EP0022873A1 - Verfahren zur herstellung eines verpackungsbehälters mit einer klebstoffschicht aus leichtlöslichem puder - Google Patents

Verfahren zur herstellung eines verpackungsbehälters mit einer klebstoffschicht aus leichtlöslichem puder Download PDF

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Publication number
EP0022873A1
EP0022873A1 EP80900062A EP80900062A EP0022873A1 EP 0022873 A1 EP0022873 A1 EP 0022873A1 EP 80900062 A EP80900062 A EP 80900062A EP 80900062 A EP80900062 A EP 80900062A EP 0022873 A1 EP0022873 A1 EP 0022873A1
Authority
EP
European Patent Office
Prior art keywords
powders
granules
container
containers
adhesive layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP80900062A
Other languages
English (en)
French (fr)
Other versions
EP0022873B1 (de
EP0022873A4 (de
Inventor
Michio Kakumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP15468678A external-priority patent/JPS5589001A/ja
Priority claimed from JP53163690A external-priority patent/JPS5852835B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of EP0022873A1 publication Critical patent/EP0022873A1/de
Publication of EP0022873A4 publication Critical patent/EP0022873A4/de
Application granted granted Critical
Publication of EP0022873B1 publication Critical patent/EP0022873B1/de
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/04—Methods of, or means for, filling the material into the containers or receptacles

Definitions

  • the present invention relates to a method of manufacturing a container, on the inner surface of which adheres a layer of easily soluble powders or granules.
  • the Applicant has proposed a package of medicinal preparations comprising a flat container, in the form of a bag, which can be used as a cup after being opened and on the inner surface of which adhere powders or granules of medicaments, intended for use in as a solution in water, such as gargles (for example, Japanese Utility Model Request, published before review # 49-37274).
  • the type of containers or packages for preparations of medicaments, described above, particularly developed to be transported by a person, is flat, has the form of a bag and comprises powders or granules of medicaments which adhere to its inner surface, it has advantages in various respects: these containers are neither bulky nor unbalanced; they can easily be transported, for example in a garment pocket, in travel bags, etc ...; they can be used by pouring water directly on them to quickly prepare a uniform solution of drugs with the prescribed concentration and can be used anytime and anywhere, provided that water is available.
  • the main object of the present invention is to manufacture, in a commercially advantageous manner, such containers or packaging for the preparation of medicaments and similar articles.
  • the manufacturing method according to the present invention is characterized by the displacement and distribution of a given quantity of readily soluble powders or granules, in a waterproof container, comprising an adhesive layer on given portions of the surface. interior of said container so as to disperse powders or granules on the entire adhesive layer to obtain uniform adhesion.
  • containers are used, one end of which is open.
  • the containers must be watertight and in general, we choose waterproof paper containers lined or not with aluminum foil, or plastic. It is advantageous that these containers are heat sealable to obtain better efficiency during the closing of their opening orifice.
  • the shape and structure of the container is not limited, but a flat bag-like container is preferred for convenience of transportation.
  • a flat bag-like container is preferred for convenience of transportation.
  • the container may be of the bag-like type having folds folded over the side parts and the bottom, which can deploy and form a cup when these folds are opened when required.
  • An adhesive layer is formed over the required area of the interior surface of the container, generally over the entire surface, except the opening area.
  • the formation of the adhesive layer on the inner surface of the container can be achieved by applying an adhesive to a given part of a sheet or film during the manufacture of the container, or by applying an adhesive to the required part of the inner surface of the manufactured container.
  • the adhesives are chosen appropriately as a function of the materials of the containers, of the nature of the powders or of the granules, which will be described below, etc.
  • adhesives include, for example, liquid paraffin, molten resins called "hot melt” and the like.
  • the powders can be applied to the adhesive layer during the process of manufacturing the container, for example, after the sheet intended to be formed into the container has been coated with adhesive, or the powders can be introduced into the container by its upper opening after formation of the container.
  • a technique of displacement and dispersion of the powders or granules is used inside. of the container.
  • Preferred examples of displacement and dispersion techniques are as follows: a method comprising injecting a gas such as air into the container, causing the gas to rotate and circulate inside the container and guiding the powders dispersed towards the wall of the container by the gas stream; and a method which communicates vibration or rotation to the container by applying suitable mechanical means. When the container is rotated, it is necessary to rotate it so that the powders move inside the container by gravity.
  • This rotation can be achieved, for example, by repeatedly rotating the container upside down, or by rotating the container while holding it in an almost horizontal plane. You can rotate the container while inverting it upside down if necessary.
  • These means for moving and dispersing powders can be used alone or in combination with one another. By For example, it is possible to vibrate or rotate the container while injecting air inside. These displacement and dispersing means can be applied during or after the introduction of the powders inside the container.
  • the powders or granules introduced into containers using the means described above for displacement and dispersion are dispersed and adhere uniformly to the entire adhesive layer which is on the interior surfaces of the containers, which allows to obtain containers on the inner surface of which adheres a layer of powders or granules.
  • the containers obtained, the opening of which is gaping, are then closed by application of heat or another suitable means. Before these openings are closed, the containers can be freed of the air they contain.
  • the manufacturing method according to the present invention thanks to the combination of the steps described above, can ensure a large series production, continuously and efficiently, of containers on the inner surface of which adheres a layer of powders or granules and the products are obtained at reduced cost prices.
  • the method according to the present invention is therefore very advantageous from the commercial point of view.
  • the above method of moving and dispersing powders in containers allows uniform dispersion and adhesion of the powders on the adhesive coated surface, not only when the powders have a relatively uniform particle size, but also when they have a wide variety of dimensions, for example in the case of multi-component systems, or when the surfaces coated with adhesive are irregular or have complex curvatures.
  • the powders contain a fragile granular component, which, if broken, can react with another component and become humid, an adhesion can be obtained. uniform rence of such powders on the inner surface of the container, without it can occur-such risks.
  • products as described above and of a very high quality can advantageously be produced on an industrial scale.
  • a waterproof container (1) is produced, in the form of a flat bag, having an opening (1a).
  • An adhesive layer (2) is formed on the inner surface of the container (1) over a desired area, for example over the area which extends about 70 to 80% of the height of the container.
  • a sheet (7) is prepared with a front portion (1A) and a rear portion (1B) interconnected by a fold (a); in the second step, an adhesive layer (3) is formed on the upper surface of said sheet (7), on its inner face and in the last step, the front part (1A) is folded over the rear part (1B) on along the fold (a) and the edges (7a) are joined by application of heat or other suitable means. While joining or assembling the edges (7a), the front (1A) and rear (1B) parts may stick together via the adhesive layers (2) and (2) deposited on their surface. interior and steps must be taken to prevent such membership.
  • These measures can for example: consist in forming a space between the adhesive layers (2) and (2) by bending outwards both the front (1A) and rear (1B) parts, before folding the front face ( 1A) on the rear part (1B), as indicated by the broken lines in the drawing of the second step in FIG. 5; consist in establishing a space between the adhesive layers (2) and (2) by placing a required quantity of powders or granules (3) on the adhesive layer (2), of the rear part (1B) before folding the part before (1A) on the rear part (1B).
  • a required quantity of powders or granules (3) is introduced into the container (1) whose inner surface carries an adhesive layer (2) as obtained in the first step.
  • the introduction of powders or granules (3) is omitted in the case where these powders or granules were introduced beforehand into the container (1) during its preparation.
  • Figures 2 and 3 respectively show the means to be applied to the flat container (1) in the form of a bag, to establish a space between the front part (1A) and the rear part (1B).
  • arrows (8) (8) indicate the directions of the compressive force which must be applied to the two ends of the front and rear parts (1A) and (1B) in order to curl them or deploy them towards the outside
  • the arrows (9) (9) indicate the directions of the application of the vacuum which must be exerted on the two parts (1A) and (1B) for the same purpose.
  • the reference (4) indicates a spacer inserted in the opening of the container (1) and arrows (10) (10) indicate the directions of application of the vacuum.
  • a gas such as air
  • the gas rotates and circulates inside the container (1) and causes the uniform adhesion of the powders or granules (3) to the entire layer coated with adhesive (3) deposited on the interior surface of the container (1 ).
  • the introduction of the gas can be carried out during the introduction of the powders.
  • Air is generally used as the gas to be introduced in the third step.
  • inert gases such as nitrogen, etc. are used.
  • the air contained in the container (1) is replaced by an inert gas before the introduction of the powders, during the second step.
  • a filter (6) can be arranged on the opening of the container (1).
  • a filter (6) can be, for example, constituted by metal cans, sintered porous metals and open cell synthetic resin foams; this filter can be of the type which includes a filtration unit placed on the opening of the container (1) as shown in the drawing of the third step of FIG. 1, or of a type consisting of a filtration unit inserted in the packaging container (1), as shown in FIG. 4.
  • the nozzle (5) may have a number of injection orifices arranged on the periphery of the bottom, in addition to a lower opening and may also be provided a device at its lower end, so as to ensure a greater gas distribution area.
  • the gas distribution device can be a hollow pipe pierced with numerous openings or a hollow plate having many openings.
  • the opening (1a) of the container (1) is closed hermetically during a fourth step, by application of heat or other suitable means to obtain the finished article.
  • FIG. 7 Another embodiment of the manufacturing method according to the present invention, as illustrated in Figure 7, differs from the example described above, in that a means of vibration or rotation is adopted instead of the introduction of gas, in the third step
  • the reference ( 55 ) designates a support means -designed to pinch the opening of the container (1).
  • the product manufactured according to the method which is the subject of the present invention contains a medicament intended for oral administration, in the form of powders or granules
  • the desired medicament solution can be easily prepared by opening the container to pour water into.
  • the juice can quickly be prepared as described above, by pouring water into the container.
  • measurement lines can be drawn on the inner surface of the container to indicate the amount of water to be poured into it.
  • a manufacturing method in accordance with the present invention is described below, with reference to the first manufacturing apparatus provided with a rotation mechanism for containers, as shown in FIGS. 8 to 13.
  • a fold is formed using a device (13) for pleating through the center of a piece of paper which is placed on a first conveyor belt (12), coming from a feed device of paper (11) and the paper moves from the conveyor belt (12) to a second conveyor belt (14) connected to the first.
  • An adhesive is applied by an adhesive coating device (15) to the required part of the surface of the paper, during the transport thereof by the strip (14).
  • a given quantity of powders is placed using a powder distributor on one of the halves of the adhesive coated surface of the paper, separated by the central fold; then the piece of paper passes from the second conveyor belt (16) to a third conveyor belt (17) to which it is connected.
  • bag The piece of paper put in the form of a bag by assembling the sides (hereinafter referred to simply as "bag") passes from the third conveyor belt (17) to a turntable (20) and undergoes the various treatments during its passage through each stations (21) to (24) arranged on the periphery of the plate (20).
  • the station (21) is provided with a device (not shown) which is designed to increase the distance between the front and rear position of the bag, by applying vacuum or other suitable means so as to create a space in the bag .
  • An apparatus for temporarily closing the open end of the bag inside which a space has been formed is mounted in the station (22), so that the powders or granules cannot come out but that the air can pass.
  • the station (24) is equipped with a device (not shown), to form one or more notches which will facilitate the opening of the bag.
  • the bag having undergone the required treatments on the turntable (20), is carried by a conveyor device (25) provided with guide fingers (see FIG. 12), from the plate (20) to an inversion cylinder (26 ) so as to be turned upside down.
  • a conveyor device (25) provided with guide fingers (see FIG. 12), from the plate (20) to an inversion cylinder (26 ) so as to be turned upside down.
  • the bag After having undergone this overturning treatment, the bag is transported from the cylinder (26) to a rotating device (28) via a second conveyor device provided with fingers (27).
  • Figure 12 shows the details of the rotating device (28); the reference (28a) designates a reversing drum and the reference (28b) designates spiral rotation devices mounted on the reversing cylinder (28a) in four positions at regular intervals of 90 °. If the spiral rotation device (28b) can realize the spiral rotation of the bags, its structure is not particularly limited.
  • the bag having been subjected to the rotation treatment which it undergoes the rotating device (28), during its transport by a conveyor device (29), passes through a deaeration device (30), an apparatus (31) for closing the opening of the bag, a device for cutting off the superfluous end of the part of the closed opening (32) and other suitable treatment devices (not shown) for undergoing the corresponding treatments.
  • the finished product is thus obtained.
  • the way in which adhesive .. (49) is applied is illustrated. in detail in Figure 15.
  • the reference (70) designates a photoelectric tube placed between the guide cylinders (46) and (47). The photoelectric tube (70) monitors movements in the longitudinal and transverse directions relative to the normal position of the film (41) and sends signals to a position adjustment mechanism (not shown).
  • the reference (50) designates a support device disposed below the adhesive applicator (48).
  • This support device (50) comprises, for example, a conveyor which moves at the same speed as the film (41).
  • the reference (40a) designates a packaging film reserve roll which can be used after consumption of the packaging film roll (40).
  • This film folding device (52) comprises a pair of left and right side plates (52a) and (52a), the spacing of which is reduced from the inlet to the outlet, thereby imparting a tendency to fold in V-shape at the cross section of the film (41) and a film holder (52b), which is mounted between these side plates (52a) and (52a) to maintain the center line of the film (41) in the required position.
  • the film (41), during its passage through the folding device (52), is guided by the side plates (52a) and (52a) of the device (52) so as to be folded along its central line along a V shape in cross section.
  • the heat-sealing device (53) consists of a pair of inner and outer side bars (53a) and (53b) of sealing: the inner sealing bar (53a) is always kept in an upright, vertical position, while that the outer sealing bar (53b) pivots around a support point situated at the lowest end between the horizontal positions and ,. vertical.
  • the outer sealing bar (53b) is constructed to operate as follows: when it is sent to the portion to be sealed (41a), it rests horizontally so as not to hinder the passage of the film (41); it is lifted in a vertical position during movement on the orbit (55) by, for example, a distance of about 10 degrees from its point of approach to the film. When it is lifted, the outer sealing bar (53b) retains between itself and the inner sealing bar (53a), the portion of the film (41) to be sealed (41a) so as to achieve this sealing.
  • the nozzle (54) for supplying powders and granules and for injecting air comprises a double pipe, an external portion of pipe (54a) with an open upper end. designed for feeding powders or granules and an inner portion of pipe (54b) with a side opening for air injection.
  • a cylindrical guide (54d) is fixed by an arm (54a) to the outer surface d 'a central part of the nozzle (54), a space (54a) being provided between them; the open lower end of the guide (54d) is closed by a wire mesh filter (54f) provided with meshes allowing deaeration but preventing the exit of powders or granules.
  • the cylindrical guide (54d) indicated in addition in dotted lines in FIG.
  • the reference (54g) designates a flange filter, which advances relative to the external surface of the cylindrical guide (54d).
  • the filter consists of two layers, an upper sintered metal filter and a flexible lower filter.
  • the cylindrical guide (54d) serves to guide the nozzle (54) in the bag-forming part (41b) and also to create a space in the bag-forming part (41b), for the ventilation of the powders or granules.
  • the film or sheet having been formed to adopt a V-shaped configuration moves on the circular orbine (55) while being accompanied by the heat-sealing apparatus (53) sent to the portion (41a) to be sealed, while the nozzle (54) is introduced into the bag-making part (41b); the portion (41a) is heat sealed by the heat seal apparatus (53) between two positions (56) and (57) on the orbit (55) and the part forming a bag (41b) receives a given quantity powders from a hopper (60), fitted with a dosing and feeding unit (59) (see Figure 14), at position (58) on the orbit (55). The powder introduced is ventilated between positions (61) and (62), on the orbit (55).
  • the reference (63) designates an air supply device and a distribution pipe (63a) of the device (63) is disposed on the orbit (55) between the positions (61) and (62
  • the distribution pipe (63a) comprises an air injection portion (63a ') over the entire length of its side which faces the orbit (55) and a receiving portion (54b'), which advances laterally ( Figure 16) from the inner tube (54b) of the nozzle (54) ; moves in contact with the air injection portion (63a ') to be supplied with air.
  • the receiving portions (54b ') of the successive nozzles (54) can be joined along the circular orbit, with or without the aid of elements covering the air injection portion (63a') and be interposed between the receiving portions so as to prevent any loss of air out of the air injection portion (63a ') of the distributor pipe (63a).
  • the air can be heated before being sent to the bag-forming part (41b).
  • the air flow introduced into the bag-forming part (41b) is indicated by arrows. Under the effect of the rotating and circulating air currents, powders or granules are distributed and glued uniformly over the entire surface of the adhesive (49) applied to the interior surface of the bag-forming part (41b). During the introduction of air, the open upper end of the portion of the outer pipe (54a) is closed by suitable means.
  • the part forming a bag (41b), still held by the support means. (67) passes through a cutting device (68) comprising a blade (68a) and a part complementary to the latter (68b), so that it is cut at the level of the sealed part (41a) to obtain the desired products.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Bag Frames (AREA)
  • Cartons (AREA)
  • Making Paper Articles (AREA)
  • Packages (AREA)
EP19800900062 1978-12-14 1980-07-01 Verfahren zur herstellung eines verpackungsbehälters mit einer klebstoffschicht aus leichtlöslichem puder Expired EP0022873B1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP15468678A JPS5589001A (en) 1978-12-14 1978-12-14 Method of making container which has powder bonding layer on inside surface
JP154686/78 1978-12-14
JP163690/78 1978-12-22
JP53163690A JPS5852835B2 (ja) 1978-12-22 1978-12-22 内面に粉粒体の接着層を有する容器の製造法

Publications (3)

Publication Number Publication Date
EP0022873A1 true EP0022873A1 (de) 1981-01-28
EP0022873A4 EP0022873A4 (de) 1981-07-16
EP0022873B1 EP0022873B1 (de) 1984-10-24

Family

ID=26482903

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19800900062 Expired EP0022873B1 (de) 1978-12-14 1980-07-01 Verfahren zur herstellung eines verpackungsbehälters mit einer klebstoffschicht aus leichtlöslichem puder

Country Status (4)

Country Link
EP (1) EP0022873B1 (de)
DE (1) DE2953433C1 (de)
GB (1) GB2057306B (de)
WO (1) WO1980001270A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626435A (en) * 1985-11-18 1986-12-02 Zimmerman Mark E Individual coffee brewing
US5316779A (en) * 1991-09-16 1994-05-31 Morey Booker W Foam-limiting drinking cup and method
US5222940A (en) * 1992-01-03 1993-06-29 Wilk Peter J Device for facilitating administration of medicine
US20010038871A1 (en) * 1999-05-11 2001-11-08 Sally Nardi Selectable agent delivery system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE398624A (de) *
US2967609A (en) * 1957-10-28 1961-01-10 Goldene Shaw Combined paper cup and package

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1152866A (en) * 1966-06-07 1969-05-21 Monsanto Chemicals Refractory Production
US3472201A (en) * 1967-05-25 1969-10-14 Nat Distillers Chem Corp Centrifugal coating apparatus for coating interior surfaces of bodies
US4024694A (en) * 1976-06-18 1977-05-24 Marvin Cooper Apparatus for filling and assembling cups and process therefore

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE398624A (de) *
US2967609A (en) * 1957-10-28 1961-01-10 Goldene Shaw Combined paper cup and package

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8001270A1 *

Also Published As

Publication number Publication date
DE2953433A1 (en) 1980-12-18
GB2057306B (en) 1983-02-09
WO1980001270A1 (en) 1980-06-26
GB2057306A (en) 1981-04-01
DE2953433C1 (de) 1984-05-30
EP0022873B1 (de) 1984-10-24
EP0022873A4 (de) 1981-07-16

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