EE03772B1 - Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamine - Google Patents
Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamineInfo
- Publication number
- EE03772B1 EE03772B1 EE9700051A EE9700051A EE03772B1 EE 03772 B1 EE03772 B1 EE 03772B1 EE 9700051 A EE9700051 A EE 9700051A EE 9700051 A EE9700051 A EE 9700051A EE 03772 B1 EE03772 B1 EE 03772B1
- Authority
- EE
- Estonia
- Prior art keywords
- alkyl
- hydrogen
- amino
- alkoxy
- phenyl
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- 125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- -1 hydroxy, amino Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK105494 | 1994-09-14 | ||
| PCT/EP1995/003594 WO1996008495A1 (en) | 1994-09-14 | 1995-09-12 | Fused indole and quinoxaline derivatives, their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9700051A EE9700051A (et) | 1997-08-15 |
| EE03772B1 true EE03772B1 (et) | 2002-06-17 |
Family
ID=8100467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9700051A EE03772B1 (et) | 1994-09-14 | 1995-09-12 | Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamine |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5801174A (et) |
| EP (1) | EP0781285B1 (et) |
| JP (1) | JP3164372B2 (et) |
| AT (1) | ATE188701T1 (et) |
| AU (1) | AU686888B2 (et) |
| CA (1) | CA2199614C (et) |
| DE (1) | DE69514533T2 (et) |
| EE (1) | EE03772B1 (et) |
| FI (1) | FI112486B (et) |
| NO (1) | NO308851B1 (et) |
| NZ (1) | NZ293266A (et) |
| WO (1) | WO1996008495A1 (et) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
| FR2781482B1 (fr) * | 1998-07-27 | 2001-08-31 | Adir | Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2369746A1 (en) | 1999-05-19 | 2000-11-30 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
| CA2394292A1 (en) * | 2000-01-24 | 2001-08-02 | Neurosearch A/S | Isatine derivatives with neurotrophic activity |
| AU2006317545B2 (en) | 2005-11-23 | 2012-04-12 | Aros Pharma Aps | Compositions and methods for modulating gated ion channels |
| AU2006326540A1 (en) | 2005-12-14 | 2007-06-21 | Amgen Inc. | Diaza heterocyclic sulfonamide derivatives and their uses |
| CA2652307A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| WO2008144931A1 (en) * | 2007-05-30 | 2008-12-04 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| EP2839015B1 (en) | 2012-04-18 | 2020-04-29 | Ramot at Tel-Aviv University Ltd. | Lipidated glycosaminoglycan particles for the delivery of nucleic acids |
| WO2016114655A1 (en) * | 2015-01-12 | 2016-07-21 | Ry Pharma B.V. | Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation |
| WO2017065602A1 (en) * | 2015-10-13 | 2017-04-20 | Ry Pharma B.V. | Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9204914A (es) * | 1991-08-28 | 1993-07-01 | Frank Watjen | Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende. |
| ES2109516T3 (es) * | 1992-10-13 | 1998-01-16 | Warner Lambert Co | Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores. |
-
1995
- 1995-09-12 WO PCT/EP1995/003594 patent/WO1996008495A1/en active IP Right Grant
- 1995-09-12 AU AU35665/95A patent/AU686888B2/en not_active Ceased
- 1995-09-12 NZ NZ293266A patent/NZ293266A/en unknown
- 1995-09-12 EP EP95932730A patent/EP0781285B1/en not_active Expired - Lifetime
- 1995-09-12 EE EE9700051A patent/EE03772B1/et not_active IP Right Cessation
- 1995-09-12 DE DE69514533T patent/DE69514533T2/de not_active Expired - Lifetime
- 1995-09-12 JP JP50990896A patent/JP3164372B2/ja not_active Expired - Fee Related
- 1995-09-12 US US08/809,086 patent/US5801174A/en not_active Expired - Lifetime
- 1995-09-12 AT AT95932730T patent/ATE188701T1/de not_active IP Right Cessation
- 1995-09-12 CA CA002199614A patent/CA2199614C/en not_active Expired - Fee Related
-
1997
- 1997-02-25 FI FI970785A patent/FI112486B/fi active
- 1997-02-27 NO NO970903A patent/NO308851B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0781285B1 (en) | 2000-01-12 |
| NO970903D0 (no) | 1997-02-27 |
| CA2199614A1 (en) | 1996-03-21 |
| JPH09511525A (ja) | 1997-11-18 |
| NO308851B1 (no) | 2000-11-06 |
| JP3164372B2 (ja) | 2001-05-08 |
| EP0781285A1 (en) | 1997-07-02 |
| DE69514533T2 (de) | 2000-07-06 |
| FI112486B (fi) | 2003-12-15 |
| US5801174A (en) | 1998-09-01 |
| DE69514533D1 (de) | 2000-02-17 |
| EE9700051A (et) | 1997-08-15 |
| NO970903L (no) | 1997-05-07 |
| AU3566595A (en) | 1996-03-29 |
| CA2199614C (en) | 2000-02-22 |
| NZ293266A (en) | 1998-01-26 |
| WO1996008495A1 (en) | 1996-03-21 |
| FI970785A (fi) | 1997-03-13 |
| FI970785A0 (fi) | 1997-02-25 |
| AU686888B2 (en) | 1998-02-12 |
| ATE188701T1 (de) | 2000-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE03772B1 (et) | Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamine | |
| UA50767C2 (uk) | Похідні індолу, що використовуються як антагоністи рецептора ендотеліну, спосіб їх одержання, фармацевтична композиція та спосіб лікування | |
| CA2404464A1 (en) | Pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative disorders | |
| NO981609L (no) | Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak | |
| NZ528997A (en) | Sulfonamides | |
| BRPI0512086A (pt) | composto e os sais farmacologicamente aceitáveis do mesmo, composição farmacêutica, e, processo para a preparação de compostos | |
| NO305287B1 (no) | AMPA antagonister | |
| HUP9700595A1 (hu) | Fluor-alkil- és fluor-alkoxicsoporttal helyettesített heterociklikus bradikinin-antagonisták, eljárás ezek előállítására, valamint ezek alkalmazása | |
| PT902684E (pt) | Derivados hexa-hidro-pirido(4,3-b)indolo utilizados como farmacos antipsicoticos | |
| ATE188700T1 (de) | Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung | |
| MXPA04005077A (es) | Derivados de benzotiazol. | |
| ES2182509T3 (es) | Derivados de n-ariloxietilamina para el tratamiento de la depresion. | |
| DE69510510T2 (de) | N-benzoylmethylsubstituierte paroxetinderivate | |
| DE69526452T2 (de) | Indolditerpen alkaloide | |
| DK0699197T3 (da) | 4-p-flourbenzoyl-1-piperidinyl-propoxy-chromen-4-on-derivater, deres fremstilling og deres anvendelse i behandlingen af psy | |
| PT1082116E (pt) | Utilizacao de derivados de 4-piperidinometanol no tratamento de desordens do neurodesenvolvimento | |
| ES2161892T3 (es) | Derivados de indol como profarmacos de agonistas de los receptores afines a 5-ht1. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20070912 |