EE03972B1 - Klopidogreelvesiniksulfaadi polümorfne vorm - Google Patents

Klopidogreelvesiniksulfaadi polümorfne vorm

Info

Publication number
EE03972B1
EE03972B1 EEP200000745A EEP200000745A EE03972B1 EE 03972 B1 EE03972 B1 EE 03972B1 EE P200000745 A EEP200000745 A EE P200000745A EE P200000745 A EEP200000745 A EE P200000745A EE 03972 B1 EE03972 B1 EE 03972B1
Authority
EE
Estonia
Prior art keywords
hydrogen sulfate
polymorphic form
clopidogrel hydrogen
clopidogrel
polymorphic
Prior art date
Application number
EEP200000745A
Other languages
English (en)
Estonian (et)
Inventor
Bousquet Andr�
Castro Bertrand
Saint-Germain Jean
Original Assignee
Sanofi-Synthlabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9527349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03972(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi-Synthlabo filed Critical Sanofi-Synthlabo
Publication of EE200000745A publication Critical patent/EE200000745A/xx
Publication of EE03972B1 publication Critical patent/EE03972B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EEP200000745A 1998-06-15 1999-06-10 Klopidogreelvesiniksulfaadi polümorfne vorm EE03972B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9807464A FR2779726B1 (fr) 1998-06-15 1998-06-15 Forme polymorphe de l'hydrogenosulfate de clopidogrel
PCT/FR1999/001371 WO1999065915A1 (fr) 1998-06-15 1999-06-10 Forme polymorphe de l'hydrogenosulfate de clopidogrel

Publications (2)

Publication Number Publication Date
EE200000745A EE200000745A (et) 2002-04-15
EE03972B1 true EE03972B1 (et) 2003-02-17

Family

ID=9527349

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000745A EE03972B1 (et) 1998-06-15 1999-06-10 Klopidogreelvesiniksulfaadi polümorfne vorm

Country Status (44)

Country Link
US (2) US6429210B1 (cs)
EP (1) EP1087976B1 (cs)
JP (1) JP3641584B2 (cs)
KR (1) KR100511238B1 (cs)
CN (1) CN1128805C (cs)
AP (1) AP1344A (cs)
AR (1) AR014854A1 (cs)
AT (1) ATE222256T1 (cs)
AU (1) AU752170B2 (cs)
BG (1) BG64508B1 (cs)
BR (1) BR9911219A (cs)
CA (1) CA2334870C (cs)
CO (1) CO5040084A1 (cs)
CZ (1) CZ299654B6 (cs)
DE (1) DE69902536T2 (cs)
DK (1) DK1087976T3 (cs)
DZ (1) DZ2817A1 (cs)
EA (1) EA002386B1 (cs)
EE (1) EE03972B1 (cs)
EG (1) EG24015A (cs)
ES (1) ES2181439T3 (cs)
FR (1) FR2779726B1 (cs)
HK (1) HK1033829A1 (cs)
HR (1) HRP20000863B1 (cs)
HU (1) HU225871B1 (cs)
ID (1) ID28264A (cs)
IL (2) IL139790A0 (cs)
IS (1) IS2469B (cs)
ME (1) ME00686B (cs)
MY (1) MY129439A (cs)
NO (1) NO327161B1 (cs)
NZ (1) NZ507914A (cs)
OA (1) OA11567A (cs)
PL (1) PL201894B1 (cs)
PT (1) PT1087976E (cs)
RS (1) RS49870B (cs)
SA (1) SA99200321B1 (cs)
SK (1) SK286340B6 (cs)
TR (1) TR200003417T2 (cs)
TW (1) TW562805B (cs)
UA (1) UA70323C2 (cs)
UY (1) UY25693A1 (cs)
WO (1) WO1999065915A1 (cs)
ZA (1) ZA200006386B (cs)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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FR2792836B3 (fr) 1999-04-30 2001-07-27 Sanofi Sa Composition pharmaceutique sous forme unitaire contenant de l'aspirine et de l'hydrogenosulfate de clopidogrel
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US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
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WO2003101991A1 (en) * 2002-05-31 2003-12-11 Schering Corporation Xanthine phosphodiesterase v inhibitor polymorphs
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
US20040067995A1 (en) * 2002-10-02 2004-04-08 Wong Pancras C. Novel combination of a factor Xa inhibitor and clopidogrel
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WO2004081015A1 (en) * 2003-03-10 2004-09-23 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate
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WO2005003138A2 (en) 2003-07-02 2005-01-13 EGIS Gyógyszergyár Rt. Process for the preparation of amorphous form of a platelet aggregation inhibitor drug
KR101155679B1 (ko) * 2003-07-02 2012-06-13 에지스 지오기스제르기아르 니일바노산 무코도 레스즈베니타르사사그 혈소판 응집 억제제 약물의 결정성 다형체를 제조하는 방법
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DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
US8907090B2 (en) * 2003-11-03 2014-12-09 Cadila Healthcare Limited Processes for preparing different forms of (S)-(+)-Clopidogrel bisulfate
CA2457459A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
WO2005080890A1 (de) * 2004-02-24 2005-09-01 Siegfried Generics International Ag Pharmakologisch akzeptierbare salze von clopidogrel
US7629465B2 (en) * 2004-03-05 2009-12-08 Ipca Laboratories Ltd. Industrial process for preparation of Clopidogrel hydrogen sulphate
EP1732932B1 (en) * 2004-04-09 2012-03-21 Hanmi Holdings Co., Ltd. Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same
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CN101766573B (zh) 2010-02-05 2013-02-13 上海安必生制药技术有限公司 硫酸氢氯吡格雷固体制剂的制备工艺
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KR101324862B1 (ko) * 2011-07-12 2013-11-01 (주)에이에스텍 클로피도그렐 황산수소염의 구형 입자, 이를 포함하는 약학적 조성물 및 이의 제조방법
CN102367257B (zh) * 2011-11-21 2014-05-07 天津红日药业股份有限公司 氯吡格雷盐酸盐的单晶晶型，它们的制备及应用
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WO2015015062A1 (fr) 2013-08-02 2015-02-05 Sanofi Comprime pharmaceutique comprenant de l'acide acetylsalicylique et du clopidogrel
CN103524528A (zh) * 2013-09-16 2014-01-22 吉林省博大伟业制药有限公司 一种改进的ⅱ型硫酸氢氯吡格雷结晶制备方法
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN107698620A (zh) 2015-06-23 2018-02-16 江苏天士力帝益药业有限公司 一种氘代噻吩并哌啶衍生物、制备方法及其应用
MX2019009213A (es) 2017-01-23 2019-09-27 Dong Wha Pharm Co Ltd Formulación compleja que comprende inhibidor de la hmg-coa reductasa y clopidogrel.
CN107163060B (zh) * 2017-05-24 2021-03-02 常州制药厂有限公司 一种硫酸氢氯吡格雷晶型ii制备方法
CN107337683B (zh) * 2017-08-16 2019-08-16 中荣凯特（北京）生物科技有限公司 一种噻吩并吡啶类衍生物硫酸氢盐的晶型ⅱ及其制备方法和应用
CN109438467B (zh) * 2018-11-14 2021-03-26 四川青木制药有限公司 一种硫酸氢氯吡格雷ⅱ型球形结晶的制备方法
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Family Cites Families (2)

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FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
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Also Published As

Publication number Publication date
CN1305483A (zh) 2001-07-25
HUP0104343A3 (en) 2003-03-28
HUP0104343A2 (hu) 2002-03-28
AR014854A1 (es) 2001-04-11
AP2000001979A0 (en) 2000-12-31
FR2779726B1 (fr) 2001-05-18
CO5040084A1 (es) 2001-05-29
IS5716A (is) 2000-11-17
NO20006395D0 (no) 2000-12-14
EA002386B1 (ru) 2002-04-25
US6504030B1 (en) 2003-01-07
HRP20000863B1 (en) 2003-04-30
DE69902536T2 (de) 2003-03-13
TR200003417T2 (tr) 2001-03-21
HU225871B1 (en) 2007-11-28
NZ507914A (en) 2002-11-26
FR2779726A1 (fr) 1999-12-17
TW562805B (en) 2003-11-21
PL201894B1 (pl) 2009-05-29
ID28264A (id) 2001-05-10
BG64508B1 (bg) 2005-05-31
IL139790A0 (en) 2002-02-10
ME00686B (me) 2008-08-07
HRP20000863A2 (en) 2001-10-31
PL344998A1 (en) 2001-11-19
SK286340B6 (en) 2008-07-07
UY25693A1 (es) 2000-03-31
IL139790A (en) 2006-10-05
CA2334870A1 (en) 1999-12-23
EP1087976B1 (fr) 2002-08-14
DZ2817A1 (fr) 2004-06-02
AU4048399A (en) 2000-01-05
AU752170B2 (en) 2002-09-05
CN1128805C (zh) 2003-11-26
EG24015A (en) 2008-03-24
AP1344A (en) 2004-12-15
SK19092000A3 (sk) 2001-05-10
OA11567A (en) 2004-05-24
HK1033829A1 (en) 2001-09-28
ATE222256T1 (de) 2002-08-15
DK1087976T3 (da) 2002-12-02
KR20010052835A (ko) 2001-06-25
DE69902536D1 (en) 2002-09-19
EA200001187A1 (ru) 2001-08-27
EE200000745A (et) 2002-04-15
NO20006395L (no) 2001-02-15
NO327161B1 (no) 2009-05-04
BR9911219A (pt) 2001-03-06
WO1999065915A1 (fr) 1999-12-23
CZ20004637A3 (cs) 2001-04-11
KR100511238B1 (ko) 2005-08-31
PT1087976E (pt) 2002-11-29
JP2002518399A (ja) 2002-06-25
US20020198229A1 (en) 2002-12-26
ZA200006386B (en) 2001-05-07
CA2334870C (en) 2005-03-15
SA99200321B1 (ar) 2006-10-11
YU77700A (sh) 2003-04-30
JP3641584B2 (ja) 2005-04-20
ES2181439T3 (es) 2003-02-16
CZ299654B6 (cs) 2008-10-08
IS2469B (is) 2008-12-15
EP1087976A1 (fr) 2001-04-04
MY129439A (en) 2007-04-30
BG104987A (en) 2001-11-30
RS49870B (sr) 2008-08-07
US6429210B1 (en) 2002-08-06
UA70323C2 (uk) 2004-10-15

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