EE200000032A - Asendatud 6-fenüülfenantridiinid - Google Patents
Asendatud 6-fenüülfenantridiinidInfo
- Publication number
- EE200000032A EE200000032A EEP200000032A EEP200000032A EE200000032A EE 200000032 A EE200000032 A EE 200000032A EE P200000032 A EEP200000032 A EE P200000032A EE P200000032 A EEP200000032 A EE P200000032A EE 200000032 A EE200000032 A EE 200000032A
- Authority
- EE
- Estonia
- Prior art keywords
- pct
- compounds
- phenylphenanthridines
- substituted
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97112793 | 1997-07-25 | ||
PCT/EP1998/004478 WO1999005113A1 (en) | 1997-07-25 | 1998-07-18 | Substituted 6-phenylphenanthridines |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200000032A true EE200000032A (et) | 2000-10-16 |
EE04189B1 EE04189B1 (et) | 2003-12-15 |
Family
ID=8227117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200000032A EE04189B1 (et) | 1997-07-25 | 1998-07-18 | Asendatud 6-fenüülfenantridiinid |
Country Status (16)
Country | Link |
---|---|
US (1) | US6121279A (et) |
EP (1) | EP1000035B1 (et) |
JP (1) | JP2001510827A (et) |
AT (1) | ATE228507T1 (et) |
AU (1) | AU756349B2 (et) |
CA (1) | CA2297911C (et) |
CZ (1) | CZ296064B6 (et) |
DE (1) | DE69809754T2 (et) |
DK (1) | DK1000035T3 (et) |
EE (1) | EE04189B1 (et) |
ES (1) | ES2189235T3 (et) |
HU (1) | HUP0003311A3 (et) |
IL (1) | IL133825A (et) |
PL (1) | PL191094B1 (et) |
PT (1) | PT1000035E (et) |
WO (1) | WO1999005113A1 (et) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1147089B1 (en) | 1999-01-15 | 2005-12-07 | ALTANA Pharma AG | Phenylphenanthridines with pde-iv inhibiting activity |
PT1147088E (pt) | 1999-01-15 | 2006-05-31 | Altana Pharma Ag | 6-arilfenantridinas com actividade inibitoria da pde-iv |
EP1147087B1 (en) * | 1999-01-15 | 2005-05-11 | ALTANA Pharma AG | Phenanthridine-n-oxides with pde-iv inhibiting activity |
WO2000042018A1 (en) | 1999-01-15 | 2000-07-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity |
WO2001010380A2 (en) | 1999-08-04 | 2001-02-15 | Icagen, Inc. | Benzanilides as potassium channel openers |
US6495550B2 (en) * | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
AU777012B2 (en) | 1999-08-21 | 2004-09-30 | Takeda Gmbh | Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist |
WO2001051470A1 (en) * | 2000-01-11 | 2001-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides |
CA2415935A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Novel 6-heteroarylphenanthridines |
AU2001281965A1 (en) * | 2000-07-14 | 2002-01-30 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Novel 6-phenylphenanthridines |
US7335680B2 (en) * | 2001-12-20 | 2008-02-26 | Laboratoires Serono Sa | Pyrrolidine derivatives as prostaglandin modulators |
CA2495597A1 (en) * | 2002-08-17 | 2004-03-04 | Altana Pharma Ag | Novel phenanthridines |
EP1539164B1 (en) * | 2002-08-29 | 2006-12-20 | ALTANA Pharma AG | 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
DE60311662T2 (de) * | 2002-08-29 | 2007-10-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren |
US6894061B2 (en) * | 2002-12-04 | 2005-05-17 | Wyeth | Substituted dihydrophenanthridinesulfonamides |
JP2007500685A (ja) * | 2003-07-31 | 2007-01-18 | アルタナ ファルマ アクチエンゲゼルシャフト | 新規の6−フェニルフェナントリジン |
CA2533636A1 (en) * | 2003-07-31 | 2005-02-10 | Altana Pharma Ag | Novel 6-phenylphenanthridines |
EP1720835B1 (en) * | 2004-02-18 | 2012-12-12 | Nycomed GmbH | Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors |
AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
SG182194A1 (en) | 2004-03-03 | 2012-07-30 | Nycomed Gmbh | Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors |
EP1745025A2 (en) * | 2004-03-09 | 2007-01-24 | Altana Pharma AG | Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
BRPI0508481A (pt) * | 2004-03-10 | 2007-07-31 | Altana Pharma Ag | hidróxi-6-fenilenantridinas amido-substituìdas e seu uso como inibidores de pde4 |
CA2558532A1 (en) * | 2004-03-10 | 2005-09-15 | Altana Pharma Ag | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
AU2005221831A1 (en) * | 2004-03-10 | 2005-09-22 | Nycomed Gmbh | Novel thio-containing hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
NZ589278A (en) | 2005-03-02 | 2012-04-27 | Nycomed Gmbh | Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives |
US20080214536A1 (en) * | 2005-03-09 | 2008-09-04 | Nycomed Gmbh | Amido-Substituted 6-Phenylphenanthridines |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249435A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
KR20090064418A (ko) | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
JP5187616B2 (ja) | 2007-07-31 | 2013-04-24 | 住友化学株式会社 | β−ニトロスチレン化合物の製造方法 |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4309545A (en) * | 1980-07-28 | 1982-01-05 | Pfizer Inc. | Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof |
EP0882021B1 (de) * | 1996-01-31 | 2003-03-05 | ALTANA Pharma AG | Neue phenanthridine |
DE59708265D1 (de) * | 1996-03-26 | 2002-10-24 | Altana Pharma Ag | Neue in 6-position substituierte phenanthridine |
GB9606425D0 (en) * | 1996-03-27 | 1996-06-05 | Binding Site Ltd | Improvements in and relating to the production of antibodies and test kits incorporating antibodies |
-
1998
- 1998-07-18 DK DK98943742T patent/DK1000035T3/da active
- 1998-07-18 WO PCT/EP1998/004478 patent/WO1999005113A1/en active IP Right Grant
- 1998-07-18 DE DE69809754T patent/DE69809754T2/de not_active Expired - Fee Related
- 1998-07-18 CZ CZ20000281A patent/CZ296064B6/cs not_active IP Right Cessation
- 1998-07-18 AT AT98943742T patent/ATE228507T1/de not_active IP Right Cessation
- 1998-07-18 JP JP2000504112A patent/JP2001510827A/ja not_active Withdrawn
- 1998-07-18 IL IL13382598A patent/IL133825A/en not_active IP Right Cessation
- 1998-07-18 PL PL338452A patent/PL191094B1/pl not_active IP Right Cessation
- 1998-07-18 AU AU91546/98A patent/AU756349B2/en not_active Ceased
- 1998-07-18 ES ES98943742T patent/ES2189235T3/es not_active Expired - Lifetime
- 1998-07-18 CA CA002297911A patent/CA2297911C/en not_active Expired - Fee Related
- 1998-07-18 HU HU0003311A patent/HUP0003311A3/hu unknown
- 1998-07-18 PT PT98943742T patent/PT1000035E/pt unknown
- 1998-07-18 US US09/462,508 patent/US6121279A/en not_active Expired - Fee Related
- 1998-07-18 EP EP98943742A patent/EP1000035B1/en not_active Expired - Lifetime
- 1998-07-18 EE EEP200000032A patent/EE04189B1/et not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL133825A0 (en) | 2001-04-30 |
PL338452A1 (en) | 2000-11-06 |
AU756349B2 (en) | 2003-01-09 |
AU9154698A (en) | 1999-02-16 |
CZ2000281A3 (cs) | 2000-08-16 |
HUP0003311A2 (en) | 2001-03-28 |
EP1000035A1 (en) | 2000-05-17 |
CZ296064B6 (cs) | 2006-01-11 |
HUP0003311A3 (en) | 2002-10-28 |
DK1000035T3 (da) | 2003-03-17 |
EP1000035B1 (en) | 2002-11-27 |
CA2297911A1 (en) | 1999-02-04 |
JP2001510827A (ja) | 2001-08-07 |
IL133825A (en) | 2005-12-18 |
PT1000035E (pt) | 2003-04-30 |
DE69809754T2 (de) | 2003-09-18 |
EE04189B1 (et) | 2003-12-15 |
PL191094B1 (pl) | 2006-03-31 |
ES2189235T3 (es) | 2003-07-01 |
CA2297911C (en) | 2007-09-04 |
US6121279A (en) | 2000-09-19 |
DE69809754D1 (en) | 2003-01-09 |
ATE228507T1 (de) | 2002-12-15 |
WO1999005113A1 (en) | 1999-02-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
MM4A | Lapsed by not paying the annual fees |
Effective date: 20090718 |