EE04017B1 - Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena - Google Patents

Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena

Info

Publication number
EE04017B1
EE04017B1 EE9800225A EE9800225A EE04017B1 EE 04017 B1 EE04017 B1 EE 04017B1 EE 9800225 A EE9800225 A EE 9800225A EE 9800225 A EE9800225 A EE 9800225A EE 04017 B1 EE04017 B1 EE 04017B1
Authority
EE
Estonia
Prior art keywords
condensed
receptor inhibitors
ampa receptor
benzodiazepine derivatives
hydrogen
Prior art date
Application number
EE9800225A
Other languages
English (en)
Other versions
EE9800225A (et
Inventor
Csuzdi Ernese
H�mori Tam�s
�brah�m Gizella
S�lyom S�ndor
Tarnawa Istv�n
Berzsenyi P�l
Andr�si Ferenc
Ling Istv�N
Simay Antal
G�l Melinda
Horv�th Katalin
Szentkuti Eszter
Sz�llosy M�rta
Pallagi Istv�n
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7785064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE04017(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of EE9800225A publication Critical patent/EE9800225A/et
Publication of EE04017B1 publication Critical patent/EE04017B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EE9800225A 1996-02-01 1997-01-29 Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena EE04017B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19604919A DE19604919A1 (de) 1996-02-01 1996-02-01 Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
PCT/DE1997/000234 WO1997028163A1 (de) 1996-02-01 1997-01-29 Kondensierte 2,3-benzodiazepin derivate und deren verwendung als ampa-rezeptoren-hemmer

Publications (2)

Publication Number Publication Date
EE9800225A EE9800225A (et) 1998-12-15
EE04017B1 true EE04017B1 (et) 2003-04-15

Family

ID=7785064

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800225A EE04017B1 (et) 1996-02-01 1997-01-29 Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena

Country Status (31)

Country Link
US (2) US6323197B1 (et)
EP (1) EP0888356B1 (et)
JP (1) JP4141499B2 (et)
KR (1) KR100465269B1 (et)
CN (1) CN1096464C (et)
AT (1) ATE214703T1 (et)
AU (1) AU724956B2 (et)
BG (1) BG63394B1 (et)
BR (1) BR9707335A (et)
CA (1) CA2245539C (et)
CZ (1) CZ289658B6 (et)
DE (2) DE19604919A1 (et)
DK (1) DK0888356T3 (et)
EE (1) EE04017B1 (et)
ES (1) ES2173435T3 (et)
HK (1) HK1018782A1 (et)
HU (1) HU224636B1 (et)
IL (1) IL125480A (et)
IS (1) IS2103B (et)
MY (1) MY119140A (et)
NO (1) NO983510L (et)
NZ (1) NZ331187A (et)
PL (1) PL187128B1 (et)
PT (1) PT888356E (et)
RU (1) RU2179557C2 (et)
SK (1) SK283563B6 (et)
TR (1) TR199801485T2 (et)
TW (1) TW438801B (et)
UA (1) UA56157C2 (et)
WO (1) WO1997028163A1 (et)
ZA (1) ZA97848B (et)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9701325A1 (hu) * 1997-07-31 2000-08-28 Gyógyszerkutató Intézet Kft. Új 2,3-benzodiazepin-származékok
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
JP2002519373A (ja) * 1998-07-02 2002-07-02 エーザイ株式会社 製薬組成物及びそれらの使用
WO2001098280A2 (en) * 2000-06-16 2001-12-27 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
DE10041671C1 (de) 2000-08-10 2002-06-13 Schering Ag Verfahren zur Herstellung von Imidazo[1,2-c][2,3]benzodiazepinen sowie Phenylessigsäureester und Oxazol-Derivate als Zwischenprodukte bei deren Herstellung
WO2005113434A1 (en) * 2004-03-25 2005-12-01 William Marsh Rice University Functionalization of carbon nanotubes in acidic media
US20060166969A1 (en) * 2005-01-14 2006-07-27 Turski Lechoslaw A AMPA antagonists for the treatment of dizziness, including vertigo and Meniere's disorder
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891871A (en) 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives

Also Published As

Publication number Publication date
ZA97848B (en) 1997-08-04
CN1096464C (zh) 2002-12-18
CZ289658B6 (cs) 2002-03-13
AU2502997A (en) 1997-08-22
BR9707335A (pt) 1999-07-20
US6600036B2 (en) 2003-07-29
HUP9901417A2 (hu) 1999-08-30
HU224636B1 (hu) 2005-12-28
CZ242798A3 (cs) 1999-01-13
US20020052364A1 (en) 2002-05-02
PL187128B1 (pl) 2004-05-31
BG63394B1 (bg) 2001-12-29
EP0888356A1 (de) 1999-01-07
DK0888356T3 (da) 2002-06-03
MY119140A (en) 2005-04-30
NO983510D0 (no) 1998-07-30
US6323197B1 (en) 2001-11-27
HK1018782A1 (en) 2000-01-07
ATE214703T1 (de) 2002-04-15
EE9800225A (et) 1998-12-15
BG102658A (en) 1999-06-30
DE59706686D1 (de) 2002-04-25
CA2245539C (en) 2005-10-04
PT888356E (pt) 2002-09-30
KR100465269B1 (ko) 2005-04-14
RU2179557C2 (ru) 2002-02-20
PL328224A1 (en) 1999-01-18
CN1210538A (zh) 1999-03-10
AU724956B2 (en) 2000-10-05
EP0888356B1 (de) 2002-03-20
IS2103B (is) 2006-05-15
KR19990082192A (ko) 1999-11-25
WO1997028163A1 (de) 1997-08-07
IS4794A (is) 1998-07-06
HUP9901417A3 (en) 2001-11-28
IL125480A (en) 2002-07-25
SK103398A3 (en) 1999-01-11
DE19604919A1 (de) 1997-08-07
TW438801B (en) 2001-06-07
NO983510L (no) 1998-09-30
UA56157C2 (uk) 2003-05-15
JP4141499B2 (ja) 2008-08-27
ES2173435T3 (es) 2002-10-16
JP2000503997A (ja) 2000-04-04
CA2245539A1 (en) 1997-08-07
IL125480A0 (en) 1999-03-12
SK283563B6 (sk) 2003-09-11
NZ331187A (en) 2000-01-28
TR199801485T2 (xx) 1998-10-21

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