ECSP024365A - Moleculas mutantes solubles ctla4 y sus aplicaciones - Google Patents

Moleculas mutantes solubles ctla4 y sus aplicaciones

Info

Publication number
ECSP024365A
ECSP024365A EC2002004365A ECSP024365A ECSP024365A EC SP024365 A ECSP024365 A EC SP024365A EC 2002004365 A EC2002004365 A EC 2002004365A EC SP024365 A ECSP024365 A EC SP024365A EC SP024365 A ECSP024365 A EC SP024365A
Authority
EC
Ecuador
Prior art keywords
ctla4
mutant molecules
applications
amino acid
molecules
Prior art date
Application number
EC2002004365A
Other languages
English (en)
Spanish (es)
Inventor
Juergen Bajorath
Robert J Peach
Joseph R Naemura
Peter S Linsley
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ECSP024365A publication Critical patent/ECSP024365A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EC2002004365A 2000-05-26 2002-11-26 Moleculas mutantes solubles ctla4 y sus aplicaciones ECSP024365A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26

Publications (1)

Publication Number Publication Date
ECSP024365A true ECSP024365A (es) 2003-03-31

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2002004365A ECSP024365A (es) 2000-05-26 2002-11-26 Moleculas mutantes solubles ctla4 y sus aplicaciones

Country Status (41)

Country Link
EP (3) EP1536234B1 (member.php)
JP (1) JP4328525B2 (member.php)
KR (2) KR100889887B1 (member.php)
CN (2) CN101255192A (member.php)
AR (1) AR031699A1 (member.php)
AT (1) ATE271066T1 (member.php)
AU (2) AU2001263466C1 (member.php)
BE (1) BE2011C041I2 (member.php)
BR (1) BRPI0111191B8 (member.php)
CA (1) CA2409748C (member.php)
CY (2) CY2011019I1 (member.php)
CZ (1) CZ304451B6 (member.php)
DE (2) DE60104282T2 (member.php)
DK (1) DK1248802T3 (member.php)
EC (1) ECSP024365A (member.php)
EE (2) EE05458B1 (member.php)
EG (1) EG24459A (member.php)
ES (2) ES2571852T3 (member.php)
FR (1) FR11C0053I2 (member.php)
GE (1) GEP20053658B (member.php)
HK (1) HK1048126B (member.php)
HU (2) HU228137B1 (member.php)
IL (1) IL152315A (member.php)
LT (1) LT5133B (member.php)
LU (1) LU91902I2 (member.php)
LV (1) LV12994B (member.php)
MX (1) MXPA02011534A (member.php)
MY (1) MY136113A (member.php)
NO (2) NO330797B1 (member.php)
PE (1) PE20011338A1 (member.php)
PL (1) PL206267B1 (member.php)
PT (1) PT1248802E (member.php)
RU (1) RU2283847C2 (member.php)
SI (1) SI1248802T1 (member.php)
SK (1) SK288131B6 (member.php)
TR (1) TR200402703T4 (member.php)
TW (2) TWI314933B (member.php)
UA (1) UA87432C2 (member.php)
UY (1) UY26723A1 (member.php)
WO (1) WO2001092337A2 (member.php)
ZA (1) ZA200208944B (member.php)

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US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
EP1372696B1 (en) * 2000-07-03 2008-07-23 Bristol-Myers Squibb Company Methods for treating rheumatic diseases using a soluble ctla4 molecule
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
PL204899B1 (pl) 2001-05-23 2010-02-26 Bristol Myers Squibb Co Zastosowanie rozpuszczalnej zmutowanej cząsteczki CTLA4
CA2482042A1 (en) * 2002-04-19 2003-10-30 Bristol-Myers Squibb Company Methods for treating an autoimmune disease using a soluble ctla4 molecule and a dmard or nsaid
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
CA2511520A1 (en) 2002-12-23 2004-07-15 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
PT1576182E (pt) 2002-12-23 2011-01-21 Bristol Myers Squibb Co Optimizador da qualidade do produto em processos de cultura celular de mamíferos destinados à produção de proteínas
CA2511823A1 (en) 2002-12-30 2004-07-22 Amgen Inc. Combination therapy with co-stimulatory factors
CA2543484C (en) 2003-10-27 2014-02-04 Amgen Inc. Modulation of immune response to an immunogen with ctla-4 and tnfbp
AU2006330922B2 (en) 2005-12-20 2012-07-26 Bristol-Myers Squibb Company Compositions and methods for producing a composition
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
US7510844B2 (en) 2006-01-24 2009-03-31 Bristol-Myers Squibb Company CD86 and CD80 receptor competition assays
WO2008005290A2 (en) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Methods for testing anti-thrombotic agents
GB0620934D0 (en) 2006-10-20 2006-11-29 Cambridge Antibody Tech Protein variants
JP2010513539A (ja) 2006-12-20 2010-04-30 エムエムアール インフォメーション システムズ,インコーポレーテッド 抗体とその製造法および使用法
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HRP20180045T1 (hr) * 2008-10-02 2018-03-23 Aptevo Research And Development Llc Proteini antagonisti cd86 koji se vežu na više meta
US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
KR20130049775A (ko) 2010-03-12 2013-05-14 애브비 바이오테라퓨틱스 인크. Ctla4 단백질 및 이의 용도
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WO2013148049A1 (en) * 2012-03-29 2013-10-03 The General Hospital Corporation Recombinant cytotoxic t-lymphocyte-associated protein 4 (ctla4)
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US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
CN113138279A (zh) 2012-06-27 2021-07-20 法姆制药有限责任公司 融合蛋白组合物的应用
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
AU2014376225C1 (en) 2014-01-13 2025-06-05 Amgen Inc. Regulating ornithine metabolism to manipulate the high mannose glycoform content of recombinant proteins
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
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EP4667012A2 (en) 2016-09-19 2025-12-24 OncoC4, Inc. Cd80 and cd86 binding protein compositions and uses thereof
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CN109453383A (zh) * 2018-11-12 2019-03-12 陈慧慧 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用
US12552853B2 (en) 2018-11-30 2026-02-17 Alpine Immune Sciences, Inc. CD86 variant immunomodulatory proteins and uses thereof
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EP1372696B1 (en) * 2000-07-03 2008-07-23 Bristol-Myers Squibb Company Methods for treating rheumatic diseases using a soluble ctla4 molecule

Also Published As

Publication number Publication date
KR20030009502A (ko) 2003-01-29
BR0111191A (pt) 2004-07-06
HUP0302201A2 (hu) 2003-10-28
UY26723A1 (es) 2001-12-28
LT5133B (lt) 2004-05-25
EE05458B1 (et) 2011-08-15
CA2409748C (en) 2008-09-16
NO330797B1 (no) 2011-07-18
TWI314933B (en) 2009-09-21
FR11C0053I2 (fr) 2013-01-11
CN1309735C (zh) 2007-04-11
HK1071931A1 (en) 2005-08-05
NO20025656L (no) 2002-11-25
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
AU2001263466C1 (en) 2006-10-26
AU2001263466B2 (en) 2006-04-27
TR200402703T4 (tr) 2004-11-22
LT2002114A (en) 2003-12-29
IL152315A0 (en) 2003-05-29
ZA200208944B (en) 2004-02-13
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
BRPI0111191B8 (pt) 2021-05-25
NO2011027I2 (member.php) 2011-12-15
EP1248802B9 (en) 2005-05-11
BE2011C041I2 (member.php) 2020-08-20
CA2409748A1 (en) 2001-12-06
JP4328525B2 (ja) 2009-09-09
CY2011019I1 (el) 2016-12-14
UA87432C2 (uk) 2009-07-27
KR100889887B1 (ko) 2009-03-24
HK1048126A1 (en) 2003-03-21
LV12994B (en) 2003-08-20
ES2571852T3 (es) 2016-05-27
FR11C0053I1 (member.php) 2012-01-13
DE60104282T2 (de) 2005-10-13
AR031699A1 (es) 2003-10-01
IL152315A (en) 2010-04-15
MXPA02011534A (es) 2004-08-12
EP1536234A3 (en) 2009-06-03
ATE271066T1 (de) 2004-07-15
NO2011027I1 (no) 2012-01-09
HUS1300012I1 (hu) 2016-08-29
EP3029062A1 (en) 2016-06-08
EP1248802B1 (en) 2004-07-14
GEP20053658B (en) 2005-11-10
SK15702002A3 (sk) 2004-01-08
JP2004511213A (ja) 2004-04-15
BRPI0111191B1 (pt) 2019-12-31
RU2283847C2 (ru) 2006-09-20
CY1117625T1 (el) 2017-04-26
HU228137B1 (en) 2012-12-28
PL206267B1 (pl) 2010-07-30
EE201100050A (et) 2011-10-17
SI1248802T1 (en) 2005-02-28
EE200200659A (et) 2004-06-15
EG24459A (en) 2009-07-16
EE05557B1 (et) 2012-08-15
DE60104282D1 (de) 2004-08-19
CN1441810A (zh) 2003-09-10
KR100895134B1 (ko) 2009-05-04
EP1536234B1 (en) 2016-03-16
PT1248802E (pt) 2004-11-30
EP1536234A2 (en) 2005-06-01
TWI319405B (en) 2010-01-11
CZ304451B6 (cs) 2014-05-14
TW200906857A (en) 2009-02-16
NO20025656D0 (no) 2002-11-25
PE20011338A1 (es) 2002-01-13
AU6346601A (en) 2001-12-11
DK1248802T3 (da) 2004-11-15
ES2225549T3 (es) 2005-03-16
SK288131B6 (sk) 2013-10-02
WO2001092337A3 (en) 2002-05-10
PL366231A1 (en) 2005-01-24
CZ20023892A3 (cs) 2003-09-17
HK1048126B (en) 2005-03-04
CN101255192A (zh) 2008-09-03
DE122011100063I1 (de) 2012-06-14
HUP0302201A3 (en) 2010-01-28
MY136113A (en) 2008-08-29
WO2001092337A2 (en) 2001-12-06

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