JOP20180109A1 (ar) * | 2005-09-29 | 2019-01-30 | Novartis Ag | تركيبة جديدة |
KR100753480B1 (ko) * | 2006-01-27 | 2007-08-31 | 씨제이 주식회사 | 잘토프로펜 함유 서방성 정제 및 그 제조방법 |
KR100762847B1 (ko) * | 2006-01-27 | 2007-10-04 | 씨제이 주식회사 | 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법 |
WO2007120135A1 (en) * | 2006-04-17 | 2007-10-25 | Forest Laboratories, Inc. | Lercanidipine immediate release composition |
ES2547226T5 (es) | 2006-08-30 | 2020-06-12 | Jagotec Ag | Formulaciones de dosificación oral de liberación controlada que comprenden un núcleo y una o más capas de barrera |
US20080249141A1 (en) * | 2007-04-06 | 2008-10-09 | Palepu Nageswara R | Co-therapy with and combinations of statins and 1,4-dihydropyridine-3,5-dicarboxydiesters |
AU2007356942B2 (en) * | 2007-07-23 | 2011-12-15 | Pharmathen S.A. | Pharmaceutical composition containing dihydropyridine calcium channel antagonist and method for the preparation thereof |
US20090285889A1 (en) * | 2008-05-14 | 2009-11-19 | Capricom Pharma Inc. | Modified release formulations of dihydropyridine compounds and methods of making same |
US20100247646A1 (en) * | 2009-03-26 | 2010-09-30 | Ranbaxy Laboratories Limited | Extended release tablets of nisoldipine |
MX2012006240A (es) | 2009-12-02 | 2012-10-03 | Aptalis Pharma Ltd | Microcapsulas de fexofenadina y composiciones que contienen las mismas. |
US8865213B2 (en) * | 2009-12-30 | 2014-10-21 | Usv Limited | Modified release pharmaceutical compositions |
CA2802831C (en) | 2010-06-16 | 2018-11-20 | Teijin Pharma Limited | Controlled release coat-core tablet |
EP2573085A1 (en) | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range |
MX2014013320A (es) | 2012-05-07 | 2015-08-10 | Bayer Pharma AG | Procedimiento de fabricacion de una forma de dosificacion farmaceutica que comprende nifedipina y candesartan cilexetilo. |
JP5819800B2 (ja) * | 2012-10-31 | 2015-11-24 | 信越化学工業株式会社 | 高粘度ヒプロメロースを分散したコーティング液及び固形製剤の製造方法 |
WO2014172372A1 (en) | 2013-04-15 | 2014-10-23 | Northwestern University | Treatment for dopaminergic disorders |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB906422A (en) * | 1958-05-02 | 1962-09-19 | Wellcome Found | Improvements in and relating to prolonged acting pharmaceutical preparations |
GB1144915A (en) * | 1966-11-24 | 1969-03-12 | Armour Pharma | Improvements in or relating to pastille formulations |
US3558768A (en) * | 1969-12-19 | 1971-01-26 | Sterling Drug Inc | Sustained release pharmaceutical compositions |
SE418247B (sv) * | 1975-11-17 | 1981-05-18 | Haessle Ab | Sett att framstella kroppar med reglerad frigoring av en aktiv komponent |
JPS5846019A (ja) * | 1981-09-14 | 1983-03-17 | Kanebo Ltd | 持続性ニフエジピン製剤 |
IT1198386B (it) * | 1982-07-06 | 1988-12-21 | Lepetit Spa | Un prodotto a rilascio protratto contenente il suloctidile |
ZA838033B (en) * | 1982-11-01 | 1984-06-27 | Merrell Dow Pharma | Sustained release solid dosage forms having non-uniform distribution of active ingredient |
DE3318649A1 (de) * | 1983-05-21 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | Zweiphasenformulierung |
JPS6038322A (ja) * | 1983-08-11 | 1985-02-27 | Fujisawa Pharmaceut Co Ltd | ジヒドロピリジンa物質含有易溶性固形製剤 |
GB8322007D0 (en) * | 1983-08-16 | 1983-09-21 | Wellcome Found | Pharmaceutical delivery system |
JPS618A (ja) * | 1984-06-09 | 1986-01-06 | Sawai Seiyaku Kk | ニフエジピン含有製剤 |
SE8404467D0 (sv) * | 1984-09-06 | 1984-09-06 | Ferrosan Ab | Controlled-release medical preparations |
US4610870A (en) * | 1984-10-05 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
GB8521494D0 (en) * | 1985-08-29 | 1985-10-02 | Zyma Sa | Controlled release tablet |
JPS6253918A (ja) * | 1985-09-02 | 1987-03-09 | Katsumi Takada | 柱状の有効成分含有部分を埋没させた錠剤 |
SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
JPS6422245A (en) * | 1987-07-20 | 1989-01-25 | Toshiba Corp | Preparation of endoscope |
-
1987
- 1987-06-24 DE DE19873720757 patent/DE3720757A1/de not_active Withdrawn
-
1988
- 1988-06-08 US US07/204,056 patent/US4892741A/en not_active Expired - Lifetime
- 1988-06-14 AT AT88109420T patent/ATE75142T1/de not_active IP Right Cessation
- 1988-06-14 ES ES88109420T patent/ES2051800T3/es not_active Expired - Lifetime
- 1988-06-14 EP EP88109420A patent/EP0299211B1/de not_active Expired - Lifetime
- 1988-06-14 DE DE8888109420T patent/DE3870338D1/de not_active Expired - Lifetime
- 1988-06-22 IL IL86827A patent/IL86827A/xx not_active IP Right Cessation
- 1988-06-22 CA CA000570069A patent/CA1309951C/en not_active Expired - Lifetime
- 1988-06-23 IE IE191688A patent/IE60352B1/en not_active IP Right Cessation
- 1988-06-23 JP JP63153676A patent/JPH0611699B2/ja not_active Expired - Lifetime
-
1992
- 1992-04-23 GR GR920400734T patent/GR3004448T3/el unknown
-
1996
- 1996-11-18 JP JP8321158A patent/JP2955524B2/ja not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9993432B2 (en) | 2008-11-27 | 2018-06-12 | Bayer Intellectual Property Gmbh | Pharmaceutical dosage form comprising nifedipine or nisoldipine and an angiotensin II antagonist and/or a diuretic |
Also Published As
Publication number | Publication date |
---|---|
JPH0611699B2 (ja) | 1994-02-16 |
JPH09183728A (ja) | 1997-07-15 |
IL86827A0 (en) | 1988-11-30 |
CA1309951C (en) | 1992-11-10 |
DE3870338D1 (de) | 1992-05-27 |
IE60352B1 (en) | 1994-06-29 |
DE3720757A1 (de) | 1989-01-05 |
GR3004448T3 (fi) | 1993-03-31 |
JP2955524B2 (ja) | 1999-10-04 |
JPS6422822A (en) | 1989-01-25 |
ES2051800T3 (es) | 1994-07-01 |
ATE75142T1 (de) | 1992-05-15 |
EP0299211A1 (de) | 1989-01-18 |
US4892741A (en) | 1990-01-09 |
IE881916L (en) | 1988-12-24 |
IL86827A (en) | 1993-02-21 |
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