EE04189B1 - Asendatud 6-fenüülfenantridiinid - Google Patents
Asendatud 6-fenüülfenantridiinidInfo
- Publication number
- EE04189B1 EE04189B1 EEP200000032A EEP200000032A EE04189B1 EE 04189 B1 EE04189 B1 EE 04189B1 EE P200000032 A EEP200000032 A EE P200000032A EE P200000032 A EEP200000032 A EE P200000032A EE 04189 B1 EE04189 B1 EE 04189B1
- Authority
- EE
- Estonia
- Prior art keywords
- pct
- compounds
- phenylphenanthridines
- substituted
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97112793 | 1997-07-25 | ||
| PCT/EP1998/004478 WO1999005113A1 (en) | 1997-07-25 | 1998-07-18 | Substituted 6-phenylphenanthridines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200000032A EE200000032A (et) | 2000-10-16 |
| EE04189B1 true EE04189B1 (et) | 2003-12-15 |
Family
ID=8227117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000032A EE04189B1 (et) | 1997-07-25 | 1998-07-18 | Asendatud 6-fenüülfenantridiinid |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6121279A (cs) |
| EP (1) | EP1000035B1 (cs) |
| JP (1) | JP2001510827A (cs) |
| AT (1) | ATE228507T1 (cs) |
| AU (1) | AU756349B2 (cs) |
| CA (1) | CA2297911C (cs) |
| CZ (1) | CZ296064B6 (cs) |
| DE (1) | DE69809754T2 (cs) |
| DK (1) | DK1000035T3 (cs) |
| EE (1) | EE04189B1 (cs) |
| ES (1) | ES2189235T3 (cs) |
| HU (1) | HUP0003311A3 (cs) |
| IL (1) | IL133825A (cs) |
| PL (1) | PL191094B1 (cs) |
| PT (1) | PT1000035E (cs) |
| WO (1) | WO1999005113A1 (cs) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2254132T3 (es) * | 1999-01-15 | 2006-06-16 | Altana Pharma Ag | Fenilfenantridinas con actividad inhibidora de pde-iv. |
| PT1147088E (pt) | 1999-01-15 | 2006-05-31 | Altana Pharma Ag | 6-arilfenantridinas com actividade inibitoria da pde-iv |
| WO2000042017A1 (en) * | 1999-01-15 | 2000-07-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides with pde-iv inhibiting activity |
| JP2002534506A (ja) | 1999-01-15 | 2002-10-15 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | Ｐｄｅ−ｉｖ抑制作用を有する多重に置換された６−フェニルフェナントリジン |
| US6495550B2 (en) * | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| DE60037321D1 (de) | 1999-08-04 | 2008-01-17 | Icagen Inc | Benzanilide als öffner des kaliumkanals |
| NZ517166A (en) | 1999-08-21 | 2004-01-30 | Altana Pharma Ag | Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonists |
| AU782908B2 (en) * | 2000-01-11 | 2005-09-08 | Altana Pharma Ag | Phenanthridine-N-oxides |
| DK1303506T3 (da) | 2000-07-14 | 2005-05-30 | Altana Pharma Ag | 6-heteroarylphenanthridiner |
| WO2002005616A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Novel 6-phenylphenanthridines |
| WO2003053923A2 (en) * | 2001-12-20 | 2003-07-03 | Applied Research Systems Ars Holding N.V. | Pyrrolidine derivatives as prostaglandin modulators |
| US20060116518A1 (en) * | 2002-08-17 | 2006-06-01 | Altana Pharma Ag | Novel phenanthridines |
| CA2495827C (en) * | 2002-08-29 | 2012-05-08 | Altana Pharma Ag | 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| ATE353217T1 (de) * | 2002-08-29 | 2007-02-15 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren |
| US6894061B2 (en) * | 2002-12-04 | 2005-05-17 | Wyeth | Substituted dihydrophenanthridinesulfonamides |
| EP1624893A2 (en) | 2003-04-01 | 2006-02-15 | Applied Research Systems ARS Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| EP1658270A1 (en) * | 2003-07-31 | 2006-05-24 | ALTANA Pharma AG | Novel 6-phenylphenantridines |
| WO2005012253A1 (en) * | 2003-07-31 | 2005-02-10 | Altana Pharma Ag | Novel 6-phenylphenanthridines |
| JP4728259B2 (ja) * | 2004-02-18 | 2011-07-20 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン |
| PT2589599E (pt) | 2004-03-03 | 2014-09-02 | Takeda Gmbh | Novas hidroxi-6-heteroarilfenantridinas e sua utilização como inibidores de pde4 |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| KR20060124784A (ko) * | 2004-03-09 | 2006-12-05 | 알타나 파마 아게 | 신규한 이소아미도 치환된 히드록시-6-페닐페난트리딘 및ｐｄｅ４ 억제제로서의 이의 용도 |
| EP1725533A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel thio containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| BRPI0508471A8 (pt) * | 2004-03-10 | 2019-01-15 | Altana Pharma Ag | compostos de hidróxi-6-fenilfenantidinas substituídas por difluoroetóxi, composição farmacêutica e uso para a produção dos mesmos |
| NZ549254A (en) * | 2004-03-10 | 2010-06-25 | Nycomed Gmbh | Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
| EA015376B1 (ru) | 2005-03-02 | 2011-08-30 | Никомед Гмбх | СОЛИ ПРОИЗВОДНЫХ 6-ГЕТЕРОАРИЛ-(1,2,3,4,4a,10b)-ГЕКСАГИДРОФЕНАНТРИДИНА И ИХ ПРИМЕНЕНИЕ |
| EA200701813A1 (ru) * | 2005-03-09 | 2008-06-30 | Никомед Гмбх | Новые амидозамещенные 6-фенилфенантридины |
| EP2275096A3 (en) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenesis via modulation of the muscarinic receptors |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| JP5187616B2 (ja) | 2007-07-31 | 2013-04-24 | 住友化学株式会社 | β−ニトロスチレン化合物の製造方法 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4309545A (en) * | 1980-07-28 | 1982-01-05 | Pfizer Inc. | Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof |
| WO1997028131A1 (de) * | 1996-01-31 | 1997-08-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue phenanthridine |
| PT889886E (pt) * | 1996-03-26 | 2003-02-28 | Altana Pharma Ag | Novas fenantridinas substituidas na posicao 6 |
| GB9606425D0 (en) * | 1996-03-27 | 1996-06-05 | Binding Site Ltd | Improvements in and relating to the production of antibodies and test kits incorporating antibodies |
-
1998
- 1998-07-18 PT PT98943742T patent/PT1000035E/pt unknown
- 1998-07-18 DK DK98943742T patent/DK1000035T3/da active
- 1998-07-18 PL PL338452A patent/PL191094B1/pl not_active IP Right Cessation
- 1998-07-18 EP EP98943742A patent/EP1000035B1/en not_active Expired - Lifetime
- 1998-07-18 CZ CZ20000281A patent/CZ296064B6/cs not_active IP Right Cessation
- 1998-07-18 ES ES98943742T patent/ES2189235T3/es not_active Expired - Lifetime
- 1998-07-18 AU AU91546/98A patent/AU756349B2/en not_active Ceased
- 1998-07-18 HU HU0003311A patent/HUP0003311A3/hu unknown
- 1998-07-18 AT AT98943742T patent/ATE228507T1/de not_active IP Right Cessation
- 1998-07-18 EE EEP200000032A patent/EE04189B1/xx not_active IP Right Cessation
- 1998-07-18 DE DE69809754T patent/DE69809754T2/de not_active Expired - Fee Related
- 1998-07-18 US US09/462,508 patent/US6121279A/en not_active Expired - Fee Related
- 1998-07-18 JP JP2000504112A patent/JP2001510827A/ja not_active Withdrawn
- 1998-07-18 CA CA002297911A patent/CA2297911C/en not_active Expired - Fee Related
- 1998-07-18 IL IL13382598A patent/IL133825A/en not_active IP Right Cessation
- 1998-07-18 WO PCT/EP1998/004478 patent/WO1999005113A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2189235T3 (es) | 2003-07-01 |
| JP2001510827A (ja) | 2001-08-07 |
| PL191094B1 (pl) | 2006-03-31 |
| DE69809754T2 (de) | 2003-09-18 |
| PL338452A1 (en) | 2000-11-06 |
| CZ296064B6 (cs) | 2006-01-11 |
| HUP0003311A3 (en) | 2002-10-28 |
| IL133825A (en) | 2005-12-18 |
| CA2297911A1 (en) | 1999-02-04 |
| EE200000032A (et) | 2000-10-16 |
| PT1000035E (pt) | 2003-04-30 |
| ATE228507T1 (de) | 2002-12-15 |
| IL133825A0 (en) | 2001-04-30 |
| AU9154698A (en) | 1999-02-16 |
| EP1000035B1 (en) | 2002-11-27 |
| WO1999005113A1 (en) | 1999-02-04 |
| US6121279A (en) | 2000-09-19 |
| CZ2000281A3 (cs) | 2000-08-16 |
| DE69809754D1 (en) | 2003-01-09 |
| CA2297911C (en) | 2007-09-04 |
| EP1000035A1 (en) | 2000-05-17 |
| DK1000035T3 (da) | 2003-03-17 |
| AU756349B2 (en) | 2003-01-09 |
| HUP0003311A2 (en) | 2001-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20090718 |