EP0213589B1 - Technetium-99m-Generator, seine Herstellung und Verwendung - Google Patents

Technetium-99m-Generator, seine Herstellung und Verwendung Download PDF

Info

Publication number
EP0213589B1
EP0213589B1 EP86111788A EP86111788A EP0213589B1 EP 0213589 B1 EP0213589 B1 EP 0213589B1 EP 86111788 A EP86111788 A EP 86111788A EP 86111788 A EP86111788 A EP 86111788A EP 0213589 B1 EP0213589 B1 EP 0213589B1
Authority
EP
European Patent Office
Prior art keywords
generator
copper
silica gel
aluminum oxide
technetium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP86111788A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0213589A3 (en
EP0213589A2 (de
Inventor
Ludwig Dr. Kuhlmann
Dietrich Pütter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to AT86111788T priority Critical patent/ATE63013T1/de
Publication of EP0213589A2 publication Critical patent/EP0213589A2/de
Publication of EP0213589A3 publication Critical patent/EP0213589A3/de
Application granted granted Critical
Publication of EP0213589B1 publication Critical patent/EP0213589B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources

Definitions

  • the invention relates to an improved technetium-99m generator based on carrier-adsorbed molybdenum-99, processes for producing such generators and their use for obtaining eluates which contain technetium-99m in the form of pertechnetate.
  • Technetium-99m is the most commonly used radioactive nuclide in nuclear medicine diagnostics. This is due to its core physical properties that are optimal for this application (short half-life of 6.0 hours, no corpuscular radiation, favorable ⁇ energy of 140 keV). It can be easily and easily obtained from a molybdenum 99 / technetium 99m generator.
  • the molybdenum-99 from which the isotope technetium-99m is continuously formed by core decay, is adsorbed onto an aluminum oxide column as molybdenum-99-molybdate.
  • Technetium-99m which is chemically pertechnetate, is separated from Molydbän-99 by washing with isotonic saline.
  • the so-called split molybdenum-99 is used almost exclusively as molybdenum-99. It is isolated from the fission product mixture that occurs during the core decay of uranium-235 and has a very high specific activity. This makes it possible to get high technetium-99m activity in small volumes of saline from a generator.
  • split molybdenum made it possible to use only small amounts (1-2 g) of aluminum oxide in the generators, whereby the minimum amount of saline solution required for the elution of the technetium-99m could be limited to a few milliliters (approx. 5 ml).
  • German Offenlegungsschrift 1 929 067 describes adding copper (II) acetate to the eluent.
  • this is not sufficient - even when using the minimum copper (II) concentrations mentioned - to prevent the aforementioned passage of copper into the eluate.
  • silica gels modified with amino groups and, if appropriate, magnesium silicates are advantageous carrier materials for technetium-99m generators which are capable of firmly binding copper (II) ions.
  • the invention thus relates to technetium-99m generators based on carrier-adsorbed molybdenum-99, which are characterized by a content of an amino group-modified silica gel and, if appropriate, magnesium silicates.
  • the amino group-modified silica gel is able to adsorb radioactive molybdenum-99. This means that the Mo-99 content in the eluate can be reduced to less than 1 ⁇ Ci Mo-99 / Ci Tc-99m.
  • a technetium-99m generator the carrier material of which consists of silica group modified with amino groups.
  • preferred embodiments of this invention additionally contain aluminum oxide and, if appropriate, magnesium silicates.
  • Generators according to the invention with a content of magnesium silicate expediently contain, in addition to the silica group-modified silica gel according to the invention, additionally aluminum oxide for the adsorption of Mo-99.
  • For generators that contain more than one carrier material it is fundamentally possible to mix the carrier materials and to fill the usual equipment with the mixture. However, since the different materials generally have a different grain size, special precautions, for example joint grinding, must be used to ensure that no "channels" remain open in the filling. It is therefore generally more convenient to fill the different materials in layers in the generators. "Layer by layer” can mean that the different materials are introduced in several, alternating layers, but it is advisable to introduce each material in the form of a single layer.
  • the amino group-modified silica gel is preferably introduced as the bottom layer in the generator column. A layer of aluminum oxide is then applied over this.
  • FIG. 1 and 2 show schematically and not necessarily to scale two embodiments of the invention:
  • (1) means the column into which the carrier material is filled, the direction of elution (from top to bottom) being indicated by the arrow.
  • (2) and (3) mean the layers of different carrier materials, in a preferred embodiment aluminum oxide as layer (2) and amino group-modified silica gel as layer (3).
  • FIG. 2 designates a corresponding arrangement with three layers, three different materials (2), (3) and (4) being used.
  • (4) means a layer of copper (II) -loaded aluminum oxide, (2) aluminum oxide and (3) amino group-modified silica gel and optionally magnesium silicates.
  • nuclide generators The technical design of nuclide generators is known and is described, for example, in German Patent Specification 1,614,486 (or the corresponding US Pat. No. 3,369,121) or GB Pat. No. 1,186,587. Details can therefore be dispensed with here.
  • the amount of carrier material depends on the dimensioning of the generator and the load; it can be easily determined by simple preliminary tests.
  • Amino group-modified silica gels are customary as support materials for chromatographic processes.
  • a preferred form contains the amino groups in the form of 1,3-propylamine groups.
  • carrier materials for example those with secondary or tertiary amino groups, such as those used as adsorbents for acidic compounds, are also possible.
  • Suitable as magnesium silicate are naturally occurring products such as forsterite, entstatite, serpentine, serpentine asbestos, talc, antigorite or meerschaum as well as corresponding synthetic products, the magnesium ortho-, di- or polysilicates, the latter with chain, ribbon or layer (sheet) ) Structure included. Such materials are used for example for chromatographic processes.
  • one glass column was filled with 1.2 g of aluminum oxide and another with 105 mg of silica gel and 1.0 g of aluminum oxide.
  • These comparative generators were eluted with copper-free eluent contaminated with organic contaminants.
  • the results are summarized in Table 2.
  • the yield of Tc-99m is given in%, based on the Mo-99 activity, the molybdenum-99 content in ppm, based on the Tc-99m activity and the copper (II) content in ppm.
  • Table 3 shows the reduction of the Mo-99 content in the eluate even when using the design according to EP-B 0 014 957. Cu (II) could not be found in any eluate.

Landscapes

  • High Energy & Nuclear Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
EP86111788A 1985-09-03 1986-08-26 Technetium-99m-Generator, seine Herstellung und Verwendung Expired - Lifetime EP0213589B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT86111788T ATE63013T1 (de) 1985-09-03 1986-08-26 Technetium-99m-generator, seine herstellung und verwendung.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853531355 DE3531355A1 (de) 1985-09-03 1985-09-03 Technetium-99m-generator, seine herstellung und verwendung
DE3531355 1985-09-03

Publications (3)

Publication Number Publication Date
EP0213589A2 EP0213589A2 (de) 1987-03-11
EP0213589A3 EP0213589A3 (en) 1988-03-16
EP0213589B1 true EP0213589B1 (de) 1991-04-24

Family

ID=6279972

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86111788A Expired - Lifetime EP0213589B1 (de) 1985-09-03 1986-08-26 Technetium-99m-Generator, seine Herstellung und Verwendung

Country Status (14)

Country Link
US (1) US4837110A (enrdf_load_stackoverflow)
EP (1) EP0213589B1 (enrdf_load_stackoverflow)
JP (1) JPS6271900A (enrdf_load_stackoverflow)
AT (1) ATE63013T1 (enrdf_load_stackoverflow)
BE (1) BE905368A (enrdf_load_stackoverflow)
CA (1) CA1276448C (enrdf_load_stackoverflow)
DE (2) DE3531355A1 (enrdf_load_stackoverflow)
DK (1) DK417786A (enrdf_load_stackoverflow)
ES (1) ES2003343A6 (enrdf_load_stackoverflow)
GR (1) GR862237B (enrdf_load_stackoverflow)
IE (1) IE59192B1 (enrdf_load_stackoverflow)
PT (1) PT83290B (enrdf_load_stackoverflow)
SU (1) SU1471959A3 (enrdf_load_stackoverflow)
ZA (1) ZA866644B (enrdf_load_stackoverflow)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110474A (en) * 1990-04-09 1992-05-05 Arch Development Corporation Method for liquid chromatographic extraction of strontium from acid solutions
RU2153357C1 (ru) * 1999-02-09 2000-07-27 Государственный научный центр РФ - Физико-энергетический институт им. акад.А.И.Лейпунского Генератор для получения стерильного радиопрепарата технеция-99m и способ его приготовления
EP1347406B1 (en) 2000-11-27 2006-09-27 Nidec Sankyo Corporation Card reader having an illuminated card insertion slot
RU2223563C2 (ru) * 2002-04-22 2004-02-10 Федеральное государственное унитарное предприятие Государственный научный центр РФ Научно-исследовательский институт атомных реакторов Способ изготовления объемных радионуклидных источников с рабочей торцевой поверхностью
US7737415B2 (en) * 2004-01-27 2010-06-15 Laboratorios Bacon, S.A. System for the control, verification and recording of the performance of a radioisotope generator's operations
US20060023829A1 (en) * 2004-08-02 2006-02-02 Battelle Memorial Institute Medical radioisotopes and methods for producing the same
US20080187489A1 (en) * 2004-10-12 2008-08-07 Mcmaster University Generator and Method for Production of Technetium-99m
WO2008083313A2 (en) * 2007-01-01 2008-07-10 Medrad, Inc. Methods and systems for integrated radiopharmaceutical generation, preparation, transportation, and administration
RU2443030C2 (ru) * 2010-02-03 2012-02-20 Федеральное государственное унитарное предприятие "Ордена Трудового Красного Знамени научно-исследовательский физико-химический институт им. Л.Я. Карпова" (ФГУП "НИФХИ им. Л.Я. Карпова") ГЕНЕРАТОР ТЕХНЕЦИЯ-99m С СУЛЬФО-КАРБОКСИЛИРОВАННЫМ КАТИОНООБМЕННЫМ ЗАЩИТНЫМ СЛОЕМ И СПОСОБ ЕГО ПОЛУЧЕНИЯ
BR112012031359A2 (pt) 2010-06-04 2016-10-25 Medrad Inc sistema e método de planejamento e monitoramento da utilização de doses múltiplas de radiofármacos em injetores de radiofármacos
US11291973B2 (en) * 2017-07-12 2022-04-05 Arlanxeo Deutschland Gmbh Reactor and method for continuous polymerization

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3369121A (en) * 1966-04-06 1968-02-13 Squibb & Sons Inc Radioactive package and container therefor
NL6607699A (enrdf_load_stackoverflow) * 1966-06-03 1967-12-04
US3664964A (en) * 1968-07-03 1972-05-23 Squibb & Sons Inc Eluent for radioisotopes
CA955035A (en) * 1970-02-05 1974-09-24 Osaka Soda Co. Treatment process for removal of metals and treating agent therefor
US3755161A (en) * 1970-02-05 1973-08-28 Osaka Soda Co Ltd Treatment process for removal of metals and treating agent therefor
US3740558A (en) * 1971-02-17 1973-06-19 Dainabot Radioisotope Labor Lt Radioactive isotope generator of short-lived nuclides
NL7503293A (nl) * 1975-03-19 1976-09-21 Leuven Res & Dev Vzw Werkwijze voor het verwijderen van metalen uit oplossing.
US4167481A (en) * 1975-03-19 1979-09-11 Leuven Research & Development Vzw Process for the removal of metals from solution
US4158700A (en) * 1976-03-08 1979-06-19 Karageozian Hampar L Method of producing radioactive technetium-99M
DE2906439A1 (de) * 1979-02-20 1980-09-04 Hoechst Ag Verfahren zur trennung von technetium-99m von molybaen-99
CA1169773A (en) * 1979-04-17 1984-06-26 Karel J. Panek Preparation and use of a su195m xxau-containing liquid
DE8533473U1 (de) * 1985-11-28 1986-02-06 Hoechst Ag, 6230 Frankfurt Technetium-99m-Generator

Also Published As

Publication number Publication date
EP0213589A3 (en) 1988-03-16
DE3531355A1 (de) 1987-03-12
PT83290B (pt) 1993-04-30
ZA866644B (en) 1987-04-29
ATE63013T1 (de) 1991-05-15
DK417786A (da) 1987-03-04
GR862237B (en) 1986-12-31
PT83290A (pt) 1986-10-01
DK417786D0 (da) 1986-09-02
BE905368A (fr) 1987-03-02
JPS6271900A (ja) 1987-04-02
DE3678880D1 (de) 1991-05-29
CA1276448C (en) 1990-11-20
US4837110A (en) 1989-06-06
EP0213589A2 (de) 1987-03-11
DE3531355C2 (enrdf_load_stackoverflow) 1992-06-11
IE862345L (en) 1987-03-03
ES2003343A6 (es) 1988-11-01
SU1471959A3 (ru) 1989-04-07
IE59192B1 (en) 1994-01-26

Similar Documents

Publication Publication Date Title
DE69031918T2 (de) Lösliche bestrahlungstargets zur herstellung von radioruthenium
DE60209818T2 (de) Verfahren und vorrichtung zur trennung der ionen von metallischen elementen in wässriger lösung
EP0213589B1 (de) Technetium-99m-Generator, seine Herstellung und Verwendung
EP0443479A1 (de) Verfahren zur Erzeugung von Aktinium-225 und Wismut-213
WO1999046779A1 (de) Adsorptionsmittel für radionuklide
DE102009049108B4 (de) Verfahren und Vorrichtung zur Gewinnung eines Radionuklids
DE2542415A1 (de) Hoch 82 sr- hoch 82 rb-radioisotop- generator
DE69017222T2 (de) Verbessertes radionukliderzeugungssystem und verfahren zu seiner herstellung und seinem gebrauch.
DE2140998C3 (de) Verfahren zur Gewinnung von Molybdän
DE3100365C2 (enrdf_load_stackoverflow)
DE2722316C2 (enrdf_load_stackoverflow)
DE102008064682B4 (de) Anionisches Boranpolymer, sowie dessen Verwendung und Herstellung
DE1210416B (de) Verfahren zur Trennung von Metallionen
DE8533473U1 (de) Technetium-99m-Generator
DE112021003173T5 (de) Chitosan/titan-verbundstoff und herstellungsverfahren und verwendung davon
DE2909648A1 (de) Verfahren zur herstellung von radioaktivem technetium-99m
EP0014957B1 (de) Verfahren zur Trennung von Technetium-99m von Molybdän-99
DE2511712C3 (de) Herstellung eines Technetium-99m-Generators
DE2213137A1 (de) Verfahren zum Wiederbeladen eines Technetium-99m-Generators
DE2030102A1 (enrdf_load_stackoverflow)
DE2030102C3 (de) Verfahren zur Gewinnung von Technet!um-99m aus einer wässrigen Lösung eines anorganischen Salzes von Molybdän-99
DE2338366C3 (de) Verfahren zur Herstellung eines Technetium-99m-Generators
DE2009492C3 (de) Verfahren zur Abtrennung von Pyrogenen aus Präparaten von L-Asparaginase
DE2511712B2 (de) Herstellung eines technetium-99m- generators
DE2806849A1 (de) Verfahren zum der reihe nach erfolgenden beladen, eluieren und wiederbeladen eines technetium-99m-generators

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT CH DE FR GB IT LI LU NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT CH DE FR GB IT LI LU NL SE

17P Request for examination filed

Effective date: 19880823

17Q First examination report despatched

Effective date: 19900926

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT CH DE FR GB IT LI LU NL SE

REF Corresponds to:

Ref document number: 63013

Country of ref document: AT

Date of ref document: 19910515

Kind code of ref document: T

ITF It: translation for a ep patent filed
REF Corresponds to:

Ref document number: 3678880

Country of ref document: DE

Date of ref document: 19910529

ET Fr: translation filed
GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
EPTA Lu: last paid annual fee
EAL Se: european patent in force in sweden

Ref document number: 86111788.5

REG Reference to a national code

Ref country code: CH

Ref legal event code: PUE

Owner name: HOECHST AKTIENGESELLSCHAFT TRANSFER- CIS BIO INTER

Ref country code: CH

Ref legal event code: NV

Representative=s name: SCHAAD, BALASS & PARTNER AG

NLS Nl: assignments of ep-patents

Owner name: CIS BIO INTERNATIONAL

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 19960731

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 19960801

Year of fee payment: 11

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19970826

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19970827

EUG Se: european patent has lapsed

Ref document number: 86111788.5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19980831

Year of fee payment: 13

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20000301

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee

Effective date: 20000301

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20020704

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20020708

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20020712

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20020724

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20020726

Year of fee payment: 17

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030826

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030826

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030831

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030831

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040302

GBPC Gb: european patent ceased through non-payment of renewal fee
REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040430

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050826