EP0006853A1 - Forme d'implant medicamenteux et procede de preparation - Google Patents

Forme d'implant medicamenteux et procede de preparation

Info

Publication number
EP0006853A1
EP0006853A1 EP19780900009 EP78900009A EP0006853A1 EP 0006853 A1 EP0006853 A1 EP 0006853A1 EP 19780900009 EP19780900009 EP 19780900009 EP 78900009 A EP78900009 A EP 78900009A EP 0006853 A1 EP0006853 A1 EP 0006853A1
Authority
EP
European Patent Office
Prior art keywords
acid
polycondensate
drug
matrix
depot
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19780900009
Other languages
German (de)
English (en)
Inventor
Heinrich Jakob Bisson
Peter Paul Speiser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Garching Instrumente Gesellschaft Zur Industriellen Nutzung Von Forschungsergebnissen Mbh
Garching Instrumente
Original Assignee
Garching Instrumente Gesellschaft Zur Industriellen Nutzung Von Forschungsergebnissen Mbh
Garching Instrumente
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Garching Instrumente Gesellschaft Zur Industriellen Nutzung Von Forschungsergebnissen Mbh, Garching Instrumente filed Critical Garching Instrumente Gesellschaft Zur Industriellen Nutzung Von Forschungsergebnissen Mbh
Publication of EP0006853A1 publication Critical patent/EP0006853A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/2045—Polyamides; Polyaminoacids, e.g. polylysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

Forme d'implant medicamenteux pour administration par voie orale et/ou parenterale comportant un ou plusieurs medicaments inclus dans une matrice de polymere. Dans des conditions physiologiques la substance s'hydrolyse lentement en elements non toxiques, physiologiquement eliminables et, ce faisant, libere le ou les medicaments. Elle est le produit de la polycondensation d'un acide dicarboxylique, d'un acide hydroxy monocarboxylique et/ou d'un acide amine bien tolere, ou constituee de plusieurs de ces acides et, si necessaire, d'un ou plusieurs des polyols propanediol-1, 2, inosite, pyridoxal, D-penthenol, pentaerythrite, adonite. Preparation de l'implant medicamenteux consistant a disperser le polycondensat encore soluble dans l'eau avec le medicament par agitation dans un milieu de dispersion legerement polaire, et a poursuivre la condensation du polycondensat jusqu'a l'obtention d'une insolubilite totale dans l'eau.
EP19780900009 1977-06-07 1978-12-28 Forme d'implant medicamenteux et procede de preparation Withdrawn EP0006853A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH708277 1977-06-07
CH7082/77 1977-06-07

Publications (1)

Publication Number Publication Date
EP0006853A1 true EP0006853A1 (fr) 1980-01-23

Family

ID=4319655

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19780900009 Withdrawn EP0006853A1 (fr) 1977-06-07 1978-12-28 Forme d'implant medicamenteux et procede de preparation

Country Status (3)

Country Link
EP (1) EP0006853A1 (fr)
DE (1) DE2856901D2 (fr)
WO (1) WO1978000011A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3360633D1 (en) * 1982-02-12 1985-10-03 Unitika Ltd Anti-cancer device
AT382076B (de) * 1982-10-15 1987-01-12 Chemie Linz Ag Verfahren zur herstellung von presslingen mit retardierter wirkstofffreisetzung
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
DE3707369A1 (de) * 1987-03-07 1988-09-15 Hoechst Ag Biologisch abbaubare polymere fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
ATE97929T1 (de) * 1986-05-15 1993-12-15 Hoechst Ag Biologisch abbaubare polymere fuer depotzubereitungen mit kontrollierter wirkstoffabgabe.
US5187150A (en) * 1987-10-14 1993-02-16 Debiopharm S.A. Polyester-based composition for the controlled release of polypeptide medicinal substances
CH672887A5 (fr) * 1987-10-14 1990-01-15 Debiopharm Sa
DE59003337D1 (de) * 1989-10-16 1993-12-09 Danubia Petrochem Polymere Pressling mit retardierter Wirkstofffreisetzung.
CA2050067C (fr) * 1990-08-30 2000-05-30 Yasushi Morita Composition medicamenteuse a liberation prolongee
FR2678168B1 (fr) * 1991-06-28 1993-09-03 Rhone Poulenc Rorer Sa Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge.
AU2572692A (en) 1991-09-09 1993-04-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods and devices for treating hemophilia and aids
US5444143A (en) * 1992-12-25 1995-08-22 Mitsui Toatsu Chemicals, Inc. Preparation process of polyhydroxycarboxylic acid
US5543202A (en) * 1994-03-14 1996-08-06 Kimberly-Clark Corporation Process for producing a crimp-bonded fibrous cellulosic laminate
DE10111767B4 (de) * 2001-03-12 2005-03-24 Schwarz Pharma Ag Verfahren zur Herstellung von Polyestern aus Hydroxycarbonsäuren und Polyolen durch Polykondensation
WO2004096178A1 (fr) * 2003-05-02 2004-11-11 The University Of Nottingham Systemes de relargage de medicaments nanoparticulaires et microparticulaires a base de polyesters contenant des residus dicarboxylate aliphatique et des residus polyols aliphatiques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297033A (en) * 1963-10-31 1967-01-10 American Cyanamid Co Surgical sutures
US3880991A (en) * 1969-03-24 1975-04-29 Brook David E Polymeric article for dispensing drugs
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
CA1045977A (fr) * 1973-05-17 1979-01-09 Arthur D. Little Implant biodegradable pour la dispensation de medicaments et procede de preparation et d'utilisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO7800011A1 *

Also Published As

Publication number Publication date
WO1978000011A1 (fr) 1978-12-21
DE2856901D2 (de) 1980-11-13

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): CH FR GB

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19810320

17P Request for examination filed

Effective date: 19790615

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SPEISER, PETER PAUL

Inventor name: BISSON, HEINRICH JAKOB