EE04017B1 - Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena - Google Patents

Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena

Info

Publication number
EE04017B1
EE04017B1 EE9800225A EE9800225A EE04017B1 EE 04017 B1 EE04017 B1 EE 04017B1 EE 9800225 A EE9800225 A EE 9800225A EE 9800225 A EE9800225 A EE 9800225A EE 04017 B1 EE04017 B1 EE 04017B1
Authority
EE
Estonia
Prior art keywords
condensed
receptor inhibitors
ampa receptor
benzodiazepine derivatives
hydrogen
Prior art date
Application number
EE9800225A
Other languages
English (en)
Other versions
EE9800225A (et
Inventor
Csuzdi Ernese
H�mori Tam�s
�brah�m Gizella
S�lyom S�ndor
Tarnawa Istv�n
Berzsenyi P�l
Andr�si Ferenc
Ling Istv�N
Simay Antal
G�l Melinda
Horv�th Katalin
Szentkuti Eszter
Sz�llosy M�rta
Pallagi Istv�n
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7785064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE04017(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of EE9800225A publication Critical patent/EE9800225A/et
Publication of EE04017B1 publication Critical patent/EE04017B1/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EE9800225A 1996-02-01 1997-01-29 Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena EE04017B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19604919A DE19604919A1 (de) 1996-02-01 1996-02-01 Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
PCT/DE1997/000234 WO1997028163A1 (de) 1996-02-01 1997-01-29 Kondensierte 2,3-benzodiazepin derivate und deren verwendung als ampa-rezeptoren-hemmer

Publications (2)

Publication Number Publication Date
EE9800225A EE9800225A (et) 1998-12-15
EE04017B1 true EE04017B1 (et) 2003-04-15

Family

ID=7785064

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800225A EE04017B1 (et) 1996-02-01 1997-01-29 Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena

Country Status (31)

Country Link
US (2) US6323197B1 (et)
EP (1) EP0888356B1 (et)
JP (1) JP4141499B2 (et)
KR (1) KR100465269B1 (et)
CN (1) CN1096464C (et)
AT (1) ATE214703T1 (et)
AU (1) AU724956B2 (et)
BG (1) BG63394B1 (et)
BR (1) BR9707335A (et)
CA (1) CA2245539C (et)
CZ (1) CZ289658B6 (et)
DE (2) DE19604919A1 (et)
DK (1) DK0888356T3 (et)
EE (1) EE04017B1 (et)
ES (1) ES2173435T3 (et)
HK (1) HK1018782A1 (et)
HU (1) HU224636B1 (et)
IL (1) IL125480A (et)
IS (1) IS2103B (et)
MY (1) MY119140A (et)
NO (1) NO983510L (et)
NZ (1) NZ331187A (et)
PL (1) PL187128B1 (et)
PT (1) PT888356E (et)
RU (1) RU2179557C2 (et)
SK (1) SK283563B6 (et)
TR (1) TR199801485T2 (et)
TW (1) TW438801B (et)
UA (1) UA56157C2 (et)
WO (1) WO1997028163A1 (et)
ZA (1) ZA97848B (et)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9701325A1 (hu) 1997-07-31 2000-08-28 Gyógyszerkutató Intézet Kft. Új 2,3-benzodiazepin-származékok
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
WO2000001376A2 (en) * 1998-07-02 2000-01-13 Eisai Co., Ltd Pharmaceutical compositions and their uses for treatment of demyelinating disorders
WO2001098280A2 (en) * 2000-06-16 2001-12-27 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
DE10041671C1 (de) * 2000-08-10 2002-06-13 Schering Ag Verfahren zur Herstellung von Imidazo[1,2-c][2,3]benzodiazepinen sowie Phenylessigsäureester und Oxazol-Derivate als Zwischenprodukte bei deren Herstellung
US20070280876A1 (en) * 2004-03-25 2007-12-06 William Marsh Rice University Functionalization of Carbon Nanotubes in Acidic Media
US20060166969A1 (en) * 2005-01-14 2006-07-27 Turski Lechoslaw A AMPA antagonists for the treatment of dizziness, including vertigo and Meniere's disorder
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891871A (en) 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives

Also Published As

Publication number Publication date
CZ289658B6 (cs) 2002-03-13
JP2000503997A (ja) 2000-04-04
RU2179557C2 (ru) 2002-02-20
TW438801B (en) 2001-06-07
BG63394B1 (bg) 2001-12-29
EP0888356A1 (de) 1999-01-07
HU224636B1 (hu) 2005-12-28
PL187128B1 (pl) 2004-05-31
BG102658A (en) 1999-06-30
DE19604919A1 (de) 1997-08-07
EE9800225A (et) 1998-12-15
DK0888356T3 (da) 2002-06-03
WO1997028163A1 (de) 1997-08-07
DE59706686D1 (de) 2002-04-25
ES2173435T3 (es) 2002-10-16
PT888356E (pt) 2002-09-30
ATE214703T1 (de) 2002-04-15
NO983510L (no) 1998-09-30
ZA97848B (en) 1997-08-04
US20020052364A1 (en) 2002-05-02
AU724956B2 (en) 2000-10-05
IS2103B (is) 2006-05-15
US6323197B1 (en) 2001-11-27
MY119140A (en) 2005-04-30
KR100465269B1 (ko) 2005-04-14
EP0888356B1 (de) 2002-03-20
CA2245539C (en) 2005-10-04
HK1018782A1 (en) 2000-01-07
IS4794A (is) 1998-07-06
US6600036B2 (en) 2003-07-29
HUP9901417A2 (hu) 1999-08-30
SK103398A3 (en) 1999-01-11
BR9707335A (pt) 1999-07-20
IL125480A (en) 2002-07-25
JP4141499B2 (ja) 2008-08-27
PL328224A1 (en) 1999-01-18
CN1210538A (zh) 1999-03-10
AU2502997A (en) 1997-08-22
NO983510D0 (no) 1998-07-30
IL125480A0 (en) 1999-03-12
HUP9901417A3 (en) 2001-11-28
CZ242798A3 (cs) 1999-01-13
UA56157C2 (uk) 2003-05-15
CA2245539A1 (en) 1997-08-07
CN1096464C (zh) 2002-12-18
KR19990082192A (ko) 1999-11-25
SK283563B6 (sk) 2003-09-11
TR199801485T2 (xx) 1998-10-21
NZ331187A (en) 2000-01-28

Similar Documents

Publication Publication Date Title
HUP0105414A2 (hu) Pirrolo-izokinolin-, azepino- és diazepino-indol-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
HUP0202757A2 (hu) Metabotróp glutamát receptor antagonista heteropoliciklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és a vegyületek alkalmazása
DE69328975D1 (de) Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
DE69719350D1 (de) 2-pyrimidinamin derivaten und verfahrens zu deren herstellung
ES2111650T3 (es) Derivados aciclicos de etilenodiamina como antagonistas de receptores de la sustancia p.
BG105596A (en) Substituted benzimidazoles and their use as parp inhibitors
ES2170252T3 (es) Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
BR9206500A (pt) Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P
FI970150A (fi) Substituoituja pyrimidiiniyhdisteitä ja niiden käyttö
DK0625977T3 (da) Piperazinderivater som 5-1A-antagonister
MX9806171A (es) Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa.
SE9702564D0 (sv) New compounds
HUP0002272A2 (hu) Piperazinszármazékok, eljárás előállításukra, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
ES2101858T3 (es) Derivados de geneserina como inhibidores de colinesterasa.
EE04017B1 (et) Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena
HUP0004142A2 (hu) 5-HT1F agonista hatású karboxamidszármazékok és a vegyületeket tartalmazó gyógyászati készítmények
ID23954A (id) Tetrahidrogama-karbolin
BR0010693A (pt) Derivados azaindol para tratamento de depressão
BG105710A (en) 5ht1 antagonists for antidepressant therapy
FR2767527B1 (fr) Derives de piperazines indoliques, utiles comme medicaments et procede de preparation
DE502004007387D1 (de) Triazolverbindungen und ihre therapeutische verwendung
ES2173167T3 (es) Derivados de benzodiazepina.
AR021094A1 (es) Compuestos heterociclicos inhibidores de la fosfodiesterasa iv y su uso para el tratamiento de enfermedades inflamatorias

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090129