DK1169460T3 - Fremstilling af biologisk aktive molekyler - Google Patents

Fremstilling af biologisk aktive molekyler

Info

Publication number
DK1169460T3
DK1169460T3 DK00919108T DK00919108T DK1169460T3 DK 1169460 T3 DK1169460 T3 DK 1169460T3 DK 00919108 T DK00919108 T DK 00919108T DK 00919108 T DK00919108 T DK 00919108T DK 1169460 T3 DK1169460 T3 DK 1169460T3
Authority
DK
Denmark
Prior art keywords
preparation
biologically active
active molecules
molecules
biologically
Prior art date
Application number
DK00919108T
Other languages
English (en)
Inventor
Menachem Rubinstein
Daniela Novick
Bianling Liu
Pierre Graber
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of DK1169460T3 publication Critical patent/DK1169460T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
DK00919108T 1999-04-13 2000-04-13 Fremstilling af biologisk aktive molekyler DK1169460T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules

Publications (1)

Publication Number Publication Date
DK1169460T3 true DK1169460T3 (da) 2006-09-18

Family

ID=11072700

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00919108T DK1169460T3 (da) 1999-04-13 2000-04-13 Fremstilling af biologisk aktive molekyler

Country Status (24)

Country Link
US (1) US7098002B1 (da)
EP (1) EP1169460B1 (da)
JP (1) JP4822587B2 (da)
KR (1) KR100682185B1 (da)
CN (1) CN1324140C (da)
AR (1) AR023468A1 (da)
AT (1) ATE326536T1 (da)
AU (1) AU781342B2 (da)
BR (1) BR0009782A (da)
CA (1) CA2368994C (da)
DE (1) DE60028022T2 (da)
DK (1) DK1169460T3 (da)
EA (1) EA006825B1 (da)
EE (1) EE05591B1 (da)
ES (1) ES2259287T3 (da)
HK (1) HK1044351A1 (da)
IL (3) IL129427A0 (da)
MX (1) MXPA01010487A (da)
NO (1) NO329525B1 (da)
PT (1) PT1169460E (da)
SI (1) SI1169460T1 (da)
UA (1) UA73940C2 (da)
WO (1) WO2000061768A2 (da)
ZA (1) ZA200108364B (da)

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WO2001029232A2 (en) * 1999-10-20 2001-04-26 Scios Inc. Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage
US7273722B2 (en) 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
ES2251610T3 (es) 2001-03-08 2006-05-01 Ares Trading S.A. Mutantes de interleuquina-18, su produccion y su uso.
IL142246A0 (en) * 2001-03-26 2002-03-10 Applied Research Systems Method and kit for quantitation of polypeptides
AU2003210996A1 (en) 2002-02-11 2003-09-04 Zymogenetics, Inc. Materials and methods for preparing dimeric growth factors
PT1597369E (pt) * 2003-02-21 2008-01-10 Univ Gent Processo de produção de polipéptidos fundidos, recombinantes, utilizando as enzimas caspases para amaturação
CN101454452B (zh) * 2003-08-06 2014-01-01 马里兰大学生物技术研究所 用于亲和纯化的工程蛋白酶及融合蛋白的加工
WO2005049847A1 (en) * 2003-11-24 2005-06-02 Novo Nordisk A/S Fusion proteins and methods of cleavage of such proteins
EP1732946B1 (en) 2004-03-08 2011-07-27 ZymoGenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
ATE463506T1 (de) * 2005-09-19 2010-04-15 Allergan Inc Mit clostriedientoxin aktivierbare clostridientoxine
JP5093783B2 (ja) * 2006-04-20 2012-12-12 クリングルファーマ株式会社 Ｈｇｆ前駆体蛋白質改変体及びその活性型蛋白質
DE102007008596B4 (de) * 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
CA3128656A1 (en) 2007-08-22 2009-02-26 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
KR100980315B1 (ko) * 2007-10-01 2010-09-07 한국생명공학연구원 대장균시스템을 이용한 인위적 활성화가 가능한 카스파제전구체 대량생산 및 활성화 방법
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
EP2385955B1 (en) 2009-01-12 2020-08-12 CytomX Therapeutics, Inc. Modified antibody compositions, methods of making and using thereof
AU2010215761B2 (en) 2009-02-23 2017-04-06 Cytomx Therapeutics, Inc Proproteins and methods of use thereof
CN103923897B (zh) * 2013-01-11 2016-06-01 中国人民解放军军事医学科学院生物工程研究所 caspase重组酶原及其编码基因与应用
CN103388001B (zh) * 2013-07-16 2016-01-20 中国人民解放军第四军医大学 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法
CA2929149A1 (en) * 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Improved recombinant polypeptide production methods
KR20230048162A (ko) 2015-03-30 2023-04-10 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
HRP20220304T1 (hr) 2015-06-24 2022-05-13 F. Hoffmann - La Roche Ag Anti-transferinska receptorska protutijela s prilagođenim afinitetom
PE20181004A1 (es) 2015-10-02 2018-06-26 Hoffmann La Roche Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
AU2017246458B2 (en) 2016-04-06 2022-08-11 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
IL273887B (en) 2017-10-11 2022-09-01 Greenlight Biosciences Inc Methods and preparations for the production of nucleoside triphosphate and ribonucleic acid
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
CA3150818A1 (en) * 2019-08-13 2021-02-18 King's College London Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily

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CA2084992A1 (en) * 1990-06-25 1991-12-26 Osi Pharmaceuticals, Inc. Tissue-derived tumor growth inhibitors, methods for preparation and uses thereof
US5824297A (en) * 1990-06-25 1998-10-20 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co Inc DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
US5476777A (en) * 1991-12-31 1995-12-19 Zymogenetics, Inc. Methods for producing thrombin
JPH06125784A (ja) * 1992-01-17 1994-05-10 Takeda Chem Ind Ltd モノクローナル抗体，ハイブリドーマ，その製造法および用途
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WO1997024441A1 (en) 1995-12-29 1997-07-10 Incyte Pharmaceuticals, Inc. Nucleic acids encoding interferon gamma inducing factor-2
JP4059941B2 (ja) * 1996-08-26 2008-03-12 社団法人芝蘭会 Ｒｈｏ標的タンパク質ｐ１４０ｍＤｉａ
AT405516B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
JPH10327872A (ja) * 1997-05-30 1998-12-15 Otsuka Pharmaceut Co Ltd Ｂｃｌ−２相互作用蛋白遺伝子ｂｉｓ
WO1999007851A1 (en) * 1997-08-07 1999-02-18 Toray Industries, Inc. CANINE INTERLEUKIN 18, CANINE INTERLEUKIN 1β CONVERTASE, DNA SEQUENCES ENCODING THE SAME, PROCESS FOR PRODUCING INTERLE UKIN 18, AND REMEDIES FOR CANINE IMMUNOLOGICAL DISEASES

Also Published As

Publication number Publication date
WO2000061768A3 (en) 2001-02-08
WO2000061768A2 (en) 2000-10-19
EE200100530A (et) 2002-12-16
KR20020007365A (ko) 2002-01-26
KR100682185B1 (ko) 2007-02-12
UA73940C2 (uk) 2005-10-17
EP1169460B1 (en) 2006-05-17
NO20014966D0 (no) 2001-10-12
IL145842A0 (en) 2002-07-25
BR0009782A (pt) 2002-01-08
EA200101078A1 (ru) 2002-04-25
EA006825B1 (ru) 2006-04-28
ES2259287T3 (es) 2006-10-01
ATE326536T1 (de) 2006-06-15
EE05591B1 (et) 2012-10-15
NO329525B1 (no) 2010-11-01
JP2002541813A (ja) 2002-12-10
DE60028022T2 (de) 2006-09-28
AR023468A1 (es) 2002-09-04
NO20014966L (no) 2001-12-11
CA2368994C (en) 2010-03-09
US7098002B1 (en) 2006-08-29
AU781342B2 (en) 2005-05-19
MXPA01010487A (es) 2002-05-06
ZA200108364B (en) 2002-10-11
AU3985100A (en) 2000-11-14
CN1324140C (zh) 2007-07-04
CN1353761A (zh) 2002-06-12
HK1044351A1 (en) 2002-10-18
IL145842A (en) 2008-06-05
DE60028022D1 (de) 2006-06-22
PT1169460E (pt) 2006-07-31
IL129427A0 (en) 2000-02-17
EP1169460A2 (en) 2002-01-09
SI1169460T1 (sl) 2006-08-31
CA2368994A1 (en) 2000-10-19
JP4822587B2 (ja) 2011-11-24

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