EP0279598B1 - Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds - Google Patents

Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds Download PDF

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Publication number
EP0279598B1
EP0279598B1 EP88301171A EP88301171A EP0279598B1 EP 0279598 B1 EP0279598 B1 EP 0279598B1 EP 88301171 A EP88301171 A EP 88301171A EP 88301171 A EP88301171 A EP 88301171A EP 0279598 B1 EP0279598 B1 EP 0279598B1
Authority
EP
European Patent Office
Prior art keywords
phenyl
piperazinyl
mmol
compound
naphthyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP88301171A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0279598A2 (en
EP0279598A3 (en
Inventor
John Adams Lowe Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Priority to AT88301171T priority Critical patent/ATE94537T1/de
Publication of EP0279598A2 publication Critical patent/EP0279598A2/en
Publication of EP0279598A3 publication Critical patent/EP0279598A3/en
Application granted granted Critical
Publication of EP0279598B1 publication Critical patent/EP0279598B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
EP88301171A 1987-02-17 1988-02-12 Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds Expired - Lifetime EP0279598B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT88301171T ATE94537T1 (de) 1987-02-17 1988-02-12 Arylpiperazinylalkylenphenylheterocyclische verbindungen.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8700340 1987-02-17
WOPCT/US87/00340 1987-02-17

Publications (3)

Publication Number Publication Date
EP0279598A2 EP0279598A2 (en) 1988-08-24
EP0279598A3 EP0279598A3 (en) 1989-07-26
EP0279598B1 true EP0279598B1 (en) 1993-09-15

Family

ID=22202287

Family Applications (1)

Application Number Title Priority Date Filing Date
EP88301171A Expired - Lifetime EP0279598B1 (en) 1987-02-17 1988-02-12 Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds

Country Status (30)

Country Link
EP (1) EP0279598B1 (ru)
JP (1) JPH0699405B2 (ru)
KR (1) KR900004126B1 (ru)
CN (1) CN1015627B (ru)
AP (1) AP88A (ru)
AR (1) AR245125A1 (ru)
AT (1) ATE94537T1 (ru)
AU (1) AU583761B2 (ru)
CA (1) CA1312080C (ru)
CS (1) CS272783B2 (ru)
DD (1) DD272080A5 (ru)
DE (1) DE3884007T2 (ru)
DK (1) DK170878B1 (ru)
EG (1) EG18635A (ru)
ES (1) ES2058249T3 (ru)
FI (1) FI91752C (ru)
HU (1) HU207731B (ru)
IE (1) IE61258B1 (ru)
IL (1) IL85368A0 (ru)
IN (1) IN171858B (ru)
MA (1) MA21183A1 (ru)
MX (1) MX174210B (ru)
MY (1) MY103210A (ru)
NO (1) NO170582C (ru)
NZ (1) NZ223530A (ru)
PL (1) PL157118B1 (ru)
PT (1) PT86766B (ru)
SU (1) SU1634136A3 (ru)
YU (1) YU46624B (ru)
ZA (1) ZA881064B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
FR2655988B1 (fr) * 1989-12-20 1994-05-20 Adir Cie Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5162321A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie 1-naphthyl piperazines useful as 5-HT1A receptor ligands
US5162324A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie Naphyl piperazines useful as 5-HT1A receptor ligands
US5166157A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
US5166156A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
ATE199147T1 (de) * 1995-06-06 2001-02-15 Aventis Pharma Inc Benzisoxazol- und indazol- derivate als antipsychotika
GB9517381D0 (en) * 1995-08-24 1995-10-25 Pharmacia Spa Aryl and heteroaryl piperazine derivatives
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
DE69624728T2 (de) * 1995-12-29 2003-07-10 Boehringer Ingelheim Pharma Phenyl thiazol derivate mit antiherpesvirus eigenschaften
WO1999001420A1 (fr) 1997-07-03 1999-01-14 Taito Co., Ltd. Procede de preparation de derives d'acide 2-aminomalonique, et intermediaires utilises dans ce procede
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2927924A (en) * 1958-04-03 1960-03-08 Lilly Co Eli Novel phenethyl-substituted piperazines
GB948766A (en) * 1959-10-20 1964-02-05 May & Baker Ltd Trifluoromethylphenylpiperazine derivatives
DE1695410A1 (de) * 1967-04-20 1971-04-08 Merck Patent Gmbh Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen
JPS5910675B2 (ja) * 1976-03-22 1984-03-10 ウェルファイド株式会社 アラルキルアミン誘導体
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4619930A (en) * 1985-01-16 1986-10-28 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
JPH075579B2 (ja) * 1986-09-01 1995-01-25 吉富製薬株式会社 アミノチアゾ−ル化合物

Also Published As

Publication number Publication date
DE3884007D1 (de) 1993-10-21
IE880420L (en) 1988-08-17
YU30388A (en) 1989-10-31
MY103210A (en) 1993-05-29
AP8800082A0 (en) 1988-02-01
CA1312080C (en) 1992-12-29
SU1634136A3 (ru) 1991-03-07
EG18635A (en) 1994-04-30
DK170878B1 (da) 1996-02-26
NO880667L (no) 1988-08-18
IE61258B1 (en) 1994-10-19
MX174210B (es) 1994-04-28
EP0279598A2 (en) 1988-08-24
JPS63216875A (ja) 1988-09-09
NZ223530A (en) 1990-07-26
FI880716A0 (fi) 1988-02-16
DK78888A (da) 1988-08-18
PL157118B1 (pl) 1992-04-30
ATE94537T1 (de) 1993-10-15
YU46624B (sh) 1994-01-20
AU583761B2 (en) 1989-05-04
DD272080A5 (de) 1989-09-27
CN1015627B (zh) 1992-02-26
PL270653A1 (en) 1988-12-08
FI91752C (fi) 1994-08-10
HU207731B (en) 1993-05-28
IN171858B (ru) 1993-01-23
NO170582B (no) 1992-07-27
KR900004126B1 (ko) 1990-06-16
ZA881064B (en) 1989-09-27
PT86766A (pt) 1988-03-01
MX10428A (es) 1993-09-01
FI880716A (fi) 1988-08-18
CN88100986A (zh) 1988-09-21
ES2058249T3 (es) 1994-11-01
CS272783B2 (en) 1991-02-12
NO880667D0 (no) 1988-02-16
AP88A (en) 1990-06-06
IL85368A0 (en) 1988-07-31
FI91752B (fi) 1994-04-29
AU1174088A (en) 1988-08-18
HUT50334A (en) 1990-01-29
EP0279598A3 (en) 1989-07-26
NO170582C (no) 1992-11-04
CS96488A2 (en) 1990-04-11
PT86766B (pt) 1992-05-29
AR245125A1 (es) 1993-12-30
DK78888D0 (da) 1988-02-16
DE3884007T2 (de) 1994-01-20
JPH0699405B2 (ja) 1994-12-07
KR880009964A (ko) 1988-10-06
MA21183A1 (fr) 1988-10-01

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