EE04500B1 - Trombiini inhibiitorid, nende saamine ja kasutamine - Google Patents
Trombiini inhibiitorid, nende saamine ja kasutamineInfo
- Publication number
- EE04500B1 EE04500B1 EE9700354A EE9700354A EE04500B1 EE 04500 B1 EE04500 B1 EE 04500B1 EE 9700354 A EE9700354 A EE 9700354A EE 9700354 A EE9700354 A EE 9700354A EE 04500 B1 EE04500 B1 EE 04500B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- thrombin inhibitors
- thrombin
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9502487A SE9502487D0 (sv) | 1995-07-06 | 1995-07-06 | New amino acid derivatives |
SE9502504A SE9502504D0 (sv) | 1995-07-07 | 1995-07-07 | New amino acid derivatives |
SE9502505A SE9502505D0 (sv) | 1995-07-07 | 1995-07-07 | New amino acid derivatives |
SE9503923A SE9503923D0 (sv) | 1995-11-07 | 1995-11-07 | New amino acid derivatives |
SE9504349A SE9504349D0 (sv) | 1995-12-05 | 1995-12-05 | New amino acid derivatives |
GBGB9526411.5A GB9526411D0 (en) | 1995-12-22 | 1995-12-22 | Compounds |
PCT/SE1996/000878 WO1997002284A1 (en) | 1995-07-06 | 1996-07-02 | New thrombin inhibitors, their preparation and use |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9700354A EE9700354A (et) | 1998-06-15 |
EE04500B1 true EE04500B1 (et) | 2005-06-15 |
Family
ID=27547251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9700354A EE04500B1 (et) | 1995-07-06 | 1996-07-02 | Trombiini inhibiitorid, nende saamine ja kasutamine |
Country Status (31)
Country | Link |
---|---|
US (4) | US6051568A (ko) |
EP (1) | EP0836615B1 (ko) |
JP (1) | JP4107682B2 (ko) |
KR (1) | KR100435008B1 (ko) |
CN (1) | CN1147504C (ko) |
AR (1) | AR003440A1 (ko) |
AT (1) | ATE238342T1 (ko) |
AU (1) | AU709710B2 (ko) |
BR (1) | BR9609447A (ko) |
CA (1) | CA2226256C (ko) |
CZ (1) | CZ298487B6 (ko) |
DE (1) | DE69627659T2 (ko) |
DK (1) | DK0836615T3 (ko) |
EE (1) | EE04500B1 (ko) |
ES (1) | ES2197240T3 (ko) |
HK (1) | HK1008995A1 (ko) |
HU (1) | HUP9802315A3 (ko) |
IL (1) | IL122813A0 (ko) |
IS (1) | IS2081B (ko) |
MX (1) | MX9800146A (ko) |
MY (1) | MY116539A (ko) |
NO (1) | NO324092B1 (ko) |
NZ (2) | NZ311854A (ko) |
PL (1) | PL185606B1 (ko) |
PT (1) | PT836615E (ko) |
RU (1) | RU2176645C2 (ko) |
SA (1) | SA96170106A (ko) |
SI (1) | SI0836615T1 (ko) |
SK (1) | SK284695B6 (ko) |
TR (1) | TR199800009T1 (ko) |
WO (1) | WO1997002284A1 (ko) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
US6200967B1 (en) | 1996-06-25 | 2001-03-13 | Eli Lilly And Company | Anticoagulant agents |
US5863929A (en) * | 1996-06-25 | 1999-01-26 | Eli Lilly And Company | Anticoagulant agents |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
SE9704543D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
EP1073449A4 (en) | 1998-04-24 | 2003-01-02 | Dimensional Pharm Inc | AMINO ACID AMIDINOHYDRAZONES, ALCOXYGUANIDINES AND AMINOGUANIDINES FOR USE AS ENZYME PROTEASE INHIBITORS |
SE9802938D0 (sv) | 1998-09-01 | 1998-09-01 | Astra Ab | Improved stability for injection solutions |
WO2000031078A1 (fr) * | 1998-11-20 | 2000-06-02 | Banyu Pharmaceutical Co., Ltd. | Derives de 1-acetylazetidine |
SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
WO2000042059A1 (en) * | 1999-01-13 | 2000-07-20 | Astrazeneca Ab | New amidinobenzylamine derivatives and their use as thrombin inhibitors |
AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
US6433186B1 (en) * | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
SI1311480T1 (sl) * | 2000-08-16 | 2008-12-31 | Astrazeneca Ab | Novi amidino derivati in njihova uporaba kot trombinski inhibitorji |
US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
SE0102921D0 (sv) * | 2001-08-30 | 2001-08-30 | Astrazeneca Ab | Pharmaceutically useful compounds |
US6528503B2 (en) * | 2000-12-18 | 2003-03-04 | Merck & Co., Inc. | Thrombin inhibitors |
WO2002064559A2 (en) * | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
SE0101762D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | New use |
AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
UA78195C2 (uk) * | 2001-08-30 | 2007-03-15 | Astrazeneca Ab | Похідні мигдалевої кислоти та їх застосування як інгібіторів тромбіну, фармацевтична композиція на їх основі |
SE0201658D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Immediate release pharmaceutical formulation |
SE0201661D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
SE0201659D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU178398B (en) * | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
CA1341029C (en) * | 1985-02-04 | 2000-06-20 | Michael Kolb | Peptidase inhibitors |
US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
EP0362002B1 (en) * | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
ZA897515B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
TW201303B (ko) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
SE9102462D0 (sv) * | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
NZ245039A (en) * | 1991-11-12 | 1994-12-22 | Lilly Co Eli | N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions |
SE9103612D0 (sv) * | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
US5760235A (en) * | 1992-03-04 | 1998-06-02 | Gyogyszerkutato Intezet Kft. | Anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for preparation thereof |
TW223629B (ko) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
US5519193A (en) | 1992-10-27 | 1996-05-21 | International Business Machines Corporation | Method and apparatus for stressing, burning in and reducing leakage current of electronic devices using microwave radiation |
AU675981B2 (en) * | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5780631A (en) * | 1993-06-03 | 1998-07-14 | Astra Aktiebolag | Starting materials in the synthesis of thrombin and kininogenase inhibitors |
DE4321444A1 (de) * | 1993-06-28 | 1995-01-05 | Bernd Prof Dr Clement | Pharmazeutische Zubereitung |
EP0648780A1 (en) * | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
TW394760B (en) * | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
AU1025795A (en) * | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5561146A (en) * | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
US5510369A (en) * | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
SK65197A3 (en) * | 1994-11-24 | 1997-12-10 | Janssen Pharmaceutica Nv | Lubeluzole intravenous solutions |
EA199700186A1 (ru) * | 1995-02-17 | 1998-02-26 | Басф Акциенгезельшафт | Новые дипептидные амидины, используемые в качестве ингибиторов тромбина |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
US5629324A (en) | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
SE9602263D0 (sv) * | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
-
1996
- 1996-06-22 SA SA96170106A patent/SA96170106A/ar unknown
- 1996-06-24 AR ARP960103292A patent/AR003440A1/es active IP Right Grant
- 1996-07-02 AU AU63253/96A patent/AU709710B2/en not_active Ceased
- 1996-07-02 US US08/687,466 patent/US6051568A/en not_active Expired - Fee Related
- 1996-07-02 SI SI9630615T patent/SI0836615T1/xx unknown
- 1996-07-02 SK SK1804-97A patent/SK284695B6/sk not_active IP Right Cessation
- 1996-07-02 KR KR10-1998-0700054A patent/KR100435008B1/ko not_active IP Right Cessation
- 1996-07-02 RU RU98102188/04A patent/RU2176645C2/ru not_active IP Right Cessation
- 1996-07-02 ES ES96922355T patent/ES2197240T3/es not_active Expired - Lifetime
- 1996-07-02 MX MX9800146A patent/MX9800146A/es active IP Right Grant
- 1996-07-02 EP EP96922355A patent/EP0836615B1/en not_active Expired - Lifetime
- 1996-07-02 JP JP50507197A patent/JP4107682B2/ja not_active Expired - Fee Related
- 1996-07-02 CZ CZ0421297A patent/CZ298487B6/cs not_active IP Right Cessation
- 1996-07-02 HU HU9802315A patent/HUP9802315A3/hu unknown
- 1996-07-02 TR TR1998/00009T patent/TR199800009T1/xx unknown
- 1996-07-02 EE EE9700354A patent/EE04500B1/xx not_active IP Right Cessation
- 1996-07-02 PL PL96324483A patent/PL185606B1/pl not_active IP Right Cessation
- 1996-07-02 IL IL12281396A patent/IL122813A0/xx unknown
- 1996-07-02 WO PCT/SE1996/000878 patent/WO1997002284A1/en active IP Right Grant
- 1996-07-02 DK DK96922355T patent/DK0836615T3/da active
- 1996-07-02 CA CA002226256A patent/CA2226256C/en not_active Expired - Fee Related
- 1996-07-02 NZ NZ311854A patent/NZ311854A/en not_active IP Right Cessation
- 1996-07-02 AT AT96922355T patent/ATE238342T1/de not_active IP Right Cessation
- 1996-07-02 CN CNB961967811A patent/CN1147504C/zh not_active Expired - Fee Related
- 1996-07-02 PT PT96922355T patent/PT836615E/pt unknown
- 1996-07-02 NZ NZ509474A patent/NZ509474A/en not_active IP Right Cessation
- 1996-07-02 DE DE69627659T patent/DE69627659T2/de not_active Expired - Fee Related
- 1996-07-02 BR BR9609447A patent/BR9609447A/pt not_active Application Discontinuation
- 1996-07-05 MY MYPI96002787A patent/MY116539A/en unknown
-
1997
- 1997-12-22 IS IS4639A patent/IS2081B/is unknown
-
1998
- 1998-01-02 NO NO19980015A patent/NO324092B1/no not_active IP Right Cessation
- 1998-08-07 HK HK98109754A patent/HK1008995A1/xx not_active IP Right Cessation
-
2000
- 2000-03-29 US US09/537,344 patent/US6337343B1/en not_active Expired - Fee Related
-
2001
- 2001-11-29 US US09/995,564 patent/US6617320B2/en not_active Expired - Fee Related
-
2003
- 2003-06-26 US US10/606,349 patent/US6921758B2/en not_active Expired - Fee Related
Also Published As
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Legal Events
Date | Code | Title | Description |
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HC1A | Change of owner name | ||
KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
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MM4A | Lapsed by not paying the annual fees |
Effective date: 20100702 |