AR023468A1 - Metodo para la produccion de citosina biologicamente activa a partir de su precursor biologicamente inactivo y cadn que codifica un precursor mutado de dicha citosina. - Google Patents
Metodo para la produccion de citosina biologicamente activa a partir de su precursor biologicamente inactivo y cadn que codifica un precursor mutado de dicha citosina.Info
- Publication number
- AR023468A1 AR023468A1 ARP000101692A ARP000101692A AR023468A1 AR 023468 A1 AR023468 A1 AR 023468A1 AR P000101692 A ARP000101692 A AR P000101692A AR P000101692 A ARP000101692 A AR P000101692A AR 023468 A1 AR023468 A1 AR 023468A1
- Authority
- AR
- Argentina
- Prior art keywords
- citosine
- biologically
- precursor
- biologically active
- active molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Se trata de la preparacion de moléculas biologicamente activas, que se presentan bajo la forma de precursores inactivados, disociables in vivo para formarmoléculas biologicamente maduras, activas, mediante proteasa; específicamente se trata de laobt encion de caspazas y citosina a partir de sus bioprecursores,vía autodisociacion, o disociacion mediada por caspazas o las proteasas-1. Específicamente se trata de un método para producir moléculas biologicamente activasde un precursorbiologicamente inactivo caracterizado porque comprende la mutacion de su sitio de disociacion natural a un sitio capaz de ser disociadomediante una proteasa, y disociar la molécula mutada para producir moléculas biologicamente activas. También sereivindican ADNc que codifica dichosprecursores mutados y las moléculas bioactivas obtenidas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12942799A IL129427A0 (en) | 1999-04-13 | 1999-04-13 | Preparation of biologically active molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
AR023468A1 true AR023468A1 (es) | 2002-09-04 |
Family
ID=11072700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000101692A AR023468A1 (es) | 1999-04-13 | 2000-04-12 | Metodo para la produccion de citosina biologicamente activa a partir de su precursor biologicamente inactivo y cadn que codifica un precursor mutado de dicha citosina. |
Country Status (24)
Country | Link |
---|---|
US (1) | US7098002B1 (es) |
EP (1) | EP1169460B1 (es) |
JP (1) | JP4822587B2 (es) |
KR (1) | KR100682185B1 (es) |
CN (1) | CN1324140C (es) |
AR (1) | AR023468A1 (es) |
AT (1) | ATE326536T1 (es) |
AU (1) | AU781342B2 (es) |
BR (1) | BR0009782A (es) |
CA (1) | CA2368994C (es) |
DE (1) | DE60028022T2 (es) |
DK (1) | DK1169460T3 (es) |
EA (1) | EA006825B1 (es) |
EE (1) | EE05591B1 (es) |
ES (1) | ES2259287T3 (es) |
HK (1) | HK1044351A1 (es) |
IL (3) | IL129427A0 (es) |
MX (1) | MXPA01010487A (es) |
NO (1) | NO329525B1 (es) |
PT (1) | PT1169460E (es) |
SI (1) | SI1169460T1 (es) |
UA (1) | UA73940C2 (es) |
WO (1) | WO2000061768A2 (es) |
ZA (1) | ZA200108364B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1336701A (en) * | 1999-10-20 | 2001-04-30 | Scios Inc. | Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage |
US7273722B2 (en) | 2000-11-29 | 2007-09-25 | Allergan, Inc. | Neurotoxins with enhanced target specificity |
AU2002324249B2 (en) | 2001-03-08 | 2007-04-05 | Ares Trading S.A. | Interleukin-18 mutants, their production and use |
IL142246A0 (en) * | 2001-03-26 | 2002-03-10 | Applied Research Systems | Method and kit for quantitation of polypeptides |
WO2003068802A2 (en) | 2002-02-11 | 2003-08-21 | Zymogenetics, Inc. | Materials and methods for preparing dimeric growth factors |
PT1597369E (pt) * | 2003-02-21 | 2008-01-10 | Univ Gent | Processo de produção de polipéptidos fundidos, recombinantes, utilizando as enzimas caspases para amaturação |
EP1651751B1 (en) * | 2003-08-06 | 2015-11-18 | University Of Maryland Biotechnology Institute | Engineered proteases for affinity purification and processing of fusion proteins |
JP2007512008A (ja) * | 2003-11-24 | 2007-05-17 | ノボ ノルディスク アクティーゼルスカブ | 融合タンパク質及び該タンパク質の切断方法 |
CA2558811A1 (en) | 2004-03-08 | 2005-09-22 | Zymogenetics, Inc. | Dimeric fusion proteins and materials and methods for producing them |
CA2610103A1 (en) | 2005-09-19 | 2007-03-19 | Allergan, Inc. | Clostridial toxin activatable clostridial toxins |
EP2014676B1 (en) * | 2006-04-20 | 2012-03-07 | Kringle Pharma Inc. | Hgf precursor protein mutant and activated form thereof |
DE102007008596B4 (de) * | 2007-02-15 | 2010-09-02 | Friedrich-Schiller-Universität Jena | Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung |
JP6035009B2 (ja) | 2007-08-22 | 2016-11-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
WO2009044988A1 (en) * | 2007-10-01 | 2009-04-09 | Korea Research Institute Of Bioscience And Biotechnology | Method for large scale preparation of procaspases, which can be artificially activated, in e. coli expression system and their activation |
DE102009043743B4 (de) | 2009-03-13 | 2016-10-13 | Friedrich-Schiller-Universität Jena | Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung |
EP3543256A1 (en) | 2009-01-12 | 2019-09-25 | Cytomx Therapeutics Inc. | Modified antibody compositions, methods of making and using thereof |
RU2011138951A (ru) * | 2009-02-23 | 2013-03-27 | Сайтомкс Терапьютикс, Инк. | Пропротеины и способы их применения |
CN103923897B (zh) * | 2013-01-11 | 2016-06-01 | 中国人民解放军军事医学科学院生物工程研究所 | caspase重组酶原及其编码基因与应用 |
CN103388001B (zh) * | 2013-07-16 | 2016-01-20 | 中国人民解放军第四军医大学 | 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法 |
MX368656B (es) | 2013-12-20 | 2019-10-10 | Hoffmann La Roche | Métodos mejorados para la producción de polipéptidos recombinantes. |
MY193444A (en) | 2015-03-30 | 2022-10-13 | Greenlight Biosciences Inc | Cell-free production of ribonucleic acid |
LT3313879T (lt) | 2015-06-24 | 2022-03-25 | F. Hoffmann-La Roche Ag | Antikūnai prieš transferino receptorių su pritaikytu giminingumu |
TWI819458B (zh) | 2015-10-02 | 2023-10-21 | 瑞士商赫孚孟拉羅股份公司 | 雙特異性抗‐人類cd20/人類轉鐵蛋白受體抗體及使用方法 |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
CR20180525A (es) | 2016-04-06 | 2019-02-14 | Greenlight Biosciences Inc | Producción de ácido ribonucleico libre de células |
KR102571743B1 (ko) | 2017-10-11 | 2023-08-29 | 그린라이트 바이오사이언시스, 아이엔씨. | 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물 |
KR20200080749A (ko) * | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법 |
WO2021028690A1 (en) * | 2019-08-13 | 2021-02-18 | King's College London | Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2084992A1 (en) * | 1990-06-25 | 1991-12-26 | Osi Pharmaceuticals, Inc. | Tissue-derived tumor growth inhibitors, methods for preparation and uses thereof |
US5824297A (en) * | 1990-06-25 | 1998-10-20 | Oncogene Science, Inc. | Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof |
EP0533350B1 (en) * | 1991-08-16 | 1999-05-26 | Merck & Co. Inc. | DNA encoding precursor interleukin 1B converting enzyme |
US5476777A (en) * | 1991-12-31 | 1995-12-19 | Zymogenetics, Inc. | Methods for producing thrombin |
JPH06125784A (ja) * | 1992-01-17 | 1994-05-10 | Takeda Chem Ind Ltd | モノクローナル抗体,ハイブリドーマ,その製造法および用途 |
US6303369B1 (en) * | 1993-09-30 | 2001-10-16 | Carl Spana | Protein expression system |
WO1997024441A1 (en) * | 1995-12-29 | 1997-07-10 | Incyte Pharmaceuticals, Inc. | Nucleic acids encoding interferon gamma inducing factor-2 |
JP4059941B2 (ja) * | 1996-08-26 | 2008-03-12 | 社団法人芝蘭会 | Rho標的タンパク質p140mDia |
AT405516B (de) * | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-analoge mit modifizierter proteasespaltstelle |
JPH10327872A (ja) * | 1997-05-30 | 1998-12-15 | Otsuka Pharmaceut Co Ltd | Bcl−2相互作用蛋白遺伝子bis |
WO1999007851A1 (en) * | 1997-08-07 | 1999-02-18 | Toray Industries, Inc. | CANINE INTERLEUKIN 18, CANINE INTERLEUKIN 1β CONVERTASE, DNA SEQUENCES ENCODING THE SAME, PROCESS FOR PRODUCING INTERLE UKIN 18, AND REMEDIES FOR CANINE IMMUNOLOGICAL DISEASES |
-
1999
- 1999-04-13 IL IL12942799A patent/IL129427A0/xx unknown
-
2000
- 2000-04-12 AR ARP000101692A patent/AR023468A1/es not_active Application Discontinuation
- 2000-04-13 AT AT00919108T patent/ATE326536T1/de active
- 2000-04-13 EA EA200101078A patent/EA006825B1/ru not_active IP Right Cessation
- 2000-04-13 ES ES00919108T patent/ES2259287T3/es not_active Expired - Lifetime
- 2000-04-13 MX MXPA01010487A patent/MXPA01010487A/es active IP Right Grant
- 2000-04-13 JP JP2000611691A patent/JP4822587B2/ja not_active Expired - Fee Related
- 2000-04-13 WO PCT/IL2000/000220 patent/WO2000061768A2/en active IP Right Grant
- 2000-04-13 EE EEP200100530A patent/EE05591B1/xx not_active IP Right Cessation
- 2000-04-13 EP EP00919108A patent/EP1169460B1/en not_active Expired - Lifetime
- 2000-04-13 DK DK00919108T patent/DK1169460T3/da active
- 2000-04-13 SI SI200030860T patent/SI1169460T1/sl unknown
- 2000-04-13 PT PT00919108T patent/PT1169460E/pt unknown
- 2000-04-13 CN CNB008080577A patent/CN1324140C/zh not_active Expired - Fee Related
- 2000-04-13 UA UA2001117751A patent/UA73940C2/uk unknown
- 2000-04-13 IL IL14584200A patent/IL145842A0/xx active IP Right Grant
- 2000-04-13 AU AU39851/00A patent/AU781342B2/en not_active Ceased
- 2000-04-13 DE DE60028022T patent/DE60028022T2/de not_active Expired - Lifetime
- 2000-04-13 CA CA002368994A patent/CA2368994C/en not_active Expired - Fee Related
- 2000-04-13 BR BR0009782-9A patent/BR0009782A/pt active Search and Examination
- 2000-04-13 US US09/958,914 patent/US7098002B1/en not_active Expired - Fee Related
- 2000-04-13 KR KR1020017012973A patent/KR100682185B1/ko not_active IP Right Cessation
-
2001
- 2001-10-10 IL IL145842A patent/IL145842A/en not_active IP Right Cessation
- 2001-10-11 ZA ZA200108364A patent/ZA200108364B/en unknown
- 2001-10-12 NO NO20014966A patent/NO329525B1/no not_active IP Right Cessation
-
2002
- 2002-08-15 HK HK02105972A patent/HK1044351A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR023468A1 (es) | Metodo para la produccion de citosina biologicamente activa a partir de su precursor biologicamente inactivo y cadn que codifica un precursor mutado de dicha citosina. | |
ATE419219T1 (de) | Chlordioxiderzeuger | |
DE69432744D1 (de) | Verbessertes verfahren zur rückfaltung der proteine | |
CO5680472A2 (es) | Hidrogeno para reformado con vapor de gas natural para dar gas de sintesis | |
DE10191656D2 (de) | Verfahren zur Herstellung kugelförmiger Aktivkohle | |
EA200501523A1 (ru) | Способ переработки природного газа в жидкие продукты | |
ATE491156T1 (de) | Bio-elektrochemisches verfahren zur herstellung von wasserstoff | |
FR15C0055I2 (fr) | Feuillets de l'epithelium corneen humain reconstitues in vitro et methode de production de ces derniers | |
ATE464338T1 (de) | Neuer schaumstoffmodifikator, aus diesem neuen schaumstoffmodifikator hergestellte schaumstoffe und verfahren zur herstellung dieser schaumstoffe | |
DK1644306T3 (da) | Fremgangsmåde til fremstilling af alkenonethere | |
DE60028777D1 (de) | Verfahren zur herstellung von 1,3-propanediol durch einen rekombinanten micro-organismus in abwesenheit von coenzym b12 | |
NO20072221L (no) | Fremgangsmate for fremstilling av hydrogenperoksid. | |
HUP0300589A2 (hu) | Fluor-metil-2,2,2-trifluor-1-(trifluor-metil)-etil-éter előállítása | |
DE60139993D1 (de) | Chondroitin synthasegen und verfahren zur dessen herstellung und anwendung | |
DE69909921D1 (de) | Verfahren zur herstellung von n-methyl-pyrrolidon | |
MA27476A1 (fr) | Procede et appareil de production d'un produit cimentaire multicouche | |
ATE328862T1 (de) | Verfahren zur industriellen herstellung von betulinsäuren | |
ATE265416T1 (de) | Kontinuierliches adiabatisches verfahren zur herstellung von nitrochlorbenzol | |
RS50075B (sr) | Postupak za proizvodnju heterolognih proteinskih supstanci u biljnom materijalu | |
AU1748101A (en) | New complex, and methods for its production and use | |
ATE321848T1 (de) | Immobilisierungsträger mit einem porösen medium | |
ATE303864T1 (de) | Herstellung von polymerteilchen | |
DE59801160D1 (de) | Verfahren zur herstellung eines granulates für die hämodialyse | |
HUP0500057A2 (hu) | Acilezett polipeptidek előállítási eljárása | |
DE60307120D1 (de) | Verfahren zur herstellung von halogenalkylpyrimidinen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed, e.g., due to non-payment of fee |