EE200200364A - Asendatud piperasiinderivaadid kui MTP inhibiitorid, nende valmistamine ja nende kasutamine ravimina - Google Patents
Asendatud piperasiinderivaadid kui MTP inhibiitorid, nende valmistamine ja nende kasutamine raviminaInfo
- Publication number
- EE200200364A EE200200364A EEP200200364A EEP200200364A EE200200364A EE 200200364 A EE200200364 A EE 200200364A EE P200200364 A EEP200200364 A EE P200200364A EE P200200364 A EEP200200364 A EE P200200364A EE 200200364 A EE200200364 A EE 200200364A
- Authority
- EE
- Estonia
- Prior art keywords
- medicaments
- preparation
- piperazine derivatives
- substituted piperazine
- mtp inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19963235A DE19963235A1 (de) | 1999-12-27 | 1999-12-27 | Substituierte Piperazinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
PCT/EP2000/012842 WO2001047899A1 (de) | 1999-12-27 | 2000-12-16 | Substituierte piperazinderivateals inhibitoren des mtp |
Publications (1)
Publication Number | Publication Date |
---|---|
EE200200364A true EE200200364A (et) | 2003-10-15 |
Family
ID=7934665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200200364A EE200200364A (et) | 1999-12-27 | 2000-12-16 | Asendatud piperasiinderivaadid kui MTP inhibiitorid, nende valmistamine ja nende kasutamine ravimina |
Country Status (26)
Country | Link |
---|---|
US (1) | US20030114442A1 (et) |
EP (1) | EP1259492A1 (et) |
JP (1) | JP2003519131A (et) |
KR (1) | KR20020065916A (et) |
CN (1) | CN1414956A (et) |
AR (1) | AR027112A1 (et) |
AU (1) | AU2366001A (et) |
BG (1) | BG106847A (et) |
BR (1) | BR0016780A (et) |
CA (1) | CA2394644A1 (et) |
CO (1) | CO5251384A1 (et) |
CZ (1) | CZ20022281A3 (et) |
DE (1) | DE19963235A1 (et) |
EA (1) | EA200200650A1 (et) |
EE (1) | EE200200364A (et) |
HU (1) | HUP0203855A3 (et) |
IL (1) | IL150357A0 (et) |
MX (1) | MXPA02006510A (et) |
NO (1) | NO20023001D0 (et) |
PL (1) | PL355394A1 (et) |
SK (1) | SK9272002A3 (et) |
TR (1) | TR200201669T2 (et) |
UY (1) | UY26501A1 (et) |
WO (1) | WO2001047899A1 (et) |
YU (1) | YU49902A (et) |
ZA (1) | ZA200205012B (et) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS50712B (sr) | 2001-06-28 | 2010-06-30 | Pfizer Products Inc. | Triamid-supstituisani indoli, benzofurani i benzotiofeni kao inhibitori mikrozomalnog triglicerid transfer proteina (mtp) i/ili sekrecije apolipoproteina b (apo b) |
DE10200633A1 (de) * | 2002-01-10 | 2003-07-24 | Boehringer Ingelheim Pharma | Kombination von MTP Inhibitoren oder apoB-Sekretions-Inhibitoren mit Fibraten zur Verwendung als Arzneimittel |
MXPA04002602A (es) * | 2002-02-28 | 2004-08-11 | Japan Tobacco Inc | Compuestos de ester y sus usos medicos. |
WO2005021486A1 (ja) * | 2003-08-29 | 2005-03-10 | Japan Tobacco Inc. | エステル誘導体及びその医薬用途 |
US20060030623A1 (en) * | 2004-07-16 | 2006-02-09 | Noboru Furukawa | Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis |
US8101774B2 (en) * | 2004-10-18 | 2012-01-24 | Japan Tobacco Inc. | Ester derivatives and medicinal use thereof |
BRPI0516772A (pt) * | 2004-10-25 | 2008-09-23 | Japan Tobacco Inc | formulação sólida com solubilidade e estabilidade melhoradas e método para produção da referida formulação |
ATE469122T1 (de) * | 2006-10-24 | 2010-06-15 | Janssen Pharmaceutica Nv | Mtp-inhibierende tetrahydronaphthalin-1- carbonsäurederivate |
JO2653B1 (en) | 2006-10-24 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Tetrahydroflavin 1-carboxylic acid substituted with pyridine or pyrazine inhibit MTB |
US8190707B2 (en) * | 2007-10-20 | 2012-05-29 | Citrix Systems, Inc. | System and method for transferring data among computing environments |
WO2009079797A1 (en) | 2007-12-26 | 2009-07-02 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
EP3023426A1 (en) | 2008-07-17 | 2016-05-25 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
CA2794952C (en) | 2010-04-01 | 2018-05-15 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
US5885983A (en) * | 1996-05-10 | 1999-03-23 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
WO1998027979A1 (en) * | 1996-12-20 | 1998-07-02 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of microsomal triglyceride transfer protein and method |
-
1999
- 1999-12-27 DE DE19963235A patent/DE19963235A1/de not_active Withdrawn
-
2000
- 2000-12-16 EA EA200200650A patent/EA200200650A1/ru unknown
- 2000-12-16 YU YU49902A patent/YU49902A/sh unknown
- 2000-12-16 TR TR2002/01669T patent/TR200201669T2/xx unknown
- 2000-12-16 IL IL15035700A patent/IL150357A0/xx unknown
- 2000-12-16 MX MXPA02006510A patent/MXPA02006510A/es unknown
- 2000-12-16 CA CA002394644A patent/CA2394644A1/en not_active Abandoned
- 2000-12-16 CZ CZ20022281A patent/CZ20022281A3/cs unknown
- 2000-12-16 AU AU23660/01A patent/AU2366001A/en not_active Abandoned
- 2000-12-16 EP EP00987409A patent/EP1259492A1/de not_active Withdrawn
- 2000-12-16 EE EEP200200364A patent/EE200200364A/et unknown
- 2000-12-16 BR BR0016780-0A patent/BR0016780A/pt active Pending
- 2000-12-16 JP JP2001549371A patent/JP2003519131A/ja active Pending
- 2000-12-16 US US10/168,926 patent/US20030114442A1/en not_active Abandoned
- 2000-12-16 HU HU0203855A patent/HUP0203855A3/hu unknown
- 2000-12-16 SK SK927-2002A patent/SK9272002A3/sk unknown
- 2000-12-16 PL PL00355394A patent/PL355394A1/xx not_active Application Discontinuation
- 2000-12-16 KR KR1020027008320A patent/KR20020065916A/ko not_active Application Discontinuation
- 2000-12-16 CN CN00817889A patent/CN1414956A/zh active Pending
- 2000-12-16 WO PCT/EP2000/012842 patent/WO2001047899A1/de not_active Application Discontinuation
- 2000-12-22 UY UY26501A patent/UY26501A1/es not_active Application Discontinuation
- 2000-12-26 CO CO00097654A patent/CO5251384A1/es not_active Application Discontinuation
- 2000-12-27 AR ARP000106940A patent/AR027112A1/es not_active Suspension/Interruption
-
2002
- 2002-06-20 BG BG106847A patent/BG106847A/xx active Pending
- 2002-06-21 ZA ZA200205012A patent/ZA200205012B/en unknown
- 2002-06-21 NO NO20023001A patent/NO20023001D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL150357A0 (en) | 2002-12-01 |
EA200200650A1 (ru) | 2002-12-26 |
CA2394644A1 (en) | 2001-07-05 |
TR200201669T2 (tr) | 2002-10-21 |
BR0016780A (pt) | 2002-08-27 |
NO20023001L (no) | 2002-06-21 |
WO2001047899A1 (de) | 2001-07-05 |
NO20023001D0 (no) | 2002-06-21 |
HUP0203855A2 (hu) | 2003-03-28 |
BG106847A (en) | 2003-02-28 |
CZ20022281A3 (cs) | 2002-10-16 |
US20030114442A1 (en) | 2003-06-19 |
DE19963235A1 (de) | 2001-07-05 |
CN1414956A (zh) | 2003-04-30 |
EP1259492A1 (de) | 2002-11-27 |
ZA200205012B (en) | 2003-01-16 |
MXPA02006510A (es) | 2002-11-29 |
HUP0203855A3 (en) | 2004-07-28 |
PL355394A1 (en) | 2004-04-19 |
UY26501A1 (es) | 2001-07-31 |
SK9272002A3 (en) | 2002-11-06 |
KR20020065916A (ko) | 2002-08-14 |
JP2003519131A (ja) | 2003-06-17 |
AR027112A1 (es) | 2003-03-12 |
YU49902A (sh) | 2005-03-15 |
CO5251384A1 (es) | 2003-02-28 |
AU2366001A (en) | 2001-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EE04527B1 (et) | Aromaatsed heterotsüklilised ühendid, nende kasutamine ja meetodid nende valmistamiseks | |
EE200100431A (et) | 16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine | |
EE04464B1 (et) | Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid | |
EE200200064A (et) | Arüülmetüülkarbonüülaminotiasooli derivaadid, nende valmistamine ja kasutamine vähivastaste toimeainetena | |
NO20015113L (no) | Nye forbindelser, deres fremstilling og anvendelse | |
NO20015362L (no) | Heterocyklisk substituerte benzimidazoler, deres fremstilling og anvendelse derav | |
NO20021689L (no) | 5-leddede heterocykliske derivater, fremstilling derav og anvendelse som medikamenter | |
EE05643B1 (et) | Ksantiini derivaadid, nende valmistamine ja kasutamine ravimina | |
EE200200251A (et) | Uued N-asabitsükloamiidi derivaadid ja nende kasutamine | |
EE200300048A (et) | Bensimidasooli derivaadid, nende valmistamine ja terapeutiline kasutamine | |
NO20024175D0 (no) | Azetidinderivater, deres fremstilling og farmasöytiske forbindelser inneholdende de samme | |
PT1307457E (pt) | Compostos heterociclicos sua preparacao e utilizacao como medicamentos noemadamente como antibacterianos | |
NO20022970L (no) | Hydrogel-drevet medikamentdoseringsform | |
NO20011216L (no) | Azetidinderivater, deres fremstilling og medikamenter inneholdende forbindelsene | |
EE04275B1 (et) | Kinoliini derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutilised kompositsioonid | |
EE200300207A (et) | Heterotsüklüülalküülpiperidiini derivaadid, nendevalmistamismeetodid ja farmatseutiline kompositsioon | |
EE200100470A (et) | Püridopüranoasepiini derivaadid, nende valmistamine ja terapeutiline kasutamine | |
EE200100391A (et) | Peptidüül-heterotsüklilised ketoonid, nende kasutamine ja farmatseutiline kompositsioon | |
EE04236B1 (et) | Bensimidasoolid, nende valmistamine ja kasutamineravimitena | |
EE200000037A (et) | Atsüülpiperasinüülpürimidiinide derivaadid, nende valmistamine ja kasutamine ravimitena | |
EE200300254A (et) | Heterotsüklilised ühendid, millel on antibakteriaalne toime, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid | |
EE200200364A (et) | Asendatud piperasiinderivaadid kui MTP inhibiitorid, nende valmistamine ja nende kasutamine ravimina | |
NO20023146L (no) | Substituerte fenyl-piperazinderivater, deres fremstilling og anvendelse | |
EE200200342A (et) | Asendatud 8-arüülkinoliinid, nende kasutamine, farmatseutiline kompositsioon ja prekursorühend | |
EE200100422A (et) | Epotilooni derivaadid, nende valmistamismeetod jafarmatseutiline kasutamine |