ECSP14013316A - ANTICUERPOS CAPACES DE NEUTRALIZAR LAS PRINCIPALES EXOTOXINAS TcdA y TcdB de Clostridium difficile - Google Patents

ANTICUERPOS CAPACES DE NEUTRALIZAR LAS PRINCIPALES EXOTOXINAS TcdA y TcdB de Clostridium difficile

Info

Publication number
ECSP14013316A
ECSP14013316A ECSP14013316A ECSP14013316A EC SP14013316 A ECSP14013316 A EC SP14013316A EC SP14013316 A ECSP14013316 A EC SP14013316A EC SP14013316 A ECSP14013316 A EC SP14013316A
Authority
EC
Ecuador
Prior art keywords
tcdb
exotoxins
main
clostridium difficile
antibodies
Prior art date
Application number
Other languages
English (en)
Spanish (es)
Inventor
Matthew Cox
Kerry Louise Tyson
David Paul Humphreys
Daniel John Lightwood
David Edward Ormonde Knight
Karine Jeannine Madeleine Hervé
Joanne Elizabeth Compson
Matthew Jon Timothy Page
Andrew Charles Payne
Nicola Louise Fisher
Brendon Mackenzie
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46881094&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP14013316(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of ECSP14013316A publication Critical patent/ECSP14013316A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91097—Hexosyltransferases (general) (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ECSP14013316 2011-09-16 2014-04-16 ANTICUERPOS CAPACES DE NEUTRALIZAR LAS PRINCIPALES EXOTOXINAS TcdA y TcdB de Clostridium difficile ECSP14013316A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161535532P 2011-09-16 2011-09-16
US201261638731P 2012-04-26 2012-04-26

Publications (1)

Publication Number Publication Date
ECSP14013316A true ECSP14013316A (es) 2014-08-29

Family

ID=46881094

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP14013316 ECSP14013316A (es) 2011-09-16 2014-04-16 ANTICUERPOS CAPACES DE NEUTRALIZAR LAS PRINCIPALES EXOTOXINAS TcdA y TcdB de Clostridium difficile

Country Status (30)

Country Link
US (2) US10752676B2 (https=)
EP (2) EP2758432B1 (https=)
JP (3) JP6152107B2 (https=)
KR (1) KR20140063825A (https=)
CN (2) CN103958544B (https=)
AU (1) AU2012307157B2 (https=)
BR (1) BR112014006175B1 (https=)
CA (1) CA2848611A1 (https=)
CL (1) CL2014000491A1 (https=)
CO (1) CO6930310A2 (https=)
CY (1) CY1121673T1 (https=)
DK (1) DK2758432T3 (https=)
EA (1) EA032475B1 (https=)
EC (1) ECSP14013316A (https=)
ES (1) ES2729278T3 (https=)
HK (1) HK1199463A1 (https=)
HR (1) HRP20190917T1 (https=)
HU (1) HUE043661T2 (https=)
IL (1) IL231167A0 (https=)
LT (1) LT2758432T (https=)
MX (1) MX2014002769A (https=)
PE (1) PE20141547A1 (https=)
PH (1) PH12014500456A1 (https=)
PL (1) PL2758432T3 (https=)
PT (1) PT2758432T (https=)
SG (2) SG11201400193SA (https=)
SI (1) SI2758432T1 (https=)
TN (1) TN2014000101A1 (https=)
WO (1) WO2013038156A1 (https=)
ZA (1) ZA201402760B (https=)

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CN109776676A (zh) * 2012-11-28 2019-05-21 Cnj控股公司 针对艰难梭菌的抗体
CN105451762A (zh) * 2013-04-22 2016-03-30 俄克拉荷马州大学评议会 艰难梭菌疫苗及使用方法
WO2015123767A1 (en) * 2014-02-18 2015-08-27 The Hospital For Sick Children Compositions and methods for treating or preventing clostridium infection
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US12071666B2 (en) * 2016-12-14 2024-08-27 Merck Sharp & Dohme Llc Human genetic markers associated with response to treatments that target clostridium difficile toxin B
CN110607314B (zh) * 2019-10-31 2022-09-23 四川农业大学 一种TcdB RBD基因、重组RBD蛋白和应用
CN111763263A (zh) * 2020-07-09 2020-10-13 宁夏医科大学 一种艰难梭菌抗原及多克隆抗体的制备方法和检测试剂盒
CN112500484B (zh) * 2021-01-29 2021-06-08 迈杰转化医学研究(苏州)有限公司 一种抗trop2抗体及其应用
CN121379975B (zh) * 2025-12-25 2026-04-17 天津一瑞生物科技股份有限公司 抗TcdB毒素杂交瘤细胞株、单克隆抗体及应用

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Also Published As

Publication number Publication date
AU2012307157B2 (en) 2017-08-03
PL2758432T3 (pl) 2019-08-30
SG10201701055WA (en) 2017-03-30
ZA201402760B (en) 2016-03-30
CN103958544B (zh) 2018-04-24
MX2014002769A (es) 2014-06-11
HUE043661T2 (hu) 2019-08-28
JP2015501286A (ja) 2015-01-15
JP6152107B2 (ja) 2017-06-21
EP3617227A2 (en) 2020-03-04
WO2013038156A1 (en) 2013-03-21
IL231167A0 (en) 2014-04-30
CY1121673T1 (el) 2020-07-31
TN2014000101A1 (en) 2015-07-01
US20200377578A1 (en) 2020-12-03
AU2012307157A1 (en) 2014-04-24
PT2758432T (pt) 2019-06-14
SG11201400193SA (en) 2014-05-29
EP2758432B1 (en) 2019-03-06
HK1199463A1 (en) 2015-07-03
CL2014000491A1 (es) 2014-12-26
CN108424449A (zh) 2018-08-21
KR20140063825A (ko) 2014-05-27
DK2758432T3 (da) 2019-06-03
CN103958544A (zh) 2014-07-30
NZ623293A (en) 2016-05-27
CA2848611A1 (en) 2013-03-21
EP3617227A3 (en) 2020-06-03
JP2020037555A (ja) 2020-03-12
US20140348844A1 (en) 2014-11-27
JP6603685B2 (ja) 2019-11-06
EA032475B1 (ru) 2019-06-28
JP2017149773A (ja) 2017-08-31
EP2758432A1 (en) 2014-07-30
ES2729278T3 (es) 2019-10-31
US10752676B2 (en) 2020-08-25
EA201400345A1 (ru) 2014-09-30
CO6930310A2 (es) 2014-04-28
PE20141547A1 (es) 2014-10-25
LT2758432T (lt) 2019-06-10
HRP20190917T1 (hr) 2019-07-26
SI2758432T1 (sl) 2019-07-31
BR112014006175A2 (pt) 2017-04-04
BR112014006175B1 (pt) 2020-02-11
PH12014500456A1 (en) 2014-04-14

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