EE05456B1 - Bensasooli derivaadid ja nende kasutamine JNK modulaatoritena - Google Patents

Bensasooli derivaadid ja nende kasutamine JNK modulaatoritena

Info

Publication number
EE05456B1
EE05456B1 EEP200200318A EEP200200318A EE05456B1 EE 05456 B1 EE05456 B1 EE 05456B1 EE P200200318 A EEP200200318 A EE P200200318A EE P200200318 A EEP200200318 A EE P200200318A EE 05456 B1 EE05456 B1 EE 05456B1
Authority
EE
Estonia
Prior art keywords
benzazole derivatives
jnk modulators
jnk
modulators
benzazole
Prior art date
Application number
EEP200200318A
Other languages
English (en)
Estonian (et)
Inventor
Halazy Serge
Church Dennis
Camps Montserrat
Gaillard Pascale
Gotteland Jean-Pierre
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200200318A publication Critical patent/EE200200318A/xx
Publication of EE05456B1 publication Critical patent/EE05456B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200200318A 1999-12-24 2000-12-20 Bensasooli derivaadid ja nende kasutamine JNK modulaatoritena EE05456B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99811207A EP1110957A1 (en) 1999-12-24 1999-12-24 Benzazole derivatives and their use as JNK modulators
PCT/EP2000/013006 WO2001047920A1 (en) 1999-12-24 2000-12-20 Benzazole derivatives and their use as jnk modulators

Publications (2)

Publication Number Publication Date
EE200200318A EE200200318A (et) 2003-10-15
EE05456B1 true EE05456B1 (et) 2011-08-15

Family

ID=8243214

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200318A EE05456B1 (et) 1999-12-24 2000-12-20 Bensasooli derivaadid ja nende kasutamine JNK modulaatoritena

Country Status (33)

Country Link
US (2) US7259162B2 (sk)
EP (2) EP1110957A1 (sk)
JP (1) JP4782344B2 (sk)
KR (2) KR20070047853A (sk)
CN (1) CN1252067C (sk)
AR (1) AR029215A1 (sk)
AT (1) ATE254123T1 (sk)
AU (1) AU780241B2 (sk)
BG (1) BG65986B1 (sk)
BR (1) BR0016911A (sk)
CA (1) CA2394809C (sk)
CZ (1) CZ300984B6 (sk)
DE (1) DE60006580T2 (sk)
DK (1) DK1240164T3 (sk)
EA (1) EA007152B1 (sk)
EE (1) EE05456B1 (sk)
ES (1) ES2206351T3 (sk)
HK (1) HK1055730A1 (sk)
HR (1) HRP20020496B1 (sk)
HU (1) HU229625B1 (sk)
IL (2) IL150346A0 (sk)
MX (1) MXPA02006242A (sk)
NO (1) NO323146B1 (sk)
NZ (1) NZ519423A (sk)
PL (1) PL356634A1 (sk)
PT (1) PT1240164E (sk)
RS (1) RS51008B (sk)
SI (1) SI1240164T1 (sk)
SK (1) SK287546B6 (sk)
TR (2) TR200302320T4 (sk)
UA (1) UA73151C2 (sk)
WO (1) WO2001047920A1 (sk)
ZA (1) ZA200204427B (sk)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2440842A1 (en) 2001-04-16 2002-10-24 Eisai Co., Ltd. Novel 1h-indazole compounds
AU2002331253B2 (en) 2001-07-23 2008-04-03 Laboratoires Serono Sa Arylsulfonamide derivatives as C-JUN-N-terminal kinases (JNK'S) inhibitors
ATE340572T1 (de) * 2001-12-07 2006-10-15 Applied Research Systems Benzazole derivate zur behandlung von scleroderma
IL164796A0 (en) * 2002-04-25 2005-12-18 Applied Res Piperazine benzothiazole derivatives, their preparation, pharmaceutical compositions containing themand their use
WO2003101968A1 (fr) 2002-05-31 2003-12-11 Eisai Co., Ltd. Compose de pyrazole et composition medicinale le contenant
CA2487948A1 (en) * 2002-06-14 2003-12-24 Applied Research Systems Ars Holding N.V. Azole methylidene cyanide derivatives and their use as protein kinase modulators
CA2501144C (en) 2002-10-23 2015-10-06 University Of Utah Research Foundation Amplicon melting analysis with saturation dyes
ES2401578T3 (es) * 2003-05-08 2013-04-22 Merck Serono Sa Piridinilacetonitrilos
WO2005026159A1 (en) * 2003-09-12 2005-03-24 Applied Research Systems Ars Holding N.V. Benzoxazole acetonitriles
SI1696909T1 (sl) * 2003-09-12 2008-02-29 Serono Lab Derivati benzotiazola za zdravljenje diabetesa
JP2007505085A (ja) * 2003-09-12 2007-03-08 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ ベンゾイミダゾールアセトニトリル
KR20060134198A (ko) * 2004-04-08 2006-12-27 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. Ｊｎｋ 저해제 및 시클로스포린을 포함하는 조성물
US9657347B2 (en) 2004-04-20 2017-05-23 University of Utah Research Foundation and BioFire Defense, LLC Nucleic acid melting analysis with saturation dyes
US7387887B2 (en) * 2004-04-20 2008-06-17 University Of Utah Research Foundation Nucleic acid melting analysis with saturation dyes
US7803824B2 (en) 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
ATE411817T1 (de) * 2004-11-17 2008-11-15 Ares Trading Sa Benzothiazolformulierungen und ihre verwendung
CA2589367C (en) 2004-12-21 2015-02-03 Laboratoires Serono S.A. Sulfonyl amino cyclic derivatives and use thereof
RS51957B (en) 2005-01-31 2012-02-29 Merck Serono Sa. N-HYDROXIAMIDE DERIVATIVES AND THEIR USE
US20060223807A1 (en) 2005-03-29 2006-10-05 University Of Massachusetts Medical School, A Massachusetts Corporation Therapeutic methods for type I diabetes
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) * 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
WO2007025991A2 (en) 2005-09-01 2007-03-08 Ares Trading S.A. Treatment of optic neuritis
JP2009521931A (ja) 2005-12-29 2009-06-11 アントフロゲネシス コーポレーション 胎盤幹細胞を収集及び保存するための改善された組成物、及び該組成物の使用方法
JP2009538882A (ja) * 2006-06-02 2009-11-12 メルク セローノ ソシエテ アノニム 皮膚疾患の治療のためのｊｎｋ阻害物質
US20090194268A1 (en) * 2006-08-28 2009-08-06 Dantherm Air Handling A/S Method for manufacturing a heat exchanger
CA2677679A1 (en) 2007-02-12 2008-08-21 Anthrogenesis Corporation Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations
EP2331534A4 (en) * 2008-08-12 2013-01-16 Sirtris Pharmaceuticals Inc BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGUES AS MODULATORS OF SIRTUINE
CA2734472A1 (en) 2008-09-29 2010-04-01 Telik, Inc. 2-[1h-benzimidazol-2(3h)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3h)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
CN102199147A (zh) * 2011-03-19 2011-09-28 陕西合成药业有限公司 用于治疗的硝基咪唑衍生物
CN113559126A (zh) 2011-06-01 2021-10-29 人类起源公司 利用胎盘干细胞治疗疼痛
WO2014114186A1 (zh) * 2013-01-24 2014-07-31 山东亨利医药科技有限责任公司 Jnk抑制剂
JP2017502016A (ja) * 2013-12-20 2017-01-19 バイオメッド バレー ディスカバリーズ，インコーポレイティド １型ｍｅｋ阻害剤およびｅｒｋ阻害剤の組み合わせを使用するがんの処置
KR101520378B1 (ko) * 2014-10-02 2015-05-26 (주)에프테크 습식 가스 스크러버의 배기유도장치
WO2016055517A1 (en) * 2014-10-08 2016-04-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Novel aminopyridine compounds useful as inhibitors of protein prenylation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2918369A (en) * 1956-06-15 1959-12-22 Gen Aniline & Film Corp Non-ionic benzimidazole cyanine dyes containing in alpha-position a cyano group on the methenyl chain
GB864131A (en) * 1957-07-17 1961-03-29 Ciba Ltd Benzimidazolyl-acetic acid derivatives
DE1963542A1 (de) 1969-12-18 1971-06-24 Siemens Ag Koppelfeldanordnung fuer Fernmelde-,insbesondere Fernsprechanlagen
JPS51123223A (en) * 1975-04-21 1976-10-27 Fuji Photo Film Co Ltd Process for producing condensation products
CH593954A5 (sk) * 1975-07-21 1977-12-30 Ciba Geigy Ag
US4933341A (en) * 1988-10-08 1990-06-12 Bayer Aktiengesellschaft Substituted 1,3,5-triazinetriones, for use against parasitic protozoa
EP0364765A3 (de) * 1988-10-08 1991-07-17 Bayer Ag Substituierte 1,3,5-Triazintrione, Verfahren zu ihrer Herstellung und ihre Verwendung gegen parasitäre Protozoen
US5523312A (en) * 1994-09-27 1996-06-04 Sterling Winthrop Inc. Antipicornaviral agents
US6043083A (en) 1997-04-28 2000-03-28 Davis; Roger J. Inhibitors of the JNK signal transduction pathway and methods of use
JP4153574B2 (ja) * 1997-09-10 2008-09-24 トーアエイヨー株式会社 新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤
GB9721437D0 (en) * 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine

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HK1055730A1 (en) 2004-01-21
CZ300984B6 (cs) 2009-09-30
CN1433414A (zh) 2003-07-30
PT1240164E (pt) 2004-02-27
TR200302320T4 (tr) 2004-01-21
IL150346A (en) 2010-12-30
AU780241B2 (en) 2005-03-10
US20030162794A1 (en) 2003-08-28
EA200200708A1 (ru) 2003-02-27
IL150346A0 (en) 2002-12-01
CA2394809C (en) 2011-03-15
BG65986B1 (bg) 2010-08-31
JP4782344B2 (ja) 2011-09-28
YU49202A (sh) 2006-01-16
PL356634A1 (en) 2004-06-28
EE200200318A (et) 2003-10-15
HRP20020496A2 (en) 2006-03-31
US20070259892A1 (en) 2007-11-08
SK287546B6 (sk) 2011-01-04
DE60006580T2 (de) 2004-09-16
US7259162B2 (en) 2007-08-21
RS51008B (sr) 2010-10-31
AR029215A1 (es) 2003-06-18
DE60006580D1 (de) 2003-12-18
KR100736012B1 (ko) 2007-07-06
SK8982002A3 (en) 2002-10-08
NO20022997L (no) 2002-06-21
ATE254123T1 (de) 2003-11-15
US7470686B2 (en) 2008-12-30
CA2394809A1 (en) 2001-07-05
BR0016911A (pt) 2002-10-22
MXPA02006242A (es) 2003-01-28
EP1110957A1 (en) 2001-06-27
SI1240164T1 (en) 2004-04-30
HUP0204557A2 (en) 2003-05-28
ES2206351T3 (es) 2004-05-16
HRP20020496B1 (en) 2009-03-31
EP1240164B1 (en) 2003-11-12
NO323146B1 (no) 2007-01-08
ZA200204427B (en) 2004-02-03
NO20022997D0 (no) 2002-06-21
AU3161601A (en) 2001-07-09
UA73151C2 (en) 2005-06-15
BG106830A (bg) 2003-02-28
HU229625B1 (hu) 2014-03-28
CZ20022169A3 (cs) 2002-09-11
KR20020072282A (ko) 2002-09-14
DK1240164T3 (da) 2004-03-01
EA007152B1 (ru) 2006-08-25
CN1252067C (zh) 2006-04-19
WO2001047920A1 (en) 2001-07-05
KR20070047853A (ko) 2007-05-07
HUP0204557A3 (en) 2009-03-30
NZ519423A (en) 2004-04-30
EP1240164A1 (en) 2002-09-18
JP2003519142A (ja) 2003-06-17
TR200201509T2 (tr) 2002-09-23

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