EP0220858A2 - Anticorps monoclonaux contrele cancer du sein humain, hybridomes correspondants, leur production et application - Google Patents

Anticorps monoclonaux contrele cancer du sein humain, hybridomes correspondants, leur production et application Download PDF

Info

Publication number
EP0220858A2
EP0220858A2 EP86307735A EP86307735A EP0220858A2 EP 0220858 A2 EP0220858 A2 EP 0220858A2 EP 86307735 A EP86307735 A EP 86307735A EP 86307735 A EP86307735 A EP 86307735A EP 0220858 A2 EP0220858 A2 EP 0220858A2
Authority
EP
European Patent Office
Prior art keywords
antibody
monoclonal antibody
breast cancer
antibodies
monoclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP86307735A
Other languages
German (de)
English (en)
Other versions
EP0220858A3 (en
EP0220858B1 (fr
Inventor
David Barratt Ring
Arthur Edward Frankel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Corp
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp, Cetus Oncology Corp filed Critical Cetus Corp
Priority to AT86307735T priority Critical patent/ATE85652T1/de
Publication of EP0220858A2 publication Critical patent/EP0220858A2/fr
Publication of EP0220858A3 publication Critical patent/EP0220858A3/en
Application granted granted Critical
Publication of EP0220858B1 publication Critical patent/EP0220858B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/804—Drug, bio-affecting and body treating compositions involving IgG3, IgG4, IgA, or IgY
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/806—Drug, bio-affecting and body treating compositions involving IgM
    • Y10S424/807—Monoclonal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/861—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgG3, IgG4, IgA, or IgY
EP86307735A 1985-10-07 1986-10-07 Anticorps monoclonaux contrele cancer du sein humain, hybridomes correspondants, leur production et application Expired - Lifetime EP0220858B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT86307735T ATE85652T1 (de) 1985-10-07 1986-10-07 Monoklonale antikoerper gegen humanen brustkrebs, korrespondierende hybridome, deren herstellung und verwendung.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78507685A 1985-10-07 1985-10-07
US785076 1985-10-07
US06/786,948 US4938948A (en) 1985-10-07 1985-10-11 Method for imaging breast tumors using labeled monoclonal anti-human breast cancer antibodies
US786948 1985-10-11

Publications (3)

Publication Number Publication Date
EP0220858A2 true EP0220858A2 (fr) 1987-05-06
EP0220858A3 EP0220858A3 (en) 1988-08-03
EP0220858B1 EP0220858B1 (fr) 1993-02-10

Family

ID=27120360

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86307735A Expired - Lifetime EP0220858B1 (fr) 1985-10-07 1986-10-07 Anticorps monoclonaux contrele cancer du sein humain, hybridomes correspondants, leur production et application

Country Status (13)

Country Link
US (1) US4938948A (fr)
EP (1) EP0220858B1 (fr)
JP (3) JP2968474B2 (fr)
AT (1) ATE85652T1 (fr)
AU (1) AU6356986A (fr)
CA (1) CA1338706C (fr)
DE (1) DE3687736T2 (fr)
DK (1) DK478886A (fr)
ES (1) ES2053440T3 (fr)
FI (1) FI864037A (fr)
IL (1) IL80231A (fr)
NO (1) NO863974L (fr)
NZ (1) NZ217829A (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0221561A2 (fr) * 1985-11-07 1987-05-13 The Trustees Of Columbia University In The City Of New York Antigène indicateur de cancer du sein humain et essais basés sur son usage
EP0268279A2 (fr) * 1986-11-19 1988-05-25 Oncogen Limited Partnership Hybridomes produisant des anticorps monoclonaux contre des épitopes de la mucine
US4863726A (en) * 1987-05-29 1989-09-05 Cetus Corporation Combination therapy using immunotoxins with interleukin-2
US4894227A (en) * 1986-08-01 1990-01-16 Cetus Corporation Composition of immunotoxins with interleukin-2
US5032521A (en) * 1984-12-05 1991-07-16 The Salk Institute For Biological Studies Monoclonal antibody specific for a mammary tumor cell surface antigen
US6004761A (en) * 1986-11-19 1999-12-21 Sanofi Method for detecting cancer using monoclonal antibodies to new mucin epitopes

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054561A (en) * 1984-02-08 2000-04-25 Chiron Corporation Antigen-binding sites of antibody molecules specific for cancer antigens
US6861511B1 (en) 1986-06-04 2005-03-01 Bayer Corporation Detection and quantification of neu related proteins in the biological fluids of humans
US5401638A (en) * 1986-06-04 1995-03-28 Oncogene Science, Inc. Detection and quantification of neu related proteins in the biological fluids of humans
US5084266A (en) * 1988-02-03 1992-01-28 The University Of Melbourne Method for tumor imaging utilizing a labelled tumor specific antibody and a non-tumor reactive antibody
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
US5849877A (en) * 1990-10-29 1998-12-15 Chiron Corporation Antigen-binding sites of antibody molecules specific for cancer antigens
US5948647A (en) * 1990-10-29 1999-09-07 Chiron Corporation Nucleic acids encoding antigen-binding sites specific for cancer antigens
US5811267A (en) * 1990-10-29 1998-09-22 Chiron Corporation Isolated nucleic acid molecules encoding antigen binding sites of antibody molecules specific for cancer antigens
US5292524A (en) * 1991-09-06 1994-03-08 California Institute Of Technology Blood platelet loaded with diagnostic or therapeutic-containing liposome or reconstituted Sendai virus
DE69334255D1 (de) * 1992-02-06 2009-02-12 Novartis Vaccines & Diagnostic Marker für Krebs und biosynthetisches Bindeprotein dafür
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US20030086922A1 (en) * 1994-12-02 2003-05-08 David B. Ring Method of promoting an immune response with a bispecific antibody
US6416960B1 (en) 1996-08-08 2002-07-09 Prolume, Ltd. Detection and visualization of neoplastic tissues and other tissues
GB9906380D0 (en) * 1999-03-19 1999-05-12 Melvin William T Monoclonal antibodies specific for cypibi
FR2811323B1 (fr) * 2000-07-07 2006-10-06 Fuma Tech Gmbh Materiau hybride, utilisation dudit materiau hybride et procede de sa fabrication
DE10141937A1 (de) * 2001-08-28 2003-03-27 Alfred Schmidt Markierung der Aromatase
EP2131198B1 (fr) 2001-09-20 2013-03-27 Board of Regents, The University of Texas System Mesure des anticorps thérapeutiques, des antigènes et des complexes antigène/anticorps circulants à l'aide d'analyse ELISA
US20040126762A1 (en) * 2002-12-17 2004-07-01 Morris David W. Novel compositions and methods in cancer
US20040166490A1 (en) * 2002-12-17 2004-08-26 Morris David W. Novel therapeutic targets in cancer
US20060040262A1 (en) * 2002-12-27 2006-02-23 Morris David W Novel compositions and methods in cancer
US20040180344A1 (en) * 2003-03-14 2004-09-16 Morris David W. Novel therapeutic targets in cancer
US20040197778A1 (en) * 2002-12-26 2004-10-07 Sagres Discovery, Inc. Novel compositions and methods in cancer
AU2003218350A1 (en) 2002-03-21 2003-10-08 Sagres Discovery, Inc. Novel compositions and methods in cancer
US6916474B2 (en) 2002-07-15 2005-07-12 Board Of Regents, The University Of Texas System Antibodies with increased affinities for anthrax antigens
US7794716B2 (en) 2002-07-25 2010-09-14 Glenveigh Pharmaceuticals, Llc Antibody composition and passive immunization against pregnancy-induced hypertension
CA2516138A1 (fr) 2003-02-14 2004-09-02 Sagres Discovery, Inc. Nouveaux cibles therapeutiques du recepteur de couplage a la proteine g dans le cancer
US7767387B2 (en) * 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US20070218071A1 (en) * 2003-09-15 2007-09-20 Morris David W Novel therapeutic targets in cancer
US20040170982A1 (en) * 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
US20070281896A1 (en) * 2003-09-30 2007-12-06 Morris David W Novel compositions and methods in cancer
EP1708752B1 (fr) * 2004-01-27 2012-02-22 University Of Southern California Agent therapeutique anticancereux constitue d'anticorps relie a un polymere
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
AU2005287090A1 (en) 2004-09-18 2006-03-30 Department Of Veterans Affairs Therapeutic agents targeting the NCca-ATP channel and methods of use thereof
EP2359832A3 (fr) 2004-09-18 2011-11-23 University of Maryland, Baltimore Agents therapeutiques ciblant le canal ncca-atp et leurs methodes d'utilisation
PL2645106T3 (pl) 2005-04-04 2017-11-30 Biogen Ma Inc. Sposoby oceniania odpowiedzi immunologicznej na środek leczniczy
WO2006110585A2 (fr) 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. Genes lies au cancer (prlr)
AU2006235276A1 (en) 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. CACNA1E in cancer diagnosis, detection and treatment
US8124351B2 (en) 2005-11-18 2012-02-28 Board Of Regents, The University Of Texas System Quantification of fusion proteins and their activity from chromosomal translocation
US20080003230A1 (en) 2006-07-03 2008-01-03 Adair Charles D Composition for modulating the expression of cell adhesion molecules
DK2102239T3 (da) 2006-11-30 2012-05-29 Res Dev Foundation Forbedrede immunoglobulin-biblioteker
EP3103451A1 (fr) 2007-01-12 2016-12-14 University of Maryland, Baltimore Ciblage de canal ncca-atp destiné à protéger les organes après un épisode ischémique
KR100855299B1 (ko) * 2007-02-16 2008-08-29 건국대학교 산학협력단 인간 ｉｌ-32 특이 항원결정기를 갖는 단일클론항체,특이항체분비 융합 세포주 및 항체들을 이용한 ｉｌ-32측정법
DK2155789T3 (da) 2007-05-01 2013-10-21 Res Dev Foundation Immunoglobulin-Fc-biblioteker
JP2010530895A (ja) * 2007-06-21 2010-09-16 アンジェリカ セラピューティックス，インク． 修飾毒素
EP2185718B1 (fr) 2007-08-03 2017-10-04 MUSC Foundation For Research Development Anticorps monoclonaux humains et procédés de production
EP2944649A1 (fr) 2008-01-10 2015-11-18 Research Development Foundation Vaccins et diagnostics pour les ehrlichioses
WO2009110944A1 (fr) 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Toxines modifiées
US20100082438A1 (en) * 2008-10-01 2010-04-01 Ronnie Jack Garmon Methods and systems for customer performance scoring
JP5805538B2 (ja) 2008-11-07 2015-11-04 リサーチ ディベロップメント ファウンデーション Ｃｒｉｐｔｏ／ＧＳＰ７８複合体形成およびシグナル伝達を阻害するための組成物および方法
WO2010065437A1 (fr) 2008-12-03 2010-06-10 Research Development Foundation Modulation de l'angiogenèse à médiation par olfml-3
US8221753B2 (en) 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
WO2011044553A1 (fr) 2009-10-11 2011-04-14 Biogen Idec Ma Inc. Tests associés à un anti-vla-4
WO2011062997A2 (fr) 2009-11-17 2011-05-26 Musc Foundation For Research Development Anticorps monoclonaux humains pour nucléoline humaine
WO2012065161A2 (fr) 2010-11-12 2012-05-18 Scott & White Healthcare Anticorps contre le marqueur 8 endothélial tumoral
AU2012214643B2 (en) 2011-02-07 2016-12-15 Research Development Foundation Engineered immunoglobulin Fc polypeptides
SG193514A1 (en) 2011-04-01 2013-10-30 Immunogen Inc Methods for increasing efficacy of folr1 cancer therapy
AU2012294814A1 (en) 2011-08-05 2014-02-27 Research Development Foundation Improved methods and compositions for modulation of Olfml3 mediated angiogenesis
US9556281B2 (en) 2011-08-15 2017-01-31 The University Of Chicago Compositions and methods related to antibodies to staphylococcal protein A
WO2013142299A1 (fr) 2012-03-20 2013-09-26 Biogen Idec Ma Inc. Anticorps neutralisant le virus jcv
EP2841101B1 (fr) 2012-04-26 2019-08-07 University Of Chicago Compositions et procédés associés à des anticorps qui neutralisent l'activité coagulase dans une maladie à staphylococcus aureus
CA2871160C (fr) 2012-05-10 2023-03-14 Massachusetts Institute Of Technology Agents convenant a la neutralisation de la grippe
AU2013299986B2 (en) 2012-08-07 2018-05-17 Massachusetts Institute Of Technology Anti-dengue virus antibodies and uses thereof
UA115789C2 (uk) 2012-09-05 2017-12-26 Трейкон Фармасутікалз, Інк. Композиція антитіла до cd105 та її застосування
DK2912064T3 (da) 2012-10-24 2019-07-22 Res Found Dev Jam-c-antistoffer og fremgangsmåder til behandling af cancer
US9388397B2 (en) 2013-02-15 2016-07-12 Research Development Foundation Deimmunized gelonin molecules and therapies
NZ631098A (en) 2013-03-15 2016-09-30 Intrinsic Lifesciences Llc Anti-hepcidin antibodies and uses thereof
HUE062021T2 (hu) 2013-03-15 2023-09-28 Gladiator Biosciences Inc GLA domének mint targetáló szerek
CA2902905A1 (fr) 2013-03-15 2014-09-25 Claude Geoffrey Davis Toxines modifiees
ES2935257T3 (es) 2013-03-15 2023-03-03 Univ Chicago Métodos y composiciones relacionadas con la actividad de las células T
WO2014197723A2 (fr) 2013-06-05 2014-12-11 Massachusetts Institute Of Technology Adaptation humaine de h7 ha
CA2916694C (fr) 2013-06-28 2023-01-17 Baylor Research Institute Immunotherapie par ciblage d'asgpr de cellules dendritiques pour la sclerose en plaques
EP3036005A4 (fr) 2013-08-21 2017-04-26 The Board Of Regents Of The University Of Texas System Compositions et méthodes de ciblage de semi-canaux de connexine
CN105814079B (zh) 2013-08-30 2021-02-09 伊缪诺金公司 用于检测叶酸受体1的抗体和测定
US20170002064A1 (en) 2013-11-08 2017-01-05 The Board Of Regents Of The University Of Texas System Vh4 antibodies against gray matter neuron and astrocyte
JP7037884B2 (ja) 2014-01-13 2022-03-17 ベイラー リサーチ インスティテュート Ｈｐｖ及びｈｐｖ関連疾患に対する新規のワクチン
JP6908381B2 (ja) 2014-01-29 2021-07-28 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｍｕｃ１−ｃ／細胞外ドメイン（ｍｕｃ１−ｃ／ｅｃｄ）に対する抗体
AU2015217149B2 (en) 2014-02-11 2020-09-10 Massachusetts Institute Of Technology Novel full spectrum anti-dengue antibody
RU2744836C2 (ru) 2014-05-08 2021-03-16 Новодиакс, Инк. Прямой иммуногистохимический анализ
WO2015179435A1 (fr) 2014-05-19 2015-11-26 Bayer Healthcare Llc Anticorps monoclonaux humanisés optimisés dirigés contre la protéine c activée et leurs utilisations
CA2959356C (fr) 2014-08-27 2024-02-20 Memorial Sloan Kettering Cancer Center Nouveaux anticorps se liant a b7h3
CA2961917A1 (fr) 2014-09-22 2016-03-31 Intrinsic Lifesciences Llc Anticorps anti-hepcidine humanises et utilisations de ceux-ci
US9926375B2 (en) 2014-11-12 2018-03-27 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
JP2017537084A (ja) 2014-11-12 2017-12-14 トラコン ファーマシューティカルズ、インコーポレイテッド 抗エンドグリン抗体及びその用途
JP6724023B2 (ja) 2015-02-09 2020-07-15 リサーチ ディベロップメント ファウンデーション 改善された補体活性化を示す操作された免疫グロブリンｆｃポリペプチド
US10988534B2 (en) 2015-02-09 2021-04-27 Memorial Sloan Kettering Cancer Center Multi-specific antibodies with affinity for human A33 antigen and DOTA metal complex and uses thereof
CA2977499C (fr) 2015-02-25 2023-10-03 Vanderbilt University Neutralisation a mediation anticorps du virus de marburg
WO2017040380A2 (fr) 2015-08-28 2017-03-09 Research Development Foundation Variants de fc d'anticorps modifiés
CA3004438A1 (fr) 2015-11-09 2017-05-18 The Children's Hospital Of Philadelphia Glypicane 2 a utiliser en tant que marqueur cancereux et cible therapeutique
EP3909983A1 (fr) 2015-12-02 2021-11-17 STCube & Co. Inc. Anticorps et molécules se liant de manière immunospécifique à btn1a1 et leurs utilisations thérapeutiques
EP3383908A1 (fr) 2015-12-02 2018-10-10 Stsciences, Inc. Anticorps spécifiques au btla glycosylé (atténuateur de lymphocytes b et t)
JP2019507582A (ja) 2015-12-04 2019-03-22 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 免疫療法用のｓｌｃ４５ａ２ペプチド
US10889637B2 (en) 2016-02-26 2021-01-12 The Board Of Regents Of The University Of Texas System Methods of treating an osteolytic tumor and spinal cord injury by administering connexin (Cx) 43 hemichannel-binding antibodies
US11660352B2 (en) 2016-03-29 2023-05-30 Stcube, Inc. Dual function antibodies specific to glycosylated PD-L1 and methods of use thereof
WO2017173091A1 (fr) 2016-03-30 2017-10-05 Musc Foundation For Research Development Méthodes pour le traitement et le diagnostic du cancer par le ciblage d'une protéine à prédominance de répétitions de glycoprotéine a (garp) et la mise en œuvre d'une immunothérapie efficace seule ou en association
US11559590B2 (en) 2016-07-01 2023-01-24 The General Hospital Corporation Granzyme B directed imaging and therapy
KR20190031299A (ko) 2016-07-20 2019-03-25 주식회사 에스티큐브 글리코실화된 pd-l1에 결합하는 항체의 조합을 사용하는 암 치료 방법
WO2018126183A2 (fr) 2016-12-29 2018-07-05 The General Hospital Corporation Peptides her3 pour imagerie et radiothérapie
JP2020522512A (ja) 2017-05-31 2020-07-30 ストキューブ アンド シーオー．， インコーポレイテッド Ｂｔｎ１ａ１に免疫特異的に結合する抗体及び分子を用いて癌を治療する方法
JP7369038B2 (ja) 2017-05-31 2023-10-25 ストキューブ アンド シーオー．， インコーポレイテッド Ｂｔｎ１ａ１に免疫特異的に結合する抗体及び分子並びにその治療的使用
JP2020522562A (ja) 2017-06-06 2020-07-30 ストキューブ アンド シーオー．， インコーポレイテッド Ｂｔｎ１ａ１又はｂｔｎ１ａ１リガンドに結合する抗体及び分子を用いて癌を治療する方法
US10759865B2 (en) 2017-08-22 2020-09-01 Eyal Levit Treatment of diabetes mellitus
JP7437301B2 (ja) 2017-08-25 2024-02-22 ファイヴ プライム セラピューティクス インク Ｂ７－ｈ４抗体及びその使用方法
CA3074678A1 (fr) 2017-09-05 2019-03-14 GLAdiator Biosciences, Inc. Procede de ciblage d'exosomes
GB2581619A (en) 2017-09-15 2020-08-26 Univ California Inhibition of aminoacylase 3 (AA3) in the treatment of cancer
US11525002B2 (en) 2017-10-11 2022-12-13 Board Of Regents, The University Of Texas System Human PD-L1 antibodies and methods of use therefor
US11851478B2 (en) 2018-01-05 2023-12-26 Vanderbilt University Antibody-mediated neutralization of chikungunya virus
EA202091810A1 (ru) 2018-03-02 2021-01-29 Файв Прайм Терапьютикс, Инк. Антитела к b7-h4 и способы их применения
WO2019182896A1 (fr) 2018-03-23 2019-09-26 Board Of Regents, The University Of Texas System Anticorps à double spécificité pour pd-l1 et pd-l2 et leurs procédés d'utilisation
WO2020056077A1 (fr) 2018-09-13 2020-03-19 The Board Of Regents Of The University Of Texas System Nouveaux anticorps anti-lilrb4 et leurs utilisations
US20220195024A1 (en) 2018-11-02 2022-06-23 Oklahoma Medical Research Foundation Monoclonal Antibodies to ELTD1 and Uses Thereof
US20220089776A1 (en) 2018-11-28 2022-03-24 Oregon Health & Science University Therapeutic factor xii antibody
US20230132386A9 (en) 2019-02-13 2023-04-27 Cytosite Biopharma Inc. Granzyme b directed imaging and therapy
JP2022541538A (ja) 2019-07-19 2022-09-26 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア グリピカン２結合ドメインを含有するキメラ抗原受容体
KR20220038415A (ko) 2019-07-26 2022-03-28 벤더르빌트 유니버시티 엔테로바이러스 d68에 대한 인간 모노클로날 항체
CN114729045A (zh) 2019-09-26 2022-07-08 斯特库比公司 对糖基化的ctla-4特异性的抗体及其使用方法
EP4041768A1 (fr) 2019-10-09 2022-08-17 StCube & Co. Anticorps spécifiques de lag3 glycosylé et leurs procédés d'utilisation
EP4103602A1 (fr) 2020-02-11 2022-12-21 Vanderbilt University Anticorps monoclonaux humains dirigés contre le coronavirus 2 du syndrome respiratoire aigu sévère (sars-cov-2)
EP4107173A1 (fr) 2020-02-17 2022-12-28 Board of Regents, The University of Texas System Procédés d'expansion de lymphocytes infiltrant les tumeurs et leur utilisation
LT4045533T (lt) 2020-03-26 2024-02-26 Vanderbilt University Žmogaus monokloniniai antikūnai prieš sunkaus ūminio respiracinio sindromo koronavirusą 2 (sars-cov-2)
WO2021195385A1 (fr) 2020-03-26 2021-09-30 Vanderbilt University Anticorps monoclonaux humains dirigés contre le coronavirus du syndrome respiratoire aigu sévère 2 (sras-cov-2)
GB202105804D0 (en) 2020-11-20 2021-06-09 Univ Cape Town Use of microvirin in the identification of mycobacterium tuberculosis mannose-capped lipoarabinomannan
GB2603166A (en) 2021-01-29 2022-08-03 Thelper As Therapeutic and Diagnostic Agents and Uses Thereof
CN117729942A (zh) 2021-03-08 2024-03-19 伊缪诺金公司 用于增加靶向adam9的免疫缀合物治疗癌症的功效的方法
GB202201137D0 (en) 2022-01-28 2022-03-16 Thelper As Therapeutic and diagnostic agents and uses thereof
WO2023192976A1 (fr) 2022-04-01 2023-10-05 Board Of Regents, The University Of Texas System Anticorps à double spécificité dirigés contre pd-l1 et pd-l2 humains et leurs méthodes d'utilisation
GB202204813D0 (en) 2022-04-01 2022-05-18 Bradcode Ltd Human monoclonal antibodies and methods of use thereof
US20240010742A1 (en) 2022-06-10 2024-01-11 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof
WO2024040020A1 (fr) 2022-08-15 2024-02-22 Absci Corporation Enrichissement de cellule spécifique à une activité d'affinité quantitative

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0118365A2 (fr) * 1983-03-04 1984-09-12 Health Research, Inc. Anticorps monoclonaux contre les cellules carcinomateuses mammaires humaines et leur application en diagnostic et en thérapie
WO1985001442A1 (fr) * 1983-09-28 1985-04-11 Summa Medical Corporation Composition a base de lectine et procede de diagnostic du cancer
US4522918A (en) * 1981-12-15 1985-06-11 Jeffery Schlom Process for producing monoclonal antibodies reactive with human breast cancer
EP0153114A2 (fr) * 1984-02-08 1985-08-28 Cetus Corporation Anticorps monoclonaux contre le cancer du sein humain, leur production et application, et hybridomes pour leur préparation et production de ces hybridomes
EP0160446A2 (fr) * 1984-05-01 1985-11-06 Ciba Corning Diagnostics Corp. Antigène associé aux tumeurs des seins et anticoprs monoclonaux spécifiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695538A (en) * 1984-06-01 1987-09-22 Sloan-Kettering Institute For Cancer Research Human monoclonal antibodies to cell surface antigens
US4707438A (en) * 1984-08-22 1987-11-17 Tel Aviv University Immunoassay for breast cancer employing monoclonal antibodies

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522918A (en) * 1981-12-15 1985-06-11 Jeffery Schlom Process for producing monoclonal antibodies reactive with human breast cancer
EP0118365A2 (fr) * 1983-03-04 1984-09-12 Health Research, Inc. Anticorps monoclonaux contre les cellules carcinomateuses mammaires humaines et leur application en diagnostic et en thérapie
WO1985001442A1 (fr) * 1983-09-28 1985-04-11 Summa Medical Corporation Composition a base de lectine et procede de diagnostic du cancer
EP0153114A2 (fr) * 1984-02-08 1985-08-28 Cetus Corporation Anticorps monoclonaux contre le cancer du sein humain, leur production et application, et hybridomes pour leur préparation et production de ces hybridomes
EP0160446A2 (fr) * 1984-05-01 1985-11-06 Ciba Corning Diagnostics Corp. Antigène associé aux tumeurs des seins et anticoprs monoclonaux spécifiques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS, vol. 79, no. 4, April 1985, page 592, abstract no. 32706, Philadelphia, PA, US; L.D. PAPSIDERO et al.: "Expression of ductal carcinoma antigen in breast cancer sera as defined using monoclonal antibody F36/22"; & CANCER RES, 44(10): 4653-4657, 1984 *
CHEMICAL ABSTRACTS, vol. 101, no. 13, September 1984, page 484, abstract no. 108736n, Columbus, Ohio, US; J.W. GREINER et al.: "Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte alpha-interferon treatment"; & CANCER RES. 1984, 44(8), 3208-14 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032521A (en) * 1984-12-05 1991-07-16 The Salk Institute For Biological Studies Monoclonal antibody specific for a mammary tumor cell surface antigen
EP0221561A2 (fr) * 1985-11-07 1987-05-13 The Trustees Of Columbia University In The City Of New York Antigène indicateur de cancer du sein humain et essais basés sur son usage
EP0221561A3 (fr) * 1985-11-07 1989-08-09 The Trustees Of Columbia University In The City Of New York Antigène indicateur de cancer du sein humain et essais basés sur son usage
US4894227A (en) * 1986-08-01 1990-01-16 Cetus Corporation Composition of immunotoxins with interleukin-2
EP0268279A2 (fr) * 1986-11-19 1988-05-25 Oncogen Limited Partnership Hybridomes produisant des anticorps monoclonaux contre des épitopes de la mucine
EP0268279A3 (fr) * 1986-11-19 1991-07-03 Oncogen Limited Partnership Hybridomes produisant des anticorps monoclonaux contre des épitopes de la mucine
US5849876A (en) * 1986-11-19 1998-12-15 Sanofi Hybridomas producing monoclonal antibodies to new mucin epitopes
US6004761A (en) * 1986-11-19 1999-12-21 Sanofi Method for detecting cancer using monoclonal antibodies to new mucin epitopes
EP0268279B2 (fr) † 1986-11-19 2003-12-03 Sanofi, Inc. Hybridomes produisant des anticorps monoclonaux contre des épitopes de la mucine
US4863726A (en) * 1987-05-29 1989-09-05 Cetus Corporation Combination therapy using immunotoxins with interleukin-2

Also Published As

Publication number Publication date
FI864037A (fi) 1987-04-08
JPH08266273A (ja) 1996-10-15
DK478886A (da) 1987-04-08
CA1338706C (fr) 1996-11-12
US4938948A (en) 1990-07-03
EP0220858A3 (en) 1988-08-03
ES2053440T3 (es) 1994-08-01
DE3687736D1 (de) 1993-03-25
JP2000000092A (ja) 2000-01-07
IL80231A (en) 1991-08-16
AU6356986A (en) 1987-04-09
FI864037A0 (fi) 1986-10-06
NO863974D0 (no) 1986-10-06
EP0220858B1 (fr) 1993-02-10
DK478886D0 (da) 1986-10-07
JP2968474B2 (ja) 1999-10-25
JP2000000091A (ja) 2000-01-07
DE3687736T2 (de) 1993-05-27
NO863974L (no) 1987-04-08
ATE85652T1 (de) 1993-02-15
NZ217829A (en) 1989-06-28

Similar Documents

Publication Publication Date Title
US4938948A (en) Method for imaging breast tumors using labeled monoclonal anti-human breast cancer antibodies
CA1215331A (fr) Anticorps monolconaux contre les cellules de cancer du sein et utilisation desdits anticorps pour le diagnostic et le traitement
EP0192657B1 (fr) Anticorps monoclonal destine au ganglioside gd 2? humain
US4472371A (en) Radiolabeled antibody to anti-tumor associated antigen and process
CA1264029A (fr) Detection de plaquettes activees a l'aide d'anticorps contre les antigenes de surface des cellules
US5183756A (en) Monoclonal antibody (D612) having selective reactivity for gastrointestinal caricinomas and method for employing the same
EP0210970A2 (fr) Détection, visualisation et thérapie de carcinomes de cellules rénales utilisant des anticorps monoclonaux
US5153118A (en) Monoclonal antibodies having binding specificity to human prostate tumor-associated antigens and methods for employing the same
CA2014304A1 (fr) Anticorps monoclonaux contre un nouvel antigene associe aux tumeurs chez les humains
US5185432A (en) Monoclonal antibodies and antigen for human non-small cell lung carcinoma and other certain human carcinomas
Epenetos et al. Antibody-guided radiolocalisation of tumours in patients with testicular or ovarian cancer using two radioiodinated monoclonal antibodies to placental alkaline phosphatase
EP0352722A2 (fr) Procédés de liaison d'antigène d'adènocarcinome et réactifs
Wilbanks et al. Localization of mammary tumors in vivo with 131i‐labeled fab fragments of antibodies against mouse mammary epithelial (mme) antigens
KR920002166B1 (ko) 방사성원소로 레이블된 단일클론항체의 제조방법
JP2574269B2 (ja) ヒト前立腺腫瘍関連抗原に対する結合特異性を有するモノクロ−ナル抗体類およびそれらを使用する方法
USRE32417E (en) Radiolabeled antibody to anti-tumor associated antigen and process
EP0282581A1 (fr) Molecule paratopique monoclonale agissant contre le ganglioside gd2 humain
US5250297A (en) Tumor-associated antigen, antibodies, compositions and uses therefor
Bourguet et al. Immunoscintigraphy of human lung squamous cell carcinoma using an iodine-131 labelled monoclonal antibody (Po66)
US6004761A (en) Method for detecting cancer using monoclonal antibodies to new mucin epitopes
EP0424107A1 (fr) Un antigène nouveau associé aux tumeurs
EP0243058B1 (fr) Antigène associé aux tumeurs
JPS6296500A (ja) 抗−ヒト乳癌モノクロ−ナル抗体
Ceriani et al. Localization of human breast tumors grafted in nude mice with a monoclonal antibody directed against a defined cell surface antigen of human mammary epithelial cells
EP0397419A2 (fr) Antigène associé à une tumeur, anticorps, compositions et leurs utilisations

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE ES FR GB GR IT LI NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE ES FR GB GR IT LI NL SE

17P Request for examination filed

Effective date: 19881221

17Q First examination report despatched

Effective date: 19900917

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CETUS ONCOLOGY CORPORATION

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE ES FR GB GR IT LI NL SE

REF Corresponds to:

Ref document number: 85652

Country of ref document: AT

Date of ref document: 19930215

Kind code of ref document: T

REF Corresponds to:

Ref document number: 3687736

Country of ref document: DE

Date of ref document: 19930325

ET Fr: translation filed
ITF It: translation for a ep patent filed

Owner name: BARZANO' E ZANARDO ROMA S.P.A.

REG Reference to a national code

Ref country code: GR

Ref legal event code: FG4A

Free format text: 3007840

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2053440

Country of ref document: ES

Kind code of ref document: T3

EAL Se: european patent in force in sweden

Ref document number: 86307735.0

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 19970926

Year of fee payment: 12

NLS Nl: assignments of ep-patents

Owner name: CHIRON CORPORATION

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19980917

Year of fee payment: 13

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 19980918

Year of fee payment: 13

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19980921

Year of fee payment: 13

Ref country code: DE

Payment date: 19980921

Year of fee payment: 13

Ref country code: AT

Payment date: 19980921

Year of fee payment: 13

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Free format text: CETUS ONCOLOGY CORPORATION TRANSFER- CHIRON CORPORATION

Ref country code: CH

Ref legal event code: NV

Representative=s name: PATENTANWAELTE SCHAAD, BALASS, MENZL & PARTNER AG

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 19981005

Year of fee payment: 13

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19981007

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 19981014

Year of fee payment: 13

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 19981022

Year of fee payment: 13

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 19981026

Year of fee payment: 13

REG Reference to a national code

Ref country code: ES

Ref legal event code: PC2A

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 19981007

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19991007

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19991008

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: THE PATENT HAS BEEN ANNULLED BY A DECISION OF A NATIONAL AUTHORITY

Effective date: 19991030

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19991031

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19991031

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19991031

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19991031

BERE Be: lapsed

Owner name: CHIRON CORP.

Effective date: 19991031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20000501

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

EUG Se: european patent has lapsed

Ref document number: 86307735.0

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20000630

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee

Effective date: 20000501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20000801

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20001113

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 20051007