RS51008B - Benzazolski derivati i njihova upotreba kao modulatora jnk - Google Patents

Benzazolski derivati i njihova upotreba kao modulatora jnk

Info

Publication number
RS51008B
RS51008B YUP-492/02A YUP49202A RS51008B RS 51008 B RS51008 B RS 51008B YU P49202 A YUP49202 A YU P49202A RS 51008 B RS51008 B RS 51008B
Authority
RS
Serbia
Prior art keywords
substituted
unsubstituted
alkyl
aryl
heteroaryl
Prior art date
Application number
YUP-492/02A
Other languages
English (en)
Inventor
Pascale Gaillard
Jean-Pierre Gotteland
Serge Halazy
Dennis Church
Montserrat Camps
Original Assignee
Laboratoires Serono Sa.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono Sa. filed Critical Laboratoires Serono Sa.
Publication of YU49202A publication Critical patent/YU49202A/sh
Publication of RS51008B publication Critical patent/RS51008B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
YUP-492/02A 1999-12-24 2000-12-20 Benzazolski derivati i njihova upotreba kao modulatora jnk RS51008B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99811207A EP1110957A1 (en) 1999-12-24 1999-12-24 Benzazole derivatives and their use as JNK modulators

Publications (2)

Publication Number Publication Date
YU49202A YU49202A (sh) 2006-01-16
RS51008B true RS51008B (sr) 2010-10-31

Family

ID=8243214

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-492/02A RS51008B (sr) 1999-12-24 2000-12-20 Benzazolski derivati i njihova upotreba kao modulatora jnk

Country Status (33)

Country Link
US (2) US7259162B2 (sr)
EP (2) EP1110957A1 (sr)
JP (1) JP4782344B2 (sr)
KR (2) KR100736012B1 (sr)
CN (1) CN1252067C (sr)
AR (1) AR029215A1 (sr)
AT (1) ATE254123T1 (sr)
AU (1) AU780241B2 (sr)
BG (1) BG65986B1 (sr)
BR (1) BR0016911A (sr)
CA (1) CA2394809C (sr)
CZ (1) CZ300984B6 (sr)
DE (1) DE60006580T2 (sr)
DK (1) DK1240164T3 (sr)
EA (1) EA007152B1 (sr)
EE (1) EE05456B1 (sr)
ES (1) ES2206351T3 (sr)
HK (1) HK1055730A1 (sr)
HR (1) HRP20020496B1 (sr)
HU (1) HU229625B1 (sr)
IL (2) IL150346A0 (sr)
MX (1) MXPA02006242A (sr)
NO (1) NO323146B1 (sr)
NZ (1) NZ519423A (sr)
PL (1) PL356634A1 (sr)
PT (1) PT1240164E (sr)
RS (1) RS51008B (sr)
SI (1) SI1240164T1 (sr)
SK (1) SK287546B6 (sr)
TR (2) TR200302320T4 (sr)
UA (1) UA73151C2 (sr)
WO (1) WO2001047920A1 (sr)
ZA (1) ZA200204427B (sr)

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WO2003047570A1 (en) * 2001-12-07 2003-06-12 Applied Research Systems Ars Holding N.V. Benzazole derivatives for the treatment of scleroderma
IL164796A (en) * 2002-04-25 2013-02-28 Pascale Gailllard Piperazine benzothiazole derivatives, their preparation, pharmaceutical compositions containing them and their use
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AU2003251721A1 (en) * 2002-06-14 2003-12-31 Laboratoires Serono Sa Azole methylidene cyanide derivatives and their use as protein kinase modulators
WO2004038038A2 (en) 2002-10-23 2004-05-06 University Of Utah Research Foundation Amplicon melting analysis with saturation dyes
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US20080039377A1 (en) * 2004-04-08 2008-02-14 Applied Research Systems Ars Holding N.V. Composition Comprising a Jnk Inhibitor and Cyclosporin
US7387887B2 (en) * 2004-04-20 2008-06-17 University Of Utah Research Foundation Nucleic acid melting analysis with saturation dyes
US9657347B2 (en) 2004-04-20 2017-05-23 University of Utah Research Foundation and BioFire Defense, LLC Nucleic acid melting analysis with saturation dyes
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BRPI0516383A (pt) 2004-12-21 2008-09-02 Serono Lab derivados cìclicos de sulfonil amino e o uso dos mesmos
WO2006079653A1 (en) 2005-01-31 2006-08-03 Laboratoires Serono S.A. N-hydroxyamide derivatives and use thereof
US20060223807A1 (en) * 2005-03-29 2006-10-05 University Of Massachusetts Medical School, A Massachusetts Corporation Therapeutic methods for type I diabetes
BRPI0613042A2 (pt) * 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
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EA013816B1 (ru) 2005-09-01 2010-08-30 Арес Трейдинг С.А. Лечение неврита зрительного нерва
CN101374941A (zh) 2005-12-29 2009-02-25 人类起源公司 采集和保存胎盘干细胞的改良组合物及其使用方法
WO2007141224A2 (en) * 2006-06-02 2007-12-13 Laboratoires Serono Sa Jnk inhibitors for treatment of skin diseases
CN101541522B (zh) * 2006-08-28 2012-07-18 丹塞姆空气调节有限公司 用于制造热交换器的方法
US10494607B2 (en) 2007-02-12 2019-12-03 Celularity, Inc. CD34+,CD45−placental stem cell-enriched cell populations
WO2010019606A1 (en) * 2008-08-12 2010-02-18 Sirtris Pharmaceuticals, Inc. Benzoxazoles, benzthiazoles and related analogs as sirtuin modulators
KR20110059740A (ko) * 2008-09-29 2011-06-03 텔리크 인코포레이티드 키나아제 억제제로서의 2-[1ｈ-벤즈이미다졸-2(3ｈ)-일리덴]-2-(피리미딘-2-일)아세트아미드 및 2-[벤조티아졸-2(3ｈ)-일리덴]-2-(피리미딘-2-일)아세트아미드
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Also Published As

Publication number Publication date
PL356634A1 (en) 2004-06-28
CN1252067C (zh) 2006-04-19
EP1240164A1 (en) 2002-09-18
JP2003519142A (ja) 2003-06-17
US7259162B2 (en) 2007-08-21
IL150346A (en) 2010-12-30
MXPA02006242A (es) 2003-01-28
NO323146B1 (no) 2007-01-08
DK1240164T3 (da) 2004-03-01
SK287546B6 (sk) 2011-01-04
HU229625B1 (hu) 2014-03-28
IL150346A0 (en) 2002-12-01
HK1055730A1 (en) 2004-01-21
NO20022997L (no) 2002-06-21
KR20070047853A (ko) 2007-05-07
BG65986B1 (bg) 2010-08-31
AU3161601A (en) 2001-07-09
EE200200318A (et) 2003-10-15
SK8982002A3 (en) 2002-10-08
CA2394809A1 (en) 2001-07-05
BG106830A (bg) 2003-02-28
DE60006580T2 (de) 2004-09-16
YU49202A (sh) 2006-01-16
EA200200708A1 (ru) 2003-02-27
TR200302320T4 (tr) 2004-01-21
CZ20022169A3 (cs) 2002-09-11
WO2001047920A1 (en) 2001-07-05
EP1240164B1 (en) 2003-11-12
HRP20020496B1 (en) 2009-03-31
KR100736012B1 (ko) 2007-07-06
ES2206351T3 (es) 2004-05-16
EA007152B1 (ru) 2006-08-25
ZA200204427B (en) 2004-02-03
AU780241B2 (en) 2005-03-10
UA73151C2 (en) 2005-06-15
CN1433414A (zh) 2003-07-30
TR200201509T2 (tr) 2002-09-23
KR20020072282A (ko) 2002-09-14
SI1240164T1 (en) 2004-04-30
NO20022997D0 (no) 2002-06-21
US20030162794A1 (en) 2003-08-28
EE05456B1 (et) 2011-08-15
AR029215A1 (es) 2003-06-18
CA2394809C (en) 2011-03-15
EP1110957A1 (en) 2001-06-27
HRP20020496A2 (en) 2006-03-31
BR0016911A (pt) 2002-10-22
HUP0204557A3 (en) 2009-03-30
HUP0204557A2 (en) 2003-05-28
US7470686B2 (en) 2008-12-30
JP4782344B2 (ja) 2011-09-28
CZ300984B6 (cs) 2009-09-30
PT1240164E (pt) 2004-02-27
NZ519423A (en) 2004-04-30
DE60006580D1 (de) 2003-12-18
US20070259892A1 (en) 2007-11-08
ATE254123T1 (de) 2003-11-15

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