EE05591B1 - Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA - Google Patents

Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA

Info

Publication number
EE05591B1
EE05591B1 EEP200100530A EEP200100530A EE05591B1 EE 05591 B1 EE05591 B1 EE 05591B1 EE P200100530 A EEP200100530 A EE P200100530A EE P200100530 A EEP200100530 A EE P200100530A EE 05591 B1 EE05591 B1 EE 05591B1
Authority
EE
Estonia
Prior art keywords
toxin
biologically active
preparation
cdna encoding
mutated precursor
Prior art date
Application number
EEP200100530A
Other languages
English (en)
Estonian (et)
Inventor
Rubinstein Menachem
Liu Bianling
Novick Daniela
Graber Pierre
Original Assignee
Yeda Research And Development Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.
Publication of EE200100530A publication Critical patent/EE200100530A/xx
Publication of EE05591B1 publication Critical patent/EE05591B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
EEP200100530A 1999-04-13 2000-04-13 Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA EE05591B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules
PCT/IL2000/000220 WO2000061768A2 (fr) 1999-04-13 2000-04-13 Preparation de molecules bioactives

Publications (2)

Publication Number Publication Date
EE200100530A EE200100530A (et) 2002-12-16
EE05591B1 true EE05591B1 (et) 2012-10-15

Family

ID=11072700

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100530A EE05591B1 (et) 1999-04-13 2000-04-13 Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA

Country Status (24)

Country Link
US (1) US7098002B1 (fr)
EP (1) EP1169460B1 (fr)
JP (1) JP4822587B2 (fr)
KR (1) KR100682185B1 (fr)
CN (1) CN1324140C (fr)
AR (1) AR023468A1 (fr)
AT (1) ATE326536T1 (fr)
AU (1) AU781342B2 (fr)
BR (1) BR0009782A (fr)
CA (1) CA2368994C (fr)
DE (1) DE60028022T2 (fr)
DK (1) DK1169460T3 (fr)
EA (1) EA006825B1 (fr)
EE (1) EE05591B1 (fr)
ES (1) ES2259287T3 (fr)
HK (1) HK1044351A1 (fr)
IL (3) IL129427A0 (fr)
MX (1) MXPA01010487A (fr)
NO (1) NO329525B1 (fr)
PT (1) PT1169460E (fr)
SI (1) SI1169460T1 (fr)
UA (1) UA73940C2 (fr)
WO (1) WO2000061768A2 (fr)
ZA (1) ZA200108364B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1336701A (en) * 1999-10-20 2001-04-30 Scios Inc. Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage
US7273722B2 (en) * 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
JP2004530432A (ja) 2001-03-08 2004-10-07 アレス・トレーディング・ソシエテ・アノニム インターロイキン−１８変異体、その産生および使用
IL142246A0 (en) * 2001-03-26 2002-03-10 Applied Research Systems Method and kit for quantitation of polypeptides
EP1483298A4 (fr) 2002-02-11 2007-03-14 Zymogenetics Inc Materiaux et procedes pour la preparation de facteurs de croissance dimeres
PT1597369E (pt) * 2003-02-21 2008-01-10 Univ Gent Processo de produção de polipéptidos fundidos, recombinantes, utilizando as enzimas caspases para amaturação
EP1651751B1 (fr) * 2003-08-06 2015-11-18 University Of Maryland Biotechnology Institute Proteases du genie genetique pour purification par affinite et traitement des proteines de fusion
MXPA06005837A (es) * 2003-11-24 2007-01-26 Novo Nordisk As Proteinas de fusion y metodos de desdoblamiento de tales proteinas.
US7381794B2 (en) 2004-03-08 2008-06-03 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
WO2008008082A2 (fr) * 2005-09-19 2008-01-17 Allergan, Inc. Toxine clostridienne activable par des toxines clostridiennes
ATE548380T1 (de) 2006-04-20 2012-03-15 Kringle Pharma Inc Mutante des hgf-precursor-proteins und aktivierte form davon
DE102007008596B4 (de) * 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
EP3492488A1 (fr) 2007-08-22 2019-06-05 The Regents of The University of California Polypeptides de liaison activables et procédés d'identification et utilisation de ceux-ci
WO2009044988A1 (fr) * 2007-10-01 2009-04-09 Korea Research Institute Of Bioscience And Biotechnology Procédé de préparation à grande échelle de procaspases pouvant être activées artificiellement dans un système d'expression de e. coli et leur activation
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
AU2010203353B2 (en) 2009-01-12 2016-06-16 Cytomx Therapeutics, Inc Modified antibody compositions, methods of making and using thereof
CN102481341B (zh) * 2009-02-23 2017-05-17 希托马克斯医疗有限公司 蛋白原及其使用方法
CN103923897B (zh) * 2013-01-11 2016-06-01 中国人民解放军军事医学科学院生物工程研究所 caspase重组酶原及其编码基因与应用
CN103388001B (zh) * 2013-07-16 2016-01-20 中国人民解放军第四军医大学 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法
BR112016012229A2 (pt) 2013-12-20 2017-09-26 Hoffmann La Roche métodos de produção de polipeptídeos
BR112017020690A2 (pt) 2015-03-30 2018-06-26 Greenlight Biosciences Inc produção livre de células de ácido ribonucleico
BR112017024610A2 (pt) 2015-06-24 2018-07-31 F. Hoffmann-La Roche Ag anticorpos para receptor antitransferrina com afinidade especificada
IL258317B1 (en) 2015-10-02 2024-08-01 Hoffmann La Roche Human anti–CD20/human transferrin receptor bispecific antibodies and methods of use
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
SG11201808721YA (en) 2016-04-06 2018-11-29 Greenlight Biosciences Inc Cell-free production of ribonucleic acid
AR113764A1 (es) 2017-10-11 2020-06-10 Greenlight Biosciences Inc Métodos y composiciones para la producción de nucleósido trifosfato y ácido ribonucleico
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
US20230000913A1 (en) * 2019-08-13 2023-01-05 King's College London Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824297A (en) * 1990-06-25 1998-10-20 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
WO1992000318A1 (fr) * 1990-06-25 1992-01-09 Oncogene Science, Inc. Inhibiteurs de croissance de tumeurs derives de tissus, procedes de preparation et utilisations desdits inhibiteurs
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co., Inc. DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
ES2134836T3 (es) * 1991-12-31 1999-10-16 Zymogenetics Inc Procedimientos para la produccion de trombina.
JPH06125784A (ja) * 1992-01-17 1994-05-10 Takeda Chem Ind Ltd モノクローナル抗体，ハイブリドーマ，その製造法および用途
US6303369B1 (en) * 1993-09-30 2001-10-16 Carl Spana Protein expression system
AU1341797A (en) 1995-12-29 1997-07-28 Incyte Pharmaceuticals, Inc. Nucleic acids encoding interferon gamma inducing factor-2
JP4059941B2 (ja) * 1996-08-26 2008-03-12 社団法人芝蘭会 Ｒｈｏ標的タンパク質ｐ１４０ｍＤｉａ
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
JPH10327872A (ja) * 1997-05-30 1998-12-15 Otsuka Pharmaceut Co Ltd Ｂｃｌ−２相互作用蛋白遺伝子ｂｉｓ
AU741138B2 (en) * 1997-08-07 2001-11-22 Toray Industries, Inc. Canine interleukin 18, canine interleukin 1beta convertase, DNA sequences encoding the same, process for producing interleukin 18, and remedies for canine immunological diseases

Also Published As

Publication number Publication date
IL145842A (en) 2008-06-05
AU3985100A (en) 2000-11-14
AU781342B2 (en) 2005-05-19
US7098002B1 (en) 2006-08-29
IL129427A0 (en) 2000-02-17
PT1169460E (pt) 2006-07-31
EP1169460B1 (fr) 2006-05-17
DE60028022T2 (de) 2006-09-28
WO2000061768A3 (fr) 2001-02-08
SI1169460T1 (sl) 2006-08-31
JP4822587B2 (ja) 2011-11-24
EP1169460A2 (fr) 2002-01-09
DE60028022D1 (de) 2006-06-22
ZA200108364B (en) 2002-10-11
IL145842A0 (en) 2002-07-25
UA73940C2 (uk) 2005-10-17
HK1044351A1 (en) 2002-10-18
MXPA01010487A (es) 2002-05-06
EE200100530A (et) 2002-12-16
NO329525B1 (no) 2010-11-01
WO2000061768A2 (fr) 2000-10-19
JP2002541813A (ja) 2002-12-10
ATE326536T1 (de) 2006-06-15
EA006825B1 (ru) 2006-04-28
CA2368994A1 (fr) 2000-10-19
CN1353761A (zh) 2002-06-12
KR100682185B1 (ko) 2007-02-12
ES2259287T3 (es) 2006-10-01
DK1169460T3 (da) 2006-09-18
KR20020007365A (ko) 2002-01-26
BR0009782A (pt) 2002-01-08
CA2368994C (fr) 2010-03-09
NO20014966D0 (no) 2001-10-12
CN1324140C (zh) 2007-07-04
EA200101078A1 (ru) 2002-04-25
NO20014966L (no) 2001-12-11
AR023468A1 (es) 2002-09-04

Similar Documents

Publication Publication Date Title
EE05591B1 (et) Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA
DE60139615D1 (de) Verbundmembran und herstellungsverfahren
AU2515000A (en) Pipe structure and method of manufacture
HUP0101714A3 (en) Enteric coated pharmaceutical composition and method of manufacturing
HUP0101064A2 (hu) Gélesítés és gáz- vagy vízgőzszárítással végzett forrógőzös örlő-szárítás útján előállított poliszacharidok vagy poliszacharidszármazékok alkalmazása építőanyag-keverékekben
DE60020737D1 (de) Sic-einkristall und herstellungsverfahren dafür
HK1042636A1 (zh) 舌的牙刷及其製造方法
AU4150200A (en) Steel-frame structure and method of construction by using the same
FR2774910B1 (fr) Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques
HUP0105398A3 (en) Counter rail and method of manufacturing thereof
DE69937596D1 (de) Verbinder und dessen Herstellungsverfahren
EP1154263A4 (fr) Detecteur d'oxygene et procede de fabrication d'un element de detection
DE60144216D1 (de) Verbindungs-Methode und Struktur
AU5251800A (en) Liposomal mixture of local anesthetics and manufacturing method thereof
DE60024667D1 (de) Sic-einkristall und herstellungsverfahren dafür
GB2340531B (en) Method of manufacturing pre-fabricated building construction elements
AU2002241691A1 (en) Biologically active composites and methods for their production and use
SI1216975T1 (en) Coated ceramic parts and method of fabricating same
AU4417700A (en) Building structure and method of making it
PL330688A1 (en) Apparatus for and method of manufacturing light-weight building materials
PL337869A1 (en) Facade structure and method of building same
PL332907A1 (en) Method of making prefabricated architectural elements, in particular cornices and prefabricated architectural element obtained thereby
FI19992634A (fi) Menetelmä kanavan muodostamiseksi ja kanava
TJ20000636A (en) A method of obtaining of a biologically active preparation chormagz
HK1035566A1 (en) A multi-storey building and a method of constructing same

Legal Events

Date Code Title Description
HH1A Change of representative
MM4A Lapsed by not paying the annual fees

Effective date: 20170413